hydrochlorothiazide has been researched along with Hypokalemia in 174 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to compare the value of potassium-magnesium citrate (KMgCit) with potassium chloride in overcoming thiazide-induced hypokalemia." | 9.09 | Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia. ( Pak, CY; Poindexter, JR; Reilly, C; Sakhaee, K; Wuermser, LA, 2000) |
| "The study was performed to ascertain the value of potassium magnesium citrate, magnesium citrate, and potassium citrate in overcoming thiazide-induced hypokalemia and magnesium loss." | 9.09 | Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss. ( Pak, CY; Ruml, LA, 1999) |
| "The efficacy and safety of the novel calcium antagonist Amlodipine (Pfizer Laboratories, New York, New York) and hydrochlorothiazide were evaluated and compared in a randomized, single-blind, parallel group study in black Africans with essential hypertension." | 9.08 | The efficacy and tolerability of amlodipine and hydrochlorothiazide in Nigerians with essential hypertension. ( Ajayi, AA; Akintomide, AO, 1995) |
| " Amiloride is a new diuretic that reduces lithium-induced polyuria in animals without affecting lithium or potassium levels." | 9.06 | Treatment of severe lithium-induced polyuria with amiloride. ( Forrest, JN; Kosten, TR, 1986) |
| "Twenty-nine patients with mild to severe essential hypertension were treated with titrated doses of xipamide, before or after treatment with 50 and , if necessary, 100 mg hydrochlorothiazide in a 13- to 25-week open crossover study." | 9.05 | Hypotensive effects of xipamide in essential hypertension. Crossover comparison with hydrochlorothiazide. ( Pasquel, R; Simon, A; Tribble, PW, 1981) |
| "This presentation is a summary of our recent clinical studies on the therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism." | 9.05 | The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. ( Griffing, GT; Melby, JC, 1983) |
| "The study reported here prospectively evaluated the prevention of diuretic-induced secondary hyperaldosteronism and hypokalemia by a converting enzyme inhibitor, enalapril (MK 421)." | 9.05 | Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by enalapril (MK-421): a new angiotensin-converting enzyme inhibitor. ( Aurecchia, SA; Griffing, GT; Melby, JC; Sindler, BH, 1983) |
| "The effects of amiloride hydrochloride on thiazide-induced hypokalemia were evaluated." | 9.05 | Response of thiazide-induced hypokalemia to amiloride. ( Chan, L; Maronde, RF; Milgrom, M; Vlachakis, ND, 1983) |
| "Hydrochlorothiazide is the most common thiazide diuretic used for hypertension in the US." | 8.31 | Hypokalaemia associated with hydrochlorothiazide used in the treatment of hypertension in NHANES 1999-2018. ( Cheung, BMY; Li, HL; Lin, Z; Tsoi, MF, 2023) |
| "Severe hypokalemia with severe neurological impairment and electrocardiogram (ECG) abnormalities due to the misuse of triamterene/hydrochlorothiazide (HCTZ) in a bodybuilder has not yet been reported." | 7.96 | Severe Acquired Hypokalemic Paralysis in a Bodybuilder After Self-Medication With Triamterene/Hydrochlorothiazide. ( Finsterer, J; Pfisterer, N; Stöllberger, C, 2020) |
| "To compare the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide added to background intravenous loop diuretic therapy among patients hospitalized with heart failure." | 7.80 | Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014) |
| "Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension." | 7.79 | Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. ( Dhalla, IA; Gomes, T; Hellings, C; Juurlink, DN; Mamdani, MM; Nagge, J; Persaud, N; Yao, Z, 2013) |
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 7.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "The effects of treatment with hydrochlorothiazide combined with amiloride were compared to hydrochlorothiazide treatment alone in 2 brothers with congenital nephrogenic diabetes insipidus." | 7.67 | Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. ( Alon, U; Chan, JC, 1985) |
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 7.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| " Dosage was 2 tablets per day of the 5 mg amiloride plus 50 mg hydrochlorothiazide combination or of 50 mg hydrochlorothiazide alone." | 6.65 | Potassium conservation with amiloride/hydrochlorothiazide ("Moduret') in thiazide-induced hypokalaemia in hypertension. ( Campbell, N; Fernandez, PG; Galway, AB; Gill, V; Granter-Button, S; Kim, BK; MacDonald, J; Sharma, JN; Snedden, W, 1982) |
| "Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage." | 6.65 | Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983) |
| "To evaluate whether the addition of hydrochlorothiazide (HCTZ) to intravenous furosemide is a safe and effective strategy for improving diuretic response in acute heart failure (AHF)." | 5.69 | Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. ( Carrera-Izquierdo, M; Casado, J; Cerqueiro, JM; Conde-Martel, A; Dávila-Ramos, MF; Formiga, F; Gil, P; Llácer, P; Manzano, L; Morales-Rull, JL; Pérez-Silvestre, J; Plasín, MÁ; Salamanca-Bautista, P; Sánchez-Marteles, M; Trullàs, JC, 2023) |
| " Two animals were kept in a hypokalemic state from day 3 of dosing on, and their mean plasma potassium levels were 2." | 5.35 | Myocardial necrosis related to hydrochlorothiazide-induced hypokalemia in cynomolgus monkeys. ( Izumisawa, N; Kajikawa, S; Matsumoto, M; Nakatsuji, S; Oishi, Y; Shirakawa, T; Tabata, H; Takeuchi, A; Toyoda, Y; Watanabe, K, 2008) |
| " Hypokalemia was the most frequently reported adverse reaction." | 5.27 | Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983) |
| "This study investigated the efficacy and tolerability of valsartan (VAL) or hydrochlorothiazide (HCTZ)-monotherapy and higher-dose combinations in patients with essential hypertension." | 5.12 | Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults. ( Alvarado, R; Glazer, R; Graff, A; Huang, J; Pool, JL; Weinberger, M, 2007) |
| "The study was performed to ascertain the value of potassium magnesium citrate, magnesium citrate, and potassium citrate in overcoming thiazide-induced hypokalemia and magnesium loss." | 5.09 | Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss. ( Pak, CY; Ruml, LA, 1999) |
| "The purpose of this study was to compare the value of potassium-magnesium citrate (KMgCit) with potassium chloride in overcoming thiazide-induced hypokalemia." | 5.09 | Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia. ( Pak, CY; Poindexter, JR; Reilly, C; Sakhaee, K; Wuermser, LA, 2000) |
| "The efficacy and safety of the novel calcium antagonist Amlodipine (Pfizer Laboratories, New York, New York) and hydrochlorothiazide were evaluated and compared in a randomized, single-blind, parallel group study in black Africans with essential hypertension." | 5.08 | The efficacy and tolerability of amlodipine and hydrochlorothiazide in Nigerians with essential hypertension. ( Ajayi, AA; Akintomide, AO, 1995) |
| "Forty-four patients with uncomplicated systemic hypertension underwent 48-hour electrocardiographic monitoring before and after four weeks of treatment with hydrochlorothiazide, 100 mg daily." | 5.06 | Thiazide therapy is not a cause of arrhythmia in patients with systemic hypertension. ( Burris, JF; Fletcher, RD; Freis, ED; Notargiacomo, A; Papademetriou, V, 1988) |
