hydrochlorothiazide and Electrolytes studies

Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)

Research Excerpts

Excerpt	Relevance	Reference
"A single-blind randomized clinical study was used; fifty patients newly diagnosed with mild to moderate hypertension (aged 33 to 60 years) were recruited and divided into two groups: amlodipine or hydrochlorothiazide each comprising of 25 subjects."	9.24	Monotherapy with amlodipine or hydrochlorothiazide in patients with mild to moderate hypertension: Comparison of their efficacy and effects on electrolytes. ( Agu, PU; Aneke, EI; Azubike, NC; Eze, AA; Nwachukwu, DC; Nwachukwu, NZ; Obika, LF; Okoye, OI, 2017)
"The objective of this randomised open, active controlled, cross-over study was to evaluate the effect of a fixed combination of verapamil SR/trandolapril compared to captopril/hydrochlorothiazide on serum lipids, lipoproteins, and other metabolic and electrolyte parameters in patients with essential hypertension."	9.09	Evaluation of the effects of fixed combinations of sustained-release verapamil/trandolapril versus captopril/hydrochlorothiazide on metabolic and electrolyte parameters in patients with essential hypertension. ( Cifková, R; Compagnone, D; Hejl, Z; Nakov, R; Novozámská, E; Petrzílková, Z; Poledne, R; Stávek, P, 2000)
"The effects of 5 mg bendroflumethiazide plus 15 mmol potassium chloride versus 50 mg hydrochlorothiazide plus 5 mg amiloride on blood pressure and serum electrolytes were investigated in a 12-week, open, randomized study with parallel treatment groups."	9.06	The effects of bendroflumethiazide/potassium chloride versus hydrochlorothiazide/amiloride on blood pressure and serum electrolytes in patients with mild to moderate hypertension seen in general practice. ( Bredesgaard, P; Johansen, P; Jørgensen, F, 1986)
"A double-blind trial was carried out in 24 patients with mild hypertension to compare the efficacy and tolerability of indapamide with that of a standard thiazide diuretic, hydrochlorothiazide."	9.05	Indapamide in the treatment of essential arterial hypertension: results of a controlled study. ( Plante, GE; Robillard, C, 1983)
"Twenty-nine patients with mild to severe essential hypertension were treated with titrated doses of xipamide, before or after treatment with 50 and , if necessary, 100 mg hydrochlorothiazide in a 13- to 25-week open crossover study."	9.05	Hypotensive effects of xipamide in essential hypertension. Crossover comparison with hydrochlorothiazide. ( Pasquel, R; Simon, A; Tribble, PW, 1981)
"The study reported here prospectively evaluated the prevention of diuretic-induced secondary hyperaldosteronism and hypokalemia by a converting enzyme inhibitor, enalapril (MK 421)."	9.05	Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by enalapril (MK-421): a new angiotensin-converting enzyme inhibitor. ( Aurecchia, SA; Griffing, GT; Melby, JC; Sindler, BH, 1983)
"This presentation is a summary of our recent clinical studies on the therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism."	9.05	The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. ( Griffing, GT; Melby, JC, 1983)
" From evidence regarding potency, cardiovascular events, and electrolytes, we hypothesized a priori that 'CHIP' diuretics [CHlorthalidone, Indapamide and Potassium-sparing Diuretic/hydrochlorothiazide (PSD/HCTZ)] would rival RASIs for reducing LVM."	8.98	Hydrochlorothiazide and alternative diuretics versus renin-angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis. ( Abdelfattah, R; Ernst, ME; Kostis, JB; Roush, GC; Sica, DA; Song, S, 2018)
" In the present study the effects of the angiotensin converting enzyme inhibitor (ACEI) enalapril and the thiazide-type diuretic, hydrochlorothiazide, on the development of the salt-induced left ventricular and kidney hypertrophy were examined in normotensive Wistar-Kyoto and Wistar rats."	7.69	Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats. ( Karppanen, H; Laakso, J; Mervaala, EM; Vapaatalo, H, 1994)
"Effects of diazoxide, a benzothiadiazine derivative, on the blood pressure, excretion of Na+, K+, and Ca2+, and the levels of these electrolytes in serum, kidney, and aorta were studied in rats with deoxycorticosterone acetate (DOCA)-induced hypertension in comparison with rats treated with hydrochlorothiazide."	7.69	Effect of diazoxide on serum and tissue electrolyte levels in rats with deoxycorticosterone acetate-induced hypertension. ( Nakai, T, 1994)
"A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency."	7.68	Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency. ( Beyer, KH; Gelarden, RT; Knutson, DW; Vary, JE; Vesell, ES; Ward, TD, 1993)
"The purpose of this study was to determine if chronic administration of the diuretics hydrochlorothiazide and amiloride alters the response to catecholamine-induced ventricular arrhythmias."	7.67	Effect of chronic diuretics on epinephrine-induced ventricular arrhythmias: a comparison of hydrochlorothiazide and amiloride in the rat. ( Rabkin, SW; Roob, O, 1987)
"Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage."	6.65	Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983)
"Heart failure was produced by ligation of the left anterior descending coronary artery in male Sprague-Dawley rats."	5.37	Effects of hydrochlorothiazide on cardiac remodeling in a rat model of myocardial infarction-induced congestive heart failure. ( Dai, G; Gao, X; Luo, J; Peng, L; Sun, H, 2011)
"Indapamide was given in doses of 2."	5.27	Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983)
"A single-blind randomized clinical study was used; fifty patients newly diagnosed with mild to moderate hypertension (aged 33 to 60 years) were recruited and divided into two groups: amlodipine or hydrochlorothiazide each comprising of 25 subjects."	5.24	Monotherapy with amlodipine or hydrochlorothiazide in patients with mild to moderate hypertension: Comparison of their efficacy and effects on electrolytes. ( Agu, PU; Aneke, EI; Azubike, NC; Eze, AA; Nwachukwu, DC; Nwachukwu, NZ; Obika, LF; Okoye, OI, 2017)
"The aim of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation study was to compare the long-term effect of the commonly used inexpensive medication with a low-dose diuretic (hydrochlorothiazide), alone or in combination with a beta-adrenoceptor (atenolol), with that of more modern but also more expensive antihypertensive treatment with an angiotensin-II-receptor blocker (candesartan), alone or in combination with a calcium antagonist (felodipine), and to do so in newly diagnosed patients with primary hypertension."	5.10	Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study). ( Alaupovic, P; Carlberg, B; Lindholm, LH; Persson, M; Samuelsson, O; Svensson, A, 2003)
"The objective of this randomised open, active controlled, cross-over study was to evaluate the effect of a fixed combination of verapamil SR/trandolapril compared to captopril/hydrochlorothiazide on serum lipids, lipoproteins, and other metabolic and electrolyte parameters in patients with essential hypertension."	5.09	Evaluation of the effects of fixed combinations of sustained-release verapamil/trandolapril versus captopril/hydrochlorothiazide on metabolic and electrolyte parameters in patients with essential hypertension. ( Cifková, R; Compagnone, D; Hejl, Z; Nakov, R; Novozámská, E; Petrzílková, Z; Poledne, R; Stávek, P, 2000)
"In the majority of hypertensive patients, treatment with 50 mg/d of hydrochlorothiazide does not cause marked hypokalemia or ventricular arrhythmias."	5.07	Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. ( Black, DM; Cheitlin, MD; Fine, R; Hearst, N; Hulley, SB; Sebastian, A; Seeley, DG; Siegel, D, 1992)
" Twelve middle-aged black women with essential hypertension, controlled with 50 mg hydrochlorothiazide per day, randomly received 3200 mg ibuprofen and a placebo for 8 days."	5.06	The effect of high-dose short-term ibuprofen on antihypertensive control with hydrochlorothiazide. ( Bryan, DL; Cooper, LW; Lambert, CM; Lehany, AM; McKenney, JM; Wright, JT, 1989)
"The effects of 5 mg bendroflumethiazide plus 15 mmol potassium chloride versus 50 mg hydrochlorothiazide plus 5 mg amiloride on blood pressure and serum electrolytes were investigated in a 12-week, open, randomized study with parallel treatment groups."	5.06	The effects of bendroflumethiazide/potassium chloride versus hydrochlorothiazide/amiloride on blood pressure and serum electrolytes in patients with mild to moderate hypertension seen in general practice. ( Bredesgaard, P; Johansen, P; Jørgensen, F, 1986)
"Twenty-nine patients with mild to severe essential hypertension were treated with titrated doses of xipamide, before or after treatment with 50 and , if necessary, 100 mg hydrochlorothiazide in a 13- to 25-week open crossover study."	5.05	Hypotensive effects of xipamide in essential hypertension. Crossover comparison with hydrochlorothiazide. ( Pasquel, R; Simon, A; Tribble, PW, 1981)
"A double-blind trial was carried out in 24 patients with mild hypertension to compare the efficacy and tolerability of indapamide with that of a standard thiazide diuretic, hydrochlorothiazide."	5.05	Indapamide in the treatment of essential arterial hypertension: results of a controlled study. ( Plante, GE; Robillard, C, 1983)
"This presentation is a summary of our recent clinical studies on the therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism."	5.05	The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. ( Griffing, GT; Melby, JC, 1983)
"The study reported here prospectively evaluated the prevention of diuretic-induced secondary hyperaldosteronism and hypokalemia by a converting enzyme inhibitor, enalapril (MK 421)."	5.05	Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by enalapril (MK-421): a new angiotensin-converting enzyme inhibitor. ( Aurecchia, SA; Griffing, GT; Melby, JC; Sindler, BH, 1983)
