hydrochlorothiazide has been researched along with Hypercalcemia in 23 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Hypercalcemia: Abnormally high level of calcium in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the frequency of hypercalcemia in hydrochlorothiazide users in a post hoc analysis of a randomized, double-blind, dose-finding trial of 328 blacks (median age 51 years) assigned to either placebo, or 1000, 2000, or 4000 international units of cholecalciferol (vitamin D3) daily for 3 months during the winter (2007-2010)." | 9.19 | Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D. ( Bennett, GG; Chan, AT; Chandler, PD; Drake, BF; Emmons, KM; Forman, JP; Fuchs, CS; Giovannucci, EL; Hollis, BW; Ng, K; Scott, JB, 2014) |
| "We assessed the frequency of hypercalcemia in hydrochlorothiazide users in a post hoc analysis of a randomized, double-blind, dose-finding trial of 328 blacks (median age 51 years) assigned to either placebo, or 1000, 2000, or 4000 international units of cholecalciferol (vitamin D3) daily for 3 months during the winter (2007-2010)." | 5.19 | Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D. ( Bennett, GG; Chan, AT; Chandler, PD; Drake, BF; Emmons, KM; Forman, JP; Fuchs, CS; Giovannucci, EL; Hollis, BW; Ng, K; Scott, JB, 2014) |
| " Treatments were as follows: idiopathic osteoporosis: calcium and vitamin D supplements (N = 10) or cyclical etidronate for 2 weeks followed by calcium and vitamin D supplements for 76 days (N = 29); moderate idiopathic phosphate diabetes: calcitriol and phosphate (N = 15); idiopathic hypercalciuria: hydrochlorothiazide (N = 6); and hypogonadism: testosterone (N = 3)." | 5.09 | Management of male osteoporosis. ( Catanzariti, L; Cortet, B; Delcambre, B; Grardel, B; Marchandise, X; Vasseur, J, 2001) |
| "Treatment with hydrochlorothiazide 12." | 1.46 | Thiazide Treatment in Primary Hyperparathyroidism-A New Indication for an Old Medication? ( Benbassat, C; Diker-Cohen, T; Gorshtein, A; Herzberg, D; Hirsch, D; Masri-Iraqi, H; Shimon, I; Shochat, T; Shraga-Slutzky, I; Tsvetov, G, 2017) |
| "The efficacy of hydrochlorothiazide, in a usual dosage of 50 mg." | 1.25 | The use of thiazides in the prevention of renal calculi. ( Garcia, DA; Guay, GF; Yendt, ER, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (73.91) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsvetov, G | 1 |
| Hirsch, D | 1 |
| Shimon, I | 1 |
| Benbassat, C | 1 |
| Masri-Iraqi, H | 1 |
| Gorshtein, A | 1 |
| Herzberg, D | 1 |
| Shochat, T | 1 |
| Shraga-Slutzky, I | 1 |
| Diker-Cohen, T | 1 |
| Chandler, PD | 1 |
| Scott, JB | 1 |
| Drake, BF | 1 |
| Ng, K | 1 |
| Forman, JP | 1 |
| Chan, AT | 1 |
| Bennett, GG | 1 |
| Hollis, BW | 1 |
| Giovannucci, EL | 1 |
| Emmons, KM | 1 |
| Fuchs, CS | 1 |
| Satoh, F | 1 |
| Okado, T | 1 |
| Iwamoto, M | 1 |
| Akita, W | 1 |
| Wakabayashi, M | 1 |
| Ohta, A | 1 |
| Sohara, E | 1 |
| Noda, Y | 1 |
| Rai, T | 1 |
| Uchida, S | 1 |
| Sasaki, S | 1 |
| Ljunghall, S | 1 |
| Backman, U | 1 |
| Danielson, BG | 1 |
| Fellström, B | 1 |
| Johansson, G | 1 |
| Wikström, B | 1 |
| Klimiuk, PS | 1 |
| Davies, M | 1 |
| Adams, PH | 1 |
| Tucker, RM | 1 |
| Van Den Berg, CJ | 1 |
| Knox, FG | 1 |
| Boulard, JC | 1 |
| Hanslik, T | 1 |
| Alterescu, R | 1 |
| Baglin, A | 1 |
| Goodrich, AL | 1 |
| Kohn, SR | 1 |
| Cortet, B | 1 |
| Vasseur, J | 1 |
| Grardel, B | 1 |
| Catanzariti, L | 1 |
| Marchandise, X | 1 |
| Delcambre, B | 1 |
| Sztriha, L | 1 |
| Beviz, J | 1 |
| Hakim, R | 1 |
| Tolis, G | 1 |
| Goltzman, D | 1 |
| Meltzer, S | 1 |
| Friedman, R | 1 |
| Gasińska, T | 1 |
