hydrochlorothiazide has been researched along with Hypotension, Orthostatic in 19 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 mg hydrochlorothiazide (HCTZ) with each drug as monotherapy in patients with moderate to severe hypertension." | 9.08 | Controlled multicenter study with quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension. ( Castellote, E; Ocón, J; Romero, R; Wagner, B, 1995) |
| "The safety and efficacy of sustained-release diltiazem, 120 to 180 mg twice daily, was compared with those of hydrochlorothiazide, 25 to 50 mg twice daily, in 207 patients with mild-to-moderate hypertension (supine diastolic blood pressure [BP] 95 to 114 mm Hg) using a baseline, placebo, parallel-design study protocol." | 9.06 | Comparison of hydrochlorothiazide and sustained-release diltiazem for mild-to-moderate systemic hypertension. ( Frishman, WH; Kirkendall, W; Lunn, J; McCarron, D; Moser, M; Schnaper, H; Smith, LK; Sowers, J; Swartz, SL; Zawada, ET, 1987) |
| "The antihypertensive mechanisms of single and combined therapy with a beta-adrenergic antagonist (propranolol) and a vasodilator (hydralazine) were investigated in 9 patients with moderately severe hypertension, who were receiving maintenance diuretic (hydrochlorothiazide) treatment." | 9.05 | Single and combined therapy for systemic hypertension with propranolol, hydralazine and hydrochlorothiazide: hemodynamic and neuroendocrine mechanisms of action. ( Blomqvist, CG; Gaffney, FA; Graham, RM; Mulvihill-Wilson, J; Neal, WW; Pettinger, WA, 1985) |
| "To determine the influence of dietary sodium intake on the effects of hydrochlorothiazide (HCT) on blood pressure (BP), serum electrolytes, renin and aldosterone, nine male patients with uncomplicated essential hypertension were studied during the following therapeutic regimes: 1) sodium restriction alone (50 mmol/day), 2) sodium restriction combined with HCT (50 MG TWICE DAILY), 3) HCT alone, and 4) sodium restriction combined with HCT." | 7.66 | Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure, serum electrolytes, renin and aldosterone in essential hypertension. ( de Graeff, J; Schalekamp, M; van Brummelen, P, 1978) |
| "A factorial design method was applied in this multicentre trial of the angiotensin-converting enzyme inhibitor quinapril hydrochloride (Accupril) in combination with the diuretic hydrochlorothiazide (HCTZ) to assess the additive effects of the combination versus monotherapy, to characterise the dose-response relationship of each drug in the presence of the other and to determine if quinapril would attenuate the hypokalemic effect of HCTZ." | 6.67 | Quinapril and hydrochlorothiazide combination for control of hypertension: assessment by factorial design. Quinapril Investigator Group. ( Canter, D; Frank, GJ; Knapp, LE; Phelps, M; Quade, M; Texter, M, 1994) |
| "5 mg hydrochlorothiazide (HCTZ) with each drug as monotherapy in patients with moderate to severe hypertension." | 5.08 | Controlled multicenter study with quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension. ( Castellote, E; Ocón, J; Romero, R; Wagner, B, 1995) |
| "The safety and efficacy of sustained-release diltiazem, 120 to 180 mg twice daily, was compared with those of hydrochlorothiazide, 25 to 50 mg twice daily, in 207 patients with mild-to-moderate hypertension (supine diastolic blood pressure [BP] 95 to 114 mm Hg) using a baseline, placebo, parallel-design study protocol." | 5.06 | Comparison of hydrochlorothiazide and sustained-release diltiazem for mild-to-moderate systemic hypertension. ( Frishman, WH; Kirkendall, W; Lunn, J; McCarron, D; Moser, M; Schnaper, H; Smith, LK; Sowers, J; Swartz, SL; Zawada, ET, 1987) |
| "The antihypertensive mechanisms of single and combined therapy with a beta-adrenergic antagonist (propranolol) and a vasodilator (hydralazine) were investigated in 9 patients with moderately severe hypertension, who were receiving maintenance diuretic (hydrochlorothiazide) treatment." | 5.05 | Single and combined therapy for systemic hypertension with propranolol, hydralazine and hydrochlorothiazide: hemodynamic and neuroendocrine mechanisms of action. ( Blomqvist, CG; Gaffney, FA; Graham, RM; Mulvihill-Wilson, J; Neal, WW; Pettinger, WA, 1985) |
| " To determine whether the variant rs4149601 A allele is a risk factor for hypertension, has an impact on the antihypertensive response to hydrochlorothiazide, and is associated with orthostatic hypotension, we performed a case-control study of hypertension (n=1686), a 4-week clinical trial (n=542), and a case-control study of orthostatic hypotension (n=793) in Chinese subjects." | 3.75 | A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension. ( Hui, R; Luo, F; Sun, K; Wang, X; Wang, Y; Zhou, X, 2009) |