" Nineteen patients with moderate arterial hypertension were treated for 5 consecutive weeks in a randomized fashion in a double-blind study with either tienilic acid or hydrochlorothiazide."	5.04	Treatment of arterial hypertension with tienilic acid, a new diuretic with uricosuric properties. ( Beauchemin, M; Gougoux, A; Lemieux, G; Vinay, P, 1978)
" From evidence regarding potency, cardiovascular events, and electrolytes, we hypothesized a priori that 'CHIP' diuretics [CHlorthalidone, Indapamide and Potassium-sparing Diuretic/hydrochlorothiazide (PSD/HCTZ)] would rival RASIs for reducing LVM."	4.98	Hydrochlorothiazide and alternative diuretics versus renin-angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis. ( Abdelfattah, R; Ernst, ME; Kostis, JB; Roush, GC; Sica, DA; Song, S, 2018)
" Daily measurements of body weight, urine volume, and concentration of sodium, potassium and uric acid in urine were performed for each rat."	3.76	Diuretic and antioxidant effects of Cacti-Nea, a dehydrated water extract from prickly pear fruit, in rats. ( Bisson, JF; Daubié, S; Guillemet, D; Hidalgo, S; Linarés, E, 2010)
"Severe dehydration and watery diarrhea were induced by administering diuretics (furosemide, hydrohlorothiazide, spironolactone) and sucrose solution."	3.70	Use of peripheral temperature and core-peripheral temperature difference to predict cardiac output in dehydrated calves housed in a thermoneutral environment. ( Constable, PD; Foreman, JH; Morin, DE; Thurmon, JC; Walker, PG, 1998)
"5 mL/kg of body weight (BW), PO], sucrose (2 g/kg in a 20% aqueous solution, p."	3.70	A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf. ( Constable, PD; Drackley, JK; Foreman, JH; Morin, DE; Thurmon, JC; Walker, PG, 1998)
" In the present study the effects of the angiotensin converting enzyme inhibitor (ACEI) enalapril and the thiazide-type diuretic, hydrochlorothiazide, on the development of the salt-induced left ventricular and kidney hypertrophy were examined in normotensive Wistar-Kyoto and Wistar rats."	3.69	Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats. ( Karppanen, H; Laakso, J; Mervaala, EM; Vapaatalo, H, 1994)
"Effects of diazoxide, a benzothiadiazine derivative, on the blood pressure, excretion of Na+, K+, and Ca2+, and the levels of these electrolytes in serum, kidney, and aorta were studied in rats with deoxycorticosterone acetate (DOCA)-induced hypertension in comparison with rats treated with hydrochlorothiazide."	3.69	Effect of diazoxide on serum and tissue electrolyte levels in rats with deoxycorticosterone acetate-induced hypertension. ( Nakai, T, 1994)
"A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency."	3.68	Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency. ( Beyer, KH; Gelarden, RT; Knutson, DW; Vary, JE; Vesell, ES; Ward, TD, 1993)
"The purpose of this study was to determine if chronic administration of the diuretics hydrochlorothiazide and amiloride alters the response to catecholamine-induced ventricular arrhythmias."	3.67	Effect of chronic diuretics on epinephrine-induced ventricular arrhythmias: a comparison of hydrochlorothiazide and amiloride in the rat. ( Rabkin, SW; Roob, O, 1987)
"Thirty-two USAF aircrewmen with mild or moderate, uncomplicated essential hypertension were treated with Aldactazide (spironolactone and hydrochlorothiazide)."	3.66	Treatment of hypertension in aviators: a clinical trial with Aldactazide. ( Hull, DH; McAfoose, DA; Triebwasser, JH; Wolthuis, RA, 1978)
"Doxazosin therapy was characterized by significant increase in the levels of mean plasma total protein and albumin, while moduretic therapy showed significant reduction in the mean values of plasma creatinine and calcium."	2.68	Biochemical changes during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients. ( Agbedana, EO; Ahaneku, JE; Salako, LA; Sowunmi, A; Taylor, GO; Walker, O, 1996)
" The dose-response curves for HCTZ and FU were both relatively flat: doubling the dose of each produced statistically insignificant increases in sodium excretion."	2.68	Diuretic effectiveness of hydrochlorothiazide and furosemide alone and in combination in chronic renal failure. ( Knauf, H; Mutschler, E, 1995)
"Hydrochlorothiazide was assayed in 24-hour urine samples."	2.66	Comparative efficacy and bioequivalence of a brand-name and a generic triamterene-hydrochlorothiazide combination product. ( Cane, RC; Costello, K; Goodwin, P; Perkal, M; Sharoky, M; Tabatznik, B, 1989)
"Diltiazem monotherapy was comparable to hydrochlorothiazide in efficacy of lowering blood pressure."	2.66	Renal-metabolic consequences of antihypertensive therapy with diltiazem versus hydrochlorothiazide. ( Horning, J; McClung, DE; McNulty, R; Simmons, J; TerWee, JA; Thomas, M; Williams, L; Zawada, ET, 1987)
"The antihypertensive and biochemical effects of 25 mg hydrochlorothiazide alone or 50 mg hydrochlorothiazide alone or in combination with triamterene (either 37."	2.66	Antihypertensive and biochemical effects of different doses of hydrochlorothiazide alone or in combination with triamterene. ( Eisalo, A; Gordin, A; Kohvakka, A; Salo, H, 1986)
"Amiloride hydrochloride has now been recognized as a safe and effective potassium-sparing diuretic alternative to triamterene with a similar mechanism of pharmacologic activity."	2.66	Antihypertensive therapy with triamterene-hydrochlorothiazide vs amiloride-hydrochlorothiazide. Comparison of effects on urinary prostaglandin E2 excretion. ( Zawada, ET, 1986)
" The dosage problem with HTZ + AMl is discussed."	2.65	Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride. ( Leary, WP; Reyes, AJ, 1981)
"In a single-blind, randomized cross-over study the bioavailability of Spironothiazid (50 mg spironolactone, 50 mg hydrochlorothiazide) was investigated in six healthy male volunteers by comparing the same dose of the well-established drugs Aldactone dragees, 50 mg, and Esidrex tablets, 25 mg."	2.65	The bioavailability of spironolactone hydrochlorothiazide combination preparation. ( Hitzenberger, G; Horwatitsch, H; Rameis, H, 1982)
"Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage."	2.65	Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983)
"The significant increase in urine volume 24 h after treatment followed a dose-response pattern."	1.42	Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii (Rutaceae) in Wistar rats. ( Abakar, D; Dimo, T; Fokam, MA; Kakesse, M; Ntchapda, F; Pancha, OM, 2015)
"Heart failure was produced by ligation of the left anterior descending coronary artery in male Sprague-Dawley rats."	1.37	Effects of hydrochlorothiazide on cardiac remodeling in a rat model of myocardial infarction-induced congestive heart failure. ( Dai, G; Gao, X; Luo, J; Peng, L; Sun, H, 2011)
" The pharmacokinetic studies show that GH increases the bioavailability and half-life, along with decrease in clearance and elimination rate of HCTZ when administered orally."	1.35	The potential for interaction of hydrochlorothiazide with garlic in rats. ( Asdaq, SM; Inamdar, MN, 2009)
"5 mg/kg/day) combined with indapamide (0."	1.31	Protective effects of delapril combined with indapamide or hydrochlorothiazide in spontaneously hypertensive stroke-prone rats: a comparative dose-response analysis. ( Agnati, LF; Biagini, G; Boschi, S; Torri, C; Vantaggiato, G; Zini, I; Zoli, M, 2000)
" The only activity observed in mice was an inhibition of spontaneous motility after oral dosing with 300 and 1000 mg/kg, respectively."	1.30	Preclinical safety studies of the combination moexipril hydrochloride/hydrochlorothiazide. ( Friehe, H; Gietl, R; Ney, P, 1998)
" The diuretic activity of this compound, evaluated in rats in a dosage range of 2."	1.29	Synthesis and diuretic activity of (E)-2-methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-5-carboxald ehyde dimethylaminoacetohydrazone. ( Andreani, A; Locatelli, A; Malandrino, S; Pifferi, G; Rambaldi, M, 1994)
"Behavioral performances of six baboons were tested during chronic oral dosing with diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs."	1.28	Behavioral effects of chronic, orally administered diuretic and verapamil in baboons. ( Hienz, RD; Turkkan, JS, 1991)
"Indapamide was given in doses of 2."	1.27	Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983)
"The bioavailability of hydrochlorothiazide was determined following single oral 25-, 50-, 100-, and 200-mg tablet and suspension doses in 12 healthy male volunteers."	1.27	Bioavailability of hydrochlorothiazide from tablets and suspensions. ( Patel, RB; Patel, UR; Prasad, VK; Rogge, MC; Selen, A; Shah, VP; Welling, PG, 1984)
"Cinnarizine failed to produce any cardiovascular or renal effects."	1.27	Cardiovascular and renal actions of calcium channel blocker chemical subgroups: a search for renal specificity. ( Barrett, RJ; Proakis, AG; Taylor, DR; Wright, KF, 1988)
"Renal hypertrophy was also decreased significantly by cicletanine at a dose of 100 mg/kg."	1.27	Comparison of cicletanine with other antihypertensive drugs in SHR-SP models. ( Braquet, P; Clostre, F; Le Hegarat, M; Malherbe, E, 1988)
" The adsorption and disposition of hydrochlorothiazide demonstrate that this drug is rapidly absorbed and produces a diuretic and natriuretic response that peaks at approximately 2 hours after dosing and is essentially terminated 12 hours after dosing."	1.26	Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. ( Benet, LZ; Berman, RS; Davies, RO; Gee, WL; Holmes, GI; Huber, P; Lin, ET; Williams, RL, 1982)
"A study was carried out of plasma electrolyte estimations made before and after long-term use of a combination of amiloride and hydrochlorothiazide in 23 patients."	1.26	Long-term effects of an amiloride/hydrochlorothiazide combination ('Moduretic') on electrolyte balance. ( Burge, PS; Montuschi, E, 1976)

