hydrochlorothiazide has been researched along with Diarrhea in 9 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors report on an 8-week double-blind, randomized study of African American patients with stage 2 hypertension that compared brachial and central BP responses (substudy of 53 patients) to combination aliskiren/hydrochlorthiazide (HCTZ) and amlodipine monotherapy." | 9.15 | Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial. ( Ferdinand, KC; Pool, J; Purkayastha, D; Townsend, R; Weitzman, R, 2011) |
| "We report a case of pulmonary edema induced by a common diuretic, hydrochlorothiazide." | 5.32 | [Acute non-cardiogenic pulmonary edema secondary to hydrochlorothiazide therapy]. ( de Miguel Díez, J; García Satue, JL; Jara Chinarro, B; Juretschke Moragues, MA; Serrano Iglesias, JA, 2003) |
| " The authors report on an 8-week double-blind, randomized study of African American patients with stage 2 hypertension that compared brachial and central BP responses (substudy of 53 patients) to combination aliskiren/hydrochlorthiazide (HCTZ) and amlodipine monotherapy." | 5.15 | Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial. ( Ferdinand, KC; Pool, J; Purkayastha, D; Townsend, R; Weitzman, R, 2011) |
| "Severe dehydration and watery diarrhea were induced by administering diuretics (furosemide, hydrohlorothiazide, spironolactone) and sucrose solution." | 3.70 | Use of peripheral temperature and core-peripheral temperature difference to predict cardiac output in dehydrated calves housed in a thermoneutral environment. ( Constable, PD; Foreman, JH; Morin, DE; Thurmon, JC; Walker, PG, 1998) |
| "5 mL/kg of body weight (BW), PO], sucrose (2 g/kg in a 20% aqueous solution, p." | 3.70 | A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf. ( Constable, PD; Drackley, JK; Foreman, JH; Morin, DE; Thurmon, JC; Walker, PG, 1998) |
| "We report a case of pulmonary edema induced by a common diuretic, hydrochlorothiazide." | 1.32 | [Acute non-cardiogenic pulmonary edema secondary to hydrochlorothiazide therapy]. ( de Miguel Díez, J; García Satue, JL; Jara Chinarro, B; Juretschke Moragues, MA; Serrano Iglesias, JA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferdinand, KC | 1 |
| Pool, J | 1 |
| Weitzman, R | 1 |
| Purkayastha, D | 1 |
| Townsend, R | 1 |
| Jara Chinarro, B | 1 |
| de Miguel Díez, J | 1 |
| García Satue, JL | 1 |
| Juretschke Moragues, MA | 1 |
| Serrano Iglesias, JA | 1 |
| FURUKAWA, W | 1 |
| TAKEUCHI, T | 1 |
| Stepan, VM | 1 |
| Hammer, HF | 1 |
| Krejs, GJ | 1 |
| Constable, PD | 2 |
| Walker, PG | 2 |
| Morin, DE | 2 |
| Foreman, JH | 2 |
| Thurmon, JC | 2 |
| Drackley, JK | 1 |
| Bissada, NK | 1 |
| Redman, JF | 1 |
| Hoss, DM | 1 |
| Nierenberg, DW | 1 |
| Hutchison, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An 8 Week Prospective, Multicenter, Randomized, Double-Blind, Active Control, Parallel Group Study to Evaluate the Efficacy and Safety of Aliskiren HCTZ Versus Amlodipine in African American Patients With Stage 2 Hypertension[NCT00739596] | Phase 4 | 332 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To compare the percentage of patients achieving BP control (<140/90 mm Hg) after 8 weeks of treatment with an aliskiren HCTZ-based treatment regimen (aliskiren HCTZ 150/12.5 mg, 300/25 mg) versus an amlodipine-based treatment regimen (amlodipine 5 mg, 10 mg) in African American patients with stage 2 hypertension. (NCT00739596)
Timeframe: 8 weeks
| Intervention | Cumulative percentage of participants (Number) |
|---|---|
| Aliskiren HCTZ | 63.6 |
| Amlodipine | 62.3 |
To compare the percentage of responders after 8 weeks of treatment with an aliskiren HCTZ based treatment regimen (aliskiren HCTZ 150/12.5 mg, 300/25 mg) versus an amlodipine-based treatment regimen (amlodipine 5 mg, 10 mg) in African American patients with stage 2 hypertension: [ Responders were defined as patients with MSSBP < 140 mm Hg or a decrease from baseline ≥ 20 mm Hg at 1st response. A response was counted when a patient first achieved MSSBP < 140 mm Hg or a decrease from baseline ≥ 20 mm Hg.] (NCT00739596)
