hydrochlorothiazide has been researched along with Hypotension in 41 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to probe the effects of low-dose irbesartan and hydrochlorothiazide in combination with levamlodipine at different times on the circadian rhythm of blood pressure, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) levels in patients with non-dipper hypertension (NDH)." | 9.69 | Effect of administration of low-dose irbesartan and hydrochlorothiazide combined with levamlodipine at different times on the circadian rhythm of blood pressure and the levels of MMPs and TIMPs in non-dipper patients with grade 1 and 2 hypertension. ( Chen, J; Dong, G; Ge, M; Liu, H; Luo, Y; Wang, J; Yan, P; Zhang, J, 2023) |
| "A 73-year-old woman presented with acute pulmonary edema and hypotension less than 1 h after taking hydrochlorothiazide 50 mg, a reaction which has been reported as a rare but classic adverse drug response." | 7.69 | Hydrochlorothiazide-induced pulmonary edema with severe acute myocardial dysfunction. ( Frierson, JH; Marvel, SL; Thomas, GM, 1995) |
| "This study aimed to probe the effects of low-dose irbesartan and hydrochlorothiazide in combination with levamlodipine at different times on the circadian rhythm of blood pressure, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) levels in patients with non-dipper hypertension (NDH)." | 5.69 | Effect of administration of low-dose irbesartan and hydrochlorothiazide combined with levamlodipine at different times on the circadian rhythm of blood pressure and the levels of MMPs and TIMPs in non-dipper patients with grade 1 and 2 hypertension. ( Chen, J; Dong, G; Ge, M; Liu, H; Luo, Y; Wang, J; Yan, P; Zhang, J, 2023) |
| " A second combination compound including verapamil 180 mg and trandolapril 2 mg daily was added 5 days prior to hospitalisation due to insufficient control of arterial hypertension." | 3.72 | [Lethal polypharmacy in a patient with arterial hypertension]. ( Diethelm, M; Joerger, M, 2004) |
| "A 73-year-old woman presented with acute pulmonary edema and hypotension less than 1 h after taking hydrochlorothiazide 50 mg, a reaction which has been reported as a rare but classic adverse drug response." | 3.69 | Hydrochlorothiazide-induced pulmonary edema with severe acute myocardial dysfunction. ( Frierson, JH; Marvel, SL; Thomas, GM, 1995) |
| " Ventilatory support must be available if apnea occurs." | 3.66 | Clonidine poisoning. A complex problem. ( Artman, M; Boerth, RC, 1983) |
| "Valsartan is a nonpeptide angiotensin receptor antagonist that selectively blocks the binding of angiotensin II to the angiotensin II type 1 receptor." | 2.45 | Valsartan: more than a decade of experience. ( Bailey, J; Black, HR; Samuel, R; Zappe, D, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (68.29) | 18.7374 |
| 1990's | 5 (12.20) | 18.2507 |
| 2000's | 4 (9.76) | 29.6817 |
| 2010's | 3 (7.32) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Skulnick, HI | 1 |
| Ludens, JH | 1 |
| Wendling, MG | 1 |
| Glenn, EM | 1 |
| Rohloff, NA | 1 |
| Smith, RJ | 1 |
| Wierenga, W | 1 |
| Yan, P | 1 |
| Luo, Y | 1 |
| Zhang, J | 1 |
| Liu, H | 1 |
| Chen, J | 1 |
| Wang, J | 1 |
| Dong, G | 1 |
| Ge, M | 1 |
| Lonn, EM | 1 |
| Bosch, J | 1 |
| López-Jaramillo, P | 1 |
| Zhu, J | 1 |
| Liu, L | 1 |
| Pais, P | 1 |
