hydrochlorothiazide has been researched along with Diabetes Mellitus in 79 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Excerpt | Relevance | Reference |
---|---|---|
"The impact of an ARB, with or without hydrochlorothiazide (HCTZ), on glycaemic factors and the risk for developing diabetes in hypertensive patients with the metabolic syndrome have not been fully assessed." | 9.14 | A 52-week prospective, cohort study of the effects of losartan with or without hydrochlorothiazide (HCTZ) in hypertensive patients with metabolic syndrome. ( Bastien, N; Hamet, P; Longo, N; Racine, N; Sampalis, JS, 2010) |
"To investigate the impact of treatment on cardiovascular mortality and morbidity, we assessed outcomes in patients with hypertension and diabetes who received co-amilozide or nifedipine in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension." | 9.10 | Outcomes with nifedipine GITS or Co-amilozide in hypertensive diabetics and nondiabetics in Intervention as a Goal in Hypertension (INSIGHT). ( Brown, M; Castaigne, A; de Leeuw, P; Mancia, G; Palmer, CR; Rosenthal, T; Ruilope, LM; Wagener, G, 2003) |
"The combination of telmisartan/HCTZ is an effective and well-tolerated treatment option for patients with hypertension." | 8.86 | Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension. ( Kjeldsen, SE; Mancia, G; Schmieder, RE; Unger, T, 2010) |
"Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice." | 7.66 | Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983) |
"In previously monotherapy-treated, uncontrolled patients with hypertension, zofenopril 30-60 mg + HCTZ 12." | 5.19 | Zofenopril plus hydrochlorothiazide and irbesartan plus hydrochlorothiazide in previously treated and uncontrolled diabetic and non-diabetic essential hypertensive patients. ( Agabiti-Rosei, E; Manolis, A; Omboni, S; Zava, D, 2014) |
"We assessed adverse metabolic effects of atenolol and hydrochlorothiazide among hypertensive patients with and without abdominal obesity using data from a randomized, open-label study of hypertensive patients without evidence of cardiovascular disease or diabetes mellitus." | 5.14 | Impact of abdominal obesity on incidence of adverse metabolic effects associated with antihypertensive medications. ( Beitelshees, AL; Boerwinkle, E; Chapman, AB; Cooper-DeHoff, RM; Gong, Y; Gums, JG; Hall, K; Johnson, JA; Parekh, V; Turner, ST; Wen, S; Zineh, I, 2010) |
"The impact of an ARB, with or without hydrochlorothiazide (HCTZ), on glycaemic factors and the risk for developing diabetes in hypertensive patients with the metabolic syndrome have not been fully assessed." | 5.14 | A 52-week prospective, cohort study of the effects of losartan with or without hydrochlorothiazide (HCTZ) in hypertensive patients with metabolic syndrome. ( Bastien, N; Hamet, P; Longo, N; Racine, N; Sampalis, JS, 2010) |
"The Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial is the first cardiovascular outcome trial designed to compare initial use of 2 different fixed-dose antihypertensive regimens, benazepril plus hydrochlorothiazide vs benazepril plus amlodipine, on cardiovascular end points in hypertensive patients at high cardiovascular risk secondary to previous major events or presence of diabetes mellitus (DM)." | 5.13 | The diabetes subgroup baseline characteristics of the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial. ( Bakris, G; Dahlof, B; Hester, A; Jamerson, K; Pitt, B; Shi, V; Staikos-Byrne, L; Velasquez, E; Weber, M, 2008) |
