hydrochlorothiazide has been researched along with Dizziness in 14 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This 8-week study in Korea aimed to evaluate the efficacy and tolerability of a telmisartan/amlodipine + hydrochlorothiazide (TAH) combination versus telmisartan/amlodipine (TA) combination in patients with essential hypertension that did not respond appropriately to 4-week treatment with TA." | 9.27 | Efficacy and Tolerability of Telmisartan/Amlodipine + Hydrochlorothiazide Versus Telmisartan/Amlodipine Combination Therapy for Essential Hypertension Uncontrolled With Telmisartan/Amlodipine: The Phase III, Multicenter, Randomized, Double-blind TAHYTI St ( Ahn, JC; Ahn, JH; Ahn, YK; Cha, DH; Chae, IH; Cho, DK; Cho, SK; Choi, YJ; Hong, SJ; Hong, TJ; Hyon, MS; Jang, JY; Jeon, DW; Jeong, JO; Kim, BS; Kim, HS; Kim, SH; Nam, CW; Oh, YS; Park, SH; Rha, SW; Song, JM; Sung, KC; Won, KH; Yang, TH; Yoo, BS; Yoo, KD; Yoon, YW, 2018) |
| "In Korean adult patients with stage II hypertension, we evaluated the efficacy and tolerability of candesartan 16 mg/hydrochlorothiazide (HCT) 12." | 9.15 | Phase IV, 8-week, multicenter, randomized, active treatment-controlled, parallel group, efficacy, and tolerability study of high-dose candesartan cilexetil combined with hydrochlorothiazide in Korean adults with stage II hypertension. ( Ahn, YK; Choi, D; Chung, WJ; Hong, BK; Jeon, DW; Jung, HO; Kim, BO; Kim, D; Kim, SH; Lee, BK; Lee, HY; Lee, SH; Park, CK, 2011) |
| "To evaluate the safety and tolerability of a titrate-to-goal, olmesartan medoxomil-based therapy in patients with stage 1 hypertension (seated systolic BP [SeSBP] of 140-159 mmHg or seated diastolic BP [SeDBP] of 90-99 mmHg)." | 9.14 | Safety and tolerability of an olmesartan medoxomil-based regimen in patients with stage 1 hypertension: a randomized, double-blind, placebo-controlled study. ( Chrysant, SG, 2010) |
| "The aim of this analysis was to assess the efficacy and safety of the angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB]) olmesartan medoxomil in elderly patients with either essential hypertension or isolated systolic hypertension." | 7.75 | Olmesartan medoxomil in elderly patients with essential or isolated systolic hypertension : efficacy and safety data from clinical trials. ( Heagerty, AM; Mallion, JM, 2009) |
| " Tolerability and safety were assessed by physical examination, laboratory parameters and evaluation of adverse events." | 6.71 | Assessment of efficacy, safety and tolerability of fixed dose combination of telmisartan 40mg and hydrochlorothiazide 12.5mg in adult Indian patients with mild to moderate hypertension. ( Chandrasekharan, S; Desai, A; Ganesan, R; Gawde, A; Jain, SD; Jayaram, S; Kadam, GS; Lahoti, S; Mishra, AB; Muralidharan, RS; Rajadhyaksha, GC; Sodhi, SS, 2004) |
| "1%) were the clinical adverse experiences most often reported in patients treated with losartan." | 6.68 | Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995) |
| "This 8-week study in Korea aimed to evaluate the efficacy and tolerability of a telmisartan/amlodipine + hydrochlorothiazide (TAH) combination versus telmisartan/amlodipine (TA) combination in patients with essential hypertension that did not respond appropriately to 4-week treatment with TA." | 5.27 | Efficacy and Tolerability of Telmisartan/Amlodipine + Hydrochlorothiazide Versus Telmisartan/Amlodipine Combination Therapy for Essential Hypertension Uncontrolled With Telmisartan/Amlodipine: The Phase III, Multicenter, Randomized, Double-blind TAHYTI St ( Ahn, JC; Ahn, JH; Ahn, YK; Cha, DH; Chae, IH; Cho, DK; Cho, SK; Choi, YJ; Hong, SJ; Hong, TJ; Hyon, MS; Jang, JY; Jeon, DW; Jeong, JO; Kim, BS; Kim, HS; Kim, SH; Nam, CW; Oh, YS; Park, SH; Rha, SW; Song, JM; Sung, KC; Won, KH; Yang, TH; Yoo, BS; Yoo, KD; Yoon, YW, 2018) |
| "In Korean adult patients with stage II hypertension, we evaluated the efficacy and tolerability of candesartan 16 mg/hydrochlorothiazide (HCT) 12." | 5.15 | Phase IV, 8-week, multicenter, randomized, active treatment-controlled, parallel group, efficacy, and tolerability study of high-dose candesartan cilexetil combined with hydrochlorothiazide in Korean adults with stage II hypertension. ( Ahn, YK; Choi, D; Chung, WJ; Hong, BK; Jeon, DW; Jung, HO; Kim, BO; Kim, D; Kim, SH; Lee, BK; Lee, HY; Lee, SH; Park, CK, 2011) |
