hydrochlorothiazide has been researched along with Hypertension, Renal in 88 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Telmisartan (Micardis, Pritor), a highly selective angiotensin II (AII) type 1 (AT1) receptor antagonist, is approved for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive agents." | 8.83 | Telmisartan: a review of its use in the management of hypertension. ( Battershill, AJ; Scott, LJ, 2006) |
| "The effect of long-term treatment of hypertension with propranolol, alone or in combination with hydrochlorothiazide and/or dihydralazine, was investigated in 93 patients with various types of hypertension." | 7.66 | [Long-term treatment of arterial hypertension with propranolol. Combination with diuretics and dihydrazinophthalazine]. ( Ambrosio, G; Corgnati, A; Dal Palù, C; Palatini, P; Pessina, AC, 1978) |
| "The objectives of this study were to compare the effects of the angiotensin II receptor blocker, losartan, to those of the angiotensin-converting enzyme inhibitor, enalapril, on albuminuria and renal function in relationship to clinic and ambulatory blood pressure (ABP) in hypertensive type 2 diabetic subjects with early nephropathy." | 5.09 | Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy. ( Bélanger, A; Godin, C; Hallé, JP; Lacourcière, Y; Marion, J; Ross, S; Wright, N, 2000) |
| "Telmisartan (Micardis, Pritor), a highly selective angiotensin II (AII) type 1 (AT1) receptor antagonist, is approved for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive agents." | 4.83 | Telmisartan: a review of its use in the management of hypertension. ( Battershill, AJ; Scott, LJ, 2006) |
| "Hydrochlorothiazide (HCTZ) is used to manage hypertension and heart failure; however, its side effects include mild hypokalemia, metabolic abnormalities, and volume depletion, which might have deleterious effects on renal and endothelial function." | 3.74 | Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia. ( Byer, K; Croker, BP; Hu, H; Johnson, RJ; Mu, W; Nakagawa, T; Patel, JM; Reungjui, S; Roncal, CA; Simoni, J; Sitprija, V; Srinivas, T; Wesson, D, 2007) |
| "The effect of long-term treatment of hypertension with propranolol, alone or in combination with hydrochlorothiazide and/or dihydralazine, was investigated in 93 patients with various types of hypertension." | 3.66 | [Long-term treatment of arterial hypertension with propranolol. Combination with diuretics and dihydrazinophthalazine]. ( Ambrosio, G; Corgnati, A; Dal Palù, C; Palatini, P; Pessina, AC, 1978) |
| "Renal artery stenosis is among the most common curable causes of hypertension." | 2.70 | Resistance to antihypertensive medication as predictor of renal artery stenosis: comparison of two drug regimens. ( Deinum, J; Derkx, FH; Krijnen, P; Postma, CT; Schalekamp, MA; van Jaarsveld, BC; Woittiez, AJ, 2001) |
| "Amiloride treatment caused a 2-fold greater increase in Na(+) excretion in knockout, compared with WT." | 1.42 | Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency. ( Boettger, T; Cornelius, RJ; Li, H; Sansom, SC; Wang, B; Wang-France, J; Warner, PC; Wen, D; Yuan, Y, 2015) |
| " Pharmacokinetic-pharmacodynamic (PK/PD) modeling was applied to investigate the pharmacokinetic and pharmacodynamic interaction between irbesartan and HCTZ in renal hypertensive dogs at non-steady-state and steady-state." | 1.33 | Pharmacokinetic and pharmacodynamic interaction between irbesartan and hydrochlorothiazide in renal hypertensive dogs. ( Huang, XH; Li, J; Qiu, FR; Xie, HT, 2005) |