| "Among 447 hypertensive patients, most with a history of diuretic-induced hypokalemia, 252 developed diuretic-induced hypokalemia while receiving hydrochlorothiazide, 50 mg/d." | 5.06 | Potassium restoration in hypertensive patients made hypokalemic by hydrochlorothiazide. ( Freis, ED; Friedman, RG; Garland, WT; Hall, WD; Hollifield, J; Jain, AK; Jenkins, P; Marks, A; McMahon, FG; Schnaper, HW, 1989) |
| "Nineteen men with mild to moderate hypertension and without a history of cardiac arrhythmias were randomized (double-blind) into groups to receive hydrochlorothiazide (HCTZ) at a dose of 25 mg/day, HCTZ at 50 mg/day, or HCTZ (25 mg) plus triamterene (50 mg) for a six-month period after a three-week (single-blind) placebo period." | 5.06 | Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension. ( Hamilton, BP; Hamilton, J; Peters, RW, 1989) |
| " Amiloride is a new diuretic that reduces lithium-induced polyuria in animals without affecting lithium or potassium levels." | 5.06 | Treatment of severe lithium-induced polyuria with amiloride. ( Forrest, JN; Kosten, TR, 1986) |
| "The effects of amiloride hydrochloride on thiazide-induced hypokalemia were evaluated." | 5.05 | Response of thiazide-induced hypokalemia to amiloride. ( Chan, L; Maronde, RF; Milgrom, M; Vlachakis, ND, 1983) |
| "Twenty-nine patients with mild to severe essential hypertension were treated with titrated doses of xipamide, before or after treatment with 50 and , if necessary, 100 mg hydrochlorothiazide in a 13- to 25-week open crossover study." | 5.05 | Hypotensive effects of xipamide in essential hypertension. Crossover comparison with hydrochlorothiazide. ( Pasquel, R; Simon, A; Tribble, PW, 1981) |
| "The study reported here prospectively evaluated the prevention of diuretic-induced secondary hyperaldosteronism and hypokalemia by a converting enzyme inhibitor, enalapril (MK 421)." | 5.05 | Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by enalapril (MK-421): a new angiotensin-converting enzyme inhibitor. ( Aurecchia, SA; Griffing, GT; Melby, JC; Sindler, BH, 1983) |
| "This presentation is a summary of our recent clinical studies on the therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism." | 5.05 | The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. ( Griffing, GT; Melby, JC, 1983) |
| "Twenty patients aged 33 to 69 years with uncomplicated hypertension, no heart disease, and normal stress test results underwent ambulatory ECG monitoring a month after receiving placebo and two and four weeks after hydrochlorothiazide therapy." | 5.05 | Nonarrhythmogenicity of diuretic-induced hypokalemia. Its evidence in patients with uncomplicated hypertension. ( Gavras, HP; Madias, JE; Madias, NE, 1984) |
| "In an open two-period crossover study hydrochlorothiazide/amiloride and chlorthalidone were compared with regard to their anti-hypertensive and biochemical properties in ambulatory patients with mild to moderate hypertension." | 5.05 | The antihypertensive and biochemical effects of hydrochlorothiazide/amiloride (Moduretic) versus chlorthalidone. ( van Soeren, F, 1980) |
| "The relative efficacies of potassium chloride, amiloride, triamterene and spironolactone in maintaining potassium balance were studied in 40 patients with essential hypertension receiving diuretic therapy." | 5.04 | Maintenance of potassium balance during diuretic therapy. ( Eisalo, A; Kohvakka, A; Manninen, V, 1979) |
| "Hydrochlorothiazide is the most common thiazide diuretic used for hypertension in the US." | 4.31 | Hypokalaemia associated with hydrochlorothiazide used in the treatment of hypertension in NHANES 1999-2018. ( Cheung, BMY; Li, HL; Lin, Z; Tsoi, MF, 2023) |
| "This cohort study found that among older adults, chlorthalidone use was associated with a higher risk of eGFR decline, cardiovascular events, and hypokalemia compared with hydrochlorothiazide use." | 4.02 | Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function. ( Bugeja, A; Burns, K; Canney, M; Edwards, C; Hundemer, GL; Knoll, G; Petrcich, W; Sood, MM, 2021) |
| "Severe hypokalemia with severe neurological impairment and electrocardiogram (ECG) abnormalities due to the misuse of triamterene/hydrochlorothiazide (HCTZ) in a bodybuilder has not yet been reported." | 3.96 | Severe Acquired Hypokalemic Paralysis in a Bodybuilder After Self-Medication With Triamterene/Hydrochlorothiazide. ( Finsterer, J; Pfisterer, N; Stöllberger, C, 2020) |
| "To compare the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide added to background intravenous loop diuretic therapy among patients hospitalized with heart failure." | 3.80 | Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014) |
| "Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension." | 3.79 | Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. ( Dhalla, IA; Gomes, T; Hellings, C; Juurlink, DN; Mamdani, MM; Nagge, J; Persaud, N; Yao, Z, 2013) |
| " In the second case, QT interval prolongation occurred in a patient taking quetiapine and citalopram, and whose use of hydrocholorothiazide and history of chronic alcohol abuse likely contributed by rendering the patient hypokalemic." | 3.76 | Multifactorial QT interval prolongation. ( Baranchuk, A; Digby, G; Machaalany, J; Malik, P; Methot, M; Redfearn, D; Simpson, CS, 2010) |
| "Changes in serum potassium and serum glucose levels were not correlated in individuals receiving hydrochlorothiazide monotherapy; thus maintenance of normal potassium levels may not attenuate the risk of thiazide diuretic-induced hyperglycemia." | 3.75 | Lack of correlation between thiazide-induced hyperglycemia and hypokalemia: subgroup analysis of results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. ( Anderson, SD; Bailey, K; Boerwinkle, E; Chapman, A; Cooper-Dehoff, RM; Feng, H; Gong, Y; Gums, JG; Hall, KL; Johnson, JA; Schwartz, GL; Smith, SM; Turner, ST; Wen, S, 2009) |
| " Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance." | 3.74 | Thiazide diuretics exacerbate fructose-induced metabolic syndrome. ( Johnson, RJ; Mu, W; Nakagawa, T; Reungjui, S; Roncal, CA; Sirivongs, D; Srinivas, TR, 2007) |
| "Hydrochlorothiazide (HCTZ) is used to manage hypertension and heart failure; however, its side effects include mild hypokalemia, metabolic abnormalities, and volume depletion, which might have deleterious effects on renal and endothelial function." | 3.74 | Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia. ( Byer, K; Croker, BP; Hu, H; Johnson, RJ; Mu, W; Nakagawa, T; Patel, JM; Reungjui, S; Roncal, CA; Simoni, J; Sitprija, V; Srinivas, T; Wesson, D, 2007) |
| " After the addition of hydrochlorothiazide (HCT) to the combination, she developed hypokalaemia with muscle cramps and weakness." | 3.71 | ['Licorice hypertension' also caused by licorice tea]. ( Brouwers, AJ; van der Meulen, J, 2001) |
| "Eleven patients with Gitelman's syndrome and 23 controls underwent acute administration of the thiazide diuretic hydrochlorothiazide and/or the loop diuretic furosemide (FUR) in order to indirectly evaluate the activity of the two electroneutral Na+/Cl(-)-reabsorptive systems of the distal nephron, namely the thiazide-sensitive Na+-Cl- symporter of the distal convoluted tubule and the FUR-sensitive Na+-K+-2Cl- symporter of the loop of Henle." | 3.69 | Abnormal reabsorption of Na+/CI- by the thiazide-inhibitable transporter of the distal convoluted tubule in Gitelman's syndrome. ( Brunati, C; Colussi, G; De Ferrari, ME; Rombolà, G, 1997) |