| "To determine the influence of dietary sodium intake on the effects of hydrochlorothiazide (HCT) on blood pressure (BP), serum electrolytes, renin and aldosterone, nine male patients with uncomplicated essential hypertension were studied during the following therapeutic regimes: 1) sodium restriction alone (50 mmol/day), 2) sodium restriction combined with HCT (50 MG TWICE DAILY), 3) HCT alone, and 4) sodium restriction combined with HCT." | 3.66 | Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure, serum electrolytes, renin and aldosterone in essential hypertension. ( de Graeff, J; Schalekamp, M; van Brummelen, P, 1978) |
| "A factorial design method was applied in this multicentre trial of the angiotensin-converting enzyme inhibitor quinapril hydrochloride (Accupril) in combination with the diuretic hydrochlorothiazide (HCTZ) to assess the additive effects of the combination versus monotherapy, to characterise the dose-response relationship of each drug in the presence of the other and to determine if quinapril would attenuate the hypokalemic effect of HCTZ." | 2.67 | Quinapril and hydrochlorothiazide combination for control of hypertension: assessment by factorial design. Quinapril Investigator Group. ( Canter, D; Frank, GJ; Knapp, LE; Phelps, M; Quade, M; Texter, M, 1994) |
| " This article also discusses the new guidelines for the prevention and treatment of orthostatic hypotension and the recently published papers on the risk of skin cancers associated with the long-term use of hydrochlorothiazide (> 5 years)." | 1.51 | [Arterial hypertension : novelties in 2018]. ( Burnier, M; Wuerzner, G, 2019) |
| "A 2 s pause with presyncope and a hypotension (blood pressure values were 80/70 mm Hg) were observed after 2 min in the provocation phase." | 1.35 | Pharmacological washout for the correct evaluation of the head-up tilt testing. ( Coglitore, S; Di Bella, G; Patanè, S; Pugliatti, P; Recupero, A, 2008) |
| " Full PH dose-response curves for standard antihypertensive drugs were explored and were compared to their hypotensive dose-response curves." | 1.27 | Antihypertensive drugs: their postural hypotensive effect and their blood pressure lowering activity in conscious normotensive rats. ( Carver, LA; Lee, CH; Strosberg, AM, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (63.16) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burnier, M | 1 |
| Wuerzner, G | 1 |
| Luo, F | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| Sun, K | 1 |
| Zhou, X | 1 |
| Hui, R | 1 |
| MILLIEZ, P | 1 |
| FRITEL, D | 1 |
| REY, LP | 1 |
| NICHOLAS, SS | 1 |
| LURIA, MH | 1 |
| FREIS, ED | 2 |
| Poon, IO | 1 |
| Braun, U | 1 |
| Pugliatti, P | 1 |
| Patanè, S | 1 |
| Recupero, A | 1 |
| Coglitore, S | 1 |
| Di Bella, G | 1 |
| Fogari, R | 1 |
| Derosa, G | 1 |
| Zoppi, A | 1 |
| Rinaldi, A | 1 |
| Preti, P | 1 |
| Lazzari, P | 1 |
| Mugellini, A | 1 |
| Lee, CH | 1 |
| Strosberg, AM | 1 |
| Carver, LA | 1 |
| Okun, R | 1 |
| Maxwell, M | 1 |
| Romero, R | 1 |
| Castellote, E | 1 |
| Ocón, J | 1 |
| Wagner, B | 1 |
| Canter, D | 1 |
| Frank, GJ | 1 |
| Knapp, LE | 1 |
| Phelps, M | 1 |
| Quade, M | 1 |
| Texter, M | 1 |
| van Brummelen, P | 1 |
| Schalekamp, M | 1 |
| de Graeff, J | 1 |
| Jansen, RW | 1 |
| Van Lier, HJ | 1 |
| Hoefnagels, WH | 1 |
| Frishman, WH | 1 |
| Zawada, ET | 1 |
| Smith, LK | 1 |
| Sowers, J | 1 |
| Swartz, SL | 1 |
| Kirkendall, W | 1 |
| Lunn, J | 1 |
| McCarron, D | 1 |
| Moser, M | 1 |
| Schnaper, H | 1 |
| Mulvihill-Wilson, J | 1 |
| Gaffney, FA | 1 |
| Neal, WW | 1 |
| Graham, RM | 1 |
| Pettinger, WA | 1 |
| Blomqvist, CG | 1 |
| Limas, CJ | 1 |
| Kim, KE | 1 |
| Onesti, G | 1 |
| Swartz, C | 1 |
| Horwitz, D | 1 |
| Alexander, RW | 1 |
| Lovenberg, W | 1 |
| Keiser, HR | 1 |
6 trials available for hydrochlorothiazide and Hypotension, Orthostatic
| Article | Year |
|---|---|
Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihyperte | 2008 |
Controlled multicenter study with quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; B | 1995 |
Quinapril and hydrochlorothiazide combination for control of hypertension: assessment by factorial design. Quinapril Investigator Group.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Double-Blind Method; Drug | 1994 |
Nitrendipine versus hydrochlorothiazide in hypertensive patients over 70 years of age.
