hydrochlorothiazide has been researched along with Weight Loss in 9 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Weight Loss: Decrease in existing BODY WEIGHT.
Excerpt | Relevance | Reference |
---|---|---|
"Seventy-seven patients received large doses of furosemide (> or = 80 mg/24 h) at some time during the postoperative course, and of these 20 responded poorly to furosemide (weight loss 0." | 5.08 | Addition of a thiazide: an effective remedy for furosemide resistance after cardiac operations. ( Broquist, M; Svedjeholm, R; Vánky, F, 1997) |
"Hypertension affects approximately 116 million adults in the US and more than 1 billion adults worldwide and is a leading cause of CVD morbidity and mortality." | 2.82 | Treatment of Hypertension: A Review. ( Carey, RM; Moran, AE; Whelton, PK, 2022) |
"Subjects' mean age was 56 years, type 2 diabetes mellitus (T2DM) duration 6." | 2.78 | Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. ( de Zeeuw, D; Lambers Heerspink, HJ; Leslie, B; List, J; Wie, L, 2013) |
"To discover whether in hypertensives with left ventricular hypertrophy (LVH) the increased muscle mass will completely regress under antihypertensive treatment and drug dosage can in consequence be reduced." | 1.29 | [Decreasing the antihypertensive dosage during longterm treatment and complete regression of left ventricular hypertrophy]. ( Behr, U; Franz, IW; Ketelhut, R; Tönnesmann, U, 1996) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (11.11) | 18.7374 |
1990's | 2 (22.22) | 18.2507 |
2000's | 2 (22.22) | 29.6817 |
2010's | 2 (22.22) | 24.3611 |
2020's | 2 (22.22) | 2.80 |
Authors | Studies |
---|---|
Carey, RM | 1 |
Moran, AE | 1 |
Whelton, PK | 1 |
Piardi, DS | 1 |
Butzke, M | 1 |
Mazzuca, ACM | 1 |
Gomes, BS | 1 |
Alves, SG | 1 |
Kotzian, BJ | 1 |
Ghisleni, EC | 1 |
Giaretta, V | 1 |
Bellaver, P | 1 |
Varaschin, GA | 1 |
Garbin, AP | 1 |
Beck-da-Silva, L | 1 |
Lambers Heerspink, HJ | 1 |
de Zeeuw, D | 1 |
Wie, L | 1 |
Leslie, B | 1 |
List, J | 1 |
El-Haddad, B | 1 |
Hammoud, D | 1 |
Shaver, T | 1 |
Shahouri, S | 1 |
Willis, SL | 1 |
Moawad, FJ | 1 |
Hartzell, JD | 1 |
Iglesias, M | 1 |
Jackson, WL | 1 |
Parhofer, KG | 1 |
Münzel, F | 1 |
Krekler, M | 1 |
Franz, IW | 1 |
Behr, U | 1 |
Ketelhut, R | 1 |
Tönnesmann, U | 1 |
Vánky, F | 1 |
Broquist, M | 1 |
Svedjeholm, R | 1 |
Freis, ED | 1 |
Reda, DJ | 1 |
Materson, BJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effect of Dapagliflozin Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion[NCT02113241] | Phase 2/Phase 3 | 24 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
A Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes[NCT02887677] | Phase 4 | 85 participants (Actual) | Interventional | 2016-10-31 | Terminated (stopped due to On February 2019 Astra-Zeneca Greece decided to stop the financial support of the study.) | ||
Assessment of the Renin-angiotensin-aldosterone System (RAAS) and Antidiuretic Function in Patients With Type 2 Diabetes Before and During Treatment With Sodium-glucose Co-transporter 2 Inhibitors (SGLT2i): the GliRACo 1 Study[NCT03917758] | 30 participants (Anticipated) | Interventional | 2018-10-10 | Recruiting | |||
Effect of Dapagliflozin on the Progression From Prediabetes to T2DM in Subjects With Myocardial Infarction[NCT03658031] | Phase 3 | 576 participants (Anticipated) | Interventional | 2019-03-01 | Not yet recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The ALT hepatic transaminase levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12.
Intervention | U/L (Mean) |
---|---|
Dapagliflozin | 32.1 |
Placebo | 38.1 |
The hepatic transaminase AST will be evaluated with standardized methods at week 12 (NCT02113241)
Timeframe: Week 12
Intervention | U/L (Mean) |
---|---|
Dapagliflozin | 31.1 |
Placebo | 29.5 |
The AUC of glucose will be calculated from the glucose values obtained from the minuted oral glucose tolerance curve at week 12 (NCT02113241)
Timeframe: Week 12
Intervention | mmol*hr/L (Mean) |
---|---|
Dapagliflozin | 1153 |
Placebo | 1129 |
The AUC will be calculated from the insulin values obtained from the minuted oral glucose tolerance curve at week 12 (NCT02113241)
Timeframe: Week 12
Intervention | pmol*h/L (Mean) |
---|---|
Dapagliflozin | 45016 |
Placebo | 119704 |
The Body Mass index it's going to be calculated at week 12 with the Quetelet index. (NCT02113241)
Timeframe: Week 12
Intervention | kg/m^2 (Mean) |
---|---|
Dapagliflozin | 32.6 |
Placebo | 32.1 |
The weight it's going to be measured at week 12 with a bioimpedance balance. (NCT02113241)
Timeframe: Week 12
Intervention | kilograms (Mean) |
---|---|
Dapagliflozin | 81.2 |
Placebo | 79.6 |
The creatinine levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12.