" STAR-LET was a 6-month extension of the Study of Trandolapril/Verapamil SR and Insulin Resistance (STAR), which assessed the effects of a fixed-dose renin-angiotensin system inhibitor (RASI)/hydrochlorothiazide (HCTZ) combination on changes in 2-hour oral glucose tolerance test (OGTT) results." | 5.13 | Reversal of diuretic-associated impaired glucose tolerance and new-onset diabetes: results of the STAR-LET study. ( Bacher, P; Bakris, G; Champion, A; Molitch, M; Sarafidis, P; Sowers, JR; Zhou, Q, 2008) |
"To investigate the impact of treatment on cardiovascular mortality and morbidity, we assessed outcomes in patients with hypertension and diabetes who received co-amilozide or nifedipine in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension." | 5.10 | Outcomes with nifedipine GITS or Co-amilozide in hypertensive diabetics and nondiabetics in Intervention as a Goal in Hypertension (INSIGHT). ( Brown, M; Castaigne, A; de Leeuw, P; Mancia, G; Palmer, CR; Rosenthal, T; Ruilope, LM; Wagener, G, 2003) |
"The combination of telmisartan/HCTZ is an effective and well-tolerated treatment option for patients with hypertension." | 4.86 | Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension. ( Kjeldsen, SE; Mancia, G; Schmieder, RE; Unger, T, 2010) |
" We investigated the effect of switching from an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) to a combination of losartan and hydrochlorothiazide on left ventricular (LV) relaxation in patients with hypertension and diastolic dysfunction." | 3.78 | Adding thiazide to a rennin-angiotensin blocker regimen to improve left ventricular relaxation in diabetes and nondiabetes patients with hypertension. ( Fukuda, S; Ishii, K; Ito, H; Iwakura, K; Shimada, K; Takami, T; Watanabe, H; Yoshikawa, J, 2012) |
"Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice." | 3.66 | Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983) |
"In patients with recurrent idiopathic nephrolithiasis we studied whether treatment with sodium cellulose phosphate leading to decreased intestinal calcium absorption could induce secondary hyperparathyroidism and whether thiazides which diminish calciuria would impair glucose tolerance." | 3.66 | [On the question of endocrine side effects in patients on medication for renal calcium stone disease (author's transl)]. ( Döring, B; Minne, H; Russmann, D; Uhl, K; Ziegler, R, 1980) |
"The biguanides were a therapeutic enrichment particularly in the treatment of adipose elderly diabetics with obligatory diet." | 1.26 | [Indications and results of an additional differentiated pharmacotherapy of obesity]. ( Kucher, E, 1978) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 56 (70.89) | 18.7374 |
1990's | 2 (2.53) | 18.2507 |
2000's | 6 (7.59) | 29.6817 |
2010's | 15 (18.99) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Roshandel, G | 1 |
Khoshnia, M | 1 |
Poustchi, H | 1 |
Hemming, K | 1 |
Kamangar, F | 1 |
Gharavi, A | 1 |
Ostovaneh, MR | 1 |
Nateghi, A | 1 |
Majed, M | 1 |
Navabakhsh, B | 1 |
Merat, S | 1 |
Pourshams, A | 1 |
Nalini, M | 1 |
Malekzadeh, F | 1 |
Sadeghi, M | 1 |
Mohammadifard, N | 1 |
Sarrafzadegan, N | 1 |
Naemi-Tabiei, M | 1 |
Fazel, A | 1 |
Brennan, P | 1 |
Etemadi, A | 1 |
Boffetta, P | 1 |
Thomas, N | 1 |