| "To compare the effect of amiloride with that of oral potassium chloride (KCl) in hypokalemia, metabolic balance studies were carried out in hospitalized subjects with mild hypertension without edema who developed negative potassium balance after 4 days on hydrochlorothiazide (HCTZ)." | 3.67 | Oral potassium chloride and amiloride in hydrochlorothiazide-induced potassium loss. ( Barr, J; Chan, L; Maronde, RF; Spencer, CA; Vlachakis, ND, 1984) |
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 3.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "The effects of treatment with hydrochlorothiazide combined with amiloride were compared to hydrochlorothiazide treatment alone in 2 brothers with congenital nephrogenic diabetes insipidus." | 3.67 | Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. ( Alon, U; Chan, JC, 1985) |
| " A combination of hydrochlorothiazide and triamterene had been previously prescribed despite no history of hypokalemia." | 3.67 | Triamterene nephrolithiasis. ( Callsen, ME; Dooley, DP; Geiling, JA, 1989) |
| "In a study of 50 patients with uncomplicated arterial hypertension the administration of hydrochlorothiazide, 50 to 100 mg daily or every other day, with or without reserpine, 0." | 3.66 | Hypokalemia during the treatment of arterial hypertension with diuretics. ( Beauchemin, M; Gougoux, A; Lemieux, G; Vinay, P, 1980) |
| "Among 54 patients attending a hospital hypertension clinic and receiving the fixed-combination diuretic Moduretic (hydrochlorothiazide 50 mg, amiloride 5 mg), there was a 44." | 3.66 | Plasma potassium levels in hypertensive patients receiving fixed-combination diuretic therapy. ( Frewin, DB; Penhall, RK, 1980) |
| " We treated 38 patients (22 low renin, 16 normal renin) with moderate diastolic hypertension with hydrochlorothiazide (HCTC) administered on a twice daily schedule." | 3.66 | Thiazide diuretics, hypokalemia and cardiac arrhythmias. ( Hollifield, JW; Slaton, PE, 1981) |
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 3.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| " We recruited 10 healthy volunteers in order to study the effects of 32 g liquorice alone or in combination with 25mg hydrochlorothiazide a day for 2 weeks." | 2.74 | Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. ( Hukkanen, J; Savolainen, MJ; Ukkola, O, 2009) |
| " Furthermore, no adverse effects were noted with either potassium chloride formulation, and patient acceptance, tolerability, and compliance to prescribed dosing regimens were similar for both products." | 2.66 | Therapeutic assessment of Slow-K and K-tab potassium chloride formulations in hypertensive patients treated with thiazide diuretics. ( Acchiardo, SR; Carter, CA; Skoutakis, VA, 1987) |
| " Dosage was 2 tablets per day of the 5 mg amiloride plus 50 mg hydrochlorothiazide combination or of 50 mg hydrochlorothiazide alone." | 2.65 | Potassium conservation with amiloride/hydrochlorothiazide ("Moduret') in thiazide-induced hypokalaemia in hypertension. ( Campbell, N; Fernandez, PG; Galway, AB; Gill, V; Granter-Button, S; Kim, BK; MacDonald, J; Sharma, JN; Snedden, W, 1982) |
| " Cyclothiazide tended to cause hypokalaemia, apparently due to increased potassium loss, but with the present dosage none of the 13 patients developed marked hypokalaemia (serum potassium less than 3." | 2.65 | Antihypertensive, saluretic and hypokalaemic effects of cyclothiazide in comparison with hydrochlorthiazide with amiloride supplement. ( Salonen, JT; Ylitalo, P, 1982) |
| "Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage." | 2.65 | Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983) |
| " This reduced bioavailability may reduce its effectiveness in hypertensive patients who change from optimally bioavailable hydrochlorothiazide tablets to Dyazide capsules in an effort to correct hypokalemia." | 2.65 | A new antihypertensive agent: Maxzide (75 mg triamterene/50 mg hydrochlorothiazide). ( Blume, CD; Williams, RL, 1984) |
| "Hydrochlorothiazide (HCTZ) has often been contrasted with chlorthalidone, but relatively little is known about HCTZ versus indapamide (INDAP)." | 2.52 | Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects. ( Ernst, ME; Kostis, JB; Roush, GC; Sica, DA; Tandon, S, 2015) |
| "Hypokalemia is a recognized adverse effect of thiazide diuretic treatment." | 2.52 | Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide. ( Bailey, K; Beitelshees, AL; Boerwinkle, E; Chapman, AB; Cooper-DeHoff, RM; Del-Aguila, JL; Gums, JG; Johnson, JA; Turner, ST, 2015) |
| "When a patient is diagnosed with GS and type 2 diabetes, sodium-glucose cotransporter 2 inhibitors (SGLT2i) can be used to control the blood glucose level and assist in raising blood magnesium." | 1.91 | Case report: Gitelman syndrome with diabetes: Confirmed by both hydrochlorothiazide test and genetic testing. ( Fan, J; Fu, H; Liu, Y; Liu, Z; Qi, H; Ren, Y; Yang, J; Yang, L, 2023) |
| "Acute myocardial infarction was not proven (later coronarography revealed preserved coronary circulation), but severe hyponatraemia and hypokalaemia was detected, explaining a possible symptomatic seizure, and which could be accounted for a 25 mg daily hydrochlorothiazide antihypertensive treatment and - as a precipitating insult - a one-week history of gastroenteritis." | 1.46 | [Differential diagnostic dilemmas after use of an out-of-date antihypertensive medication. Case report]. ( Arányi, P; Tomcsányi, J, 2017) |
| "Amiloride treatment caused a 2-fold greater increase in Na(+) excretion in knockout, compared with WT." | 1.42 | Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency. ( Boettger, T; Cornelius, RJ; Li, H; Sansom, SC; Wang, B; Wang-France, J; Warner, PC; Wen, D; Yuan, Y, 2015) |
| "Although the diagnosis of Gitelman syndrome (GS) and Bartter syndrome (BS) is now feasible by genetic analysis, implementation of genetic testing for these disorders is still hampered by several difficulties, including large gene dimensions, lack of hot-spot mutations, heavy workup time, and costs." | 1.34 | A thiazide test for the diagnosis of renal tubular hypokalemic disorders. ( Bettinelli, A; Bianchetti, MG; Borsa, N; Casari, G; Colussi, G; De Ferrari, ME; Mattiello, C; Syrén, ML; Tedeschi, S, 2007) |
| "Gitelman's syndrome is an important differential diagnosis in the evaluation of the normotensive patient with hypokalemia." | 1.32 | [Gitelman's syndrome: an important differential diagnosis of hypokalemia]. ( Grabensee, B; Heering, P; Kurschat, C, 2003) |
| "Xipamide is a sulfonamide-like diuretic whose action does not depend on transtubular secretion." | 1.31 | Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid. ( Bellmann, R; Heininger, D; Joannidis, M; Kähler, C; Sandhofer, A; Wiedermann, CJ, 2002) |
| " Hypokalemia was the most frequently reported adverse reaction." | 1.27 | Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983) |
| "Sixteen patients were being treated for hypertension and three for fluid retention; five hypertensive patients were also taking non-steroidal anti-inflammatory drugs (NSAID)." | 1.27 | Renal failure with potassium-sparing diuretics. ( Bailey, RR; Low, WI; Lynn, KL; Sainsbury, R; Swainson, CP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 117 (67.24) | 18.7374 |
| 1990's | 13 (7.47) | 18.2507 |
| 2000's | 19 (10.92) | 29.6817 |
| 2010's | 17 (9.77) | 24.3611 |
| 2020's | 8 (4.60) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, C | 1 |