Research

Studies (154)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Change in Diastolic Blood Pressure

Change in Extracellular Water

Timeframe	Studies, this research(%)	All Research%
pre-1990	118 (76.62)	18.7374
1990's	20 (12.99)	18.2507
2000's	9 (5.84)	29.6817
2010's	7 (4.55)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Stokker, GE	1
Smith, RL	1
Cragoe, EJ	1
Ludden, CT	1
Russo, HF	1
Sweet, CS	1
Watson, LS	1
Nwachukwu, DC	1
Eze, AA	1
Nwachukwu, NZ	1
Aneke, EI	1
Agu, PU	1
Azubike, NC	1
Obika, LF	1
Okoye, OI	1
Roush, GC	1
Abdelfattah, R	1
Song, S	1
Kostis, JB	1
Ernst, ME	1
Sica, DA	1
Frenkel, NJ	1
Vogt, L	1
De Rooij, SE	1
Trimpert, C	1
Levi, MM	1
Deen, PM	1
van den Born, BJ	1
Dalila, N	1
Brockmöller, J	1
Tzvetkov, MV	1
Schirmer, M	1
Haubrock, M	1
Vormfelde, SV	1
Ntchapda, F	1
Kakesse, M	1
Fokam, MA	1
Pancha, OM	1
Abakar, D	1
Dimo, T	1
Asdaq, SM	1
Inamdar, MN	1
Bisson, JF	1
Daubié, S	1
Hidalgo, S	1
Guillemet, D	1
Linarés, E	1
Luo, J	1
Gao, X	1
Peng, L	1
Sun, H	1
Dai, G	1
Nijenhuis, T	1
Hoenderop, JG	1
Loffing, J	1
van der Kemp, AW	1
van Os, CH	1
Bindels, RJ	1
Lindholm, LH	1
Persson, M	1
Alaupovic, P	1
Carlberg, B	1
Svensson, A	1
Samuelsson, O	1
RABAGLIATI, U	1
JANUSZEWICZ, W	1
HEINEMANN, HO	1
DEMARTINI, FE	1
LARAGH, JH	1
CORA, D	1
GHIOTTO, G	1
MAGGIA, A	1
CURRI, G	1
GARGANO, N	1
REGOLI, D	1
BARTORELLI, C	1
KOVACEVIC, M	1
BRCELJ, S	1
PERISIC, Z	1
CAVAGNA, G	1
FALK, W	1
HINRICHS, R	1
KOESTENBERGER, R	1
FORD, RV	1
VELASCO, M	1
KATZ, R	1
KATZ, E	1
GARCIA, H	1
GAZMURI, R	1
ALEKSANDROW, D	1
WYSZNACKA, W	1
BACZKO, A	1
BAER, JE	1
BROOKS, AV	1
NOLL, RM	1
BEYER, KH	2
CAVALCA, L	1
GILARDI, FF	1
MARINI, U	1
BERETTA, R	1
D'AMICO, G	1
CESANA, A	1
SHCHEGLOV, AIu	1
FRANK, H	1
DENTLER, H	1
SCHULTZ, J	1
HOLTZ, M	1
HAGEMANN, I	1
VILLAMIL, MF	1
YEYATI, N	1
ENERO, MA	1
RUBIANES, C	1
TAQUINI, AC	1
KENNEDY, GC	1
PARKER, RA	1
KRUECK, F	1
LAAS, H	1
BETZIEN, G	1
BRANCHRZ, H	1
GUTMAN, J	1
COMOLI, G	1
GHIRINGHELLI, L	1
MADULI, S	1
OZDOGAN, E	1
ANIBALDI, A	1
BOSCHERINI, B	1
MARANGONI, R	2
MELLONI, G	1
CASCIO, G	1
PALAZZOADRIANO, M	1
CASIROLA, G	1
CHERIE LIGNIERE, EL	1
POZZI, E	1
MELLONI, GF	1
BARATTA, C	1
MERLO, L	1
ANTOGNETTI, R	1
WOHLRABE, JC	1
PITTS, FN	1
SIMONIAN, ZN	1
SANNER, E	1
MOLTENI, A	1
BALDRATTI, G	1
SANTARATO, R	1
MAGID, GJ	1
HEALEY, LA	1
ROBERTO, A	1
KAGAWA, CM	1
DRILL, VA	1
Ma, J	1
Albornoz, F	1
Yu, C	1
Byrne, DW	1
Vaughan, DE	1
Brown, NJ	1
Knauf, H	2
Bailey, MA	1
Hasenfuss, G	1
Mutschler, E	2
Martín-Herrera, D	1
Abdala, S	1
Benjumea, D	1
Gutiérrez-Luis, J	1
Singh, BN	1
Richmond, DE	1
Wilson, JD	1
Simmonds, HA	1
North, JD	1
Hofmann, LM	1
Shen, JQ	1
Wang, LD	1
Griffing, GT	2
Sindler, BH	1
Aurecchia, SA	1
Melby, JC	2
Morledge, JH	1
Plante, GE	1
Robillard, C	1
Leary, WP	4
Reyes, AJ	3
van der Byl, K	2
Alon, U	1
Costanzo, LS	1
Chan, JC	1
Burke, TJ	1
Nobles, EM	1
Wolf, PS	1
Erickson, AL	1
Matzkies, F	1
Webs, B	1
Patel, RB	1
Patel, UR	1
Rogge, MC	1
Shah, VP	1
Prasad, VK	1
Selen, A	1
Welling, PG	1
Sundberg, S	1
Salo, H	2
Gordin, A	2
Melamies, L	1
Lamminsivu, U	1
Nuotto, E	1
Keränen, A	1
Odlind, B	1
Lönnerholm, G	1
Slotkoff, L	1
Roeckel, A	1
Heidland, A	1
Myers, JB	1
Gillies, A	1
Waga, S	1
Morgan, TO	1
Scholz, D	1
Schwille, PO	1
Pasquel, R	1
Tribble, PW	1
Simon, A	1
Lijnen, P	1
Fagard, R	2
Staessen, J	1
Amery, A	2
Angelkort, B	1
Letzel, H	1
Williams, RL	1
Davies, RO	1
Berman, RS	1
Holmes, GI	1
Huber, P	1
Gee, WL	1
Lin, ET	1
Benet, LZ	1
Rameis, H	1
Hitzenberger, G	2
Horwatitsch, H	1
Birkenhäger, W	1
Bogaert, M	1
Brixko, P	1
Bulpitt, C	1
Clement, D	1
De Leeuw, P	1
De Plaen, JF	1
Deruyttere, M	1
De Schaepdryver, A	1
Forette, F	1
Forte, J	1
Hamdy, R	1
Hellemans, J	1
Henry, JF	1
Koistinen, A	1
Laaser, U	1
Laher, M	1
Leonetti, G	1
Lewis, P	1
Lund-Johansen, P	2
MacFarlane, J	1
Meurer, K	1
Miguel, P	1
Morris, J	1
Mutsers, A	1
Nissinen, A	1
O'Brien, E	1
Ohm, OJ	1
O'Malley, K	1
Pelemans, W	1
Perera, N	1
Tuomilehto, J	1
Verschueren, LJ	1
Willemse, P	1
Williams, B	1
Zanchetti, A	1
Sutton, RA	1
Walker, VR	1
Lumme, JA	1
Jounela, AJ	2
Terai, T	1
Kita, Y	1
Kusunoki, T	1
Shimazaki, T	1
Ando, T	1
Horiai, H	1
Akahane, A	1
Shiokawa, Y	1
Yoshida, K	1
Mervaala, EM	1
Laakso, J	1
Vapaatalo, H	1
Karppanen, H	1
Streckfus, CF	1
Wu, AJ	1
Ship, JA	1
Brown, LJ	1
Andreani, A	1
Rambaldi, M	1
Locatelli, A	1
Malandrino, S	1
Pifferi, G	1
Nakai, T	1
Siegel, D	2
Saliba, P	1
Haffner, S	1
Ward, TD	1
Vary, JE	1
Gelarden, RT	1
Knutson, DW	1
Vesell, ES	1
Ahaneku, JE	1
Taylor, GO	1
Walker, O	1
Agbedana, EO	1
Sowunmi, A	1
Salako, LA	2
Khedun, SM	1
Maharaj, B	1
Naicker, T	1
Gietl, R	1
Friehe, H	1
Ney, P	1
Constable, PD	2
Walker, PG	2
Morin, DE	2
Foreman, JH	2
Thurmon, JC	2
Drackley, JK	1
Hnatyszyn, O	1
Miño, J	1
Gorzalczany, S	1
Opezzo, J	1
Ferraro, G	1
Coussio, J	1
Acevedo, C	1
Cifková, R	1
Nakov, R	1
Novozámská, E	1
Hejl, Z	1
Petrzílková, Z	1
Poledne, R	1
Stávek, P	1
Compagnone, D	1
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Vantaggiato, G	1
Torri, C	1
Zini, I	1
Agnati, LF	1
Zoli, M	1
Biagini, G	1
Sripanidkulchai, B	1
Wongpanich, V	1
Laupattarakasem, P	1
Suwansaksri, J	1
Jirakulsomchok, D	1
Lemieux, G	2
Beauchemin, M	1
Gougoux, A	2
Vinay, P	2
Gudbrandsson, T	1
Hansson, L	1
Levy, B	1
Ponticelli, C	1
Lechi, A	2
di Perri, T	1
Redaelli, B	1
Locatelli, F	1
Rivolta, E	1
Covi, G	2
Messa, GL	1
Pincella, G	1
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Recchia, M	1
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Riva, AD	1
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Hull, DH	1
Wolthuis, RA	1
Triebwasser, JH	1
McAfoose, DA	1
Araoye, MA	1
Khatri, IM	1
Yao, LL	1
Freis, ED	1
Lammintausta, R	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of Antihypertensive Treatment on Cardiac Remodelling and Metabolic Profile in HIV Infected Patients: Randomized Longitudinal Study With Candesartan Versus Lercanidipine[NCT00564057]	Phase 4	30 participants (Anticipated)	Interventional	2007-09-30	Recruiting
Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761]	Phase 4	471 participants (Actual)	Interventional	2018-02-13	Completed
[NCT00000525]	Phase 3	233 participants (Actual)	Interventional	1986-07-31	Completed
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933]	Phase 2	34 participants (Actual)	Interventional	2019-06-18	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	mmHg (Mean)
Placebo	-3.4
Treatment Grup	-13.5

Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Extracellular Water / Total Body Water Ratio

Intervention	litres (Mean)
Placebo	-0.15
Treatment Grup	2.55

Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Mean Arterial Pressure

Intervention	percentage of ECW/TBW (Mean)
Placebo	-0.24
Treatment Grup	-2.92

decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Systolic Blood Pressure

Change in the Fractional Excretion of Sodium

Intervention	mmHg (Mean)
Placebo	-5.4
Treatment Grup	-18.1

Intervention	mmHg (Mean)
Placebo	-10
Treatment Grup	-26.1

Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Total Body Water

Intervention	percentage of sodium excreted (Mean)
Placebo	-0.348
Treatment Grup	0.598

Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28

Article	Year
Monotherapy with amlodipine or hydrochlorothiazide in patients with mild to moderate hypertension: Comparison of their efficacy and effects on electrolytes. Malawi medical journal : the journal of Medical Association of Malawi, 2017, Volume: 29, Issue:2 Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Dose-Respo	2017
Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs. Pharmacogenomics, 2015, Volume: 16, Issue:2 Topics: Adolescent; Adult; Bumetanide; Cross-Over Studies; Diuretics; Electrolytes; Furosemide; Genetic Asso	2015
Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study). Journal of hypertension, 2003, Volume: 21, Issue:8 Topics: Antihypertensive Agents; Apolipoproteins; Atenolol; Blood Glucose; Blood Pressure; Drug Therapy, Com	2003
Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:2 Topics: Adult; Cross-Over Studies; Diuretics; Double-Blind Method; Electrolytes; Female; Fibrinolysis; Hemod	2005
The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects. European journal of clinical pharmacology, 2006, Volume: 62, Issue:11 Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting	2006
Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by enalapril (MK-421): a new angiotensin-converting enzyme inhibitor. Metabolism: clinical and experimental, 1983, Volume: 32, Issue:7 Topics: Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Diuretics; Electrolytes; Enalapril; Humans; Hy	1983
The therapeutic use of a new potassium-sparing diuretic, amiloride, and a converting enzyme inhibitor, MK-421, in preventing hypokalemia associated with primary and secondary hyperaldosteronism. Clinical and experimental hypertension. Part A, Theory and practice, 1983, Volume: 5, Issue:6 Topics: Adult; Aged; Aldosterone; Amiloride; Angiotensin-Converting Enzyme Inhibitors; Dipeptides; Diuretics	1983
Clinical efficacy and safety of indapamide in essential hypertension. American heart journal, 1983, Volume: 106, Issue:1 Pt 2 Topics: Adult; Aged; Animals; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electrolytes; Humans	1983
Indapamide in the treatment of essential arterial hypertension: results of a controlled study. Current medical research and opinion, 1983, Volume: 8 Suppl 3 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electrolytes; Femal	1983
Effects of hydrochlorothiazide plus sotalol on acute urinary electrolyte excretion in normal subjects. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1984, Nov-03, Volume: 66, Issue:18 Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Electrolytes; H	1984
Effect of low dose diuretics on plasma and blood cell electrolytes, plasma uric acid and blood glucose. Acta medica Scandinavica. Supplementum, 1982, Volume: 668 Topics: Adult; Amiloride; Blood Glucose; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electroly	1982
Effect of tienilic acid and amiloride in healthy volunteers and in hypertensives with normal renal function. British journal of clinical pharmacology, 1980, Volume: 10, Issue:4 Topics: Adolescent; Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Therap	1980
[Efficacy of thiazide in idiopathic calcium urolithiasis. Results of a one-year double-blind study (author's transl)]. Arzneimittel-Forschung, 1980, Volume: 30, Issue:11 Topics: Adult; Blood Pressure; Calcium; Clinical Trials as Topic; Double-Blind Method; Electrolytes; Female;	1980
Hypotensive effects of xipamide in essential hypertension. Crossover comparison with hydrochlorothiazide. Journal of clinical pharmacology, 1981, Volume: 21, Issue:7 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Electrolytes; Female; Humans; Hydr	1981
Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Sep-05, Volume: 60, Issue:10 Topics: Adult; Aged; Amiloride; Blood Proteins; Blood Urea Nitrogen; Cholesterol; Clinical Trials as Topic;	1981
[Clinical aspects and therapy of hydropic heart insufficiency. Results of a multicenter field study]. Fortschritte der Medizin, 1981, Dec-03, Volume: 99, Issue:45 Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Edema, Cardiac;	1981
The bioavailability of spironolactone hydrochlorothiazide combination preparation. International journal of clinical pharmacology, therapy, and toxicology, 1982, Volume: 20, Issue:7 Topics: Adult; Antihypertensive Agents; Biological Availability; Drug Combinations; Electrolytes; Humans; Hy	1982
Antihypertensive therapy in patients above age 60 with systolic hypertension. A progress report of the European Working Party on High Blood Pressure in the Elderly (EWPHE). Clinical and experimental hypertension. Part A, Theory and practice, 1982, Volume: 4, Issue:7 Topics: Aged; Blood Glucose; Blood Pressure; Creatinine; Drug Therapy, Combination; Electrolytes; Female; Hu	1982
Left ventricular mass, serum electrolyte levels and cardiac arrhythmias in patients with mild hypertension treated with cilazapril or hydrochlorothiazide. International journal of cardiology, 1993, Volume: 42, Issue:1 Topics: Cardiac Complexes, Premature; Cilazapril; Double-Blind Method; Echocardiography; Electrocardiography	1993
Glucose and insulin levels during diuretic therapy in hypertensive men. Hypertension (Dallas, Tex. : 1979), 1994, Volume: 23, Issue:6 Pt 1 Topics: Adult; Aged; Blood Glucose; Chlorthalidone; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Hy	1994
Diuretic effectiveness of hydrochlorothiazide and furosemide alone and in combination in chronic renal failure. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:3 Topics: Adult; Aged; Calcium; Chlorides; Diuretics; Dose-Response Relationship, Drug; Drug Synergism; Electr	1995
Biochemical changes during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients. JPMA. The Journal of the Pakistan Medical Association, 1996, Volume: 46, Issue:4 Topics: Adult; Aged; Amiloride; Amlodipine; Antihypertensive Agents; Blood Proteins; Calcium; Creatinine; Cr	1996
Evaluation of the effects of fixed combinations of sustained-release verapamil/trandolapril versus captopril/hydrochlorothiazide on metabolic and electrolyte parameters in patients with essential hypertension. Journal of human hypertension, 2000, Volume: 14, Issue:6 Topics: Adolescent; Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihyperte	2000
Treatment of arterial hypertension with tienilic acid, a new diuretic with uricosuric properties. Canadian Medical Association journal, 1978, May-06, Volume: 118, Issue:9 Topics: Adult; Blood Pressure; Blood Urea Nitrogen; Calcium; Clinical Trials as Topic; Diuretics; Double-Bli	1978
Combination therapy with saluretics and atenolol in essential hypertension. Effects on blood pressure, electrolytes and uric acid. Acta medica Scandinavica. Supplementum, 1979, Volume: 625 Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Bendroflumethiazide; Chlorthalidone; Diuretics;	1979
The efficacy and safety of furosemide and a combination of spironolactone and hydrochlorothiazide in congestive heart failure. Journal of clinical pharmacology, 1977, Volume: 17, Issue:7 Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug Evaluation; Elec	1977
Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients. European journal of clinical pharmacology, 1979, Volume: 16, Issue:5 Topics: Adolescent; Adult; Aged; Blood Cell Count; Blood Glucose; Clinical Trials as Topic; Electrolytes; Fe	1979
An evaluation of tienilic acid, a new diuretic uricosuric agent, in the therapy of arterial hypertension. Clinical science (London, England : 1979), 1979, Volume: 57 Suppl 5 Topics: Adolescent; Adult; Aged; Blood Glucose; Blood Pressure; Cholesterol; Clinical Trials as Topic; Creat	1979
Renin-aldosterone system and urinary electrolytes after amiloride, hydrochlorothiazide and the combination. International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:11 Topics: Adolescent; Adult; Aldosterone; Amiloride; Drug Combinations; Electrolytes; Female; Humans; Hydrochl	1978
Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA, 1992, Feb-26, Volume: 267, Issue:8 Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Chlorthalidone; Double-Blind Method; Electrocardi	1992
Renal excretory actions of antihypertensive agents. Effects of rilmenidine. The American journal of medicine, 1989, Sep-18, Volume: 87, Issue:3C Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypert	1989
Comparative efficacy and bioequivalence of a brand-name and a generic triamterene-hydrochlorothiazide combination product. Clinical pharmacy, 1989, Volume: 8, Issue:7 Topics: Adolescent; Adult; Aged; Blood Pressure; Chromatography, High Pressure Liquid; Drug Combinations; El	1989
The effect of high-dose short-term ibuprofen on antihypertensive control with hydrochlorothiazide. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:4 Topics: Adult; Aged; Blood Pressure; Dinoprostone; Double-Blind Method; Drug Administration Schedule; Electr	1989
Renal-metabolic consequences of antihypertensive therapy with diltiazem versus hydrochlorothiazide. Mineral and electrolyte metabolism, 1987, Volume: 13, Issue:2 Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diltiazem; Double-Blind Method; E	1987
Antihypertensive and biochemical effects of different doses of hydrochlorothiazide alone or in combination with triamterene. Acta medica Scandinavica, 1986, Volume: 219, Issue:4 Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy	1986
Antihypertensive therapy with triamterene-hydrochlorothiazide vs amiloride-hydrochlorothiazide. Comparison of effects on urinary prostaglandin E2 excretion. Archives of internal medicine, 1986, Volume: 146, Issue:7 Topics: Amiloride; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dinoprostone; Drug Com	1986
The effects of bendroflumethiazide/potassium chloride versus hydrochlorothiazide/amiloride on blood pressure and serum electrolytes in patients with mild to moderate hypertension seen in general practice. Pharmatherapeutica, 1986, Volume: 4, Issue:10 Topics: Adult; Aged; Amiloride; Bendroflumethiazide; Blood Pressure; Drug Therapy, Combination; Electrolytes	1986
Comparison of cyclothiazide and hydrochlorthiazide in hypertension. Effects of different doses of diuretics. Cor et vasa, 1985, Volume: 27, Issue:6 Topics: Adult; Antihypertensive Agents; Benzothiadiazines; Blood Glucose; Blood Pressure; Clinical Trials as	1985
Effects of muzolimine and of a combination of hydrochlorothiazide/triamterene in healthy subjects and in nephrotic patients. Zeitschrift fur Kardiologie, 1985, Volume: 74 Suppl 2 Topics: Adolescent; Adult; Aged; Body Weight; Creatinine; Drug Therapy, Combination; Electrolytes; Female; H	1985
Hemodynamic changes in long-term diuretic therapy of essential hypertension. A comparative study of chlorthalidone, polythiazide and hydrochlorothiazide. Acta medica Scandinavica, 1970, Volume: 187, Issue:6 Topics: Adult; Blood Pressure; Blood Volume; Cardiac Output; Chlorthalidone; Electrolytes; Heart Rate; Human	1970