| Rozek-Lesiak, K | 1 |
| Harbut-Gryłka, A | 1 |
| Coffey, RJ | 1 |
| Lee, TC | 1 |
| Canary, JJ | 1 |
| Claus-Walker, J | 1 |
| Carter, RE | 1 |
| Compos, RJ | 1 |
| Spencer, WA | 1 |
| Słowińska-Srzednicka, J | 1 |
| Zgliczyński, S | 1 |
| Tołłoczko, T | 1 |
| Moss, AH | 1 |
| Hubert, C | 1 |
| Demanet, JC | 1 |
| Degaute, JP | 1 |
| Fichefet, JP | 1 |
| Paduart, P | 1 |
| Raszeja-Wanic, B | 1 |
| Smith, LH | 1 |
| Yendt, ER | 1 |
| Guay, GF | 1 |
| Garcia, DA | 1 |
| Koppel, MH | 1 |
| Massry, SG | 1 |
| Shinaberger, JH | 1 |
| Hartenbower, DL | 1 |
| Coburn, JW | 1 |
| Duarte, CG | 1 |
| Winnacker, JL | 1 |
| Becker, KL | 1 |
| Pace, A | 1 |
| Pickleman, JR | 1 |
| Straus, FH | 1 |
| Forland, M | 1 |
| Paloyan, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Defining Optimal Doses of Vitamin D for Chemoprevention in Blacks.[NCT00585637] | Phase 1 | 328 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Examine the influence of oral vitamin D supplementation on inflammatory marker CRP from baseline to the 3 month follow-up. (NCT00585637)
Timeframe: From baseline to 3 months
| Intervention | mg/L (Median) |
|---|---|
| No Vitamin D | -0.05 |
| 1000 IU of Vitamin D | 0.07 |
| 2000 IU of Vitamin D | 0.02 |
| 4000 IU of Vitamin D | 0.03 |
Examine the influence of oral vitamin D supplementation on inflammatory marker IL-10 from baseline to the 3 month follow-up. (NCT00585637)
Timeframe: From baseline to 3 months
| Intervention | pg/mL (Median) |
|---|---|
| No Vitamin D | 0 |
| 1000 IU of Vitamin D | -0.01 |
| 2000 IU of Vitamin D | -0.02 |
| 4000 IU of Vitamin D | 0.00 |
Examine the influence of oral vitamin D supplementation on inflammatory marker IL-6 from baseline to the 3 month follow-up. (NCT00585637)
Timeframe: From baseline to 3 months
| Intervention | pg/mL (Median) |
|---|---|
| No Vitamin D | -0.03 |
| 1000 IU of Vitamin D | -0.07 |
| 2000 IU of Vitamin D | 0.01 |
| 4000 IU of Vitamin D | 0.08 |
Examine the influence of oral vitamin D supplementation on inflammatory marker sTNF-R2 from baseline to the 3 month follow-up. (NCT00585637)
Timeframe: From baseline to 3 months
| Intervention | pg/mL (Median) |
|---|---|
| No Vitamin D | -0.89 |
| 1000 IU of Vitamin D | -9.88 |
| 2000 IU of Vitamin D | 59.16 |
| 4000 IU of Vitamin D | 13.29 |
Among Blacks, identify a dose of oral vitamin D supplementation that will result in levels of plasma 25(OH)D that would be predicted to reduce colorectal cancer incidence. Community-based African Americans drawn from the Open Doors to Health, which is a colorectal cancer prevention study in 1554 subjects from 12 public-housing communities and community- and faith-based organizations in Boston. (NCT00585637)
Timeframe: Baseline, 3months, 6months
| Intervention | ng/mL (Median) | ||
|---|---|---|---|
| Baseline 25(OH)D | 25(OH)D at 3 months | 25(OH)D at 6 months | |
| 1000 IU of Vitamin D | 16.2 | 29.7 | 21.2 |
| 2000 IU of Vitamin D | 13.9 | 34.8 | 27.0 |
| 4000 IU of Vitamin D | 15.7 | 45.9 | 31.2 |
| No Vitamin D | 15.1 | 13.7 | 18.1 |
1 review available for hydrochlorothiazide and Hypercalcemia
| Article | Year |
|---|---|
[Effect of thiazide preparations on calcium levels in serum and urine].
Topics: Animals; Calcium; Dogs; Humans; Hydrochlorothiazide; Hypercalcemia; Hypocalcemia; Intestinal Absorpt | 1974 |
2 trials available for hydrochlorothiazide and Hypercalcemia
| Article | Year |
|---|---|
Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D.
Topics: Adult; Aged; Black People; Bone Density Conservation Agents; Calcium; Diuretics; Dose-Response Relat | 2014 |
Management of male osteoporosis.