| Hundemer, GL | 1 |
| Petrcich, W | 1 |
| Canney, M | 1 |
| Knoll, G | 1 |
| Burns, K | 1 |
| Bugeja, A | 1 |
| Sood, MM | 1 |
| Qin, L | 1 |
| Zhang, N | 1 |
| Ishigami, J | 1 |
| Miller, ER | 1 |
| Pfister, M | 1 |
| Moran, AE | 1 |
| Cox, E | 1 |
| Lin, Z | 1 |
| Li, HL | 1 |
| Tsoi, MF | 1 |
| Cheung, BMY | 1 |
| Bashir, K | 1 |
| Burns, T | 1 |
| Pirruccello, SJ | 1 |
| Aurit, SJ | 1 |
| Hilleman, DE | 1 |
| Chekka, LMS | 1 |
| Cooper-DeHoff, RM | 3 |
| Gums, JG | 3 |
| Chapman, AB | 2 |
| Johnson, JA | 3 |
| Trullàs, JC | 3 |
| Morales-Rull, JL | 3 |
| Casado, J | 3 |
| Carrera-Izquierdo, M | 3 |
| Sánchez-Marteles, M | 3 |
| Conde-Martel, A | 3 |
| Dávila-Ramos, MF | 3 |
| Llácer, P | 3 |
| Salamanca-Bautista, P | 3 |
| Pérez-Silvestre, J | 3 |
| Plasín, MÁ | 3 |
| Cerqueiro, JM | 3 |
| Gil, P | 3 |
| Formiga, F | 3 |
| Manzano, L | 3 |
| Yang, L | 1 |
| Fan, J | 1 |
| Liu, Y | 1 |
| Ren, Y | 1 |
| Liu, Z | 1 |
| Fu, H | 1 |
| Qi, H | 1 |
| Yang, J | 2 |
| Pfisterer, N | 1 |
| Stöllberger, C | 1 |
| Finsterer, J | 1 |
| Liang, W | 1 |
| Ma, H | 1 |
| Cao, L | 1 |
| Yan, W | 1 |
| Wang, MX | 1 |
| Cuevas, CA | 1 |
| Su, XT | 1 |
| Wu, P | 1 |
| Gao, ZX | 1 |
| Lin, DH | 1 |
| McCormick, JA | 1 |
| Yang, CL | 1 |
| Wang, WH | 1 |
| Ellison, DH | 1 |
| Dhalla, IA | 1 |
| Gomes, T | 1 |
| Yao, Z | 1 |
| Nagge, J | 1 |
| Persaud, N | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Platelet Effects of Chlorthalidone and Hydrochlorothiazide[NCT02100462] | Phase 4 | 30 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | ||
| Effect of Licorice and Hydrochlorothiazide on Plasma Potassium[NCT00605202] | Phase 4 | 10 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)[NCT00246519] | Phase 4 | 1,701 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients With Left Ventricular Hypertrophy[NCT00338260] | Phase 3 | 496 participants (Actual) | Interventional | 1995-06-30 | Completed | ||
| Uric Acid and Hypertension in African Americans[NCT00241839] | Phase 3 | 150 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761] | Phase 4 | 471 participants (Actual) | Interventional | 2018-02-13 | Completed | ||
| Once Versus Twice Daily Electrolyte Monitoring in CHF; a Study Monitoring Electrolytes in Congestive Heart Failure Patients Being Actively Diuresed in Hospital[NCT02497742] | 96 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate[NCT02665117] | 61 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| A Multi-Site Placebo-Controlled Randomized Double-Blind Study to Evaluate the Efficacy and Safety of Using MPC-5971 as Adjuvant Therapy in Subjects Undergoing Shock Wave Lithotripsy[NCT00860093] | Phase 2 | 135 participants (Actual) | Interventional | 2010-04-30 | Terminated (stopped due to Sponsor Corporate Business Decision) | ||
| [NCT00000487] | Phase 3 | 0 participants | Interventional | 1972-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Plasma potassium measured with indirect ion specific electrode method (NCT00605202)
Timeframe: Baseline and 2 weeks
| Intervention | mmol/l (Mean) | |
|---|---|---|
| Baseline | 2 weeks | |
| Licorice | 4.0 | 4.1 |
| Licorice and HCTZ | 4.0 | 3.7 |
(NCT00246519)
Timeframe: baseline to 18 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| Atenolol +HCTZ Arm | -12.06 |
| HCTZ + Atenolol | -13.33 |
"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 3.44 |
| B (Placebo) | -0.83 |
Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | -5.9 |
| B (Placebo) | 0.90 |
"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 0.21 |
| B (Placebo) | -0.95 |
Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)
| Intervention | mg/dl (Mean) |
|---|---|
| A (Allopurinol) | 2.29 |
| B (Placebo) | 0.14 |
Will be measured using hepatic magnetic resonance imaging at baseline and at week 16 (NCT02665117)
Timeframe: baseline to week 16
| Intervention | percent (Mean) |
|---|---|
| KMgCit + Chlorthalidone | 0.31 |
| KCl + Chlorthalidone | 1.59 |
Fasting plasma glucose was measured from venous blood sample at week 4 and week 16 (NCT02665117)
Timeframe: week 4 and week 16
| Intervention | mg/dL (Mean) |
|---|---|
| KMgCit + Chlorthalidone | -5.6 |
| KCl + Chlorthalidone | 2.3 |
Will be measured from venous blood sample from week 4 to week 16 (NCT02665117)
Timeframe: week 4 to week 16
| Intervention | pg/ml (Mean) |
|---|---|
| KMgCit + Chlorthalidone | 38.1 |
| KCl + Chlorthalidone | 13.6 |
Will be measured using magnetic resonance imaging at baseline and at week 16 (NCT02665117)
Timeframe: baseline to week 16
| Intervention | mM (Mean) |
|---|---|
| KMgCit + Chlorthalidone | -0.01 |
| KCl + Chlorthalidone | 0.02 |
8 reviews available for hydrochlorothiazide and Hypokalemia
| Article | Year |
|---|---|
Dyskalemia risk associated with fixed-dose anti-hypertensive medication combinations.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2022 |
Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Chlorthalidone; Cholesterol; Diuretics; Huma | 2017 |
Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide.
Topics: Antihypertensive Agents; Bayes Theorem; Black or African American; Carrier Proteins; Cation Transpor | 2015 |
Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects.
Topics: Blood Pressure; Chlorthalidone; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; I | 2015 |
Managing diuretic-induced hypokalemia in ambulatory hypertensive patients.
Topics: Aged; Ambulatory Care; Chlorthalidone; Diuretics; Food; Humans; Hydrochlorothiazide; Hypertension; H | 1982 |
[Properties and indications of potassium-sparing diuretics].
Topics: Amiloride; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hy | 1986 |
Significance of hypokalaemia due to diuretics.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorothiazide; Diuretics; Ethacrynic Acid; Extracellular Space; Fu | 1973 |
[Hypertension--diuretics as antihypertensive agents].
Topics: Aged; Antihypertensive Agents; Arthritis; Benzothiadiazines; Blood Pressure; Chlorothiazide; Chlorth | 1970 |
49 trials available for hydrochlorothiazide and Hypokalemia
| Article | Year |
|---|---|
Comparative antiplatelet effects of chlorthalidone and hydrochlorothiazide.
Topics: Antihypertensive Agents; Aspirin; Blood Pressure; Chlorthalidone; Diuretics; Double-Blind Method; Dr | 2022 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial.
Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro | 2023 |
Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers.
Topics: Adolescent; Adult; Aldosterone; Cross-Over Studies; Female; Glycyrrhiza; Humans; Hydrochlorothiazide | 2009 |
The relationship of electrocardiographic left ventricular hypertrophy to decreased serum potassium.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Atenolol; Double-Blind Method; Female; Humans; Hyd | 2012 |
Comparison of valsartan/hydrochlorothiazide combination therapy at doses up to 320/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method | 2007 |
[Potassium metabolism during antihypertensive treatment with beta-receptor blocker and diuretic treatment].
Topics: Adrenergic beta-Antagonists; Amiloride; Clopamide; Diuretics; Drug Therapy, Combination; Humans; Hyd | 1981 |
Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by enalapril (MK-421): a new angiotensin-converting enzyme inhibitor.
Topics: Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Diuretics; Electrolytes; Enalapril; Humans; Hy | 1983 |
The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism.