| Diaz, R | 1 |
| Xavier, D | 1 |
| Sliwa, K | 1 |
| Dans, A | 1 |
| Avezum, A | 1 |
| Piegas, LS | 1 |
| Keltai, K | 1 |
| Keltai, M | 1 |
| Chazova, I | 1 |
| Peters, RJ | 1 |
| Held, C | 1 |
| Yusoff, K | 1 |
| Lewis, BS | 1 |
| Jansky, P | 1 |
| Parkhomenko, A | 1 |
| Khunti, K | 1 |
| Toff, WD | 1 |
| Reid, CM | 1 |
| Varigos, J | 1 |
| Leiter, LA | 1 |
| Molina, DI | 1 |
| McKelvie, R | 1 |
| Pogue, J | 1 |
| Wilkinson, J | 1 |
| Jung, H | 1 |
| Dagenais, G | 1 |
| Yusuf, S | 1 |
| Lewin, AJ | 1 |
| Weir, MR | 1 |
| Black, HR | 1 |
| Bailey, J | 1 |
| Zappe, D | 1 |
| Samuel, R | 1 |
| Yang, SS | 1 |
| Lo, YF | 1 |
| Wu, CC | 1 |
| Lin, SW | 1 |
| Yeh, CJ | 1 |
| Chu, P | 1 |
| Sytwu, HK | 1 |
| Uchida, S | 1 |
| Sasaki, S | 1 |
| Lin, SH | 1 |
| Rosendorff, C | 1 |
| GARGANO, N | 1 |
| REGOLI, D | 1 |
| BARTORELLI, C | 1 |
| GORI, E | 2 |
| SCROLLINI, F | 2 |
| PREZIOSI, P | 3 |
| MARMO, E | 3 |
| MIELE, E | 3 |
| BARATH, J | 1 |
| TARJAN, P | 1 |
| BENATI, E | 1 |
| TOLVA, D | 1 |
| BORHANI, NO | 1 |
| FRIEDMAN, SM | 1 |
| NAKASHIMA, M | 1 |
| FRIEDMAN, CL | 1 |
| BOETTIGER, LE | 1 |
| MALMBORG, RO | 1 |
| MICHAELI, EW | 1 |
| TATUM, HJ | 1 |
| SCHULTZ, FB | 1 |
| MILLIEZ, P | 1 |
| FRITEL, D | 1 |
| REY, LP | 1 |
| BELLUSCHI, A | 1 |
| VACCHINI, V | 1 |
| NICHOLAS, SS | 1 |
| CONWAY, J | 1 |
| LEONETTI, G | 1 |
| LURIA, MH | 1 |
| FREIS, ED | 1 |
| LAROTONDA, A | 1 |
| ZUCAL, C | 1 |
| RATNER, NA | 1 |
| GLEZER, GA | 1 |
| SPIVAK, GL | 1 |
| SHARAPOV, UB | 1 |
| Joerger, M | 1 |
| Diethelm, M | 1 |
| Goetschalckx, K | 1 |
| Ceuppens, J | 1 |
| Van Mieghem, W | 1 |
| Artman, M | 1 |
| Boerth, RC | 1 |
| Frierson, JH | 1 |
| Marvel, SL | 1 |
| Thomas, GM | 1 |
| Leser, C | 1 |
| Bolliger, CT | 1 |
| Winnewisser, J | 1 |
| Burkart, F | 1 |
| Perruchoud, AP | 1 |
| Omboni, S | 1 |
| Parati, G | 1 |
| Palatini, P | 1 |
| Vanasia, A | 1 |
| Muiesan, ML | 1 |
| Cuspidi, C | 1 |
| Mancia, G | 1 |
| Clarfield, AM | 1 |
| Friedman, R | 1 |
| Bergman, H | 1 |
| Clarke, PF | 1 |
| Kendall, R | 1 |
| Hornby, R | 1 |
| Kendall, MJ | 1 |
| Solomon, RJ | 1 |
| Stillman, N | 1 |
| Weinberg, MS | 1 |
| Carstens, E | 1 |
| Ekbom, KA | 1 |
| Ghani, MF | 1 |
| Parker, BM | 1 |
| Oda, T | 1 |
| Kubota, K | 1 |
| Ishibahsi, Y | 1 |
| Iida, K | 1 |
| Okano, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Heart Outcomes Prevention Evaluation-3[NCT00468923] | Phase 4 | 12,705 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for hydrochlorothiazide and Hypotension
| Article | Year |
|---|---|
Valsartan: more than a decade of experience.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihyperte | 2009 |
Hydrochlorothiazide-associated noncardiogenic pulmonary oedema and shock: a case report and review of the literature.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Cardiac Output; Diuretics; Drug Hypersensitivity; Fem | 2007 |
5 trials available for hydrochlorothiazide and Hypotension
| Article | Year |
|---|---|
Effect of administration of low-dose irbesartan and hydrochlorothiazide combined with levamlodipine at different times on the circadian rhythm of blood pressure and the levels of MMPs and TIMPs in non-dipper patients with grade 1 and 2 hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Hu | 2023 |
Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease.
