hydrochlorothiazide has been researched along with Lassitude in 13 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One thousand four hundred and two patients with essential hypertension were treated by their general practitioners for 3 months with one tablet daily consisting of 200 mg acebutolol plus 12." | 9.05 | Treatment of essential hypertension with beta-blocker plus diuretic: a study of 1402 patients treated by general practitioners with acebutolol 200 mg combined with hydrochlorothiazide 12.5 mg ('Secadrex') once daily for 3 months. ( Baker, PG; McGowan, GK, 1984) |
| " Tolerability and safety were assessed by physical examination, laboratory parameters and evaluation of adverse events." | 6.71 | Assessment of efficacy, safety and tolerability of fixed dose combination of telmisartan 40mg and hydrochlorothiazide 12.5mg in adult Indian patients with mild to moderate hypertension. ( Chandrasekharan, S; Desai, A; Ganesan, R; Gawde, A; Jain, SD; Jayaram, S; Kadam, GS; Lahoti, S; Mishra, AB; Muralidharan, RS; Rajadhyaksha, GC; Sodhi, SS, 2004) |
| "1%) were the clinical adverse experiences most often reported in patients treated with losartan." | 6.68 | Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995) |
| "The effects of monotherapy with once-daily ketanserin (40 mg) were compared to those of ketanserin (40 mg) plus hydrochlorothiazide (25 mg) once daily in 21 patients with mild essential hypertension." | 5.06 | Comparative antihypertensive effects of ketanserin and a ketanserin-hydrochlorothiazide combination administered once daily. ( Leary, WP; Maharaj, B; Reyes, AJ; van der Byl, K, 1987) |
| "One thousand four hundred and two patients with essential hypertension were treated by their general practitioners for 3 months with one tablet daily consisting of 200 mg acebutolol plus 12." | 5.05 | Treatment of essential hypertension with beta-blocker plus diuretic: a study of 1402 patients treated by general practitioners with acebutolol 200 mg combined with hydrochlorothiazide 12.5 mg ('Secadrex') once daily for 3 months. ( Baker, PG; McGowan, GK, 1984) |
| " Adverse events (AEs) were reported in 75." | 2.82 | Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study. ( Barger, B; Handley, A; Lloyd, E; Roberts, A, 2016) |
| " Tolerability and safety were assessed by physical examination, laboratory parameters and evaluation of adverse events." | 2.71 | Assessment of efficacy, safety and tolerability of fixed dose combination of telmisartan 40mg and hydrochlorothiazide 12.5mg in adult Indian patients with mild to moderate hypertension. ( Chandrasekharan, S; Desai, A; Ganesan, R; Gawde, A; Jain, SD; Jayaram, S; Kadam, GS; Lahoti, S; Mishra, AB; Muralidharan, RS; Rajadhyaksha, GC; Sodhi, SS, 2004) |
| "1%) were the clinical adverse experiences most often reported in patients treated with losartan." | 2.68 | Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995) |
| "Amlodipine treatment was associated with a slightly higher incidence of side effects compared with placebo, but most of this difference was the result of edema, which was usually well tolerated." | 2.66 | The safety of amlodipine. ( Osterloh, I, 1989) |
| "After treatments, her fatigue symptoms were reduced, blood potassium and magnesium levels were increased, and blood glucose levels were well controlled." | 1.91 | Case report: Gitelman syndrome with diabetes: Confirmed by both hydrochlorothiazide test and genetic testing. ( Fan, J; Fu, H; Liu, Y; Liu, Z; Qi, H; Ren, Y; Yang, J; Yang, L, 2023) |
| "Gitelman's syndrome is an important differential diagnosis in the evaluation of the normotensive patient with hypokalemia." | 1.32 | [Gitelman's syndrome: an important differential diagnosis of hypokalemia]. ( Grabensee, B; Heering, P; Kurschat, C, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, L | 1 |
| Fan, J | 1 |
| Liu, Y | 1 |
| Ren, Y | 1 |
| Liu, Z | 1 |