Topics: Absorptiometry, Photon; Bone Density; Calcitriol; Calcium; Dietary Supplements; Etidronic Acid; Femu | 2001 |
20 other studies available for hydrochlorothiazide and Hypercalcemia
| Article | Year |
|---|---|
Thiazide Treatment in Primary Hyperparathyroidism-A New Indication for an Old Medication?
Topics: Aged; Calcium; Diuretics; Female; Humans; Hydrochlorothiazide; Hypercalcemia; Hyperparathyroidism; M | 2017 |
Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide.
Topics: Acute Kidney Injury; Aged; Blood Chemical Analysis; Combined Modality Therapy; Disease Progression; | 2010 |
Calcium metabolism in renal stone disease.
Topics: Calcium; Diagnosis, Differential; Humans; Hydrochlorothiazide; Hypercalcemia; Hyperparathyroidism; I | 1980 |
Primary hyperparathyroidism and thiazide diuretics.
Topics: Aged; Bendroflumethiazide; Calcium; Female; Humans; Hydrochlorothiazide; Hypercalcemia; Hyperparathy | 1981 |
Diuretics: role of sodium balance.
Topics: Acute Kidney Injury; Adult; Calcium; Diet, Sodium-Restricted; Diuretics; Furosemide; Humans; Hydroch | 1980 |
[Symptomatic hypercalcemia after vitamin D-thiazide diuretics combination. Two cases in elderly women].
Topics: Aged; Aged, 80 and over; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Female; Humans; Hy | 1994 |
Hydrochlorothiazide-induced lupus erythematosus: a new variant?
Topics: Aged; Antibodies, Antinuclear; Female; Humans; Hydrochlorothiazide; Hypercalcemia; Hypertension; Lup | 1993 |
[Idiopathic hypercalcaemia. The effect of hypercalcaemia on renal function (author's transl)].
Topics: Humans; Hydrochlorothiazide; Hypercalcemia; Infant; Kidney Diseases; Male; Nephrocalcinosis; Prednis | 1979 |
Severe hypercalcemia associated with hydrochlorothiazide and calcium carbonate therapy.
Topics: Aged; Antacids; Calcium Carbonate; Diagnosis, Differential; Female; Furosemide; Hormones; Humans; Hy | 1979 |
[Effect of hydrochlorothiazide on various parameters of calcium and phosphate metabolism in patients with increased bone resorption caused by malignant metastases to the skeleton].
Topics: Adult; Aged; Bone Resorption; Calcium; Female; Humans; Hydrochlorothiazide; Hypercalcemia; Male; Mid | 1979 |
The surgical treatment of primary hyperparathyroidism: a 20 year experience.
Topics: Adenoma; Humans; Hydrochlorothiazide; Hypercalcemia; Hyperparathyroidism; Hyperplasia; Methods; Para | 1977 |
Hypercalcemia in early traumatic quadriplegia.
Topics: Adolescent; Calcitonin; Furosemide; Humans; Hydrochlorothiazide; Hypercalcemia; Male; Norethandrolon | 1975 |
[Differential diagnosis of hypercalcemic crisis associated with hypokalemia, adenoma of the parathyroid, thyroid adenomatosis, thyrotoxicosis and arterial hypertension treated with hydrochlorothiazide].
Topics: Adenoma; Diagnosis, Differential; Female; Humans; Hydrochlorothiazide; Hypercalcemia; Hypertension; | 1987 |
Renal colic, arthralgia in a hypercalcemic man.
Topics: Adult; Calcium; Colic; Humans; Hydrochlorothiazide; Hypercalcemia; Hyperparathyroidism; Joint Diseas | 1985 |
Tolerance and side-effects of the association hydrochlorothiazide-amiloride in long-term treatment of arterial hypertension.
Topics: Adult; Aged; Amiloride; Calcium; Creatinine; Drug Combinations; Drug Tolerance; Humans; Hydrochlorot | 1974 |
Nephrolithiasis. Current concepts in pathogenesis and management.
Topics: Acidosis, Renal Tubular; Citrates; Cystinuria; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentrati | 1972 |
The use of thiazides in the prevention of renal calculi.
Topics: Adult; Blood Chemical Analysis; Calcium; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentration; Hy | 1970 |
Thiazide-induced rise in serum calcium and magnesium in patients on maintenance hemodialysis.
Topics: Acute Kidney Injury; Adult; Calcium; Humans; Hydrochlorothiazide; Hypercalcemia; Magnesium; Male; Mi | 1970 |
Thiazide-induced hypercalcemia.
Topics: Adult; Blood Proteins; Calcium; Humans; Hydrochlorothiazide; Hypercalcemia; Hypertension; Male; Phos | 1971 |
Thiazide-induced parathyroid stimulation.
Topics: Animals; Dogs; Hydrochlorothiazide; Hypercalcemia; Hypertension; Male; Organ Size; Parathyroid Gland | 1969 |