hydrochlorothiazide has been researched along with Uremia in 15 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite maintenance of these NIDDM patients on their current antihypertensive medication, PZG reduced further their systolic and diastolic pressures." | 2.67 | Effects of pyrazinoylguanidine on the glucose-fatty acid cycle in normal subjects and patients with non-insulin-dependent diabetes mellitus. ( Beyer, KH; Chambers, CE; Demers, LM; Passananti, GT; Vesell, ES, 1993) |
| "Treatment with losartan, captopril, and the TRx prevented the rhEPO-induced increased in systolic BP." | 1.33 | Antihypertensive and renal protective effects of renin-angiotensin system blockade in uremic rats treated with erythropoietin. ( Agharazii, M; Larivière, R; Lebel, M; Rodrigue, ME, 2006) |
| "Xipamide is a sulfonamide-like diuretic whose action does not depend on transtubular secretion." | 1.31 | Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid. ( Bellmann, R; Heininger, D; Joannidis, M; Kähler, C; Sandhofer, A; Wiedermann, CJ, 2002) |
| "In the present study we induced chronic renal failure by administration of lithium for 16 weeks to new-born rats, and examined the spontaneous course of this nephropathy and the effects of antihypertensive treatment with either perindopril (12 mg/kg diet) or hydrochlorothiazide (500-1000 mg/kg diet) during a 24 weeks follow up period without lithium." | 1.30 | Effects of perindopril and hydrochlorothiazide on the long-term progression of lithium-induced chronic renal failure in rats. ( Christensen, S; Hansen, AK; Marcussen, N; Shalmi, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sandhofer, A | 1 |
| Kähler, C | 1 |
| Heininger, D | 1 |
| Bellmann, R | 1 |
| Wiedermann, CJ | 1 |
| Joannidis, M | 1 |
| BERNSTEIN, A | 1 |
| ODZE, M | 1 |
| CREWS, A | 1 |
| SIMON, F | 1 |
| Lebel, M | 1 |
| Rodrigue, ME | 1 |
| Agharazii, M | 1 |
| Larivière, R | 1 |
| Wollam, GL | 1 |
| Tarazi, RC | 1 |
| Bravo, EL | 1 |
| Dustan, HP | 1 |
| Vesell, ES | 1 |
| Chambers, CE | 1 |
| Passananti, GT | 1 |
| Demers, LM | 1 |
| Beyer, KH | 1 |
| Champ, JD | 1 |
| Christensen, S | 1 |
| Shalmi, M | 1 |
| Hansen, AK | 1 |
| Marcussen, N | 1 |
| Pessina, AC | 1 |
| Palatini, P | 1 |
| Pigato, R | 1 |
| Hlede, M | 1 |
| Zawada, ET | 1 |
| Hollenberg, NK | 1 |
| Bannon, JA | 1 |
| Precht, K | 1 |
| Klinkmann, H | 1 |
| Freis, ED | 1 |
| Kim, KE | 1 |
| Onesti, G | 1 |
| Swartz, C | 1 |
| Seedat, YK | 1 |
| Naidoo, DN | 1 |
| Ackerman, GL | 1 |
| Flanigan, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933] | Phase 2 | 34 participants (Actual) | Interventional | 2019-06-18 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -3.4 |
| Treatment Grup | -13.5 |
Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.15 |
| Treatment Grup | 2.55 |
Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of ECW/TBW (Mean) |
|---|---|
| Placebo | -0.24 |
| Treatment Grup | -2.92 |
decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -5.4 |
| Treatment Grup | -18.1 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -10 |
| Treatment Grup | -26.1 |
Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of sodium excreted (Mean) |
|---|---|
| Placebo | -0.348 |
| Treatment Grup | 0.598 |
Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.075 |
| Treatment Grup | -4.36 |
1 review available for hydrochlorothiazide and Uremia
| Article | Year |
|---|---|
Effectiveness of drug therapy in hypertension: present status. A review.
Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block | 1971 |
4 trials available for hydrochlorothiazide and Uremia
| Article | Year |
|---|---|
Diuretic potency of combined hydrochlorothiazide and furosemide therapy in patients with azotemia.
Topics: Adult; Body Weight; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Furosemide; Huma | 1982 |
Effects of pyrazinoylguanidine on the glucose-fatty acid cycle in normal subjects and patients with non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Down-Regulation; Fatty Acids; Female; Glucose | 1993 |
Renal hemodynamic changes after beta-blocker-diuretic combination therapy in azotemic hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Drug Therapy, Combination; Glomerular Filtration Rate; Hum | 1986 |
The PACT study: post-marketing surveillance in 47,465 patients treated with Maxzide (triamterene/hydrochlorothiazide). An interim report.
Topics: Age Factors; Antihypertensive Agents; Clinical Trials as Topic; Drug Combinations; Female; Humans; H | 1986 |
10 other studies available for hydrochlorothiazide and Uremia
| Article | Year |
|---|---|
Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid.
Topics: Age Factors; Aged; Aged, 80 and over; Diuretics; Drug Therapy, Combination; Emergencies; Female; Fur | 2002 |
ETHACRYNIC ACID: A NEW POTENT DIURETIC.
Topics: Alkalosis; Blood Chemical Analysis; Blood Urea Nitrogen; Body Weight; Digitalis Glycosides; Diuresis | 1965 |
Antihypertensive and renal protective effects of renin-angiotensin system blockade in uremic rats treated with erythropoietin.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihype | 2006 |
Case report: azotemia secondary to enalapril and diuretic use and the diagnosis of renovascular hypertension.
Topics: Acute Kidney Injury; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension, Renovascular; Mid | 1993 |
Effects of perindopril and hydrochlorothiazide on the long-term progression of lithium-induced chronic renal failure in rats.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blood Pressure; Body Weight; Creatinine; Disease | 1997 |
[Changes in kidney function during hypotensive treatment].
Topics: Adult; Aged; Clonidine; Dihydralazine; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazid | 1976 |
[The nephrotic syndrome, clinical features and therapy].
Topics: Adrenocorticotropic Hormone; Adult; Humans; Hydrochlorothiazide; Male; Nephrotic Syndrome; Penicilli | 1965 |
Problems in therapy for the hypertensive patient.
Topics: Antihypertensive Agents; Blood Pressure; Carotid Sinus; Diuretics; Electric Stimulation; Ethacrynic | 1973 |
Evaluation of amiloride combined with hydrochlorothiazide (Moduretic) in the treatment of hypertension.
Topics: Adult; Aged; Amiloride; Benzothiadiazines; Diuretics; Drug Combinations; Female; Guanethidine; Human | 1973 |
Reversible insufficiency in chronic renal disease.
Topics: Aged; Blood Urea Nitrogen; Creatine; Diet Therapy; Humans; Hydrochlorothiazide; Kidney Failure, Chro | 1966 |