Page last updated: 2024-10-28

hydrochlorothiazide and Weight Loss

hydrochlorothiazide has been researched along with Weight Loss in 9 studies

Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

Weight Loss: Decrease in existing BODY WEIGHT.

Research Excerpts

ExcerptRelevanceReference
"Seventy-seven patients received large doses of furosemide (> or = 80 mg/24 h) at some time during the postoperative course, and of these 20 responded poorly to furosemide (weight loss 0."5.08Addition of a thiazide: an effective remedy for furosemide resistance after cardiac operations. ( Broquist, M; Svedjeholm, R; Vánky, F, 1997)
"Hypertension affects approximately 116 million adults in the US and more than 1 billion adults worldwide and is a leading cause of CVD morbidity and mortality."2.82Treatment of Hypertension: A Review. ( Carey, RM; Moran, AE; Whelton, PK, 2022)
"Subjects' mean age was 56 years, type 2 diabetes mellitus (T2DM) duration 6."2.78Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. ( de Zeeuw, D; Lambers Heerspink, HJ; Leslie, B; List, J; Wie, L, 2013)
"To discover whether in hypertensives with left ventricular hypertrophy (LVH) the increased muscle mass will completely regress under antihypertensive treatment and drug dosage can in consequence be reduced."1.29[Decreasing the antihypertensive dosage during longterm treatment and complete regression of left ventricular hypertrophy]. ( Behr, U; Franz, IW; Ketelhut, R; Tönnesmann, U, 1996)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's2 (22.22)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Carey, RM1
Moran, AE1
Whelton, PK1
Piardi, DS1
Butzke, M1
Mazzuca, ACM1
Gomes, BS1
Alves, SG1
Kotzian, BJ1
Ghisleni, EC1
Giaretta, V1
Bellaver, P1
Varaschin, GA1
Garbin, AP1
Beck-da-Silva, L1
Lambers Heerspink, HJ1
de Zeeuw, D1
Wie, L1
Leslie, B1
List, J1
El-Haddad, B1
Hammoud, D1
Shaver, T1
Shahouri, S1
Willis, SL1
Moawad, FJ1
Hartzell, JD1
Iglesias, M1
Jackson, WL1
Parhofer, KG1
Münzel, F1
Krekler, M1
Franz, IW1
Behr, U1
Ketelhut, R1
Tönnesmann, U1
Vánky, F1
Broquist, M1
Svedjeholm, R1
Freis, ED1
Reda, DJ1
Materson, BJ1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Dapagliflozin Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion[NCT02113241]Phase 2/Phase 324 participants (Actual)Interventional2014-04-30Completed
A Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes[NCT02887677]Phase 485 participants (Actual)Interventional2016-10-31Terminated (stopped due to On February 2019 Astra-Zeneca Greece decided to stop the financial support of the study.)
Assessment of the Renin-angiotensin-aldosterone System (RAAS) and Antidiuretic Function in Patients With Type 2 Diabetes Before and During Treatment With Sodium-glucose Co-transporter 2 Inhibitors (SGLT2i): the GliRACo 1 Study[NCT03917758]30 participants (Anticipated)Interventional2018-10-10Recruiting
Effect of Dapagliflozin on the Progression From Prediabetes to T2DM in Subjects With Myocardial Infarction[NCT03658031]Phase 3576 participants (Anticipated)Interventional2019-03-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Alanine Aminotransferase (ALT) at Week 12.

The ALT hepatic transaminase levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12.

InterventionU/L (Mean)
Dapagliflozin32.1
Placebo38.1

Aspartate Aminotransferase (AST) at Week 12.

The hepatic transaminase AST will be evaluated with standardized methods at week 12 (NCT02113241)
Timeframe: Week 12

InterventionU/L (Mean)
Dapagliflozin31.1
Placebo29.5

AUC of Glucose at Week 12.

The AUC of glucose will be calculated from the glucose values obtained from the minuted oral glucose tolerance curve at week 12 (NCT02113241)
Timeframe: Week 12

Interventionmmol*hr/L (Mean)
Dapagliflozin1153
Placebo1129

AUC of Insulin at Week 12.

The AUC will be calculated from the insulin values obtained from the minuted oral glucose tolerance curve at week 12 (NCT02113241)
Timeframe: Week 12

Interventionpmol*h/L (Mean)
Dapagliflozin45016
Placebo119704

Body Mass Index at Week 12

The Body Mass index it's going to be calculated at week 12 with the Quetelet index. (NCT02113241)
Timeframe: Week 12

Interventionkg/m^2 (Mean)
Dapagliflozin32.6
Placebo32.1

Body Weight at Week 12.

The weight it's going to be measured at week 12 with a bioimpedance balance. (NCT02113241)
Timeframe: Week 12

Interventionkilograms (Mean)
Dapagliflozin81.2
Placebo79.6

Creatinine at Week 12.

The creatinine levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12.

Interventionmmol/L (Mean)
Dapagliflozin0.07
Placebo0.05

Diastolic Blood Pressure at Week 12.

The diastolic blood pressure is going to be evaluated at week 12 with a digital sphygmomanometer. (NCT02113241)
Timeframe: Week 12

InterventionmmHg (Mean)
Dapagliflozin76
Placebo79

Fat Mass at Week 12.

The fat mass is going to be evaluated at week 12 through bioimpedance. (NCT02113241)
Timeframe: Week 12

Interventionkilograms (Mean)
Dapagliflozin32.7
Placebo34.4

Glucose at Minute 120 at Week 12.

The glucose at minute 120 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin8.5
Placebo8.8

Glucose at Minute 30 at Week 12.

The glucose at minute 30 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin10.5
Placebo10.0

Glucose at Minute 60 at Week 12.