| "Perindopril was associated with significantly lower AER than lacidipine, whereas lacidipine was more potent in preventing increases in ocular AVC." | 1.29 | Organ specificity of antihypertensive therapy on ocular albumin vascular clearance and albuminuria in the hypertensive diabetic rat. ( Cooper, M; Gin, T; Jerums, G; Joon, TL; Panagiotopoulos, S; Taylor, H, 1996) |
| "When nitrendipine was combined with thiazides, a lowering of plasma potassium levels could be found, which, however, did not necessitate any therapy." | 1.27 | Safety aspects of long-term nitrendipine therapy. ( Corsing, C; Deck, K; Ingram, C; Stoepel, K; Vanov, SK, 1984) |
| " Its effect is dosage dependent." | 1.25 | [Pharmacological and toxicological properties of the saluretic xipamide (4-chloro-5-sulfamoyl-2',6'-salicyloxylidide)]. ( Bahrmann, H; Leuschner, F; Neumann, W, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (77.27) | 18.7374 |
| 1990's | 5 (5.68) | 18.2507 |
| 2000's | 13 (14.77) | 29.6817 |
| 2010's | 2 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M | 1 |
| Uchida, S | 1 |
| Kawamura, T | 1 |
| Kuwahara, M | 1 |
| Nangaku, M | 1 |
| Iino, Y | 1 |
| Wen, D | 1 |
| Yuan, Y | 1 |
| Warner, PC | 1 |
| Wang, B | 1 |
| Cornelius, RJ | 1 |
| Wang-France, J | 1 |
| Li, H | 1 |
| Boettger, T | 1 |
| Sansom, SC | 1 |
| Xie, HH | 1 |
| Zhang, XF | 1 |
| Chen, YY | 1 |
| Shen, FM | 1 |
| Su, DF | 1 |
| Tiwari, S | 1 |
| Li, L | 1 |
| Riazi, S | 1 |
| Halagappa, VK | 1 |
| Ecelbarger, CM | 1 |
| Handler, J | 1 |
| TAKEUCHI, J | 1 |
| TAKEDA, T | 1 |
| UCHIDA, E | 1 |
| OKADA, R | 1 |
| SHINTANI, F | 1 |
| SCHULTZ, J | 1 |
| HOLTZ, M | 1 |
| HAGEMANN, I | 1 |
| LIU, JF | 1 |
| LI, HY | 1 |
| TING, KS | 1 |
| SANCHETTI, P | 1 |
| FAVERO, S | 1 |
| LONGARETTI, A | 1 |
| BELSITO, F | 1 |
| SHULGA, IuD | 1 |
| GIRALDI, A | 1 |
| CHERIELIGNIERE, EL | 1 |
| DIMARCO, N | 1 |
| CASIROLA, G | 1 |
| TARTARA, A | 1 |
| CHERIE LIGNIERE, E | 1 |
| PARDO, EG | 1 |
| VIDRIO, H | 1 |
| VARGAS, R | 1 |
| GELFAND, ML | 1 |
| GARREN, MG | 1 |
| ROWAN, RL | 1 |
| Griffin, KA | 1 |
| Picken, MM | 1 |
| Bidani, AK | 1 |
| Soto, K | 1 |
| Gómez-Garre, D | 1 |
| Largo, R | 1 |
| Gallego-Delgado, J | 1 |
| Tejera, N | 1 |
| Catalán, MP | 1 |
| Ortiz, A | 1 |
| Plaza, JJ | 1 |
| Alonso, C | 1 |
| Egido, J | 1 |
| Minutolo, R | 1 |
| De Nicola, L | 1 |
| Zamboli, P | 1 |
| Chiodini, P | 1 |
| Signoriello, G | 1 |
| Toderico, C | 1 |
| Arfè, G | 1 |
| Boschi, G | 1 |
| Brancati, C | 1 |
| Iaccarino, P | 1 |
| Conte, G | 1 |
| Huang, XH | 1 |
| Qiu, FR | 1 |
| Xie, HT | 1 |
| Li, J | 1 |
| Battershill, AJ | 1 |
| Scott, LJ | 1 |
| Reungjui, S | 1 |
| Hu, H | 1 |
| Mu, W | 1 |
| Roncal, CA | 1 |
| Croker, BP | 1 |
| Patel, JM | 1 |
| Nakagawa, T | 1 |
| Srinivas, T | 1 |
| Byer, K | 1 |
| Simoni, J | 1 |
| Wesson, D | 1 |
| Sitprija, V | 1 |
| Johnson, RJ | 1 |
| Westhoff, JH | 1 |
| Hilgers, KF | 1 |
| Steinbach, MP | 1 |
| Hartner, A | 1 |
| Klanke, B | 1 |
| Amann, K | 1 |
| Melk, A | 1 |
| Stoepel, K | 1 |
| Deck, K | 1 |
| Corsing, C | 1 |
| Ingram, C | 1 |
| Vanov, SK | 1 |
| Bauer, JH | 3 |
| Cushman, DW | 2 |
| Ondetti, MA | 1 |
| Cheung, HS | 1 |
| Antonaccio, MJ | 2 |
| Murthy, VS | 1 |
| Rubin, B | 2 |
| Sweet, CS | 3 |
| Gross, DM | 1 |
| Arbegast, PT | 1 |
