hydrochlorothiazide has been researched along with Muscle Contraction in 17 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with ramipril reduced blood pressure and force development in response to Bay K8644 in adult SHRSP, although not to levels of WKY rats, whereas WKY rats were unaffected by treatment." | 1.29 | Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats. ( Traub, O; Webb, RC, 1993) |
| "Indapamide was a far more potent inhibitor, a 10 microM concentration shifting the calcium dose-response curve 3 log units to the right and reducing maximal calcium contraction by 72% (P < ." | 1.29 | Ion channel involvement in the acute vascular effects of thiazide diuretics and related compounds. ( Calder, JA; Schachter, M; Sever, PS, 1993) |
| "5-OH-Indapamide is a principal metabolite of indapamide, and possesses similar antihypertensive and diuretic properties." | 1.29 | Vasorelaxant actions of 5-OH-indapamide, a major metabolite of indapamide: comparison with indapamide, hydrochlorothiazide and cicletanine. ( Calder, JA; Schachter, M; Sever, PS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Middeke, M | 1 |
| Holzgreve, H | 1 |
| Mironneau, J | 1 |
| Savineau, JP | 1 |
| Mironneau, C | 1 |
| Traub, O | 2 |
| Webb, RC | 2 |
| Contard, F | 1 |
| Glukhova, M | 1 |
| Sabri, A | 1 |
| Marotte, F | 1 |
| Sartore, S | 1 |
| Narcisse, G | 1 |
| Schatz, C | 1 |
| Guez, D | 1 |
| Rappaport, L | 1 |
| Samuel, JL | 1 |
| Pickkers, P | 1 |
| Hughes, AD | 1 |
| Terai, T | 1 |
| Kita, Y | 1 |
| Kusunoki, T | 1 |
| Shimazaki, T | 1 |
| Ando, T | 1 |
| Horiai, H | 1 |
| Akahane, A | 1 |
| Shiokawa, Y | 1 |
| Yoshida, K | 1 |
| Calder, JA | 2 |
| Schachter, M | 2 |
| Sever, PS | 2 |
| Künneke, M | 1 |
| Lorenz, W | 1 |
| Duda, D | 1 |
| Künkel, D | 1 |
| Schunack, W | 1 |
| Wang, GS | 1 |
| Li, YS | 1 |
| Fu, SX | 1 |
| Lloyd, MC | 1 |
| Klotz, U | 1 |
| Vapaatalo, H | 1 |
| Schenkel, R | 1 |
| Petter, A | 1 |
| Engelmann, K | 1 |
| Lamid, S | 1 |
| Wolff, FW | 1 |
| Jusic, A | 1 |
| Dogan, S | 1 |
| Stojanovic, V | 1 |
| Trunova, TL | 1 |
| Daniel, EE | 1 |
| Nash, CW | 1 |
1 trial available for hydrochlorothiazide and Muscle Contraction
| Article | Year |
|---|---|
[Blood pressure during isometric and dynamic exercise under long-term antihypertensive treatment with beta receptor blockaders and diuretics].
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Diuretics; E | 1983 |
16 other studies available for hydrochlorothiazide and Muscle Contraction
| Article | Year |
|---|---|
Compared effects of indapamide, hydrochlorothiazide and chlorthalidone on electrical and mechanical activities in vascular smooth muscle.
Topics: Animals; Calcium; Chlorthalidone; Diuretics; Hydrochlorothiazide; In Vitro Techniques; Indapamide; M | 1981 |
Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Comparative effects of indapamide and hydrochlorothiazide on cardiac hypertrophy and vascular smooth-muscle phenotype in the stroke-prone, spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Vessels; Hydrochlorothiazide; Hypertension; Indapami | 1993 |
Relaxation and decrease in [Ca2+]i by hydrochlorothiazide in guinea-pig isolated mesenteric arteries.
Topics: Animals; Caffeine; Calcium; Charybdotoxin; Guinea Pigs; Hydrochlorothiazide; In Vitro Techniques; Ma | 1995 |
A novel non-xanthine adenosine A1 receptor antagonist.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Diuretics; Electrolytes; Guinea Pigs; Heart | 1995 |
Ion channel involvement in the acute vascular effects of thiazide diuretics and related compounds.
Topics: Animals; Calcium Channels; Charybdotoxin; Diuretics; Drug Interactions; Glyburide; Guinea Pigs; Hydr | 1993 |
Unknown effects of clinically used drugs as bias in clinical trials: antihistaminergic activity of the antihypertensive fixed-dose combination Betathiazid.
Topics: Animals; Antihypertensive Agents; Carbachol; Drug Combinations; Guinea Pigs; Histamine; Histamine H1 | 1994 |
Effects of hydrochlorothiazide on contraction and 86Rb efflux in rat aorta.
Topics: Animals; Aorta, Thoracic; Barium Compounds; Chlorides; Glyburide; Hydrochlorothiazide; In Vitro Tech | 1993 |
Vasorelaxant actions of 5-OH-indapamide, a major metabolite of indapamide: comparison with indapamide, hydrochlorothiazide and cicletanine.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Calcium Channels; Electromyography; Endothelium, Vasc | 1994 |
Long-term effects of brief antihypertensive treatment on systolic blood pressure and vascular reactivity in young genetically hypertensive rats.
Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; B | 1995 |
Rat diaphragm cyclic nucleotide-phosphodiesterase: influence of drugs affecting skeletal muscle contractility.
Topics: Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Dialysis; Diaphragm; Hydrochlorothiazide; Hydrogen-Ion | 1974 |
[Effect of several saluretic agents on smooth muscle. A contribution to the varied effects of saluretic agents on glomerular filtration (author's transl)].
Topics: Animals; Chlorthalidone; Diuretics; Female; Furans; Furosemide; Glomerular Filtration Rate; Hemodyna | 1974 |
Drug failure in reducing pressor effect of isometric handgrip stress test in hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Electrocardiogra | 1973 |
Hereditary persistent distal cramps.
Topics: Action Potentials; Adolescent; Adult; Age Factors; Aged; Anesthesia, Spinal; Carbamazepine; Child; E | 1972 |
[Effect of Hypothiazide on the phase structure of heart contraction in patients with hypertension].
Topics: Adult; Aged; Electrocardiography; Heart; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Mus | 1969 |
The effects of diuretic and non-diuretic benzothiadiazine and of structurally related diuretic drugs on active ion transport and contractility in smooth muscles.
Topics: Animals; Aorta; Biological Transport, Active; Chlorides; Female; Hydrochlorothiazide; In Vitro Techn | 1965 |