Topics: Adult; Aged; Aldosterone; Amiloride; Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Diuretics | 1983 |
Clinical efficacy and safety of indapamide in essential hypertension.
Topics: Adult; Aged; Animals; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electrolytes; Humans | 1983 |
Long-term experience with indapamide.
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Humans; Hydrochloroth | 1983 |
Advantages of diuretics.
Topics: Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Humans; Hydrochlorothiazide; Hyperten | 1984 |
A new antihypertensive agent: Maxzide (75 mg triamterene/50 mg hydrochlorothiazide).
Topics: Antihypertensive Agents; Biological Availability; Blood Pressure; Clinical Trials as Topic; Dose-Res | 1984 |
Nonarrhythmogenicity of diuretic-induced hypokalemia. Its evidence in patients with uncomplicated hypertension.
Topics: Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Hydrochlorothiazide; Hyperte | 1984 |
Response of thiazide-induced hypokalemia to amiloride.
Topics: Aldosterone; Amiloride; Bicarbonates; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypert | 1983 |
The antihypertensive and biochemical effects of hydrochlorothiazide/amiloride (Moduretic) versus chlorthalidone.
Topics: Adult; Aged; Amiloride; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; | 1980 |
Hypotensive effects of xipamide in essential hypertension. Crossover comparison with hydrochlorothiazide.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Electrolytes; Female; Humans; Hydr | 1981 |
Potassium conservation with amiloride/hydrochlorothiazide ("Moduret') in thiazide-induced hypokalaemia in hypertension.
Topics: Amiloride; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; | 1982 |
Antihypertensive, saluretic and hypokalaemic effects of cyclothiazide in comparison with hydrochlorthiazide with amiloride supplement.
Topics: Adult; Amiloride; Antihypertensive Agents; Benzothiadiazines; Drug Therapy, Combination; Humans; Hyd | 1982 |
The efficacy and tolerability of amlodipine and hydrochlorothiazide in Nigerians with essential hypertension.
Topics: Amlodipine; Blood Pressure; Drug Tolerance; Female; Heart Rate; Humans; Hydrochlorothiazide; Hyperte | 1995 |
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia.
Topics: Adult; Citrates; Diuretics; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiaz | 2000 |
Glucose intolerance during diuretic therapy. Results of trial by the European Working Party on Hypertension in the Elderly.
Topics: Aged; Blood Glucose; Clinical Trials as Topic; Female; Follow-Up Studies; Glucose Tolerance Test; Hu | 1978 |
Maintenance of potassium balance during diuretic therapy.
Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Drug Therapy, | 1979 |
Hypokalaemia in hypertensive Blacks treated with diuretics.
Topics: Black or African American; Black People; Diuretics; Female; Humans; Hydrochlorothiazide; Hypokalemia | 1978 |
Long-term effects of furosemide and hydrochlorothiazide in patients with essential hypertension a two-year comparison of efficacy and safety.
Topics: Double-Blind Method; Female; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Mal | 1977 |
[Letter: Ascrtogenicliver cirrhosis. Effect of amiloride on water-electrolytemetabolsim].
Topics: Amiloride; Ascites; Chlorides; Clinical Trials as Topic; Furosemide; Humans; Hydrochlorothiazide; Hy | 1975 |
[Effect of combined treatment with hydrochlorothiazide and amiloride on serum and urinary potassium].
Topics: Amiloride; Clinical Trials as Topic; Drug Therapy, Combination; Heart Failure; Humans; Hydrochloroth | 1975 |
Introduction to lisinopril-hydrochlorothiazide combination.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Double-Blind Method; Drug Combinations; En | 1991 |
Thiazide therapy is not a cause of arrhythmia in patients with systemic hypertension.
Topics: Cardiac Complexes, Premature; Cardiomegaly; Clinical Trials as Topic; Electrocardiography; Humans; H | 1988 |
Potassium restoration in hypertensive patients made hypokalemic by hydrochlorothiazide.
Topics: Adult; Aged; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Magnesium; Middle Aged; Patient | 1989 |
Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension.
Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Drug Administratio | 1989 |
[Predictability and prevention of hypokalemia induced by hydrochlorothiazide].
Topics: Clinical Trials as Topic; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Random | 1985 |
Hydrochlorothiazide with or without amiloride for hypertension in the elderly. A dose-titration study.
Topics: Aged; Aged, 80 and over; Amiloride; Blood Pressure; Clinical Trials as Topic; Dose-Response Relation | 1987 |
The PACT study: post-marketing surveillance in 47,465 patients treated with Maxzide (triamterene/hydrochlorothiazide). An interim report.
Topics: Age Factors; Antihypertensive Agents; Clinical Trials as Topic; Drug Combinations; Female; Humans; H | 1986 |
Selected mechanisms of diuretic-induced electrolyte changes.
Topics: Aldosterone; Amiloride; Clinical Trials as Topic; Diuresis; Diuretics; Double-Blind Method; Humans; | 1986 |
Role of diuretics in treatment of essential hypertension.
Topics: Clinical Trials as Topic; Diuretics; Double-Blind Method; Humans; Hydrochlorothiazide; Hypertension; | 1986 |
Hypokalemia in thiazide-treated systemic hypertension.
Topics: Aldosterone; Amiloride; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydrochlorothia | 1986 |
Treatment of severe lithium-induced polyuria with amiloride.
Topics: Adult; Amiloride; Clinical Trials as Topic; Diabetes Insipidus; Female; Humans; Hydrochlorothiazide; | 1986 |
Therapeutic assessment of Slow-K and K-tab potassium chloride formulations in hypertensive patients treated with thiazide diuretics.
Topics: Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Hydrochlorothiaz | 1987 |
Comparison of the potassium- retaining effects of amiloride and spironolactone in hypertensive patients with thiazide-induced hypokalaemia.
Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Therapy, Combination; Female; H | 1973 |
Effects of hydrochlorothiazide in hypertensive patients and the need for potassium supplementation.
Topics: Adult; Aged; Blood Pressure; Body Weight; Carbon Dioxide; Chlorides; Clinical Trials as Topic; Human | 1973 |
[Effect of amiloride on potassium loss induced by hydrochlorothiazide].
Topics: Amiloride; Chlorides; Diuresis; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure; | 1974 |
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.
Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu | 1972 |
[Clinical testing of a new potassium-saving diuretic for the treatment of hypertension].
Topics: Aged; Amiloride; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Diuretics; Drug | 1973 |
The effects of amiloride during diuretic therapy in elderly subjects.
Topics: Administration, Oral; Aged; Amiloride; Calcium; Clinical Trials as Topic; Diuretics; Drug Combinatio | 1972 |
Dosage of potassium chloride elixir to correct thiazide-induced hypokalemia.
Topics: Clinical Trials as Topic; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Plac | 1974 |
A clinical trial of alpha-methyldopa (Aldomet) and hydrochlorthiazide (Dichlotride) alone and in combination in hypertension.
Topics: Adult; Clinical Trials as Topic; Drug Interactions; Female; Humans; Hydrochlorothiazide; Hypertensio | 1971 |
Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels.
Topics: Alanine Transaminase; Amiloride; Aspartate Aminotransferases; Diuretics; Drug Combinations; Humans; | 1972 |
[Treatment of the hypertensive patient. Value of Amiloride during saldiuretic treatment].
Topics: Adult; Amiloride; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Kidney | 1972 |
117 other studies available for hydrochlorothiazide and Hypokalemia
| Article | Year |
|---|---|
Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function.
Topics: Aged; Chlorthalidone; Drug-Related Side Effects and Adverse Reactions; Female; Glomerular Filtration | 2021 |
Hypokalaemia associated with hydrochlorothiazide used in the treatment of hypertension in NHANES 1999-2018.