| Gaul, SL | 1 |
| Britt, PM | 1 |
| Ludden, CT | 1 |
| Weitz, D | 1 |
| Stone, CA | 1 |
| Havelka, J | 1 |
| Vetter, H | 2 |
| Studer, A | 1 |
| Greminger, P | 1 |
| Lüscher, T | 1 |
| Wollnik, S | 1 |
| Siegenthaler, W | 1 |
| Vetter, W | 1 |
| Wenting, GJ | 1 |
| de Bruyn, JH | 1 |
| Man in't Veld, AJ | 1 |
| Woittiez, AJ | 2 |
| Derkx, FH | 2 |
| Schalekamp, MA | 2 |
| Roeckel, A | 1 |
| Heidland, A | 1 |
| Ribeiro, AB | 1 |
| Alves Filho, G | 1 |
| de Almeida, FA | 1 |
| Kohlmann Junior, O | 1 |
| Stella, SR | 1 |
| Ramos, OL | 1 |
| Chan, PS | 1 |
| Ronsberg, MA | 1 |
| Cervoni, P | 1 |
| Emmerson, BT | 1 |
| Renshaw, PJ | 1 |
| Ravenscroft, PJ | 1 |
| Denham, I | 1 |
| Schey, S | 1 |
| Amery, A | 1 |
| Birkenhäger, W | 1 |
| Bogaert, M | 1 |
| Brixko, P | 1 |
| Bulpitt, C | 1 |
| Clement, D | 1 |
| De Leeuw, P | 1 |
| De Plaen, JF | 1 |
| Deruyttere, M | 1 |
| De Schaepdryver, A | 1 |
| Fagard, R | 1 |
| Forette, F | 1 |
| Forte, J | 1 |
| Hamdy, R | 1 |
| Hellemans, J | 1 |
| Henry, JF | 1 |
| Koistinen, A | 1 |
| Laaser, U | 1 |
| Laher, M | 1 |
| Leonetti, G | 1 |
| Lewis, P | 1 |
| Lund-Johansen, P | 1 |
| MacFarlane, J | 1 |
| Meurer, K | 1 |
| Miguel, P | 1 |
| Morris, J | 1 |
| Mutsers, A | 1 |
| Nissinen, A | 1 |
| O'Brien, E | 1 |
| Ohm, OJ | 1 |
| O'Malley, K | 1 |
| Pelemans, W | 1 |
| Perera, N | 1 |
| Tuomilehto, J | 1 |
| Verschueren, LJ | 1 |
| Willemse, P | 1 |
| Williams, B | 1 |
| Zanchetti, A | 1 |
| Beretta, R | 1 |
| Cassi, E | 1 |
| Colombo, A | 1 |
| De Paoli, A | 1 |
| Marciandi, C | 1 |
| Renzetti, GA | 1 |
| Pessina, AC | 2 |
| Hlede, M | 1 |
| Pigato, R | 1 |
| Palatini, P | 2 |
| Dal Palù, C | 2 |
| Juncos, LI | 1 |
| Carrasco Dueñas, S | 1 |
| Cornejo, JC | 1 |
| Broglia, CA | 1 |
| Cejas, H | 1 |
| Gin, T | 1 |
| Joon, TL | 1 |
| Panagiotopoulos, S | 1 |
| Cooper, M | 1 |
| Taylor, H | 1 |
| Jerums, G | 1 |
| Schwenger, V | 1 |
| Zeier, M | 1 |
| Ritz, E | 1 |
| Lottermoser, K | 1 |
| Hertfelder, HJ | 1 |
| Düsing, R | 1 |
| Lacourcière, Y | 1 |
| Bélanger, A | 1 |
| Godin, C | 1 |
| Hallé, JP | 1 |
| Ross, S | 1 |
| Wright, N | 1 |
| Marion, J | 1 |
| van Jaarsveld, BC | 1 |
| Krijnen, P | 1 |
| Deinum, J | 1 |
| Postma, CT | 1 |
| Finch, L | 1 |
| Hicks, PE | 1 |
| Moore, RA | 1 |
| Gulati, OP | 1 |
| Chakravarti, RN | 1 |
| Sharma, PL | 1 |
| Mandradjieff, M | 1 |
| De Giorgio, LA | 1 |
| Innocenti, F | 1 |
| Bartolomei, GC | 1 |
| Cade, R | 1 |
| Juncos, L | 1 |
| Tarrant, D | 1 |
| Mahoney, J | 1 |
| Raulerson, D | 1 |
| Horovitz, ZP | 1 |
| Panasevich, RE | 1 |
| Inada, Y | 2 |
| Nishikawa, K | 2 |
| Nagaoka, A | 1 |
| Kikuchi, S | 1 |
| Corgnati, A | 1 |
| Ambrosio, G | 1 |
| Molnár, K | 1 |
| Kömíves, S | 1 |
| Kalmár, J | 1 |
| Gerzon, J | 1 |
| Gunnells, JC | 1 |
| McGuffin, WL | 1 |
| Depner, TA | 1 |
| Sullivan, MJ | 1 |
| Ryan, KG | 1 |
| Winn, DF | 1 |
| McCusker, JJ | 1 |
| Yamauchi, H | 1 |
| Leuschner, F | 1 |
| Neumann, W | 1 |
| Bahrmann, H | 1 |
| DeForrest, JM | 1 |
| Waldron, TL | 1 |
| Harvey, C | 1 |
| Scalese, B | 1 |
| Mitch, S | 1 |
| Powell, JR | 1 |
| Petrillo, W | 1 |
| Gurgenian, SV | 1 |
| Mikaelian, ES | 1 |
| Dzhandzhapanian, AZ | 1 |
| Babaian, AS | 1 |
| Anderson, S | 2 |
| Rennke, HG | 2 |
| Garcia, DL | 1 |
| Brenner, BM | 2 |
| Reams, GP | 2 |
| Lal, SM | 1 |
| Tanabe, M | 1 |
| Kawazoe, K | 1 |
| Gaddy, P | 1 |
| Dworkin, LD | 1 |
| Feiner, HD | 1 |
| Randazzo, J | 1 |
