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hydrochlorothiazide and Hypoparathyroidism

hydrochlorothiazide has been researched along with Hypoparathyroidism in 10 studies

Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

Hypoparathyroidism: A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.

Research Excerpts

ExcerptRelevanceReference
" We treated two patients with TIO and FGF-23-mediated hypophosphatemia with cinacalcet to test the hypothesis that medicinally induced hypoparathyroidism would decrease renal phosphate wasting."9.12Cinacalcet in the management of tumor-induced osteomalacia. ( Adams, JS; Collins, MT; Geller, JL; Kelly, MH; Khosravi, A; Riminucci, M, 2007)
" Chronic administration of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] can normalize plasma calcium in human hypoparathyroidism and in thyroparathyroidectomized animals."5.26Effect of hydrochlorothiazide on 1,25-dihydroxyvitamin D3-induced changes in calcium metabolism in experimental hypoparathyroidism in rats. ( Bonjour, JP; Fleisch, H; Hugi, K; Rizzoli, R, 1981)
" We treated two patients with TIO and FGF-23-mediated hypophosphatemia with cinacalcet to test the hypothesis that medicinally induced hypoparathyroidism would decrease renal phosphate wasting."5.12Cinacalcet in the management of tumor-induced osteomalacia. ( Adams, JS; Collins, MT; Geller, JL; Kelly, MH; Khosravi, A; Riminucci, M, 2007)
"Studies were undertaken in man to evaluate the roles of volume depletion and of the parathyroid glands in mediating the changes in serum and urinary calcium which follow the administration of hydrochlorothiazide, 100 mg twice daily, for 4 days, 42 studies were carried out in 16 normal subjects, 9 patients with hyperparathyroidism, and 7 vitamin D-treated subjects with hypoparathyroidism."5.03changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms. ( Brickman, AS; Coburn, JW; Massry, SG, 1972)
" The effects of increases of calcitriol dosage and modifications of calciuria with hydrochlorothiazide were systematically examined."1.27Hypercalciuria associated with long-term administration of calcitriol (1,25-dihydroxyvitamin D3). Action of hydrochlorothiazide. ( Chan, JC; Santos, F; Smith, MJ, 1986)
" Chronic administration of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] can normalize plasma calcium in human hypoparathyroidism and in thyroparathyroidectomized animals."1.26Effect of hydrochlorothiazide on 1,25-dihydroxyvitamin D3-induced changes in calcium metabolism in experimental hypoparathyroidism in rats. ( Bonjour, JP; Fleisch, H; Hugi, K; Rizzoli, R, 1981)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19905 (50.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's0 (0.00)24.3611
2020's2 (20.00)2.80

Authors

AuthorsStudies
Bossoni, S1
Chiesa, L1
Giustina, A1
Ji, Y1
Kang, C1
Chen, J1
Zhang, L1
Suzuki, M1
Aso, T1
Sato, T1
Michimata, M1
Kazama, I1
Saiki, H1
Hatano, R1
Ejima, Y1
Miyama, N1
Sato, A1
Matsubara, M1
Geller, JL1
Khosravi, A1
Kelly, MH1
Riminucci, M1
Adams, JS1
Collins, MT1
Rizzoli, R1
Hugi, K1
Fleisch, H1
Bonjour, JP1
Kurzel, RB1
Hagen, GA1
Santos, F1
Smith, MJ1
Chan, JC1
Middler, S1
Pak, CY1
Murad, F1
Bartter, FC1
Brickman, AS2
Massry, SG2
Coburn, JW2
Koppel, MH1
Peacock, M1

Trials

2 trials available for hydrochlorothiazide and Hypoparathyroidism

ArticleYear
Cinacalcet in the management of tumor-induced osteomalacia.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007, Volume: 22, Issue:6

    Topics: Bone and Bones; Calcitriol; Calcium; Cinacalcet; Drug Therapy, Combination; Fibroblast Growth Factor

2007
changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Aged; Blood Proteins; Bone Resorption; Calcium; Clinical Trials as Topic; Ergocalciferols; Ex

1972

Other Studies

8 other studies available for hydrochlorothiazide and Hypoparathyroidism

ArticleYear
Severe hypocalcemia in a thyroidectomized woman with Covid-19 infection.
    Endocrine, 2020, Volume: 68, Issue:2

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Betacoronavirus; Calcium; Calcium Gluconate; Coronav

2020
Identification of p.Arg205Cys in CASR in an autosomal dominant hypocalcaemia type 1 pedigree: A case report.
    Medicine, 2021, Jun-25, Volume: 100, Issue:25

    Topics: Calcitriol; Calcium; DNA Mutational Analysis; Drug Therapy, Combination; Female; Genetic Testing; He

2021
A case of gain-of-function mutation in calcium-sensing receptor: supplemental hydration is required for renal protection.
    Clinical nephrology, 2005, Volume: 63, Issue:6

    Topics: Administration, Oral; Calcium; Child; DNA; DNA Mutational Analysis; Extracellular Fluid; Female; Fol

2005
Effect of hydrochlorothiazide on 1,25-dihydroxyvitamin D3-induced changes in calcium metabolism in experimental hypoparathyroidism in rats.
    Clinical science (London, England : 1979), 1981, Volume: 60, Issue:1

    Topics: Animals; Calcitriol; Calcium; Dihydroxycholecalciferols; Hydrochlorothiazide; Hydroxycholecalciferol

1981
Use of thiazide diuretics to reduce the hypercalciuria of hypoparathyroidism during pregnancy.
    American journal of perinatology, 1990, Volume: 7, Issue:4

    Topics: Adult; Calcium; Diet, Sodium-Restricted; Female; Humans; Hydrochlorothiazide; Hypocalcemia; Hypopara

1990
Hypercalciuria associated with long-term administration of calcitriol (1,25-dihydroxyvitamin D3). Action of hydrochlorothiazide.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:2

    Topics: Adolescent; Animals; Calcitriol; Calcium; Child, Preschool; Chronic Kidney Disease-Mineral and Bone

1986
Thiazide diuretics and calcium metabolism.
    Metabolism: clinical and experimental, 1973, Volume: 22, Issue:2

    Topics: Adult; Calcium; Chlorothiazide; Cyclic AMP; Female; Furosemide; Humans; Hydrochlorothiazide; Hydroxy

1973
The effect of hydrochlorothiazide administration on serum and urinary calcium in normal, hypoparathyroid and hyperparathyroid subjects. Studies on mechanisms.
    Israel journal of medical sciences, 1971, Volume: 7, Issue:3

    Topics: Calcium; Humans; Hydrochlorothiazide; Hyperparathyroidism; Hypoparathyroidism; Magnesium; Parathyroi

1971