Topics: Adult; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hype | 2023 |
Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Humans; Hydrochl | 2022 |
Case report: Gitelman syndrome with diabetes: Confirmed by both hydrochlorothiazide test and genetic testing.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Fatigue; Female; Genetic Testing; Gitelman Syndrome; Human | 2023 |
Severe Acquired Hypokalemic Paralysis in a Bodybuilder After Self-Medication With Triamterene/Hydrochlorothiazide.
Topics: Diuretics; Electrocardiography; Fluid Therapy; Humans; Hydrochlorothiazide; Hypokalemia; Male; Muscl | 2020 |
Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel.
Topics: Alkalosis; Animals; Disease Models, Animal; Female; Homeostasis; Hydrochlorothiazide; Hypokalemia; K | 2018 |
Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study.
Topics: Aged; Antihypertensive Agents; Chlorthalidone; Follow-Up Studies; Hospitalization; Humans; Hydrochlo | 2013 |
Genetic predictors of thiazide-induced serum potassium changes in nondiabetic hypertensive patients.
Topics: Adult; Aged; Female; Genotype; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle | 2014 |
Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure.
Topics: Administration, Intravenous; Administration, Oral; Aged; Chlorothiazide; Diuretics; Drug Therapy, Co | 2014 |
Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.
Topics: Amiloride; Animals; Antihypertensive Agents; Disease Models, Animal; Diuretics; Epithelial Sodium Ch | 2015 |
Chlorthalidone vs. Hydrochlorothiazide for Treatment of Hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Chlorthalidone; Evidence-Base | 2015 |
Whole-exome sequencing reveals an inherited R566X mutation of the epithelial sodium channel β-subunit in a case of early-onset phenotype of Liddle syndrome.
Topics: Adult; Aldosterone; Alleles; Amiloride; Child, Preschool; Epithelial Sodium Channels; Exome; Exome S | 2016 |
Community-acquired hypokalemia in elderly patients: related factors and clinical outcomes.
Topics: Aged; Aged, 80 and over; Cause of Death; Comorbidity; Female; Hospital Costs; Humans; Hydrochlorothi | 2017 |
Diuretic, natriuretic and potassium-sparing effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats.
Topics: Animals; Antioxidants; Cell Line; Chalcones; Diuretics, Potassium Sparing; Hydrochlorothiazide; Hype | 2017 |
[Differential diagnostic dilemmas after use of an out-of-date antihypertensive medication. Case report].
Topics: Antihypertensive Agents; Diagnosis, Differential; Female; Humans; Hydrochlorothiazide; Hypokalemia; | 2017 |
Myocardial necrosis related to hydrochlorothiazide-induced hypokalemia in cynomolgus monkeys.
Topics: Animals; Biomarkers; Diuretics; Electrocardiography; Female; Hydrochlorothiazide; Hypokalemia; Macac | 2008 |
Benazepril plus amlodipine or hydrochlorothiazide for hypertension.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzazepines; Calcium | 2009 |
Finger drop following a potassium drop.
Topics: Aged; Diuretics; Humans; Hydrochlorothiazide; Hypokalemia; Male | 2009 |
Lack of correlation between thiazide-induced hyperglycemia and hypokalemia: subgroup analysis of results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Glucose; Female; Humans; Hydrochlorothiazide | 2009 |
Multifactorial QT interval prolongation.
Topics: Alcoholism; Amiodarone; Antipsychotic Agents; Arrhythmias, Cardiac; Biomarkers; Citalopram; Cyclohex | 2010 |
Cushing's syndrome with uncontrolled hypertension, occasional hypokalemia, and two pregnancies.
Topics: Adrenalectomy; Adrenocortical Adenoma; Adult; Antihypertensive Agents; Cushing Syndrome; Dexamethaso | 2010 |
Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.
Topics: Acidosis; Amiloride; Animals; Diuretics; Furosemide; Humans; Hydrochlorothiazide; Hypokalemia; Kidne | 2011 |
Hypokalaemia and hyponatraemia due to indapamide.
Topics: Amiloride; Australia; France; Humans; Hydrochlorothiazide; Hypokalemia; Hyponatremia; Indapamide; Ph | 2002 |
Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid.
Topics: Age Factors; Aged; Aged, 80 and over; Diuretics; Drug Therapy, Combination; Emergencies; Female; Fur | 2002 |
[Gitelman's syndrome: an important differential diagnosis of hypokalemia].
Topics: Adult; Alkalosis; Calcium; Carrier Proteins; Diagnosis, Differential; Diuretics; Fatigue; Female; Fu | 2003 |
The effect of hydrochlorothiazide on the kidney of the electrolyte-deficient rat.
Topics: Animals; Desoxycorticosterone; Electrolytes; Hydrochlorothiazide; Hypokalemia; Kidney; Potassium Def | 1963 |
TRIAMTERENE WITH HYDROCHLOROTHIAZIDE IN THE TREATMENT OF HYPERTENSION.
Topics: Diuretics; Hydrochlorothiazide; Hypertension; Hypokalemia; Potassium; Pterins; Sodium; Sodium, Dieta | 1963 |
[RENAL CARBONIC ANHYDRASE: ITS PHYSIOLOGICAL ACTION; ITS INHIBITORS].
Topics: Acetazolamide; Acidosis; Ammonia; Carbonic Anhydrases; Chlorothiazide; Chlorthalidone; Dichlorphenam | 1963 |
[ACUTE MALIGNANT HYPERTENSION WITH SECONDARY ALDOSTERONISM. A CASE IN A 31-YEAR-OLD MAN WITH CONGENITAL UNILATERAL RENAL HYPOPLASIA].
Topics: Alkalosis; Antihypertensive Agents; Blood Chemical Analysis; Congenital Abnormalities; Guanethidine; | 1964 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
[APROPOS OF HYPOTHIAZIDE THERAPY OF ATRIOVENTRICULAR BLOCK COMPLICATED BY ADAMS-STOKES SYNDROME].
Topics: Adams-Stokes Syndrome; Atrioventricular Block; Benzothiadiazines; Cardiovascular Diseases; Diuretics | 1963 |
THE EFFECT OF SALURETICS ON PULSE RATE, BLOOD PRESSURE AND ELECTROCARDIOGRAM DURING EXERCISE IN NORMAL SUBJECTS.
Topics: Aspirin; Biomedical Research; Blood; Blood Pressure; Blood Pressure Determination; Chlorides; Chlort | 1964 |
CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE.
Topics: Arrhythmias, Cardiac; Canada; Chlorides; Digitalis Glycosides; Diuretics; Edema; Heart Failure; Hydr | 1964 |
A NEW EFFECTIVE DIURETIC--LASIX.
Topics: Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiazide; Hypokalemia | 1964 |
THE PERIODIC PARALYSES: DIFFERENTIAL FEATURES AND PATHOLOGICAL OBSERVATIONS IN PERMANENT MYOPATHIC WEAKNESS.
Topics: Acetazolamide; Drug Therapy; Epinephrine; Humans; Hydrochlorothiazide; Hydrocortisone; Hyperkalemia; | 1964 |
DIURETIC THERAPY. VI. METABOLIC COMPLICATIONS OF THIAZIDE THERAPY AND THEIR CORRECTION.
Topics: Bendroflumethiazide; Blood; Blood Urea Nitrogen; Diuretics; Humans; Hydrochlorothiazide; Hyperglycem | 1964 |
DELIRIUM AND COMPLEX ELECTROLYTE DISTURBANCE.
Topics: Alkalosis; Chlorothiazide; Delirium; Diet, Sodium-Restricted; Drug Therapy; Electrolytes; Hydrochlor | 1965 |
HYPOKALEMIC ALKALOSIS WITH ADRENAL TUMOR: A CASE REPORT. CONN'S SYNDROME OR DRUG-INDUCED HYPOKALEMIC ALKALOSIS.