| Neugarten, J | 1 |
| Kaminetsky, B | 1 |
| Feiner, H | 1 |
| Schacht, RG | 1 |
| Liu, DT | 1 |
| Baldwin, DS | 1 |
| Schiffl, H | 2 |
| Schollmeyer, P | 2 |
| Bailey, DM | 1 |
| DeGrazia, CG | 1 |
| Wood, D | 1 |
| Siggins, J | 1 |
| Harding, HR | 1 |
| Potts, GO | 1 |
| Skulan, TW | 1 |
| Peters, G | 1 |
| Kubota, K | 1 |
| Nicholas, TE | 1 |
| Teichmann, G | 1 |
| Löper, W | 1 |
| Wenger, HC | 1 |
| O'Malley, TA | 1 |
| Fukuchi, S | 1 |
| Nakajima, K | 1 |
| Takenouchi, T | 1 |
| Nishisato, K | 1 |
| Kusumoto, M | 1 |
| Constantopoulos, G | 1 |
| Genest, J | 1 |
| Ganten, D | 1 |
| Ganten, U | 1 |
| Rojo-Ortega, JM | 1 |
| Boucher, R | 1 |
| Freis, ED | 1 |
| Spanos, PK | 1 |
| Simmons, RL | 1 |
| Kjellstrand, CM | 1 |
| Buselmeier, TJ | 1 |
| Najarian, JS | 1 |
| Dargie, HJ | 1 |
| Kennedy, AC | 1 |
| Ward, DM | 1 |
| Boddy, K | 1 |
| King, PC | 1 |
| Kim, KE | 1 |
| Onesti, G | 1 |
| Swartz, C | 1 |
| Murphy, AV | 1 |
| Paris, GL | 1 |
| Macoul, KL | 1 |
| Anderson, J | 1 |
| Godfrey, BE | 1 |
| Hill, DM | 1 |
| Munro-Faure, AD | 1 |
| Sheldon, J | 1 |
| Sales, EJ | 1 |
| Villa, JJ | 1 |
| Mendez, MA | 1 |
| Schubert, R | 1 |
| Pasz, T | 1 |
| Maebashi, M | 1 |
| Yoshinaga, K | 1 |
| Miura, K | 1 |
| Goto, K | 1 |
| Katsushima, I | 1 |
| Cagli, V | 1 |
| Ruotolo, V | 1 |
| Bossini, A | 1 |
| Bologna, E | 1 |
| Frotscher, U | 1 |
| Wilbrandt, R | 1 |
| Piehl, W | 1 |
| Freyland, MD | 1 |
| Messerschmidt, W | 1 |
| Pavesi, V | 1 |
| Campus, G | 1 |
| Glezer, GA | 1 |
| Repetto, S | 1 |
| Rezzonico, A | 1 |
| Gervasini, N | 1 |
| Anfossi, F | 1 |
| Guaraggi, A | 1 |
| Rossi, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Uric Acid and Hypertension in African Americans[NCT00241839] | Phase 3 | 150 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| Delaying the Progression of Diabetic Nephropathy in Pima Indians[NCT00353600] | 25 participants (Anticipated) | Observational | 1994-08-19 | Completed | |||
| Renoprotection in Early Diabetic Nephropathy in Pima Indians[NCT00340678] | Phase 3 | 170 participants (Actual) | Interventional | 1995-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 3.44 |
| B (Placebo) | -0.83 |
Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | -5.9 |
| B (Placebo) | 0.90 |
"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 0.21 |
| B (Placebo) | -0.95 |
Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)
| Intervention | mg/dl (Mean) |
|---|---|
| A (Allopurinol) | 2.29 |
| B (Placebo) | 0.14 |
(NCT00340678)
Timeframe: 6 years after first treatment
| Intervention | *10^6 cubic microns (Mean) |
|---|---|
| Normoalbuminuria Losartan | 5.4 |
| Normoalbuminuria Placebo | 5.6 |
| Microalbuminuria Losartan | 6.4 |
| Microalbuminuria Placebo | 7.0 |
Participants were monitored for up to 6 years. This is the number of participants who had a decline in GFR to less than or equal to 60 ml/min or to half the baseline value in subjects that enter the study with a GFR of less than 120 ml/min during the time of observation. (NCT00340678)
Timeframe: Up to 6 years
| Intervention | participants (Number) |
|---|---|
| Normoalbuminuria Losartan | 2 |
| Normoalbuminuria Placebo | 2 |
| Microalbuminuria Losartan | 1 |
| Microalbuminuria Placebo | 4 |
4 reviews available for hydrochlorothiazide and Hypertension, Renal
| Article | Year |
|---|---|
Telmisartan: a review of its use in the management of hypertension.