Topics: Aged; Body Weight; Double-Blind Method; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazid | 1989 |
Comparison of hydrochlorothiazide and sustained-release diltiazem for mild-to-moderate systemic hypertension.
Topics: Adult; Age Factors; Clinical Trials as Topic; Delayed-Action Preparations; Diltiazem; Double-Blind M | 1987 |
Single and combined therapy for systemic hypertension with propranolol, hydralazine and hydrochlorothiazide: hemodynamic and neuroendocrine mechanisms of action.
Topics: Adult; Drug Therapy, Combination; Exercise Test; Female; Hemodynamics; Humans; Hydralazine; Hydrochl | 1985 |
13 other studies available for hydrochlorothiazide and Hypotension, Orthostatic
| Article | Year |
|---|---|
[Arterial hypertension : novelties in 2018].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Combinations; Humans; Hydrochlorothiazide; Hype | 2019 |
A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.
Topics: Aged; Alleles; Biomarkers; Case-Control Studies; Diuretics; Endosomal Sorting Complexes Required for | 2009 |
[CLINICAL TRIAL OF A HYPOTENSIVE DRUG: 3,4-DIHYDROXY-D-L-PHENYLALANINE OR METHYLDOPA].
Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Eye Manifestations; Humans; Hydrochlorothia | 1964 |
ORTHOSTATIC HYPOTENSION.
Topics: Drug Therapy; Fludrocortisone; Geriatrics; Humans; Hydrochlorothiazide; Hydrocortisone; Hypotension; | 1965 |
TREATMENT OF HYPERTENSION WITH DEBRISOQUIN SULFATE (DECLINAX).
Topics: Antihypertensive Agents; Biomedical Research; Debrisoquin; Drug Therapy; Hydrochlorothiazide; Hypert | 1965 |
High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Antipsychotic Agents; Drug Therapy; Female; Furosemi | 2005 |
Pharmacological washout for the correct evaluation of the head-up tilt testing.
Topics: Aged; Antihypertensive Agents; Carbazoles; Carvedilol; Diagnostic Errors; Drug Therapy, Combination; | 2008 |
Antihypertensive drugs: their postural hypotensive effect and their blood pressure lowering activity in conscious normotensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Hydrochlorothiazide; Hypoten | 1983 |
[Long-term antihypertensive treatment with prazosin in combination with a diuretic].
Topics: Adult; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Hyp | 1980 |
Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure, serum electrolytes, renin and aldosterone in essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Humans; Hydrochlorothiazid | 1978 |
Minoxidil in severe hypertension with renal failure. Effect of its addition to conventional antihypertensive drugs.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Evaluation Studies as Topic; Female; Follow-Up Studi | 1973 |
Problems in therapy for the hypertensive patient.
Topics: Antihypertensive Agents; Blood Pressure; Carotid Sinus; Diuretics; Electric Stimulation; Ethacrynic | 1973 |
Human serum dopamine- -hydroxylase. Relationship to hypertension and sympathetic activity.
Topics: Adrenal Gland Neoplasms; Adult; Amphetamine; Blood Flow Velocity; Blood Pressure; Dopamine beta-Hydr | 1973 |