hydrochlorothiazide has been researched along with Genetic Predisposition in 12 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that selected signals from hypertension genome-wide association studies may predict BP response to atenolol and hydrochlorothiazide when assessed through risk scoring." | 5.16 | Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study. ( Bailey, KR; Beitelshees, AL; Boerwinkle, E; Chapman, AB; Cooper-DeHoff, RM; Gong, Y; Gums, JG; Hou, W; Johnson, JA; Langaee, TY; McDonough, CW; Turner, ST; Wang, Z, 2012) |
| "A community-based sample of 585 adults with essential hypertension (291 African Americans [150 women and 141 men] and 294 non-Hispanic whites [126 women and 168 men]) underwent monotherapy with hydrochlorothiazide for 4 weeks." | 5.11 | Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects. ( Boerwinkle, E; Chapman, AB; Klungel, OH; Maitland-van der Zee, AH; Schwartz, GL; Turner, ST, 2005) |
| " To determine whether the variant rs4149601 A allele is a risk factor for hypertension, has an impact on the antihypertensive response to hydrochlorothiazide, and is associated with orthostatic hypotension, we performed a case-control study of hypertension (n=1686), a 4-week clinical trial (n=542), and a case-control study of orthostatic hypotension (n=793) in Chinese subjects." | 3.75 | A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension. ( Hui, R; Luo, F; Sun, K; Wang, X; Wang, Y; Zhou, X, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, P | 1 |
| Zhao, YM | 1 |
| Zhang, D | 1 |
| Liao, Y | 1 |
| Yang, KQ | 1 |
| Tian, T | 1 |
| Lou, Y | 1 |
| Luo, F | 2 |
| Ma, WJ | 1 |
| Zhang, HM | 1 |
| Song, L | 1 |
| Cai, J | 1 |
| Liu, YX | 1 |
| Zhou, XL | 1 |
| Karnes, JH | 1 |
| Gong, Y | 3 |
| Pacanowski, MA | 1 |
| McDonough, CW | 3 |
| Arwood, MJ | 1 |
| Langaee, TY | 2 |
| Pepine, CJ | 1 |
| Johnson, JA | 3 |
| Cooper-Dehoff, RM | 3 |
| Chen, J | 1 |
| Zhao, X | 1 |
| Wang, H | 1 |
| Chen, Y | 1 |
| Wang, W | 1 |
| Zhou, W | 1 |
| Wang, X | 2 |
| Tang, J | 1 |
| Zhao, Y | 1 |
| Lu, X | 1 |
| Chen, S | 1 |
| Wang, L | 1 |
| Shen, C | 1 |
| Yang, S | 1 |
| Shahin, MH | 1 |
| Rotroff, DM | 1 |
| Beitelshees, AL | 2 |
| Garrett, TJ | 1 |
| Gums, JG | 2 |
| Motsinger-Reif, A | 1 |
| Chapman, AB | 5 |
| Turner, ST | 5 |
| Boerwinkle, E | 5 |
| Frye, RF | 1 |
| Fiehn, O | 1 |
| Kaddurah-Daouk, R | 1 |
| Bailey, KR | 3 |
| Fridley, BL | 1 |
| Schwartz, GL | 3 |
| Chai, HS | 2 |
| Sicotte, H | 1 |
| Kocher, JP | 1 |
| Rodin, AS | 1 |
| Wang, Y | 1 |
| Sun, K | 1 |
| Zhou, X | 1 |
| Hui, R | 1 |
| Wang, Z | 1 |
| Hou, W | 1 |
| Maitland-van der Zee, AH | 1 |
| Klungel, OH | 1 |
| Zhou, Y | 1 |
| Wu, SL | 1 |
| Liu, JQ | 1 |
| Liang, WN | 1 |
| Liu, GF | 1 |
| Maddison, PJ | 1 |
| Ester, A | 1 |
| Teuben, E | 1 |
| Nossent, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)[NCT00246519] | Phase 4 | 1,701 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00246519)
Timeframe: baseline to 18 weeks of treatment
| Intervention | mmHg (Mean) |
|---|---|
| Atenolol +HCTZ Arm | -12.06 |
| HCTZ + Atenolol | -13.33 |
1 review available for hydrochlorothiazide and Genetic Predisposition
| Article | Year |
|---|---|
Nature and nurture in systemic lupus erythematosus.
Topics: Adrenergic beta-Antagonists; Autoantigens; Cytokines; Environment; Genes, MHC Class II; Genetic Pred | 1999 |
5 trials available for hydrochlorothiazide and Genetic Predisposition
| Article | Year |
|---|---|
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Black or African | 2012 |
Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study.
Topics: Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Female; Genetic Loci; Genetic Predi | 2012 |
Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects.
Topics: Adult; Black or African American; Blood Glucose; Blood Pressure; Cholesterol; Diuretics; Female; Gen | 2005 |
Possible association of ACE gene I/D polymorphism with blood pressure--lowering response to hydrochlorothiazide.
Topics: Aged; Alleles; Antihypertensive Agents; Female; Genetic Predisposition to Disease; Genotype; Humans; | 2007 |
Diuretic therapy in Afrocaribbeans with uncomplicated essential hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Black People; Caribbean Region; Cost-Benefit Analysis; Diu | 2000 |
6 other studies available for hydrochlorothiazide and Genetic Predisposition
| Article | Year |
|---|---|
A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia.
Topics: Adolescent; Aged; Amiloride; Antihypertensive Agents; Biomarkers; Blood Pressure; Child; Drug Combin | 2019 |
Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes.
Topics: Aged; Antihypertensive Agents; Black or African American; Case-Control Studies; Coronary Artery Dise | 2013 |
Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population.
Topics: Aged; Antihypertensive Agents; Asian People; Case-Control Studies; Child; Chrysanthemum; Clonidine; | 2014 |
A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.
Topics: Adult; Aged; AMP-Activated Protein Kinases; Antihypertensive Agents; Blood Pressure Monitoring, Ambu | 2016 |
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
Topics: Adult; Black People; Blood Pressure Determination; Case-Control Studies; Chromosomes, Human, Pair 12 | 2008 |
A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.
Topics: Aged; Alleles; Biomarkers; Case-Control Studies; Diuretics; Endosomal Sorting Complexes Required for | 2009 |