Topics: Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Diabetes Mellitus, Type 2; Drug | 2006 |
Role of angiotensin converting enzyme inhibitors in essential and renal hypertension. Effects of captopril and enalapril on renin-angiotensin-aldosterone, renal function and hemodynamics, salt and water excretion, and body fluid composition.
Topics: Body Fluids; Captopril; Dipeptides; Drug Evaluation; Enalapril; Glomerular Filtration Rate; Hemodyna | 1984 |
Low renin hypertension.
Topics: Adult; Age Factors; Diagnosis, Differential; Female; Humans; Hydrochlorothiazide; Hyperaldosteronism | 1975 |
The treatment of hypertension. Why, when and how.
Topics: Arteriosclerosis; Cardiovascular Diseases; Diuretics; Female; Guanethidine; Humans; Hydralazine; Hyd | 1972 |
11 trials available for hydrochlorothiazide and Hypertension, Renal
| Article | Year |
|---|---|
Prospective randomized study of the tolerability and efficacy of combination therapy for hypertensive chronic kidney disease: results of the PROTECT-CKD study.
Topics: Adult; Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhi | 2015 |
Ticrynafen and hydrochlorothiazide. A comparison in hypertensive patients with renal impairment.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Glycolates; Huma | 1982 |
Antihypertensive therapy in patients above age 60 with systolic hypertension. A progress report of the European Working Party on High Blood Pressure in the Elderly (EWPHE).
Topics: Aged; Blood Glucose; Blood Pressure; Creatinine; Drug Therapy, Combination; Electrolytes; Female; Hu | 1982 |
Fibrinolytic function in diuretic-induced volume depletion.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Blood Volume; Diuretics; Drug Therapy, Combination; | 2000 |
Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy.
Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neph | 2000 |
Resistance to antihypertensive medication as predictor of renal artery stenosis: comparison of two drug regimens.
Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Atenolol; Blood Pressure; Cohort Studi | 2001 |
Renal physiology and the treatment of hypertension.
Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Depression, Chemical; Drug Therapy, Combinati | 1977 |
Metabolic consequences of long-term thiazide-based antihypertensive treatment of renal hypertension.
Topics: Adolescent; Adult; Aged; Amiloride; Blood Glucose; Blood Pressure; Cholesterol; Coronary Disease; Dr | 1985 |
Total body potassium in long-term Lasix therapy.
Topics: Aldosterone; Clinical Trials as Topic; Diuresis; Furosemide; Humans; Hydrochlorothiazide; Hypertensi | 1974 |
A comparison of the effects of hydrochlorothiazide and of frusemide in the treatment of hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Blood Proteins; Carbon Dioxide; Clinical Trials as Topic; Female; Furos | 1971 |
[Comparative mass studies on alpha-methyldopa (Presinol), Sali-Presinol and Cyclazenine in hypertensives of various origin].
Topics: Adult; Aged; Clinical Trials as Topic; Female; Guanine; Humans; Hydrochlorothiazide; Hypertension; H | 1965 |
73 other studies available for hydrochlorothiazide and Hypertension, Renal
| Article | Year |
|---|---|
Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.
Topics: Amiloride; Animals; Antihypertensive Agents; Disease Models, Animal; Diuretics; Epithelial Sodium Ch | 2015 |
Synergism of hydrochlorothiazide and nifedipine on blood pressure variability reduction and organ protection in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Calcium Channel Blockers; Drug Synergi | 2008 |
Sex and age result in differential regulation of the renal thiazide-sensitive NaCl cotransporter and the epithelial sodium channel in angiotensin II-infused mice.
Topics: Age Factors; Aging; Angiotensin II; Animals; Blood Pressure; Diuretics; Epithelial Sodium Channels; | 2009 |
Lithium and antihypertensive medication: a potentially dangerous interaction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Antimanic Agents; Bipolar Disorde | 2009 |
Vascular lesions in experimental renal hypertension, with special reference to effect of hypotensive treatment.
Topics: Arteries; Cerebral Hemorrhage; Coronary Vessels; Guanethidine; Humans; Hydralazine; Hydrochlorothiaz | 1963 |
[The effect of prolonged administration of hydrochlorothiazide on the development of experimental renal hypertension and on electrolyte metabolism in rats].
Topics: Animals; Chlorides; Electrolytes; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Kidney; Po | 1963 |
[EFFECTS OF 6 DRUGS ON THE PRODUCTION OF RENAL HYPERTENSION IN RATS].
Topics: Alkaloids; Bretylium Compounds; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Pharmacology | 1962 |
[CLINICAL STUDY OF A NEW COMPLEX HYPOTENSIVE DRUG COMBINATION].