| "To evaluate the safety and tolerability of a titrate-to-goal, olmesartan medoxomil-based therapy in patients with stage 1 hypertension (seated systolic BP [SeSBP] of 140-159 mmHg or seated diastolic BP [SeDBP] of 90-99 mmHg)." | 5.14 | Safety and tolerability of an olmesartan medoxomil-based regimen in patients with stage 1 hypertension: a randomized, double-blind, placebo-controlled study. ( Chrysant, SG, 2010) |
| "The antihypertensive effect of the combination of ketanserin, a new antiserotonergic agent, and thiazide has been evaluated in 35 patients with arterial hypertension of mild to moderate degree in the greater than 50-year-old age group." | 5.06 | Antihypertensive efficacy of the combination of ketanserin + thiazide in hypertensives older than 50 years. ( Fasano, ML; Ferrara, LA; Mancini, M; Pasanisi, F; Soro, S, 1987) |
| "The aim of this analysis was to assess the efficacy and safety of the angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB]) olmesartan medoxomil in elderly patients with either essential hypertension or isolated systolic hypertension." | 3.75 | Olmesartan medoxomil in elderly patients with essential or isolated systolic hypertension : efficacy and safety data from clinical trials. ( Heagerty, AM; Mallion, JM, 2009) |
| " Adverse events (AEs) were reported in 75." | 2.82 | Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study. ( Barger, B; Handley, A; Lloyd, E; Roberts, A, 2016) |
| " Tolerability and safety were assessed by physical examination, laboratory parameters and evaluation of adverse events." | 2.71 | Assessment of efficacy, safety and tolerability of fixed dose combination of telmisartan 40mg and hydrochlorothiazide 12.5mg in adult Indian patients with mild to moderate hypertension. ( Chandrasekharan, S; Desai, A; Ganesan, R; Gawde, A; Jain, SD; Jayaram, S; Kadam, GS; Lahoti, S; Mishra, AB; Muralidharan, RS; Rajadhyaksha, GC; Sodhi, SS, 2004) |
| "1%) were the clinical adverse experiences most often reported in patients treated with losartan." | 2.68 | Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sung, KC | 1 |
| Oh, YS | 1 |
| Cha, DH | 1 |
| Hong, SJ | 1 |
| Won, KH | 1 |
| Yoo, KD | 1 |
| Rha, SW | 1 |
| Ahn, YK | 2 |
| Ahn, JC | 1 |
| Jang, JY | 1 |
| Hong, TJ | 1 |
| Cho, SK | 1 |
| Park, SH | 1 |
| Hyon, MS | 1 |
| Nam, CW | 1 |
| Chae, IH | 1 |
| Yoo, BS | 1 |
| Song, JM | 1 |
| Jeong, JO | 1 |
| Yoon, YW | 1 |
| Kim, BS | 1 |
| Yang, TH | 1 |
| Cho, DK | 1 |
| Kim, SH | 2 |
| Choi, YJ | 1 |
| Ahn, JH | 1 |
| Jeon, DW | 2 |
| Kim, HS | 1 |
| Handley, A | 1 |
| Lloyd, E | 1 |
| Roberts, A | 1 |
| Barger, B | 1 |
| Heagerty, AM | 1 |
| Mallion, JM | 1 |
| Lewin, AJ | 1 |
| Weir, MR | 1 |
| Chrysant, SG | 1 |
| Lee, HY | 1 |
| Hong, BK | 1 |
| Chung, WJ | 1 |
| Lee, BK | 1 |
| Lee, SH | 1 |
| Kim, D | 1 |
| Park, CK | 1 |
| Jung, HO | 1 |
| Kim, BO | 1 |
| Choi, D | 1 |
| Jayaram, S | 1 |
| Lahoti, S | 1 |
| Chandrasekharan, S | 1 |
| Ganesan, R | 1 |
| Muralidharan, RS | 1 |
| Mishra, AB | 1 |
| Sodhi, SS | 1 |
| Rajadhyaksha, GC | 1 |
| Jain, SD | 1 |
| Kadam, GS | 1 |
| Gawde, A | 1 |
| Desai, A | 1 |
| Goldberg, AI | 2 |
| Dunlay, MC | 1 |
| Sweet, CS | 2 |
| Ruilope, LM | 1 |
| Simpson, RL | 1 |
| Toh, J | 1 |
| Arcuri, KE | 1 |
| Benz, JR | 1 |
| Black, HR | 1 |
| Graff, A | 1 |
| Reed, A | 1 |
| Fitzsimmons, S | 1 |
| Shi, Y | 1 |
| Ferrara, LA | 1 |
| Fasano, ML | 1 |
| Soro, S | 1 |
| Pasanisi, F | 1 |
| Mancini, M | 1 |
| Groom, P | 1 |
| Simpson, RJ | 1 |
| Singh, B | 1 |
| Ward, DE | 1 |
| Peers, E | 1 |
| Richardson, PD | 1 |
| Bannon, JA | 1 |
| Stewart, KA | 1 |
| Schrogie, JJ | 1 |
| Delisser, O | 1 |
| Flamenbaum, W | 1 |
| Weber, MA | 1 |
| McMahon, FG | 1 |
| Materson, BJ | 1 |
| Carr, AA | 1 |
| Poland, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blind, Multi-Center, Phase 3 Trial to Evaluate the Efficacy and Safety of Telmisartan/Amlodipine/Hydrochlorothiazide Combination in Comparison With Telmisartan/Amlodipine Combination for Essential Hypertension Patients Not Controlled by[NCT02738632] | Phase 3 | 300 participants (Anticipated) | Interventional | 2015-05-31 | Completed | ||