Marshall, T | 1 |
Cheng, KK | 1 |
Malekzadeh, R | 1 |
Agabiti-Rosei, E | 2 |
Manolis, A | 2 |
Zava, D | 1 |
Omboni, S | 2 |
Karnes, JH | 2 |
Gong, Y | 3 |
Arwood, MJ | 1 |
Gums, JG | 3 |
Hall, KL | 1 |
Limacher, MC | 1 |
Johnson, JA | 3 |
Cooper-DeHoff, RM | 3 |
Chowdhury, EK | 1 |
Ademi, Z | 1 |
Moss, JR | 1 |
Wing, LMH | 1 |
Reid, CM | 1 |
Malacco, E | 2 |
Napoli, C | 1 |
Modesti, PA | 1 |
Parati, G | 1 |
Borghi, C | 1 |
Bakris, G | 2 |
Hester, A | 1 |
Weber, M | 1 |
Dahlof, B | 1 |
Pitt, B | 1 |
Velasquez, E | 1 |
Staikos-Byrne, L | 1 |
Shi, V | 1 |
Jamerson, K | 1 |
Manrique, C | 1 |
Johnson, M | 1 |
Sowers, JR | 2 |
Wen, S | 1 |
Beitelshees, AL | 2 |
Zineh, I | 1 |
Turner, ST | 2 |
Hall, K | 1 |
Parekh, V | 1 |
Chapman, AB | 2 |
Boerwinkle, E | 1 |
Kjeldsen, SE | 1 |
Schmieder, RE | 1 |
Unger, T | 1 |
Mancia, G | 2 |
Racine, N | 1 |
Hamet, P | 1 |
Sampalis, JS | 1 |
Longo, N | 1 |
Bastien, N | 1 |
Rosendorff, C | 1 |
McDonough, CW | 1 |
Vo, TT | 1 |
Langaee, TY | 1 |
Bailey, KR | 1 |
Del-Aguila, JL | 1 |
Boerwinkle, EA | 1 |
Pepine, CJ | 2 |
Takami, T | 1 |
Ito, H | 1 |
Ishii, K | 1 |
Shimada, K | 1 |
Iwakura, K | 1 |
Watanabe, H | 1 |
Fukuda, S | 1 |
Yoshikawa, J | 1 |
Suzuki, H | 1 |
Shimada, Y | 1 |
Fujiwara, K | 1 |
Al Balushi, KA | 1 |
Habib, JQ | 1 |
Al-Zakwani, I | 1 |
Brown, M | 1 |
Castaigne, A | 1 |
de Leeuw, P | 1 |
Palmer, CR | 1 |
Rosenthal, T | 1 |
Wagener, G | 1 |
Ruilope, LM | 1 |
KENNEDY, GC | 1 |
CRAWFORD, JD | 1 |
NICOLE, JC | 1 |
PULVER, W | 1 |
BOMPIANI, GD | 1 |
PANVINO, C | 1 |
SCHOTLAND, MG | 1 |
GRUMBACH, MM | 1 |
WEISSEL, W | 1 |
DOLLERY, CT | 3 |
PENTECOST, BL | 1 |
SAMAAN, NA | 1 |
MASSZI, F | 1 |
VARGA, P | 1 |
RICCI, PD | 1 |
LOMBARDI, M | 1 |
MASINI, G | 1 |
VALIENSI, M | 1 |
SAMAAN, N | 1 |
FRASER, R | 1 |
SCHWARTZ, W | 1 |
CALI, G | 1 |
PIETROPAOLO, C | 1 |
GELFAND, ML | 1 |
GARREN, MG | 1 |
ROWAN, RL | 1 |
VEHARANTA, T | 1 |
WOLFF, FW | 1 |
LANGDON, RG | 1 |
ANICHINI, M | 1 |
GARGANO, N | 1 |
BARTORELLI, C | 1 |
CHAZAN, JA | 1 |
BOSHELL, BR | 1 |
MAEKILAE, E | 1 |
VAAJA, U | 1 |
Ong, HT | 1 |
Staessen, JA | 1 |
Thijisq, L | 1 |
Fagard, R | 1 |
Celis, H | 1 |
Birkenhäger, WH | 1 |
Bulpitt, CJ | 1 |
de Leeuw, PW | 1 |
Fletcher, AE | 1 |
Forette, F | 1 |
Leonetti, G | 1 |
McCormack, P | 1 |
Nachev, C | 1 |
O'Brien, E | 1 |
Rodicio, JL | 1 |
Rosenfeld, J | 1 |
Sarti, C | 1 |
Tuomilehto, J | 1 |
Webster, J | 1 |
Yodfat, Y | 1 |
Zanchetti, A | 1 |
Cooper-Dehoff, R | 1 |
Cohen, JD | 1 |
Bakris, GL | 1 |
Messerli, FH | 1 |
Erdine, S | 1 |
Hewkin, AC | 1 |
Kupfer, S | 1 |
Molitch, M | 1 |
Zhou, Q | 1 |
Sarafidis, P | 1 |
Champion, A | 1 |
Bacher, P | 1 |
Jones, IG | 1 |
Pickens, PT | 1 |
Bloomgarden, ZT | 1 |
Ginsberg-Fellner, F | 1 |
Rayfield, EJ | 1 |
Bookman, J | 1 |
Brown, WV | 1 |
Mor, R | 1 |
Pitlik, S | 1 |
Rosenfeld, JB | 1 |
Rames, I | 1 |
Kristůfek, V | 1 |
Garrett, BN | 1 |
Raskin, P | 1 |
Kaplan, NM | 1 |
Marks, P | 1 |
Nimalasuriya, A | 1 |
Anderson, J | 1 |
Ziegler, R | 1 |
Uhl, K | 1 |
Minne, H | 1 |
Russmann, D | 1 |
Döring, B | 1 |
Himmel, W | 1 |
Lönker, B | 1 |
Kochen, MM | 1 |
Minker, E | 1 |
Koltai, M | 1 |
Blazsó, G | 1 |
McMahon, FG | 1 |
Ryan, JR | 1 |
Jain, AK | 1 |
Kucher, E | 1 |
Pakrashi, A | 1 |
Mukherjee, SK | 1 |
Káldor, A | 1 |
Gachályi, B | 1 |
Sebestyén, K | 1 |
Kmoch, J | 2 |
Svoboda, Z | 2 |
Lundgren, H | 1 |
Bengtsson, C | 1 |
Lapidus, L | 1 |