Topics: Antihypertensive Agents; Arteriosclerosis; Carbamates; Cerebrovascular Disorders; Coronary Disease; | 1963 |
[CLINICAL RESEARCH WITH A COMPOUND HYPOTENSIVE PREPARATION (MEBUTAMATE + 1-4 DIHYDRAZINOPHTHALAZINE + DIHYDROCHLOROTHIAZIDE + POTASSIUM)].
Topics: Antihypertensive Agents; Arteriosclerosis; Carbamates; Humans; Hydralazine; Hydrochlorothiazide; Hyp | 1963 |
[APPLICATION OF HYPOTHIAZIDE IN CHRONIC KIDNEY DISEASES].
Topics: Acute Kidney Injury; Blood Chemical Analysis; Glomerulonephritis; Hydrochlorothiazide; Hypertension; | 1963 |
[ACTION OF ALPHA-METHYLDOPA IN COMBINATION WITH DIHYDROCHLOROTHIAZIDE ON RENAL HEMODYNAMICS IN HYPERTENSIVE SUBJECTS].
Topics: Antihypertensive Agents; Arteriosclerosis; Blood Circulation; Diuresis; Hemodynamics; Humans; Hydroc | 1963 |
[ON THE ACTION OF TRIAMTERENE ON SALIDIURESIS CAUSED BY HYDROCHLOROTHIAZIDE].
Topics: Ascites; Diuresis; Diuretics; Edema; Heart Failure; Hepatitis; Hydrochlorothiazide; Hypertension; Hy | 1963 |
[CONTRIBUTION TO THE STUDY OF EXPERIMENTAL MODELS OF ARTERIAL HYPERTENSION].
Topics: Animals; Chlorisondamine; Classification; Cortisone; Dogs; Ganglionic Blockers; Hydrochlorothiazide; | 1964 |
ACUTE ANURIA ASSOCIATED WITH CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE THERAPY: RECOVERY.
Topics: Acute Kidney Injury; Anuria; Chlorothiazide; Diabetes Mellitus; Digoxin; Geriatrics; Gout; Hydrochlo | 1964 |
Blood pressure lability and glomerulosclerosis after normotensive 5/6 renal mass reduction in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Enalapril; Glomeruloscl | 2004 |
Tight blood pressure control decreases apoptosis during renal damage.
Topics: Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; Cell Division; Drug Therapy, Combinatio | 2004 |
Management of hypertension in patients with CKD: differences between primary and tertiary care settings.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzy | 2005 |
Pharmacokinetic and pharmacodynamic interaction between irbesartan and hydrochlorothiazide in renal hypertensive dogs.
Topics: Animals; Biphenyl Compounds; Dogs; Drug Interactions; Drug Therapy, Combination; Hydrochlorothiazide | 2005 |
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Diuretics; Hydrochlorothiazide; Hypertension, Ren | 2007 |
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Antihypertensive Ag | 2008 |
Safety aspects of long-term nitrendipine therapy.
Topics: Calcium Channel Blockers; Drug Therapy, Combination; Electrocardiography; Humans; Hydrochlorothiazid | 1984 |
Inhibitors of angiotensin-converting enzyme.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Binding Sites; Binding, Competitiv | 1980 |
Antihypertensive activity of N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro (MK-421), an orally active converting enzyme inhibitor.
Topics: Administration, Oral; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihyperten | 1981 |
Acute and chronic effects of the angiotensin-converting enzyme inhibitor captopril in severe hypertension.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; Creatinine; Dose-R | 1982 |
Hemodynamic effects of captopril in essential hypertension, renovascular hypertension and cardiac failure: correlations with short- and long-term effects on plasma renin.
Topics: Blood Pressure; Captopril; Drug Therapy, Combination; Female; Heart Failure; Hemodynamics; Humans; H | 1982 |
Acute and chronic renal effects of guanfacine in essential and renal hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Creatinine; Drug Therapy, Combination; Electrolytes; Glomer | 1980 |
[Captopril in the clinical treatment of renovascular hypertension].
Topics: Adult; Blood Pressure; Captopril; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hy | 1980 |
Studies on the mechanism of the synergistic antihypertensive activity of captopril and hydrochlorothiazide following acute administration in spontaneously hypertensive rats.
Topics: Animals; Captopril; Drug Synergism; Drug Therapy, Combination; Hydrochlorothiazide; Hypertension; Hy | 1982 |
[Treatment of hypertensive states with a combination of alpha-methyldopa and a diuretic].
Topics: Adult; Aged; Antihypertensive Agents; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypert | 1982 |
[Alpha-methyldopa and renal function in arterial hypertension].
Topics: Antihypertensive Agents; Clonidine; Dihydralazine; Humans; Hydrochlorothiazide; Hypertension; Hypert | 1980 |
Long-term enalapril and hydrochlorothiazide in radiation nephritis.