Article	Year
2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol. Journal of medicinal chemistry, 1981, Volume: 24, Issue:1 Topics: Animals; Blood Pressure; Chemical Phenomena; Chemistry; Diuretics; Dogs; Electrolytes; Hypertension;	1981
Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2. Journal of hypertension, 2015, Volume: 33, Issue:3 Topics: Aged; Aged, 80 and over; Aquaporin 2; Drinking; Electrolytes; Female; Humans; Hydrochlorothiazide; H	2015
Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii (Rutaceae) in Wistar rats. Journal of integrative medicine, 2015, Volume: 13, Issue:5 Topics: Animals; Carbonic Anhydrase Inhibitors; Diuretics; Electrolytes; Female; Furosemide; Hydrochlorothia	2015
The potential for interaction of hydrochlorothiazide with garlic in rats. Chemico-biological interactions, 2009, Oct-30, Volume: 181, Issue:3 Topics: Animals; Antihypertensive Agents; Area Under Curve; Blood Pressure; Dose-Response Relationship, Drug	2009
Diuretic and antioxidant effects of Cacti-Nea, a dehydrated water extract from prickly pear fruit, in rats. Phytotherapy research : PTR, 2010, Volume: 24, Issue:4 Topics: Administration, Oral; Animals; Antioxidants; Body Weight; Diuretics; Drinking; Drug Evaluation, Prec	2010
Effects of hydrochlorothiazide on cardiac remodeling in a rat model of myocardial infarction-induced congestive heart failure. European journal of pharmacology, 2011, Sep-30, Volume: 667, Issue:1-3 Topics: Animals; Collagen; Cytokines; Disease Models, Animal; Electrolytes; Gene Expression Regulation; Hear	2011
Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Kidney international, 2003, Volume: 64, Issue:2 Topics: Animals; Calcium; Calcium Channels; Diuretics; Electrolytes; Hydrochlorothiazide; Immunoblotting; Im	2003
[Observations on the diuretic effect & on behavior of urinary electrolytes in the course of treatment with hydrochlorothiazide]. Minerva medica, 1959, May-26, Volume: 50, Issue:42 Topics: Acetazolamide; Diuretics; Electrolytes; Humans; Hydrochlorothiazide	1959
A clinical study of the effects of hydrochlorothiazide on the renal excretion of electrolytes and free water. The New England journal of medicine, 1959, Aug-06, Volume: 261, Issue:6 Topics: Acetazolamide; Biomedical Research; Body Fluids; Electrolytes; Humans; Hydrochlorothiazide; Kidney;	1959
[Effects of intravenous administration of hydrochlorothiazide on renal hemodynamics and excretion of electrolytes in hypertensive patients]. La Clinica terapeutica, 1960, Volume: 19 Topics: Administration, Intravenous; Chlorothiazide; Electrolytes; Hemodynamics; Hydrochlorothiazide; Hypert	1960
[Alterations of electrolyte equilibrium induced by prolonged treatment with hydrochlorothiazide and their relation to the hypotensive action of saluretic drugs]. Bollettino della Societa italiana di biologia sperimentale, 1961, Jul-31, Volume: 37 Topics: Chlorothiazide; Diuretics; Electrolytes; Hydrochlorothiazide; Hypertension; Hypotension; Water-Elect	1961
[Hydrochlorothiazide in the treatment of cardiac edema and of its effects on electrolyte metabolism]. Srpski arhiv za celokupno lekarstvo, 1960, Volume: 88 Topics: Chlorothiazide; Edema, Cardiac; Electrolytes; Heart Failure; Hydrochlorothiazide	1960
[Water-electrolyte metabolism in the course of prolonged treatment with chlorothiazide and hydrochlorothiazide]. Minerva medica, 1960, Mar-10, Volume: 51 Topics: Chlorothiazide; Electrolytes; Humans; Hydrochlorothiazide; Water; Water-Electrolyte Balance	1960
[Balance studies on the electrolyte effect of hydrochlorothiazide in children. Contribution to the mechanism of action of conteben diuresis]. Zeitschrift fur mikroskopisch-anatomische Forschung, 1960, Volume: 83 Topics: Child; Diuresis; Electrolytes; Humans; Hydrochlorothiazide; Infant; Nephrotic Syndrome; Thioacetazon	1960
Comparative effects of benzydroflumethiazide and hydrochlorothiazide on urinary electrolyte excretion. Current therapeutic research, clinical and experimental, 1960, Volume: 2 Topics: Bendroflumethiazide; Chlorothiazide; Electrolytes; Hydrochlorothiazide	1960
[Effect of SC 9420, mercurial diuretic and hydrochlorothiazide on electrolyte excretion in liver cirrhosis]. Revista medica de Chile, 1959, Volume: 87 Topics: Aldosterone; Chlorothiazide; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhosis;	1959
[Studies on the mechanism of hypotensive effects of diuril. III. Effect of hydrochlorothiazide on the electrolyte content in arterial walls and skeletal muscles in rats with experimental hypertension]. Polskie Archiwum Medycyny Wewnetrznej, 1961, Volume: 31 Topics: Animals; Aorta; Arteries; Chlorothiazide; Electrolytes; Humans; Hydrochlorothiazide; Hypertension; M	1961
Effect of hydrochlorothiazide on renal electrolyte gradient in glucose diuresis and experimental diabetes insipidus. The Journal of pharmacology and experimental therapeutics, 1962, Volume: 137 Topics: Chlorothiazide; Diabetes Insipidus; Diuresis; Electrolytes; Glucose; Hydrochlorothiazide; Kidney	1962
[Plasmatic, urinary and tissular water-electrolyte changes in dogs with hypertension induced by baroceptive deafferentation, treated with hydrochlorothiazide]. Folia endocrinologica; mensile di incretologia e incretoterapia, 1961, Volume: 14 Topics: Animals; Chlorothiazide; Dogs; Electrolytes; Hydrochlorothiazide; Hypertension; Neurosurgical Proced	1961
[Effect of hydrochlorothiazide on the electrolyte equilibrium of human erythrocytes in vitro]. La Riforma medica, 1962, Jan-27, Volume: 76 Topics: Chlorothiazide; Electrolytes; Erythrocytes; Hydrochlorothiazide; In Vitro Techniques; Water-Electrol	1962
[Electrolyte metabolism in patients with circulatory insufficiency during the treatment with novurit, hypothiazide and fonurit. (Preliminary communication)]. Terapevticheskii arkhiv, 1962, Volume: 34 Topics: Acetazolamide; Alkylmercury Compounds; Chlorothiazide; Diuretics; Drug Combinations; Electrolytes; H	1962
[Effect of 1-oxo-3-(3'-sulfamoyl-4'-chlorophenyl)-3-hydroxyisoindolinum on urinary electrolyte excretion in comparison with some other diuretics]. Arzneimittel-Forschung, 1963, Volume: 13 Topics: Chlorthalidone; Diuretics; Electrolytes; Humans; Hydrochlorothiazide	1963
[The effect of prolonged administration of hydrochlorothiazide on the development of experimental renal hypertension and on electrolyte metabolism in rats]. Acta biologica et medica Germanica, 1963, Volume: 10 Topics: Animals; Chlorides; Electrolytes; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Kidney; Po	1963
Effect of long-term treatment with hydrochlorothiazide on water and electrolytes of muscle in hypertensive subjects. American heart journal, 1963, Volume: 65 Topics: Electrolytes; Humans; Hydrochlorothiazide; Hypertension; Muscles; Potassium; Sodium; Sodium, Dietary	1963
The effect of hydrochlorothiazide on the kidney of the electrolyte-deficient rat. Quarterly journal of experimental physiology and cognate medical sciences, 1963, Volume: 48 Topics: Animals; Desoxycorticosterone; Electrolytes; Hydrochlorothiazide; Hypokalemia; Kidney; Potassium Def	1963
[OSMOTIC CLEARANCE, ELECTROLYTE EXCRETION AND ACID-BASE EQUILIBRIUM UNDER THE INFLUENCE OF VARIOUS DIURETICS]. Arzneimittel-Forschung, 1963, Volume: 13 Topics: Acid-Base Equilibrium; Diuretics; Electrolytes; Hydrochlorothiazide; Kidney; Pharmacology; Water-Ele	1963
[ON THE ANTIHYPERTENSIVE EFFECT OF THE SUBSTANCES ISOBUTYLHYDROCHLOROTHIAZIDE, SPIRONOLACTONE AND TRIAMTERENE ACTING ON ELECTROLYTES]. Klinische Wochenschrift, 1963, Oct-01, Volume: 41 Topics: Antihypertensive Agents; Diuretics; Electrolytes; Geriatrics; Humans; Hydrochlorothiazide; Hypertens	1963
AN EXTRARENAL EFFECT OF HYDROCHLOROTHIAZIDE. Experientia, 1963, Oct-15, Volume: 19 Topics: Blood Chemical Analysis; Electrolytes; Hydrochlorothiazide; Metabolism; Nephrectomy; Pharmacology; R	1963