Bengtsson, L | 1 |
Ferguson, RP | 1 |
Kohner, EM | 1 |
Lowy, C | 1 |
Schumer, B | 1 |
Ravina, A | 1 |
Kain, T | 1 |
Hicks, BH | 1 |
Ward, JD | 1 |
Jarrett, RJ | 1 |
Keen, H | 1 |
Wise, P | 1 |
Nath, K | 2 |
Sikka, KK | 2 |
Saxena, S | 1 |
Tandon, AP | 2 |
Kusus, T | 1 |
Lydtin, H | 1 |
Zöllner, N | 1 |
Ikeda, T | 1 |
Agarwal, SN | 1 |
Guidoux, R | 1 |
Heimsoth, V | 1 |
Drásilová, L | 2 |
Kocí, V | 2 |
Senft, G | 2 |
Schwarzbach, W | 1 |
Bossini, A | 1 |
Bologna, E | 1 |
Standl, E | 2 |
Haslbeck, H | 1 |
Geser, CA | 2 |
Mehnert, H | 2 |
Haslbeck, M | 1 |
Förster, H | 1 |
Gross, W | 1 |
Spech, HJ | 1 |
Wiecko, W | 1 |
el-Ebrashy, N | 1 |
el-Danasoury, M | 1 |
Higazi, AM | 1 |
Pistolese, M | 1 |
Rosica, V | 1 |
Gallo Curcio, C | 1 |
Fabian, D | 1 |
Scotti, G | 1 |
Gatti, A | 1 |
Shul'tsev, GP | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Polypill Strategy for Evidence-Based Management of Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention in an Underserved Patient Population[NCT05514938] | Phase 2 | 60 participants (Anticipated) | Interventional | 2022-11-30 | Recruiting | ||
Effectiveness of Polypill for Primary Prevention of Cardiovascular Disease (PolyPars): Study Design and Rationale for a Pragmatic Cluster Randomized Controlled Trial[NCT03459560] | Phase 3 | 4,415 participants (Actual) | Interventional | 2015-12-20 | Active, not recruiting | ||
Fixed-dose Combination Therapy (PolyPill) in Primary and Secondary Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranians[NCT01271985] | Phase 3 | 8,410 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
Polipill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt in Primary Health Care[NCT05155137] | Phase 3 | 12,268 participants (Anticipated) | Interventional | 2021-12-20 | Recruiting | ||
Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)[NCT00246519] | Phase 4 | 1,701 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
52 Week Study to Evaluate the Effects of LOSARTAN 50 mg, 100 mg, 100/12.5 mg HCTZ, 100/25 mg HCTZ on Metabolic Parameters, Blood Pressure and Safety in Hypertensive Patients With Metabolic Syndrome[NCT00546052] | Phase 3 | 1,738 participants (Actual) | Interventional | 2005-09-01 | Completed | ||
Stroke Prediction Study Using a Model Based on Internet Search Queries[NCT04755959] | 450 participants (Anticipated) | Observational | 2021-02-28 | Not yet recruiting | |||
INternational VErapamil SR Trandolapril STudy[NCT00133692] | Phase 4 | 22,000 participants | Interventional | 1997-09-30 | Completed | ||
A Randomised, Double-blind, Placebo Controlled, Parallel Group, Multi-centre Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of Verapamil SR on Preservation of Beta-cell Function (Ver-A-T1D)[NCT04545151] | Phase 2 | 138 participants (Anticipated) | Interventional | 2021-02-08 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
(NCT00246519)
Timeframe: baseline to 18 weeks of treatment
Intervention | mmHg (Mean) |
---|---|
Atenolol +HCTZ Arm | -12.06 |
HCTZ + Atenolol | -13.33 |
Absolute Change in C Reactive Protein Between Baseline and 52 week assessments: C Reactive Protein 52 weeks - C Reactive Protein Baseline. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | mg/L (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -0.36 |