| Fu, H | 1 |
| Qi, H | 1 |
| Yang, J | 1 |
| Handley, A | 1 |
| Lloyd, E | 1 |
| Roberts, A | 1 |
| Barger, B | 1 |
| El-Haddad, B | 1 |
| Hammoud, D | 1 |
| Shaver, T | 1 |
| Shahouri, S | 1 |
| Kurschat, C | 1 |
| Heering, P | 1 |
| Grabensee, B | 1 |
| Jayaram, S | 1 |
| Lahoti, S | 1 |
| Chandrasekharan, S | 1 |
| Ganesan, R | 1 |
| Muralidharan, RS | 1 |
| Mishra, AB | 1 |
| Sodhi, SS | 1 |
| Rajadhyaksha, GC | 1 |
| Jain, SD | 1 |
| Kadam, GS | 1 |
| Gawde, A | 1 |
| Desai, A | 1 |
| McGowan, GK | 1 |
| Baker, PG | 1 |
| Goldberg, AI | 1 |
| Dunlay, MC | 1 |
| Sweet, CS | 1 |
| Benz, JR | 1 |
| Black, HR | 1 |
| Graff, A | 1 |
| Reed, A | 1 |
| Fitzsimmons, S | 1 |
| Shi, Y | 1 |
| Leary, WP | 1 |
| Reyes, AJ | 1 |
| van der Byl, K | 1 |
| Maharaj, B | 1 |
| Osterloh, I | 1 |
| Bannon, JA | 1 |
| Stewart, KA | 1 |
| Schrogie, JJ | 1 |
| Delisser, O | 1 |
| Flamenbaum, W | 1 |
| Weber, MA | 1 |
| McMahon, FG | 1 |
| Materson, BJ | 1 |
| Carr, AA | 1 |
| Poland, M | 1 |
| Snaith, RP | 1 |
| McCoubrie, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761] | Phase 4 | 471 participants (Actual) | Interventional | 2018-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for hydrochlorothiazide and Lassitude
| Article | Year |
|---|---|
Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study.
Topics: Adult; Aged; Benzimidazoles; Chlorthalidone; Cohort Studies; Dizziness; Drug Therapy, Combination; E | 2016 |
Assessment of efficacy, safety and tolerability of fixed dose combination of telmisartan 40mg and hydrochlorothiazide 12.5mg in adult Indian patients with mild to moderate hypertension.
Topics: Adolescent; Adult; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; | 2004 |
Treatment of essential hypertension with beta-blocker plus diuretic: a study of 1402 patients treated by general practitioners with acebutolol 200 mg combined with hydrochlorothiazide 12.5 mg ('Secadrex') once daily for 3 months.
Topics: Acebutolol; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Dru | 1984 |
Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Conver | 1995 |
Valsartan and hydrochlorothiazide in patients with essential hypertension. A multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Dizziness; Dose-Response Relationship, Drug; Double- | 1998 |
Comparative antihypertensive effects of ketanserin and a ketanserin-hydrochlorothiazide combination administered once daily.
Topics: Blood Pressure; Drug Therapy, Combination; Erectile Dysfunction; Fatigue; Heart Rate; Humans; Hydroc | 1987 |
The safety of amlodipine.
Topics: Adrenergic beta-Antagonists; Aged; Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; D | 1989 |
Monotherapy with labetalol compared with propranolol. Differential effects by race.
Topics: Adult; Aged; Black or African American; Bradycardia; Clinical Trials as Topic; Dizziness; Double-Bli | 1985 |
5 other studies available for hydrochlorothiazide and Lassitude
| Article | Year |
|---|---|
Case report: Gitelman syndrome with diabetes: Confirmed by both hydrochlorothiazide test and genetic testing.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Fatigue; Female; Genetic Testing; Gitelman Syndrome; Human | 2023 |
Malignancy-associated multicentric reticulohistiocytosis.
Topics: Antihypertensive Agents; Antineoplastic Agents; Arthralgia; Atenolol; Combined Modality Therapy; Dru | 2011 |
[Gitelman's syndrome: an important differential diagnosis of hypokalemia].
Topics: Adult; Alkalosis; Calcium; Carrier Proteins; Diagnosis, Differential; Diuretics; Fatigue; Female; Fu | 2003 |
Postmarketing study of timolol-hydrochlorothiazide antihypertensive therapy.
Topics: Adolescent; Adult; Aged; Dizziness; Drug Combinations; Fatigue; Female; Humans; Hydrochlorothiazide; | 1985 |
Antihypertensive drugs and depression.
Topics: Adult; Aged; Antihypertensive Agents; Bethanidine; Chlorthalidone; Depression; Diuretics; Drug Thera | 1974 |