[DIURETIC THERAPY OF DECOMPENSATED HEPATIC CIRRHOSIS]. Minerva medica, 1963, Sep-22, Volume: 54 Topics: Blood Chemical Analysis; Chlorothiazide; Chlorthalidone; Diuresis; Diuretics; Electrolytes; Humans;	1963
[ON ION TRANSPORT BEFORE AND AFTER TREATMENT OF CONGESTIVE HEART FAILURE]. Turk Tip Cemiyeti mecmuasi, 1963, Volume: 29 Topics: Chlorthalidone; Coronary Disease; Digitalis Glycosides; Diuretics; Electrolytes; Heart Failure; Huma	1963
[STUDIES OF THE PATHOGENESIS AND THERAPY OF INFANTILE NEPHROTIC EDEMA. OBSERVATIONS ON 8 CASES TREATED WITH COMBINED HYDROCHLOROTHIAZIDE AND ALDOSTERONE ANTAGONISTS]. Archivio italiano di pediatria e puericoltura, 1963, Volume: 23 Topics: Child; Diuretics; Edema; Electrolytes; Humans; Hydrochlorothiazide; Kidney Function Tests; Metabolis	1963
[OBSERVATIONS ON ELECTROLYTE CHANGES IN CONGESTIVE HEART FAILURE DURING CARDIOKINETIC OR DEPLETIVE TREATMENT]. Atti della Societa italiana di cardiologia, 1964, Volume: 25 Topics: Aortic Diseases; Arteriosclerosis; Blood Chemical Analysis; Diuretics; Electrolytes; Heart Failure;	1964
[PHARMACOLOGICAL ACTIONS OF 2 HETEROCYCLIC GLYOXYLIC ALDEHYDES WITH NOTABLE DIURETIC ACTIVITY]. Il Farmaco; edizione scientifica, 1964, Volume: 19 Topics: Aldehydes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorothiazide; C	1964
[INFLUENCE OF TRIAMTERENE ON SALIDIURESIS AND RENAL HEMODYNAMICS OF INDIVIDUALS WITH ASCITOGENIC HEPATIC CIRRHOSIS IN TREATMENT WITH HYDROCHLOROTHIAZIDE]. Rivista di patologia e clinica, 1963, Volume: 18 Topics: Ascites; Blood Circulation; Diuresis; Diuretics; Electrolytes; Hemodynamics; Hydrochlorothiazide; Ki	1963
[ON MODIFICATIONS OF PLASMA AND URINARY ELECTROLYTES IN ASCITOGENIC HEPATIC CIRRHOSIS IN TREATMENT WITH TRIAMTERENE ALONE AND ASSOCIATED WITH HYDROCHLOROTHIAZIDE AND WITH SPIRONOLACTONE]. Minerva medica, 1964, Sep-15, Volume: 55 Topics: Ascites; Biomedical Research; Chlorides; Electrolytes; Geriatrics; Humans; Hydrochlorothiazide; Live	1964
DELIRIUM AND COMPLEX ELECTROLYTE DISTURBANCE. Diseases of the nervous system, 1965, Volume: 26 Topics: Alkalosis; Chlorothiazide; Delirium; Diet, Sodium-Restricted; Drug Therapy; Electrolytes; Hydrochlor	1965
[EFFECT OF HYPOTHIAZIDE ON THE WATER-ELECTROLYTE METABOLISM IN CIRCULATORY INSUFFICIENCY]. Zhurnal eksperimental'noi i klinicheskoi meditsiny, 1964, Volume: 4 Topics: Electrolytes; Heart Failure; Humans; Hydrochlorothiazide; Water; Water-Electrolyte Balance	1964
STUDIES ON BIOGENIC AMINES AND RESERPINE INDUCED BLOCK OF THE DIURETIC ACTION OF HYDROCHLOROTHIAZIDE AND THEOPHYLLINE IN THE CHICKEN. Acta pharmacologica et toxicologica, 1965, Volume: 22 Topics: Animals; Blood Pressure; Blood Pressure Determination; Chickens; Diuretics; Dopamine; Electrolytes;	1965
[ACTIVITY ON URINARY ELECTROLYTES OF VARIOUS TRIAMTERENE AND HYDROCHLOROTHIAZIDE ASSOCIATIONS]. Il Farmaco; edizione pratica, 1965, Volume: 20 Topics: Electrolytes; Hydrochlorothiazide; Potassium; Rats; Research; Sodium; Sodium, Dietary; Triamterene;	1965
A comparative study of hydrochlorothiazide and chlorothiazide on blood ammonia and electrolyte balance in cirrhotic patients. The American journal of gastroenterology, 1960, Volume: 33 Topics: Ammonia; Chlorothiazide; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhosis; Water-Electroly	1960
[Hydrochlorothiazide and physiopathology of water-electrolyte metabolism in obstetrics and gynecology]. Quaderni di clinica ostetrica e ginecologica, 1959, Volume: 14 Topics: Chlorothiazide; Electrolytes; Female; Gynecology; Hydrochlorothiazide; Obstetrics; Pre-Eclampsia; Pr	1959
Influence of spironolactone in modifying the renal electrolyte effects of hydrochlorothiazide in laboratory animals. Archives internationales de pharmacodynamie et de therapie, 1962, Apr-01, Volume: 136 Topics: Aldosterone; Animals; Animals, Laboratory; Chlorothiazide; Electrolytes; Hydrochlorothiazide; Kidney	1962
Diuretic activity of some Withania aristata Ait. fractions. Journal of ethnopharmacology, 2008, May-22, Volume: 117, Issue:3 Topics: Animals; Chemical Phenomena; Chemistry, Physical; Diuretics; Electrolytes; Flowers; Fruit; Hydrochlo	2008
Evaluation of MK-870: a new potassium-sparing diuretic. British medical journal, 1967, Jan-21, Volume: 1, Issue:5533 Topics: Adult; Aged; Diuresis; Diuretics; Drug Synergism; Edema; Electrolytes; Ethacrynic Acid; Evaluation S	1967
Azido pyrimidine diuretics (SC-16102, SC-16100): ADH antagonism assay in the rat. Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 169, Issue:1 Topics: Animals; Diuretics; Electrolytes; Furosemide; Hydrochlorothiazide; Male; Prednisone; Pyrimidines; Ra	1967
[Combined effect of hydrochlorothiazide and atenolol in antihypertensive therapy of 42 patients]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1983, Volume: 4, Issue:4 Topics: Adult; Atenolol; Blood Pressure; Drug Therapy, Combination; Electrolytes; Heart Rate; Humans; Hydroc	1983
Additive hypocalciuric effects of amiloride and hydrochlorothiazide in patients treated with calcitriol. Mineral and electrolyte metabolism, 1984, Volume: 10, Issue:6 Topics: Absorption; Adolescent; Adult; Amiloride; Calcitriol; Calcium; Child; Child, Preschool; Diuretics; D	1984
Effect of indapamide on volume-dependent hypertension, renal haemodynamics, solute excretion and proximal nephron fractional reabsorption in the dog. Current medical research and opinion, 1983, Volume: 8 Suppl 3 Topics: Animals; Blood Pressure; Chlorides; Diuretics; Dogs; Dose-Response Relationship, Drug; Electrolytes;	1983
[Electrolyte excretion following administration of various diuretics in healthy females]. Fortschritte der Medizin, 1984, Feb-09, Volume: 102, Issue:6 Topics: Bendroflumethiazide; Circadian Rhythm; Diuretics; Drug Therapy, Combination; Electrolytes; Female; F	1984
Bioavailability of hydrochlorothiazide from tablets and suspensions. Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:3 Topics: Adult; Biological Availability; Electrolytes; Humans; Hydrochlorothiazide; Intestinal Absorption; Ma	1984
Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: a study in the avian kidney. Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:3 Topics: Animals; Blood Proteins; Carbonic Anhydrases; Chickens; Chlorothiazide; Clopamide; Electrolytes; Fem	1982
Clinical efficacy and safety of indapamide in the treatment of edema. American heart journal, 1983, Volume: 106, Issue:1 Pt 2 Topics: Body Weight; Diuretics; Double-Blind Method; Edema; Electrolytes; Female; Humans; Hydrochlorothiazid	1983
Acute and chronic renal effects of guanfacine in essential and renal hypertension. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Antihypertensive Agents; Blood Pressure; Creatinine; Drug Therapy, Combination; Electrolytes; Glomer	1980
Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension. British journal of clinical pharmacology, 1981, Volume: 12, Issue:3 Topics: Adult; Aldosterone; Angiotensins; Diuretics; Electrolytes; Female; Humans; Hydrochlorothiazide; Hype	1981
Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. Journal of clinical pharmacology, 1982, Volume: 22, Issue:1 Topics: Adult; Diet; Double-Blind Method; Drug Interactions; Electrolytes; Humans; Hydrochlorothiazide; Indo	1982
Responses to hydrochlorothiazide and acetazolamide in patients with calcium stones. Evidence suggesting a defect in renal tubular function. The New England journal of medicine, 1980, Mar-27, Volume: 302, Issue:13 Topics: Acetazolamide; Adult; Calcium; Creatinine; Electrolytes; Female; Humans; Hydrochlorothiazide; Kidney	1980
A novel non-xanthine adenosine A1 receptor antagonist. European journal of pharmacology, 1995, Jun-12, Volume: 279, Issue:2-3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Diuretics; Electrolytes; Guinea Pigs; Heart	1995
Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats. Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 350, Issue:4 Topics: Administration, Oral; Animals; Blood Pressure; Calcium; Cardiomegaly; Dose-Response Relationship, Dr	1994
Stimulated parotid salivary flow rates in normotensive, hypertensive, and hydrochlorothiazide-medicated. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1994, Volume: 23, Issue:6 Topics: Aged; Analysis of Variance; Baltimore; Black People; Case-Control Studies; Citrates; Citric Acid; El	1994
Synthesis and diuretic activity of (E)-2-methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-5-carboxald ehyde dimethylaminoacetohydrazone. Arzneimittel-Forschung, 1994, Volume: 44, Issue:5 Topics: Animals; Diuretics; Electrolytes; Furosemide; Hydrazones; Hydrochlorothiazide; Male; Rats; Rats, Spr	1994
Effect of diazoxide on serum and tissue electrolyte levels in rats with deoxycorticosterone acetate-induced hypertension. Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:5 Topics: Animals; Aorta; Blood Pressure; Calcium; Desoxycorticosterone; Diazoxide; Electrolytes; Hydrochlorot	1994
Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency. Journal of clinical pharmacology, 1993, Volume: 33, Issue:6 Topics: Adult; Aged; Blood Glucose; Cholesterol; Electrolytes; Female; Guanidines; Humans; Hydrochlorothiazi	1993
The effect of a low dose versus a conventional dose of hydrochlorothiazide on ventricular fibrillation threshold and electrolyte levels in laboratory rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1996, Volume: 29, Issue:10 Topics: Animals; Diuretics; Electrolytes; Hydrochlorothiazide; Male; Potassium; Rats; Rats, Wistar; Sodium C	1996
Preclinical safety studies of the combination moexipril hydrochloride/hydrochlorothiazide. Arzneimittel-Forschung, 1998, Volume: 48, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Autonomic Nervous System	1998
Use of peripheral temperature and core-peripheral temperature difference to predict cardiac output in dehydrated calves housed in a thermoneutral environment. American journal of veterinary research, 1998, Volume: 59, Issue:7 Topics: Animals; Animals, Newborn; Blood Pressure; Body Temperature; Cardiac Output; Cattle; Cattle Diseases	1998
A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 1998, Volume: 62, Issue:3 Topics: Animals; Animals, Newborn; Blood Glucose; Blood Proteins; Body Temperature; Body Weight; Cattle; Col	1998
Diuretic activity of an aqueous extract of Phyllanthus sellowianus. Phytomedicine : international journal of phytotherapy and phytopharmacology, 1999, Volume: 6, Issue:3 Topics: Animals; Diabetes Mellitus, Experimental; Diuretics; Electrolytes; Euphorbiaceae; Female; Hydrochlor	1999
Protective effects of delapril combined with indapamide or hydrochlorothiazide in spontaneously hypertensive stroke-prone rats: a comparative dose-response analysis. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Diuretics; Dose-Resp	2000
Diuretic effects of selected Thai indigenous medicinal plants in rats. Journal of ethnopharmacology, 2001, Volume: 75, Issue:2-3 Topics: Animals; Chlorides; Diuresis; Diuretics; Electrolytes; Hydrochlorothiazide; Male; Osmolar Concentrat	2001
Metabolic effects in man of tienilic acid, a new diuretic with uricosuric properties. Nephron, 1978, Volume: 20, Issue:1 Topics: Acid-Base Equilibrium; Adult; Body Weight; Diuretics; Electrolytes; Glycolates; Humans; Hydrochlorot	1978
Treatment of hypertension in aviators: a clinical trial with Aldactazide. Aviation, space, and environmental medicine, 1978, Volume: 49, Issue:3 Topics: Adult; Aerospace Medicine; Blood Volume; Drug Combinations; Electrolytes; Humans; Hydrochlorothiazid	1978
Leukocyte intracellular cations in hypertension: Effect of antihypertensive drugs. American heart journal, 1978, Volume: 96, Issue:6 Topics: Adult; Antihypertensive Agents; Electrolytes; Humans; Hydralazine; Hydrochlorothiazide; Hypertension	1978
Antihypertensive effect of trichlormethiazide in spontaneously hypertensive rats. Japanese journal of pharmacology, 1978, Volume: 28, Issue:4 Topics: Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Diuretics; Drinking; Electrolytes;	1978
The effect of diuretics on the faecal excretion of water and electrolytes in horses. British journal of pharmacology, 1977, Volume: 60, Issue:4 Topics: Animals; Body Water; Chlorides; Electrolytes; Feces; Furosemide; Horses; Hydrochlorothiazide; Male;	1977
Long-term effects of an amiloride/hydrochlorothiazide combination ('Moduretic') on electrolyte balance. Current medical research and opinion, 1976, Volume: 4, Issue:4 Topics: Adult; Aged; Amiloride; Drug Combinations; Electrolytes; Female; Humans; Hydrochlorothiazide; Hypert	1976
Interaction between an angiotensin converting enzyme inhibitor, perindopril, and a thiazide diuretic in the spontaneously hypertensive rat. The Canadian journal of cardiology, 1992, Volume: 8, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Dose-Response Relationship, Drug;	1992
The diurnal rhythm of plasma potassium: relationship to diuretic therapy. Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:5 Topics: Adult; Aldosterone; Amiloride; Animals; Blood Pressure; Circadian Rhythm; Cricetinae; Diuretics; Ele	1991
Behavioral effects of chronic, orally administered diuretic and verapamil in baboons. Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:1 Topics: Animals; Behavior, Animal; Blood Pressure; Color Perception; Conditioning, Operant; Desoxycorticoste	1991
Nonazotemic hyperkalemia with renal and extrarenal defects in potassium transport: association with high levels of digoxin-like immunoreactive factor. The Journal of laboratory and clinical medicine, 1990, Volume: 116, Issue:3 Topics: Acid-Base Equilibrium; Adult; Biological Transport; Blood Proteins; Cardenolides; Digoxin; Electroly	1990
Effect of chronic diuretics on epinephrine-induced ventricular arrhythmias: a comparison of hydrochlorothiazide and amiloride in the rat. Journal of cardiovascular pharmacology, 1987, Volume: 10, Issue:2 Topics: Amiloride; Animals; Arrhythmias, Cardiac; Blood Pressure; Diuretics; Dose-Response Relationship, Dru	1987
Udder edema in cattle: effects of diuretics (furosemide, hydrochlorothiazide, acetazolamide, and 50% dextrose) on serum and urine electrolytes. American journal of veterinary research, 1989, Volume: 50, Issue:8 Topics: Acetazolamide; Animals; Calcium; Cattle; Cattle Diseases; Diuretics; Edema; Electrolytes; Female; Fu	1989
Cardiovascular and renal actions of calcium channel blocker chemical subgroups: a search for renal specificity. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Amiloride; Animals; Blood Pressure; Calcium Channel Blockers; Cinnarizine; Drug Interactions; Electr	1988
Interaction of amiloride and hydrochlorothiazide with atrial natriuretic factor in the medullary collecting duct. Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:5 Topics: Amiloride; Animals; Atrial Natriuretic Factor; Drug Interactions; Electrolytes; Hydrochlorothiazide;	1988
Comparison of cicletanine with other antihypertensive drugs in SHR-SP models. Drugs under experimental and clinical research, 1988, Volume: 14, Issue:2-3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Diuresis; Di	1988
Long-term effects of enalapril monotherapy and enalapril/hydrochlorothiazide combination therapy on blood pressure, renal function, and body fluid composition. Journal of clinical hypertension, 1986, Volume: 2, Issue:1 Topics: Adult; Aged; Blood Pressure; Body Fluids; Drug Therapy, Combination; Electrolytes; Enalapril; Glomer	1986