Absolute Change in Uric Acid Between Baseline and 52 week assessments: Uric Acid 52 weeks - Uric Acid Baseline. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | mmol/L (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -19.17 |
Absolute change in Body Mass Index Baseline and 52 week assessments (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | Kg/m2 (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -7.3 |
Absolute change in Diastolic Blood Pressure between baseline and 52 week assessments. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | mm Hg (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -9.84 |
Absolute Change in Fasting Blood Glucose Measurements between Baseline and 52 week assessments. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | mmol/L (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | 0.02 |
Absolute Change in Hemoglobin A1c between 52 week measurement and baseline value. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | Percent (Median) |
---|---|
Losartan +/- Hydrochlorothiazide | 0.04 |
Absolute change in Systolic Blood Pressure between baseline and 52 week assessments. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | mm Hg (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -16.95 |
Absolute change in Waist Circumference between baseline and 52 week assessments (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | cm (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -1.28 |
Percent Change in HDL-C Between Baseline and 52 week assessments: 100% x [(HDL-C 52 Weeks - HDL-C 52 Baseline) / (HDL-C Baseline)]. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | Percent Change (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | 0.21 |
Percent Change in LDL-C Between Baseline and 52 week assessments: 100% x [(LDL-C 52 Weeks - LDL-C Baseline) / (LDL-C Baseline)]. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | Percent Change (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -1.49 |
Percent Change in Total Cholesterol Between Baseline and 52 week assessments: 100% x [(Total Cholesterol 52 weeks - Total Cholesterol Baseline) / (Total Cholesterol Baseline)]. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | Percent Change (Mean) |
---|---|
Losartan +/- Hydrochlorothiazide | -2.98 |
Percent Change in Triglycerides Between Baseline and 52 week assessments: 100% x [(Triglycerides 52 Weeks - Triglycerides Baseline) / (Triglycerides Baseline)]. (NCT00546052)
Timeframe: 52 Weeks - Baseline
Intervention | Percent Change (Median) |
---|---|
Losartan +/- Hydrochlorothiazide | 1.09 |
Target Blood Pressure defined as Systolic Blood Pressure/Diastolic Blood Pressure ≤ 140/90 mm Hg at 52 weeks (NCT00546052)
Timeframe: 52 Weeks
Intervention | Participants (Number) | |
---|---|---|
Achieved Target Blood Pressure | Did NOT achieve target Blood Pressure | |
Overall Intend to Treat | 1200 | 514 |
Overall Per Protocol | 1200 | 311 |
Overall Total | 1200 | 538 |
3 reviews available for hydrochlorothiazide and Diabetes Mellitus
Article | Year |
---|---|
Efficacy of Zofenopril vs. Irbesartan in Combination with a Thiazide Diuretic in Hypertensive Patients with Multiple Risk Factors not Controlled by a Previous Monotherapy: A Review of the Double-Blind, Randomized "Z" Studies.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive A | 2017 |
Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; B | 2010 |
[Hypertension--diuretics as antihypertensive agents].