Timeframe: 8 weeks
| Intervention | Cumulative percentage of responders (Number) |
|---|---|
| Aliskiren HCTZ | 84.6 |
| Amlodipine | 90.7 |
To assess the change from baseline in mean sitting diastolic blood pressure (MSDBP) after 8 weeks of treatment with an aliskiren HCTZ-based treatment regimen (aliskiren HCTZ 150/12.5 mg, 300/25 mg) versus an amlodipine-based treatment regimen (amlodipine 5 mg, 10 mg) in African American patients with stage 2 hypertension. (NCT00739596)
Timeframe: Baseline and 8 weeks
| Intervention | mm Hg (Mean) | ||
|---|---|---|---|
| Baseline | Week 8 | Change from Baseline to Week 8 | |
| Aliskiren HCTZ | 96.0 | 86.0 | -10.0 |
| Amlodipine | 95.0 | 84.0 | -11.0 |
To compare the change from baseline in mean sitting pulse pressure (MSPP) after 8 weeks of treatment with an aliskiren HCTZ-based treatment regimen (aliskiren HCTZ 150/12.5 mg, 300/25 mg) versus an amlodipine-based treatment regimen (amlodipine 5 mg, 10 mg) in African American patients with stage 2 hypertension. (NCT00739596)
Timeframe: Baseline and 8 weeks
| Intervention | mm Hg (Mean) | ||
|---|---|---|---|
| Baseline | Week 8 | Change from Baseline to Week 8 | |
| Aliskiren HCTZ | 72.2 | 52.7 | -19.4 |
| Amlodipine | 73.1 | 55.1 | -18.0 |
To assess the change from baseline in MSSBP after 8 weeks of treatment with an aliskiren HCTZ-based treatment regimen (aliskiren HCTZ 150/12.5 mg, 300/25 mg) versus an amlodipine-based treatment regimen (amlodipine 5 mg, 10 mg) in African American patients with stage 2 hypertension. (NCT00739596)
Timeframe: Baseline and 8 weeks
| Intervention | mm Hg (Mean) | ||
|---|---|---|---|
| Baseline | Week 8 | Change from baseline to Week 8 | |
| Aliskiren HCTZ | 168.2 | 138.8 | -29.4 |
| Amlodipine | 168.1 | 139.1 | -29.0 |
2 trials available for hydrochlorothiazide and Diarrhea
| Article | Year |
|---|---|
Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial.
Topics: Adult; Amides; Amlodipine; Antihypertensive Agents; Black or African American; Blood Pressure; Brach | 2011 |
The hypotensive action of ethacrynic acid.
Topics: Abdomen; Adult; Aged; Antihypertensive Agents; Black People; Blood Glucose; Blood Pressure Determina | 1968 |
7 other studies available for hydrochlorothiazide and Diarrhea
| Article | Year |
|---|---|
[Acute non-cardiogenic pulmonary edema secondary to hydrochlorothiazide therapy].
Topics: Acute Disease; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diarrhea; Diuretic | 2003 |
[CLINICAL TRIAL OF PARAMETHASONE ACETATE IN PEDIATRICS].
Topics: Adolescent; Adrenal Cortex Hormones; Aminophylline; Asthma; Biomedical Research; Child; Dexamethason | 1964 |
Hyperkalaemia and diarrhoea in a patient with surreptitious ingestion of potassium sparing diuretics.
Topics: Chronic Disease; Diarrhea; Diuretics; Female; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hyper | 1997 |
Use of peripheral temperature and core-peripheral temperature difference to predict cardiac output in dehydrated calves housed in a thermoneutral environment.
Topics: Animals; Animals, Newborn; Blood Pressure; Body Temperature; Cardiac Output; Cattle; Cattle Diseases | 1998 |
A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf.
Topics: Animals; Animals, Newborn; Blood Glucose; Blood Proteins; Body Temperature; Body Weight; Cattle; Col | 1998 |
Medical management of urolithiasis.
Topics: Anti-Bacterial Agents; Calcium; Cystinuria; Diarrhea; Female; Humans; Hydrochlorothiazide; Intestina | 1976 |
Severe shaking chills and fever following hydrochlorothiazide administration.
Topics: Diarrhea; Drug Hypersensitivity; Female; Fever; Headache; Humans; Hydrochlorothiazide; Middle Aged; | 1988 |