[Electrolyte disorders resulting from treatment with a diuretic combination of hydrochlorothiazide and amiloride. A case report with acute symptomatic hyponatremia and a review of reports to the National Board of Adverse Drug Reactions over a period of 10 Ugeskrift for laeger, 1988, Oct-03, Volume: 150, Issue:40 Topics: Acute Disease; Aged; Amiloride; Denmark; Drug Combinations; Electrolytes; Female; Humans; Hydrochlor	1988
The influence of dietary potassium on the renal tubular effect of hydrochlorothiazide in the rat. British journal of pharmacology, 1987, Volume: 91, Issue:3 Topics: Aldosterone; Animals; Blood Cell Count; Diet; Electrolytes; Glomerular Filtration Rate; Hydrochlorot	1987
[Clinical evaluation of penbutolol (Hoe 893d) (beta adrenergic blocker), alone and in combination with hydrochlorothiazide, in the treatment of arterial hypertension. II. Effect on plasma electrolytes, renal function, plasma renin and aldosterone activity Medicina clinica, 1985, Jun-08, Volume: 85, Issue:2 Topics: Aldosterone; Antihypertensive Agents; Drug Therapy, Combination; Electrolytes; Humans; Hydrochloroth	1985
Effects of an acebutolol-hydrochlorothiazide combination on urinary solute excretion in healthy adults. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Jan-18, Volume: 69, Issue:2 Topics: Acebutolol; Adolescent; Adult; Calcium; Chlorides; Creatinine; Drug Interactions; Electrolytes; Huma	1986
The Spitzer-Weinstein syndrome: one form of type IV renal tubular acidosis and its response to hydrochlorothiazide. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1986, Volume: 7, Issue:3 Topics: Acidosis, Renal Tubular; Child; Electrolytes; Female; Growth Disorders; Humans; Hydrochlorothiazide;	1986
The effect of prolonged thiazide administration on thyroid function. Archives of internal medicine, 1967, Volume: 119, Issue:3 Topics: Blood Proteins; Electrolytes; Humans; Hydrochlorothiazide; Hypertension; Iodine; Iodine Radioisotope	1967
[Therapy of cardiac edema with a combination of hydrochlorthiazide and amiloride-HCl (author's transl)]. Wiener klinische Wochenschrift, 1973, Dec-28, Volume: 85, Issue:52 Topics: Alkalosis; Diuretics; Drug Combinations; Electrolytes; Heart Failure; Hydrochlorothiazide; Hypokalem	1973
[Changes in electrolyte movements induced by diuretics in isolated adipose tissue]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2 Topics: Adipose Tissue; Biological Transport; Depression, Chemical; Diuretics; Electrolytes; Ethacrynic Acid	1968
[Angiotensin and saluretics in nephrogenic diabetes insipidus of early infancy]. Zeitschrift fur Kinderheilkunde, 1967, Volume: 101, Issue:1 Topics: Angiotensin II; Body Temperature; Chlorthalidone; Diabetes Insipidus; Electrolytes; Female; Furosemi	1967
[Effect of hypothiazide on water-salt metabolism in the middle-aged and elderly]. Vrachebnoe delo, 1974, Volume: 5, Issue:0 Topics: Adult; Age Factors; Aged; Circadian Rhythm; Electrolytes; Humans; Hydrochlorothiazide; Kidney; Middl	1974
Effect of amiloride and hydrochlorothiazide on body fluids and electrolytes in geriatric patients with congestive cardiac failure. Gerontologia clinica, 1974, Volume: 16, Issue:1 Topics: Aged; Amiloride; Body Fluids; Diuretics; Electrolytes; Heart Failure; Humans; Hydrochlorothiazide; P	1974
[Comparison of the effectiveness and mechanism of action of the saluretic preparations triamterene and hypothiazide and their combination (triampur) in circulatory insufficiency]. Kardiologiia, 1973, Volume: 13, Issue:4 Topics: Acid-Base Equilibrium; Adult; Aged; Arteriosclerosis; Circadian Rhythm; Coronary Disease; Creatinine	1973
A comparison of moduretic and hydrochlorothiazide in the treatment of hypertension in African patients. East African medical journal, 1973, Volume: 50, Issue:1 Topics: Adult; Aged; Amiloride; Blood Pressure; Diuretics; Electrolytes; Female; Humans; Hydrochlorothiazide	1973
Prolonged administration of hydrochlorothiazide on cardiac function in beagle dogs. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 144, Issue:3 Topics: Administration, Oral; Animals; Blood Pressure; Blood Volume; Body Weight; Cardiac Output; Dogs; Elec	1973
[Effects of hydrochlorothiazide, furosemide and ethacrynic acid on the electrolyte composition of the urine, plasma and edema fluid]. Bollettino della Societa italiana di biologia sperimentale, 1973, Jul-30, Volume: 49, Issue:12 Topics: Adult; Aged; Body Fluids; Edema; Electrolytes; Ethacrynic Acid; Female; Furosemide; Heart Failure; H	1973
[Pharmacological studies of diuretics. 4. Changes of serum uric acid level by the succesive administration of thiazide diuretics and other drugs and effects of uricosuric drugs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1971, Volume: 67, Issue:1 Topics: Administration, Oral; Allopurinol; Ammonium Chloride; Animals; Barbiturates; Blood Glucose; Chloroth	1971
Comparative assay of diuretic activity of 2-(2,2-Dicyclohexylethyl)-piperidine-maleate and Hydrochlorothiazide in rat by oral administration. Arzneimittel-Forschung, 1971, Volume: 21, Issue:1 Topics: Administration, Oral; Animals; Diuresis; Electrolytes; Hydrochlorothiazide; Maleates; Piperidines; R	1971
[Diabetes insipidus--antidiuretic action of diuretics]. Nihon rinsho. Japanese journal of clinical medicine, 1970, Volume: 28, Issue:4 Topics: Chlorothiazide; Diabetes Insipidus; Diuresis; Diuretics; Electrolytes; Humans; Hydrochlorothiazide;	1970
[Saluretic-diuretic and hypotensive effect of hypothiazide in hypertension]. Sovetskaia meditsina, 1970, Volume: 33, Issue:12 Topics: Adult; Aged; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Natriu	1970
Renal effects of uricosuric agents in the chimpanzee. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 177, Issue:3 Topics: Aminohippuric Acids; Animals; Benzoates; Benzyl Compounds; Chlorothiazide; Electrolytes; Glomerular	1971
[Research on hyperglycemia caused by saluretics]. Il Policlinico. Sezione medica, 1967, Volume: 74, Issue:2 Topics: Diabetes Mellitus; Diuresis; Diuretics; Electrolytes; Female; Furosemide; Heart Diseases; Humans; Hy	1967
[The influence of hydrochlorothiazide on various serum kations and their excretion in essential hypertension]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1968, Aug-01, Volume: 23, Issue:15 Topics: Adult; Alkaline Phosphatase; Calcium; Copper; Electrolytes; Enzymes; Female; Humans; Hydrochlorothia	1968
[Clinical and biochemical study of the therapeutic effect of the diuretic triamterene in ascitogenic cirrhosis]. Medicina interna, 1968, Volume: 20, Issue:5 Topics: Adrenal Cortex Hormones; Ascites; Diuresis; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhos	1968
[Laboratory diagnosis of hyperbilirubinemia. Biochemical examination of the electrolyte metabolism]. Rinsho byori. The Japanese journal of clinical pathology, 1969, Volume: 17, Issue:4 Topics: Adolescent; Adult; Electrolytes; Female; Humans; Hydrochlorothiazide; Hyperbilirubinemia; Liver Cirr	1969
[Effect of oxytocin and oxytocin associated with hydrochlorothiazide on diuresis]. Bollettino della Societa italiana di biologia sperimentale, 1964, Nov-30, Volume: 40, Issue:22 Topics: Animals; Diuresis; Electrolytes; Hydrochlorothiazide; Male; Oxytocin; Rats	1964
[Clinical trials of a new antihypertensive drug association in aged subjects. Behavior of the electrolyte pattern]. Minerva medica, 1966, Aug-11, Volume: 57, Issue:63 Topics: Aged; Carbamates; Electrolytes; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Potassium Ch	1966
Depletion of body potassium by diuretics. Circulation, 1966, Volume: 33, Issue:5 Topics: Adult; Aged; Blood; Dichlorphenamide; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Middle A	1966
[The clinical use of an association of hydrochlorothiazide and triamterene in nephrotic syndromes]. Giornale di clinica medica, 1966, Volume: 47, Issue:11 Topics: Adolescent; Adult; Aged; Amyloidosis; Child; Diabetic Nephropathies; Diuresis; Electrolytes; Female;	1966

hydrochlorothiazide and Electrolytes