| Open-label, Randomised, 2-Arm Parallel Group, Multicentre, 8-week, Phase IV Study to Assess the Antihypertensive Efficacy and Safety of the Candesartan Cilexetil 16 mg and Hydrochlorothiazide 12.5 mg Combination Therapy in Comparison With Candesartan 16 m[NCT00621153] | Phase 4 | 214 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean of the changed DBP from baseline after 4 weeks (NCT00621153)
Timeframe: 4 weeks
| Intervention | mmHg (Least Squares Mean) |
|---|---|
| Candesartan Cilexetil/Hydroclorozide Combination Therapy | -17.0 |
| Candesartan Cilexetil Monotherapy | -14.1 |
12 trials available for hydrochlorothiazide and Dizziness
| Article | Year |
|---|---|
Efficacy and Tolerability of Telmisartan/Amlodipine + Hydrochlorothiazide Versus Telmisartan/Amlodipine Combination Therapy for Essential Hypertension Uncontrolled With Telmisartan/Amlodipine: The Phase III, Multicenter, Randomized, Double-blind TAHYTI St
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; Dizzine | 2018 |
Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study.
Topics: Adult; Aged; Benzimidazoles; Chlorthalidone; Cohort Studies; Dizziness; Drug Therapy, Combination; E | 2016 |
Antihypertensive efficacy and tolerability of irbesartan/hydrochlorothiazide in hypertensive patients stratified by body mass index and type 2 diabetes mellitus status: a post hoc subgroup analysis of the Irbesartan/HCTZ Blood Pressure Reductions in Diver
Topics: Aged; Antihypertensive Agents; Biphenyl Compounds; Body Mass Index; Body Weight; Cluster Analysis; D | 2008 |
Safety and tolerability of an olmesartan medoxomil-based regimen in patients with stage 1 hypertension: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Dizziness; Double-Blind Method; Drug Therapy, Combina | 2010 |
Phase IV, 8-week, multicenter, randomized, active treatment-controlled, parallel group, efficacy, and tolerability study of high-dose candesartan cilexetil combined with hydrochlorothiazide in Korean adults with stage II hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Asian People; Benzimidazoles; Biphenyl Compounds; Blood Pressu | 2011 |
Assessment of efficacy, safety and tolerability of fixed dose combination of telmisartan 40mg and hydrochlorothiazide 12.5mg in adult Indian patients with mild to moderate hypertension.
Topics: Adolescent; Adult; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; | 2004 |
Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Conver | 1995 |
Controlled trial of losartan given concomitantly with different doses of hydrochlorothiazide in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Asthenia; Biphenyl Compounds; Blood Pressure; Controlled Clinical Tr | 1996 |
Valsartan and hydrochlorothiazide in patients with essential hypertension. A multiple dose, double-blind, placebo controlled trial comparing combination therapy with monotherapy.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Dizziness; Dose-Response Relationship, Drug; Double- | 1998 |
Antihypertensive efficacy of the combination of ketanserin + thiazide in hypertensives older than 50 years.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Dizziness; Drug Therapy, Combination; Female; Humans | 1987 |
A double-blind comparison of felodipine and hydrochlorothiazide added to metoprolol to control hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dizziness; Double-Bl | 1988 |
Monotherapy with labetalol compared with propranolol. Differential effects by race.
Topics: Adult; Aged; Black or African American; Bradycardia; Clinical Trials as Topic; Dizziness; Double-Bli | 1985 |
2 other studies available for hydrochlorothiazide and Dizziness
| Article | Year |
|---|---|
Olmesartan medoxomil in elderly patients with essential or isolated systolic hypertension : efficacy and safety data from clinical trials.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Dizziness; D | 2009 |
Postmarketing study of timolol-hydrochlorothiazide antihypertensive therapy.
Topics: Adolescent; Adult; Aged; Dizziness; Drug Combinations; Fatigue; Female; Humans; Hydrochlorothiazide; | 1985 |