Topics: Aged; Antihypertensive Agents; Arthritis; Benzothiadiazines; Blood Pressure; Chlorothiazide; Chlorth | 1970 |
16 trials available for hydrochlorothiazide and Diabetes Mellitus
Article | Year |
---|---|
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.
Topics: Adult; Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Blood Pressur | 2019 |
Zofenopril plus hydrochlorothiazide and irbesartan plus hydrochlorothiazide in previously treated and uncontrolled diabetic and non-diabetic essential hypertensive patients.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Biphenyl Compounds; Captopril; Case-Control Studie | 2014 |
Cost-utility of angiotensin-converting enzyme inhibitor-based treatment compared with thiazide diuretic-based treatment for hypertension in elderly Australians considering diabetes as comorbidity.
Topics: Age Factors; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Australia; Cardiovas | 2015 |
The diabetes subgroup baseline characteristics of the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial.
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Blood Glucose; Blood Press | 2008 |
Impact of abdominal obesity on incidence of adverse metabolic effects associated with antihypertensive medications.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Diabetes Mellitus; Drug Therapy, Combina | 2010 |
A 52-week prospective, cohort study of the effects of losartan with or without hydrochlorothiazide (HCTZ) in hypertensive patients with metabolic syndrome.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Blood Glu | 2010 |
Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.
Topics: Aged; Antihypertensive Agents; Atenolol; Diabetes Mellitus; Fasting; Female; Glucose; Haplotypes; Hu | 2013 |
Outcomes with nifedipine GITS or Co-amilozide in hypertensive diabetics and nondiabetics in Intervention as a Goal in Hypertension (INSIGHT).
Topics: Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiovascular D | 2003 |
Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus; Dihydrop | 2004 |
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann | 2006 |
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann | 2006 |
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann | 2006 |
Predictors of development of diabetes mellitus in patients with coronary artery disease taking antihypertensive medications (findings from the INternational VErapamil SR-Trandolapril STudy [INVEST]).
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Body Mass Index; Calcium Chann | 2006 |
Reversal of diuretic-associated impaired glucose tolerance and new-onset diabetes: results of the STAR-LET study.
Topics: Analysis of Variance; Chi-Square Distribution; Diabetes Mellitus; Diuretics; Female; Glucose Toleran | 2008 |
The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Double-Blind Method; Drug A | 1979 |
Antihypertensive drugs and glucose metabolism: comparison between a diuretic, a beta-blocker and felodipine, a new calcium antagonist in subjects with arterial hypertension and diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus; Double-Blind Method; Felodipine; Female; Glucose Tolerance T | 1990 |
Effect of diuretic therapy on glucose tolerance in hypertensive patients.
Topics: Age Factors; Blood Glucose; Body Weight; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Fasting; Fat | 1971 |
A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics.
Topics: Adult; Aged; Amides; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Clopamide | 1973 |
[Saluretic treatment of hypertension and uric acid level in serum. Clinical test of a combination of hydrochlorothiazide and probenecid].
Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Blood Protein Electrophoresis; Bod | 1969 |
60 other studies available for hydrochlorothiazide and Diabetes Mellitus
Article | Year |
---|---|
Alteration in fasting glucose after prolonged treatment with a thiazide diuretic.
Topics: Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus; Diuretics; Fasting; Female; Follow-Up Stu | 2014 |
Thiazide diuretics alone or with beta-blockers impair glucose metabolism in hypertensive patients with abdominal obesity.
Topics: Adrenergic beta-Antagonists; Atenolol; Diabetes Mellitus; Diuretics; Drug Therapy, Combination; Fast | 2010 |
Nebivolol/hydrochlorothiazide (HCTZ) combination in patients with essential hypertension: a pooled analysis from five non-interventional studies with a focus on diabetic and elderly patients.
Topics: Age Factors; Aged; Aged, 80 and over; Antihypertensive Agents; Benzopyrans; Blood Pressure; Diabetes | 2010 |
Why are we still using hydrochlorothiazide?