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 0.07 |
Placebo | 0.05 |
The diastolic blood pressure is going to be evaluated at week 12 with a digital sphygmomanometer. (NCT02113241)
Timeframe: Week 12
Intervention | mmHg (Mean) |
---|---|
Dapagliflozin | 76 |
Placebo | 79 |
The fat mass is going to be evaluated at week 12 through bioimpedance. (NCT02113241)
Timeframe: Week 12
Intervention | kilograms (Mean) |
---|---|
Dapagliflozin | 32.7 |
Placebo | 34.4 |
The glucose at minute 120 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 8.5 |
Placebo | 8.8 |
The glucose at minute 30 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 10.5 |
Placebo | 10.0 |
The glucose at minute 60 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 11.1 |
Placebo | 11.4 |
The glucose at minute 90 is going to be evaluated at week 12 during a minuted oral glucose tolerance curve (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 9.8 |
Placebo | 9.9 |
The fasting glucose (0') levels are going to be evaluated at week 12 with enzymatic/colorimetric techniques. (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 5.7 |
Placebo | 5.8 |
The c-HDL levels are going to be evaluated at week 12 with enzymatic/colorimetric techniques. (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 1.3 |
Placebo | 1.3 |
"The insulinogenic index is a ratio that relates enhancement of circulating insulin to the magnitude of the corresponding glycemic stimulus.~Total insulin secretion was calculated with the insulinogenic index (ΔAUC insulin/ΔAUC glucose), the entered values reflect the total insulin secretion at week 12." (NCT02113241)
Timeframe: Week 12
Intervention | index (Mean) |
---|---|
Dapagliflozin | 0.35 |
Placebo | 0.99 |
The c-LDL levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 3.1 |
Placebo | 2.8 |
Matsuda Index value is used to indicate insulin resistance on diabetes. Insulin sensitivity was calculated with Matsuda index [10,000 / √glucose 0' x insulin 0') (mean glucose oral glucose tolerance test (OGTT) x mean insulin OGTT)]. The entered values reflect the insulin sensitivity at week 12. (NCT02113241)
Timeframe: Week 12
Intervention | index (Mean) |
---|---|
Dapagliflozin | 2.7 |
Placebo | 1.6 |
"Human studies support the critical physiologic role of the first-phase of insulin secretion in the maintenance of postmeal glucose homeostasis.~First phase of insulin secretion was estimated using the Stumvoll index (1283+ 1.829 x insulin 30' - 138.7 x glucose 30' + 3.772 x insulin 0'), the entered values reflect the frst phase of insulin secretion at week 12." (NCT02113241)
Timeframe: Week 12
Intervention | index (Mean) |
---|---|
Dapagliflozin | 1463 |
Placebo | 2198 |
The systolic blood pressure is going to be evaluated at week 12 with a digital sphygmomanometer. (NCT02113241)
Timeframe: Week 12
Intervention | mmHg (Mean) |
---|---|
Dapagliflozin | 117 |
Placebo | 121 |
The total cholesterol will be estimated by standardized techniques at week 12. (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 5.2 |
Placebo | 4.9 |
The triglycerides levels are going to be evaluated at week 12 with enzymatic-colorimetric techniques. (NCT02113241)
Timeframe: Week 12
Intervention | mmol/L (Mean) |
---|---|
Dapagliflozin | 1.7 |
Placebo | 1.7 |
The uric acid levels are going to be measured at week 12 with standardized techniques. (NCT02113241)
Timeframe: Week 12.
Intervention | umol/L (Mean) |
---|---|
Dapagliflozin | 243.9 |
Placebo | 339.0 |
The waist circumference is going to be evaluated at week 12 with a flexible tape with standardized techniques. (NCT02113241)
Timeframe: Week 12
Intervention | centimeters (Mean) |
---|---|
Dapagliflozin | 97.6 |
Placebo | 97.2 |
1 review available for hydrochlorothiazide and Weight Loss
Article | Year |
---|---|
Treatment of Hypertension: A Review.
Topics: Adult; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2022 |
5 trials available for hydrochlorothiazide and Weight Loss
Article | Year |
---|---|
Effect of adding hydrochlorothiazide to usual treatment of patients with acute decompensated heart failure: a randomized clinical trial.
Topics: Creatinine; Diuretics; Double-Blind Method; Female; Furosemide; Heart Failure; Humans; Hydrochloroth | 2021 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2013 |
Effect of the angiotensin receptor blocker irbesartan on metabolic parameters in clinical practice: the DO-IT prospective observational study.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure | 2007 |
Addition of a thiazide: an effective remedy for furosemide resistance after cardiac operations.
Topics: Administration, Oral; Aged; Amiloride; Coronary Artery Bypass; Creatinine; Diuretics; Drug Administr | 1997 |
Volume (weight) loss and blood pressure response following thiazide diuretics.
Topics: Black People; Blood Pressure; Diuretics; Dose-Response Relationship, Drug; Humans; Hydrochlorothiazi | 1988 |
3 other studies available for hydrochlorothiazide and Weight Loss
Article | Year |
---|---|
Malignancy-associated multicentric reticulohistiocytosis.
Topics: Antihypertensive Agents; Antineoplastic Agents; Arthralgia; Atenolol; Combined Modality Therapy; Dru | 2011 |
Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut.
Topics: Adult; Antihypertensive Agents; Humans; Hydrochlorothiazide; Hypertension, Malignant; Male; Plant Pr | 2006 |
[Decreasing the antihypertensive dosage during longterm treatment and complete regression of left ventricular hypertrophy].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Echocardiography; Exercis | 1996 |