Topics: Animals; Blood Pressure; Enalapril; Hydrochlorothiazide; Hypertension, Renal; Nephrectomy; Nephritis | 1993 |
Organ specificity of antihypertensive therapy on ocular albumin vascular clearance and albuminuria in the hypertensive diabetic rat.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Press | 1996 |
Antihypertensive therapy in renal patients - benefits and difficulties.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive A | 1999 |
Changes in vascular reactivity in experimental hypertensive animals following treatment with indapamide.
Topics: Animals; Blood Pressure; Brain; Cats; Desoxycorticosterone; Diuretics; Hydrochlorothiazide; Hyperten | 1977 |
Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys.
Topics: Animals; Female; Haplorhini; Hydrochlorothiazide; Hypertension, Renal; Macaca mulatta; Male; Spirono | 1978 |
Enhancement of the antihypertensive effect of hydrochlorothiazide in dogs after suppression of renin release by beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Dogs; Drug Synergism; Hydrochlorothiazide; Hyp | 1975 |
[Antihypertensive effectiveness and tolerability of a combination of methyldopa and hydrochlorothiazide with and without potassium supplementation].
Topics: Adult; Aged; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Hydrochlorothiazide; Hyperte | 1979 |
Influence of various antihypertensive agents on lifespan of renal hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Diuretics; Hydralazine; Hydrochlorothiazide; Hypert | 1979 |
Comparison of the hypotensive and diuretic effects of 1,4-dimorpholino-7-phenylpyrido[3,4]pyridazine (DS-511) and hydrochlorothiazide in Doca, renal and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Diuretics; Hydrochlorothiazide; Hypertension; Hyperte | 1977 |
[Long-term treatment of arterial hypertension with propranolol. Combination with diuretics and dihydrazinophthalazine].
Topics: Adult; Dihydralazine; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydro | 1978 |
The use of the drug combination of hypothiazide+Visken+Halidor in hypertension.
Topics: Adult; Bencyclane; Cycloheptanes; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hy | 1978 |
Posttraumatic renal artery stenosis. Cure of hypertension by late revascularization.
Topics: Abdominal Injuries; Accidents, Traffic; Adult; Aortography; Blood Pressure; Female; Humans; Hydrochl | 1975 |
[Pharmacological and toxicological properties of the saluretic xipamide (4-chloro-5-sulfamoyl-2',6'-salicyloxylidide)].
Topics: Animals; Blood Glucose; Chlorides; Diuresis; Diuretics; Dogs; Dose-Response Relationship, Drug; Drug | 1975 |
Blood pressure lowering and renal hemodynamic effects of fosinopril in conscious animal models.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Dogs; Female; Fosinopril; He | 1990 |
Efficacy of intravenous verapamil in arterial hypertension refractory to three-step antihypertensive therapy.
Topics: Adult; Antihypertensive Agents; Clonidine; Echocardiography; Female; Hemodynamics; Humans; Hydrochlo | 1991 |
Short and long term effects of antihypertensive therapy in the diabetic rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Diabetic Nephropathies; Drug Administra | 1989 |
Short and long term effects of antihypertensive therapy in the diabetic rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Diabetic Nephropathies; Drug Administra | 1989 |
Short and long term effects of antihypertensive therapy in the diabetic rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Diabetic Nephropathies; Drug Administra | 1989 |
Short and long term effects of antihypertensive therapy in the diabetic rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Diabetic Nephropathies; Drug Administra | 1989 |
Renal protective effect of strict blood pressure control with enalapril therapy.
Topics: Blood Pressure; Drug Therapy, Combination; Enalapril; Female; Follow-Up Studies; Humans; Hydrochloro | 1987 |
Antihypertensive action of a new angiotensin converting enzyme inhibitor, (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo-2,3,4,5-tetr ahy dro-1,5-benzothiazepine-5-acetic acid (CV-5975), in various hypertensive models.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Dogs; En | 1988 |
Use of the converting enzyme inhibitor enalapril in renovascular hypertension. Effect on blood pressure, renal function, and the renin-angiotensin-aldosterone system.
Topics: Angiography; Blood Pressure; Creatinine; Drug Therapy, Combination; Enalapril; Female; Glomerular Fi | 1986 |
Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Glomerular Filtration Rate; Hydralazin | 1986 |
Glomerular hypertension and injury in desoxycorticosterone-salt rats on antihypertensive therapy.
Topics: Animals; Blood Pressure; Capillaries; Desoxycorticosterone; Hydralazine; Hydrochlorothiazide; Hypert | 1987 |
Nephrotoxic serum nephritis with hypertension: amelioration by antihypertensive therapy.
Topics: Animals; Antihypertensive Agents; Dietary Proteins; Glomerular Filtration Rate; Hydralazine; Hydroch | 1985 |
Clinical efficacy and safety of long-term diuretic treatment in renal parenchymal hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Cholesterol; Chronic Disease; Diuretics; Drug Therapy, Combi | 1985 |
Amine functions of reduced basicity. Hypoglycemic and natriuretic alpha-alkoxybenzylamidoximes, amidines, and cycloamidines.