The glucose at minute 60 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin11.1
Placebo11.4

Glucose at Minute 90 at Week 12.

The glucose at minute 90 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin9.8
Placebo9.9

Glucose Levels at Minute 0 at Week 12.

The fasting glucose (0') levels are going to be evaluated at week 12 with enzymatic/colorimetric techniques. (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin5.7
Placebo5.8

High Density Lipoprotein (c-HDL) Levels at Week 12.

The c-HDL levels are going to be evaluated at week 12 with enzymatic/colorimetric techniques. (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin1.3
Placebo1.3

Insulinogenic Index (Total Insulin Secretion) at Week 12.

"The insulinogenic index is a ratio that relates enhancement of circulating insulin to the magnitude of the corresponding glycemic stimulus.~Total insulin secretion was calculated with the insulinogenic index (ΔAUC insulin/ΔAUC glucose), the entered values reflect the total insulin secretion at week 12." (NCT02113241)
Timeframe: Week 12

Interventionindex (Mean)
Dapagliflozin0.35
Placebo0.99

Low Density Lipoproteins (c-LDL) at Week 12

The c-LDL levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin3.1
Placebo2.8

Matsuda Index (Total Insulin Sensitivity) at Week 12.

Matsuda Index value is used to indicate insulin resistance on diabetes. Insulin sensitivity was calculated with Matsuda index [10,000 / √glucose 0' x insulin 0') (mean glucose oral glucose tolerance test (OGTT) x mean insulin OGTT)]. The entered values reflect the insulin sensitivity at week 12. (NCT02113241)
Timeframe: Week 12

Interventionindex (Mean)
Dapagliflozin2.7
Placebo1.6

Stumvoll Index (First Phase of Insulin Secretion) at Week 12.

"Human studies support the critical physiologic role of the first-phase of insulin secretion in the maintenance of postmeal glucose homeostasis.~First phase of insulin secretion was estimated using the Stumvoll index (1283+ 1.829 x insulin 30' - 138.7 x glucose 30' + 3.772 x insulin 0'), the entered values reflect the frst phase of insulin secretion at week 12." (NCT02113241)
Timeframe: Week 12

Interventionindex (Mean)
Dapagliflozin1463
Placebo2198

Systolic Blood Pressure at Week 12.

The systolic blood pressure is going to be evaluated at week 12 with a digital sphygmomanometer. (NCT02113241)
Timeframe: Week 12

InterventionmmHg (Mean)
Dapagliflozin117
Placebo121

Total Cholesterol at Week 12

The total cholesterol will be estimated by standardized techniques at week 12. (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin5.2
Placebo4.9

Triglycerides Levels at Week 12.

The triglycerides levels are going to be evaluated at week 12 with enzymatic-colorimetric techniques. (NCT02113241)
Timeframe: Week 12

Interventionmmol/L (Mean)
Dapagliflozin1.7
Placebo1.7

Uric Acid at Week 12.

The uric acid levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12.

Interventionumol/L (Mean)
Dapagliflozin243.9
Placebo339.0

Waist Circumference at Week 12.

The waist circumference is going to be evaluated at week 12 with a flexible tape with standardized techniques. (NCT02113241)
Timeframe: Week 12

Interventioncentimeters (Mean)
Dapagliflozin97.6
Placebo97.2

Reviews

1 review available for hydrochlorothiazide and Weight Loss

ArticleYear
Treatment of Hypertension: A Review.
    JAMA, 2022, 11-08, Volume: 328, Issue:18

    Topics: Adult; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive

2022

Trials

5 trials available for hydrochlorothiazide and Weight Loss

ArticleYear
Effect of adding hydrochlorothiazide to usual treatment of patients with acute decompensated heart failure: a randomized clinical trial.
    Scientific reports, 2021, 08-13, Volume: 11, Issue:1

    Topics: Creatinine; Diuretics; Double-Blind Method; Female; Furosemide; Heart Failure; Humans; Hydrochloroth

2021
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ

2013
Effect of the angiotensin receptor blocker irbesartan on metabolic parameters in clinical practice: the DO-IT prospective observational study.
    Cardiovascular diabetology, 2007, Nov-27, Volume: 6

    Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure

2007
Addition of a thiazide: an effective remedy for furosemide resistance after cardiac operations.
    The Annals of thoracic surgery, 1997, Volume: 63, Issue:4

    Topics: Administration, Oral; Aged; Amiloride; Coronary Artery Bypass; Creatinine; Diuretics; Drug Administr

1997
Volume (weight) loss and blood pressure response following thiazide diuretics.
    Hypertension (Dallas, Tex. : 1979), 1988, Volume: 12, Issue:3

    Topics: Black People; Blood Pressure; Diuretics; Dose-Response Relationship, Drug; Humans; Hydrochlorothiazi

1988

Other Studies

3 other studies available for hydrochlorothiazide and Weight Loss

ArticleYear
Malignancy-associated multicentric reticulohistiocytosis.
    Rheumatology international, 2011, Volume: 31, Issue:9

    Topics: Antihypertensive Agents; Antineoplastic Agents; Arthralgia; Atenolol; Combined Modality Therapy; Dru

2011
Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut.
    MedGenMed : Medscape general medicine, 2006, Sep-28, Volume: 8, Issue:3

    Topics: Adult; Antihypertensive Agents; Humans; Hydrochlorothiazide; Hypertension, Malignant; Male; Plant Pr

2006
[Decreasing the antihypertensive dosage during longterm treatment and complete regression of left ventricular hypertrophy].
    Deutsche medizinische Wochenschrift (1946), 1996, Apr-12, Volume: 121, Issue:15

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Echocardiography; Exercis

1996