Topics: Aged; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiovascular Di | 2016 |
Antihypertensive efficacy and tolerability of irbesartan/hydrochlorothiazide in hypertensive patients stratified by body mass index and type 2 diabetes mellitus status: a post hoc subgroup analysis of the Irbesartan/HCTZ Blood Pressure Reductions in Diver
Topics: Aged; Antihypertensive Agents; Biphenyl Compounds; Body Mass Index; Body Weight; Cluster Analysis; D | 2008 |
Reproducibility and clinical value of nocturnal hypotension: prospective evidence from the SAMPLE study. Study on Ambulatory Monitoring of Pressure and Lisinopril Evaluation.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadi | 1998 |
Captopril and hydrochlorthiazide--a safe antihypertensive for use in general practice?
Topics: Aged; Antihypertensive Agents; Blood Pressure; Captopril; Drug Therapy, Combination; Female; Heart R | 1991 |
34 other studies available for hydrochlorothiazide and Hypotension
| Article | Year |
|---|---|
Pyrimidinones. 3. N-substituted 6-phenylpyrimidinones and pyrimidinediones with diuretic/hypotensive and antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Arthritis; Diuresis; Dose-Response Relationship | 1986 |
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Diuretics; Female; Furosemide; Gitelman Synd | 2010 |
Why are we still using hydrochlorothiazide?
Topics: Antihypertensive Agents; Diabetes Mellitus; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hy | 2011 |
[Alterations of electrolyte equilibrium induced by prolonged treatment with hydrochlorothiazide and their relation to the hypotensive action of saluretic drugs].
Topics: Chlorothiazide; Diuretics; Electrolytes; Hydrochlorothiazide; Hypertension; Hypotension; Water-Elect | 1961 |
[Dihydrochlorothiazide as sensitizer to hypotension induced by carbethoxysyringoyl methyl-reserpate and to its antagonists].
Topics: Chlorothiazide; Hydrochlorothiazide; Hypotension; Learning; Nervous System Physiological Phenomena; | 1960 |
[Effects of chlorothiazide and hydrochlorothiazide on the hypotensive activity of reserpine].
Topics: Blood Pressure; Blood Pressure Determination; Chlorothiazide; Hydrochlorothiazide; Hypotension; Pres | 1960 |
[Effects of chlorothiazide and of hydrochlorothiazide on the hypotensive activity of reserpine].
Topics: Chlorothiazide; Humans; Hydrochlorothiazide; Hypotension; Reserpine | 1961 |
[Experimental studies on comparative hypotensive properties of a new diuretic drug (dihydrochlorothiazide)].
Topics: Antihypertensive Agents; Diuretics; Hydrochlorothiazide; Hypotension | 1959 |
[Hypotensive activity of combined dihydrochlorothiazide-carbethoxysyringoyl methylreserpate].
Topics: Antihypertensive Agents; Hydrochlorothiazide; Hypotension | 1959 |
Chlorothiazide and hydrochlorothiazide: a comparative study of their hypotensive, saluretic and hyperuricemic action.
Topics: Chlorothiazide; Hydrochlorothiazide; Hypertension; Hypotension | 1960 |
Relation of saluretic and hypotensive effects of hydrochlorothiazide in the rat.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Chlorothiazide; Diuretics; Hydrochlorothiazid | 1960 |
[Dihydrochlorothiazide as a sensitizer of hypotension induced by carbethoxy-syringoyl-methyl-reserpate and its antagonists].
Topics: Chlorothiazide; Hydrochlorothiazide; Hypotension; Learning; Nervous System Physiological Phenomena; | 1959 |
[SEVERE NEUROLOGICAL SIDE-EFFECTS IN HYPOTENSION THERAPY].
Topics: Amobarbital; Antihypertensive Agents; Arteriosclerosis; Chlorothiazide; Chlorthalidone; Guanethidine | 1964 |
THE OBSTETRIC PATIENT WITH TOXEMIA.