Topics: Amidines; Animals; Blood Glucose; Blood Pressure; Cats; Codeine; Dogs; Haplorhini; Hydrochlorothiazi | 1974 |
Effects of val-5-angiotensin II-amide and of hydrochlorothiazide on the kidneys of renal hypertensive rats.
Topics: Angiotensin II; Animals; Desoxycorticosterone; Diuresis; Hydrochlorothiazide; Hypertension, Renal; I | 1965 |
[Study on the renin-angiotensin-aldosterone system. Effects of sodium restriction and postural changes on plasma renin activity and fluctuation in urinary aldosterone].
Topics: Aldosterone; Angiotensin II; Blood Pressure; Chromatography, Thin Layer; Diet, Sodium-Restricted; Hu | 1969 |
Responses of mean arterial pressure to pressor agents and diuretics in renal hypertensive and salt hypertensive rats.
Topics: Anesthesia, General; Angiotensin II; Animals; Arteries; Autonomic Nerve Block; Blood Pressure; Desox | 1971 |
[Use, association and contraindications of hypotensive drugs].
Topics: Antihypertensive Agents; Blood Pressure; Coronary Disease; Diuretics; Furosemide; Ganglionic Blocker | 1969 |
Antagonism of hydrochlorothiazide-induced elevations in plasma-renin activity by methyldopa in conscious renal-hypertensive dogs.
Topics: Animals; Blood Pressure; Dogs; Female; Hydrochlorothiazide; Hypertension, Renal; Kidney; Male; Methy | 1974 |
Plasma aldosterone in essential hypertension with low renin activity.
Topics: Aldosterone; Body Weight; Corticosterone; Cushing Syndrome; Furosemide; Humans; Hydrochlorothiazide; | 1974 |
Effects of hydrochlorothiazide on water, cation, and norepinephrine contents of cardiovascular tissues of renovascular hypertensive dogs.
Topics: Animals; Aorta, Thoracic; Arteries; Blood Pressure; Blood Volume; Calcium; Carotid Arteries; Dogs; E | 1974 |
Kidney transplantation from living related donors with multiple vessels. A problem revisited.
Topics: Adolescent; Adult; Blood Pressure; Cadaver; Child; Child, Preschool; Creatinine; Female; Follow-Up S | 1973 |
Problems in therapy for the hypertensive patient.
Topics: Antihypertensive Agents; Blood Pressure; Carotid Sinus; Diuretics; Electric Stimulation; Ethacrynic | 1973 |
Value and toxicity of therapy for idiopathic nephrotic syndrome in the child.
Topics: Anti-Bacterial Agents; Blood Protein Disorders; Child; Chlorothiazide; Cyclophosphamide; Diet, Sodiu | 1973 |
Reversible bullous retinal detachment in chronic renal disease.
Topics: Adult; Angiography; Diet; Female; Fluorescence; Humans; Hydrochlorothiazide; Hypertension, Renal; Hy | 1969 |
[Treatment of essential and nephrogenic hypertension using alpha-methyldopa and alpha-methyldopa+hydrochlorothiazide. Comparative study].
Topics: Administration, Oral; Adult; Aged; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertension, | 1971 |
Suppressed plasma renin activity in in hypertensive patients--its evaluation for the diagnosis of primary aldosteronism.
Topics: Aldosterone; Cushing Syndrome; Diet, Sodium-Restricted; Glomerulonephritis; Humans; Hydrochlorothiaz | 1969 |
[Renal excretion of uric acid in various conditions inducing hyperuricemia].
Topics: Adolescent; Adult; Aged; Female; Gout; Humans; Hydrochlorothiazide; Hypertension, Renal; Kidney Fail | 1970 |
[Influence of a combinated adelphan-esidrix and clonidin therapy on blood pressure and renal function in renal hypertension].
Topics: Adult; Aniline Compounds; Blood Pressure Determination; Blood Urea Nitrogen; Drug Synergism; Female; | 1971 |
[Results of hypotensive treatment in a hospital environment].
Topics: Adult; Aged; Arteriosclerosis; Carbamates; Female; Humans; Hydralazine; Hydrochlorothiazide; Hyperte | 1968 |
[Effect of hypotensive substances (hypothiazide, guanetidine, alpha-methyldopa) on basic hemodynamic indices].
Topics: Blood Pressure; Blood Volume; Cardiac Output; Cardiovascular System; Guanethidine; Hematocrit; Hemod | 1968 |
[Considerations on ambulatory therapy in a group of hypertensive patients].
Topics: Adult; Aged; Ambulatory Care; Carbamates; Female; Guanethidine; Humans; Hydralazine; Hydrochlorothia | 1969 |
[On the antihypertensive activity of some drugs alone or in various associations].
Topics: Adult; Aged; Antihypertensive Agents; Arteriosclerosis; Carbamates; Female; Humans; Hydrazines; Hydr | 1966 |