Topics: Adenoma; Adrenal Gland Neoplasms; Alkalosis; Drug Therapy; Humans; Hydrochlorothiazide; Hyperaldoste | 1965 |
CORRECTION OF DIURETIC-INDUCED HYPOKALEMIA AND HYPERURICEMIA.
Topics: Bicarbonates; Blood Chemical Analysis; Chlorthalidone; Diuretics; Drug Therapy; Geriatrics; Hydrochl | 1965 |
[USE OF SODIUM AND POTASSIUM CHLORIDE IN THE TREATMENT IN HYPOTHIAZIDE THERAPY].
Topics: Anions; Drug Therapy; Humans; Hydrochlorothiazide; Hypokalemia; Ions; Potassium; Potassium Chloride; | 1965 |
SIX-MONTH DOUBLE-BLIND STUDY OF BENZOTHIADIAZINE DRUG EFFECTS ON HYPERTENSION AND SELECTED BLOOD CHEMISTRIES.
Topics: Bendroflumethiazide; Biomedical Research; Blood Chemical Analysis; Double-Blind Method; Drug Therapy | 1965 |
Images in clinical medicine. "T-U-P" syndrome, or pseudoatrial flutter.
Topics: Aged; Antihypertensive Agents; Atrial Flutter; Electrocardiography; Humans; Hydrochlorothiazide; Hyp | 2003 |
Images in clinical medicine. Hypokalemia.
Topics: Adult; Amiloride; Diuretics; Drug Combinations; Electrocardiography; Humans; Hydrochlorothiazide; Hy | 2003 |
A thiazide test for the diagnosis of renal tubular hypokalemic disorders.
Topics: Adolescent; Adult; Bartter Syndrome; Child; Chronic Disease; Cohort Studies; Diagnosis, Differential | 2007 |
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Diuretics; Fructose; Gout Suppressants; Hydrochlo | 2007 |
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Diuretics; Hydrochlorothiazide; Hypertension, Ren | 2007 |
Differential response to thiazides and spironolactone in primary aldosteronism.
Topics: Adult; Alkalosis; Blood Pressure; Diagnosis, Differential; Humans; Hydrochlorothiazide; Hyperaldoste | 1967 |
Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias.
Topics: Adult; Aged; Ambulatory Care; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Complexes, Prem | 1983 |
Sotalol, hypokalaemia, syncope, and torsade de pointes.
Topics: Adult; Aged; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; H | 1984 |
Diuretic regimens in essential hypertension. A comparison of hypokalemic effects, BP control, and cost.
Topics: Blood Pressure; Chlorthalidone; Cost-Benefit Analysis; Diuretics; Female; Furosemide; Humans; Hydroc | 1983 |
[Case of recurrent ventricular fibrillation caused by iatrogenic hypokalemia].
Topics: Female; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Iatrogenic Disease; Midd | 1984 |
Oral potassium chloride and amiloride in hydrochlorothiazide-induced potassium loss.
Topics: Administration, Oral; Adult; Aldosterone; Amiloride; Biological Availability; Creatinine; Drug Evalu | 1984 |
Role of dietary potassium and magnesium in diuretic-treated patients with cardiac insufficiency.
Topics: Diet; Female; Heart Diseases; Humans; Hydrochlorothiazide; Hypokalemia; Magnesium; Male; Middle Aged | 1984 |
Early changes in plasma and urinary potassium in diuretic-treated patients with systemic hypertension.
Topics: Blood Pressure; Body Weight; Creatinine; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Mid | 1984 |
Combination diuretics in the elderly.
Topics: Aged; Aged, 80 and over; Amiloride; Drug Combinations; Humans; Hydrochlorothiazide; Hypokalemia; Hyp | 1983 |
Hypokalaemia induced by a combination of a beta-blocker and a thiazide.
Topics: Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypokalemia; Middle Aged; Sotalol | 1982 |
Female preponderance in diuretic-associated hypokalemia: a retrospective study in seven long-term care facilities.
Topics: Aged; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypokalemia; Long-Term Care | 1982 |
Clinical efficacy and safety of indapamide in the treatment of edema.
Topics: Body Weight; Diuretics; Double-Blind Method; Edema; Electrolytes; Female; Humans; Hydrochlorothiazid | 1983 |
Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents.
Topics: Adult; Antihypertensive Agents; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Humans; Hy | 1983 |
Thiazide diuretics, hypokalemia and cardiac arrhythmias.
Topics: Adult; Arrhythmias, Cardiac; Diuretics; Female; Heart Ventricles; Humans; Hydrochlorothiazide; Hyper | 1981 |
Potassium and magnesium balance in thiazide-treated cardiac patients with special reference to diet.
Topics: Adult; Aged; Diet; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Magnesium; Male; | 1982 |
Diuretic induced hypokalemia in the elderly.
Topics: Aged; Chlorthalidone; Diet; Diuretics; Female; Furosemide; Humans; Hydrochlorothiazide; Hypokalemia; | 1982 |
Diuretic-induced ventricular ectopic activity.
Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Exercise Test; Heart Ventricles; Humans; Hydrochlo | 1981 |
Hypokalemia during the treatment of arterial hypertension with diuretics.
Topics: Adult; Aged; Bicarbonates; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertens | 1980 |
Hypokalaemia and diuretics: an analysis of publications.
Topics: Chlorothiazide; Chlorthalidone; Coronary Disease; Diuretics; Dose-Response Relationship, Drug; Furos | 1980 |
Plasma potassium levels in hypertensive patients receiving fixed-combination diuretic therapy.
Topics: Adult; Aged; Amiloride; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension | 1980 |
Cortisol metabolism in hypertensive patients who do and do not develop hypokalemia from diuretics.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adult; Cortisone; Creatinine; Humans; Hydrochlorothiazide; Hy | 1995 |
Abnormal reabsorption of Na+/CI- by the thiazide-inhibitable transporter of the distal convoluted tubule in Gitelman's syndrome.
Topics: Adolescent; Adult; Bartter Syndrome; Carrier Proteins; Case-Control Studies; Diuretics; Female; Furo | 1997 |
[Severe and recent hyponatremia and hypokalemia associated to the use of hydrochlorothiazide, enalapril and citalopram. Clinical case].
Topics: Aged; Antidepressive Agents, Second-Generation; Antihypertensive Agents; Citalopram; Enalapril; Fema | 1999 |
['Licorice hypertension' also caused by licorice tea].
Topics: Adult; Antihypertensive Agents; Diagnostic Errors; Female; Food-Drug Interactions; Glycyrrhiza; Huma | 2001 |
Preventing hypokalemia
Topics: Angiotensin-Converting Enzyme Inhibitors; Diabetes Complications; Diuretics; Drug Interactions; Huma | 1987 |
[Persistent hypokalemia in a young woman].
Topics: Adult; Aged; Diuretics; Female; Homes for the Aged; Humans; Hydrochlorothiazide; Hypokalemia; Nursin | 1998 |
Hypokalemic rhabdomyolysis aggravated by diuretics complicating Conn's syndrome without acute renal failure.
Topics: Acute Kidney Injury; Adult; Diuretics; Female; Furosemide; Humans; Hydrochlorothiazide; Hyperaldoste | 2002 |
Dent's disease.
Topics: Calcium; Diuretics; Humans; Hydrochlorothiazide; Hypokalemia; Kidney Diseases; Kidney Failure, Chron | 2002 |
Hyponatraemia and hypokalaemia due to indapamide.
Topics: Amiloride; Australia; Chlorothiazide; Diuretics; Drug Combinations; Drug Utilization; Humans; Hydroc | 2002 |
Hypokalemic periodic paralysis.