Topics: Adrenal Insufficiency; Body Weight; Chlorides; Delivery, Obstetric; Diet, Sodium-Restricted; Diureti | 1964 |
A NEW HYPOTENSIVE DRUG COMBINATION (GUANETHIDINE-HYDROCHLOROTHIAZIDE).
Topics: Biomedical Research; Drug Combinations; Drug Therapy; Geriatrics; Guanethidine; Hydrochlorothiazide; | 1964 |
[CLINICAL TRIAL OF A HYPOTENSIVE DRUG: 3,4-DIHYDROXY-D-L-PHENYLALANINE OR METHYLDOPA].
Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Eye Manifestations; Humans; Hydrochlorothia | 1964 |
[CLINICAL EVALUATION OF A PHARMACOLOGIC ASSOCIATION WITH HYPOTENSIVE ACTION].
Topics: Antihypertensive Agents; Biomedical Research; Carbamates; Drug Therapy; Electric Impedance; Humans; | 1964 |
ORTHOSTATIC HYPOTENSION.
Topics: Drug Therapy; Fludrocortisone; Geriatrics; Humans; Hydrochlorothiazide; Hydrocortisone; Hypotension; | 1965 |
HYPOTENSIVE EFFECT OF ETHACRYNIC ACID.
Topics: Biomedical Research; Blood Chemical Analysis; Diet, Sodium-Restricted; Diuretics; Drug Therapy; Etha | 1965 |
TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX).
Topics: Antihypertensive Agents; Biomedical Research; Debrisoquin; Drug Therapy; Hydrochlorothiazide; Hypert | 1965 |
[Hypotensive action of hydrochlorothiazide in the treatment of arterial hypertension].
Topics: Chlorothiazide; Hydrochlorothiazide; Hypertension; Hypotension | 1960 |
[Diverse effect of hydrochlorothiazide in relation to the hypotensive activity of reserpine, rescinnamine, syrosingopine, 1, 4-dihydrazino-phthlazine (alone or associated with reserpine), hexamethonium and guanethidine].
Topics: Alkaloids; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Chlorothiazide; Gu | 1961 |
[On diuretic and hypotensive effects of hypothiazide].
Topics: Chlorothiazide; Diuretics; Hydrochlorothiazide; Hypotension | 1961 |
[Lethal polypharmacy in a patient with arterial hypertension].
Topics: Aged; Aged, 80 and over; Amiloride; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent | 2004 |
Clonidine poisoning. A complex problem.
Topics: Apnea; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Fluid Therapy; Gastric Lavage; Hu | 1983 |
Hydrochlorothiazide-induced pulmonary edema with severe acute myocardial dysfunction.
Topics: Acute Disease; Aged; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypotension; Pulmonary Edema | 1995 |
Pulmonary oedema and hypotension induced by hydrochlorothiazide.
Topics: Anaphylaxis; Diagnosis, Differential; Dyspnea; Female; Humans; Hydrochlorothiazide; Hypotension; Mid | 1994 |
Diuretics, potassium, and ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Diuretics; Humans; Hydrochlorothiazide; Hypokalemia; Hypotension; | 1992 |
Thiazide induced hypotension: the role of plasma volume reduction and the urinary kallikrein system.
Topics: Aldosterone; Blood Pressure; Humans; Hydrochlorothiazide; Hypertension; Hypotension; Kallikreins; Ma | 1986 |
[Antihypertensive agents].
Topics: Acetazolamide; Antihypertensive Agents; Bis-Trimethylammonium Compounds; Bretylium Compounds; Chlori | 1972 |
Scotoma due to arterial hypotension.
Topics: Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Hypotension; Male; Middle Aged; Scotoma; Sy | 1973 |
Hypotension, heart block and reversed pulsus alternans in a patient with hypertrophic subaortic stenosis following digitalis and diuretic therapy.
Topics: Aortic Valve; Cardiac Catheterization; Cardiomyopathy, Hypertrophic; Chlordiazepoxide; Digitalis Gly | 1974 |
Report of the panels on cardiovascular drugs from the drug efficacy study.
Topics: Angina Pectoris; Cardiovascular Diseases; Chlorothiazide; Digitalis Glycosides; Drug Industry; Drug | 1970 |
[Interesting case of normokalemic primary aldosteronism with thiazide hypokalemia developing into true hypokalemia after relatively short period (4 months)].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Female; Humans; Hydrochlorothiazide; Hypera | 1967 |