Topics: Adolescent; Humans; Hydrochlorothiazide; Hypokalemia; Male; Paralyses, Familial Periodic; Potassium | 1979 |
[Hypokalemic myopathy caused by a long-term administration of a thiazide preparation].
Topics: Aged; Humans; Hydrochlorothiazide; Hypokalemia; Male; Muscular Diseases; Time Factors | 1977 |
Spironolactone, a reassessment.
Topics: Diuresis; Drug Combinations; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hypertension; Hypokale | 1975 |
Diuretic induced hyponatraemia in the elderly.
Topics: Aged; Diagnosis, Differential; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; H | 1992 |
Diuretics, potassium, and ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Diuretics; Humans; Hydrochlorothiazide; Hypokalemia; Hypotension; | 1992 |
Diuretics, potassium, and ventricular arrhythmias.
Topics: Adolescent; Aged; Arrhythmias, Cardiac; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hypoka | 1992 |
[Collateral effects induced by therapy with diuretics (clinical case of ventricular fibrillation caused by hypokalemia].
Topics: Aged; Captopril; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypokalemia; Male; Ventricu | 1991 |
Diuretics and electrolyte disturbances in 1000 consecutive geriatric admissions.
Topics: Age Factors; Aged; Amiloride; Diuretics; Drug Combinations; Drug Prescriptions; Humans; Hydrochlorot | 1990 |
[2 cases of severe hypokalemia with acute rhabdomyolysis].
Topics: Acute Disease; Aged; Diet; Female; Humans; Hydrochlorothiazide; Hypokalemia; Male; Rhabdomyolysis | 1990 |
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid | 1986 |
Hemodynamic consequences of diuretic-induced hypokalemia.
Topics: Adult; Cardiac Complexes, Premature; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Hypoka | 1988 |
Triamterene nephrolithiasis.
Topics: Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypokalemia; Kidney Calculi; Lithotripsy; Ma | 1989 |
[A beta blockader-diuretic combination in long-term anti-hypertensive therapy. Undesirable effects on blood potassium].
Topics: Adrenergic beta-Antagonists; Adult; Chlorthalidone; Drug Therapy, Combination; Female; Follow-Up Stu | 1985 |
Problems with the use of diuretics in the treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Coronary Disease; Diuretics; Female; Humans; Hydrochlor | 1986 |
Mechanism of diuretic-induced hypopotassemia in human hypertension.
Topics: Calcium; Erythrocyte Membrane; Erythrocytes; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; | 1985 |
[Differential diagnosis of hypercalcemic crisis associated with hypokalemia, adenoma of the parathyroid, thyroid adenomatosis, thyrotoxicosis and arterial hypertension treated with hydrochlorothiazide].
Topics: Adenoma; Diagnosis, Differential; Female; Humans; Hydrochlorothiazide; Hypercalcemia; Hypertension; | 1987 |
[Hypokalemic myopathy caused by thiazides].
Topics: Humans; Hydrochlorothiazide; Hypokalemia; Male; Middle Aged; Quadriplegia | 1987 |
What's new in diuretic therapy.
Topics: Acetazolamide; Acid-Base Imbalance; Biological Transport; Diuretics; Drug Resistance; Ethacrynic Aci | 1986 |
Renal failure with potassium-sparing diuretics.
Topics: Acute Kidney Injury; Aged; Amiloride; Anti-Inflammatory Agents; Blood Volume; Diuretics; Drug Synerg | 1985 |
Salt substitute as potassium replacement in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Diet; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia | 1986 |
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus.
Topics: Adult; Alkalosis; Amiloride; Body Weight; Child; Diabetes Insipidus; Drug Therapy, Combination; Foll | 1985 |
[Factitious Bartter's syndrome induced by the surreptitious ingestion of diuretics].
Topics: Adult; Bartter Syndrome; Diagnosis, Differential; Diuretics; Factitious Disorders; Female; Furosemid | 1985 |
[Side effects of treatment of arterial hypertension with hypothiazide].
Topics: Adult; Diuretics; Female; Humans; Hydrochlorothiazide; Hyperglycemia; Hyperlipidemias; Hypertension; | 1985 |
[Prevention of hypokalemia in the diuretic treatment of hypertensives].
Topics: Aged; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypok | 1985 |
Torsade de pointes induced by sotalol and hypokalaemia.
Topics: Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypokalemia; Male; Middle | 1985 |
[Therapy of cardiac edema with a combination of hydrochlorthiazide and amiloride-HCl (author's transl)].
Topics: Alkalosis; Diuretics; Drug Combinations; Electrolytes; Heart Failure; Hydrochlorothiazide; Hypokalem | 1973 |
Low renin hypertension and the adrenal cortex.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Blood Pressure; Cor | 1972 |
The effect of triamterene on plasma and extracellular fluid volume and blood pressure in ten thiazide-treated hypokalemic patients with essential hypertension.
Topics: Adult; Blood Pressure; Blood Volume; Drug Interactions; Extracellular Space; Female; Humans; Hydroch | 1972 |
A cure for iatrogenic disease: look before you leap.
Topics: Chlordiazepoxide; Digitoxin; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and | 1973 |
Diuretic-induced hyponatremia.
Topics: Adult; Aged; Alkalosis; Bendroflumethiazide; Biological Assay; Blood Urea Nitrogen; Bromine; Carbon | 1971 |
Renal effects and side effects of diuretics.
Topics: Absorption; Acetazolamide; Acidosis; Animals; Antihypertensive Agents; Bicarbonates; Chlorides; Chlo | 1970 |
[Possibilities of potassium substitution in rats with increased diuresis].
Topics: Animals; Diuresis; Diuretics; Furosemide; Hydrochlorothiazide; Hypokalemia; Natriuresis; Potassium; | 1970 |
Glucagon in prevention and abolition of ouabain-induced ventricular tachycardia in normokalemic and hypokalemic dogs.
Topics: Animals; Anti-Arrhythmia Agents; Diet; Digitalis Glycosides; Dogs; Female; Glucagon; Heart Block; Hy | 1971 |
Relationship of sodium and potassium intake to blood pressure.
Topics: Blood Pressure; Body Weight; Edema; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Potassiu | 1971 |
The carbohydrate metabolism of normal subjects during potassium depletion.
Topics: Adrenal Cortex Hormones; Adult; Alkalosis; Bicarbonates; Carbohydrate Metabolism; Chlorides; Diet; F | 1971 |
[On the problem of the effect of hypothiazide on the potassium content of blood plasma in patients with hypertension].
Topics: Adult; Aged; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Wate | 1967 |
[Interesting case of normokalemic primary aldosteronism with thiazide hypokalemia developing into true hypokalemia after relatively short period (4 months)].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Female; Humans; Hydrochlorothiazide; Hypera | 1967 |
[Experiences with the treatment of hypertension with a combination of guanethidine and hydrochlorothiazide (Esimil)].
Topics: Adult; Drug Synergism; Female; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; | 1967 |
[Effect of triamterene on serum potassium and serum creatinine in long-term treatment with thiazides].
Topics: Creatinine; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Polythiazide; Potassium; Triamte | 1968 |
Thiazide-induced hypokalemia with associated major ventricular arrhythmias. Report of a case and comment on therapeutic use of bretylium.
Topics: Arrhythmias, Cardiac; Bretylium Compounds; Electrocardiography; Female; Humans; Hydrochlorothiazide; | 1968 |
Effects of diuretic agents on serum and tissue electrolytes in rats.
Topics: Animals; Blood; Chlorthalidone; Diuretics; Hydrochlorothiazide; Hypokalemia; Polythiazide; Potassium | 1966 |
[Primary hyperaldosteronism (Conn's syndrome)].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Diet; Female; Humans; Hydrochlorothiazide; Hyperaldosteronis | 1966 |