Topics: Antihypertensive Agents; Diabetes Mellitus; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hy | 2011 |
Adding thiazide to a rennin-angiotensin blocker regimen to improve left ventricular relaxation in diabetes and nondiabetes patients with hypertension.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; C-Reactive | 2012 |
Combination therapy with losartan/hydrochlorothiazide for blood pressure reduction and goal attainment in a real-world clinical setting in Japan.
Topics: Age Factors; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; | 2012 |
Comparative efficacy of irbesartan/ hydrochlorothiazide and valsartan/hydrochlorothiazide combination in lowering blood pressure: a retrospective observational study in Oman.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diabete | 2013 |
Treatment of diabetes insipidus with hydrochlorothiazide.
Topics: Acetazolamide; Diabetes Insipidus; Diabetes Mellitus; Diabetes Mellitus, Experimental; Hydrochloroth | 1959 |
[Hyperglycemic effect by means of salidiuretics in diabetes mellitus].
Topics: Chlorthalidone; Diabetes Mellitus; Humans; Hydrochlorothiazide; Hyperglycemia | 1962 |
[The influence of sulfonamide diuretics on blood sugar regulation].
Topics: Blood Glucose; Chlorothiazide; Chlorthalidone; Diabetes Mellitus; Diuretics; Hydrochlorothiazide; Su | 1962 |
Neutropenia in an infant secondary to hydrochlorothiazide therapy: with a review of hematologic reactions to "thiazide" drugs.
Topics: Agranulocytosis; Diabetes Mellitus; Drug Hypersensitivity; Humans; Hydrochlorothiazide; Neutropenia; | 1963 |
[Clinical contribution to the diabetogenic effect of saluretics].
Topics: Chlorothiazide; Chlorthalidone; Diabetes Mellitus; Diuretics; Humans; Hydrochlorothiazide | 1962 |
Drug-induced diabetes.
Topics: Benzothiadiazines; Diabetes Mellitus; Humans; Hydrochlorothiazide; Hypertension | 1962 |
[ON THIAZIDE DERIVATIVES AND CARBOHYDRATE METABOLISM].
Topics: Antihypertensive Agents; Carbohydrate Metabolism; Chlorothiazide; Diabetes Mellitus; Glucose Toleran | 1963 |
[MODERN DIURETICS AND DIABETES MELLITUS].
Topics: Diabetes Mellitus; Diuresis; Diuretics; Glucose Tolerance Test; Glycosuria; Humans; Hydrochlorothiaz | 1963 |
DIABETOGENIC ACTION OF BENZOTHIADIAZINES: SERUM-INSULIN-LIKE ACTIVITY IN DIABETES WORSENED OR PRECIPITATED BY THIAZIDE DIURETICS.
Topics: Benzothiadiazines; Blood Chemical Analysis; Chlorothiazide; Diabetes Mellitus; Glucose Tolerance Tes | 1963 |
MEBUTAMATE AND HYDROCHLOROTHIAZIDE IN HYPERTENSION.
Topics: Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure Determination; Carbamates; | 1964 |
[GRAVE DISORDER OF CARBOHYDRATE METABOLISM IN A PATIENT WITH HEPATIC CIRRHOSIS FOLLOWING TREATMENT WITH HYDROCHLOROTHIAZIDE].
Topics: Acidosis; Blood Chemical Analysis; Carbohydrate Metabolism; Diabetes Mellitus; Hydrochlorothiazide; | 1963 |
ACUTE ANURIA ASSOCIATED WITH CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE THERAPY: RECOVERY.
Topics: Acute Kidney Injury; Anuria; Chlorothiazide; Diabetes Mellitus; Digoxin; Geriatrics; Gout; Hydrochlo | 1964 |
[THIAZIDE DIURETICS AS DIABETOGENIC AGENTS].
Topics: Chlorothiazide; Diabetes Mellitus; Diuretics; Hydrochlorothiazide; Pharmacology; Sodium Chloride Sym | 1964 |
CONJOINT CLINIC ON DRUGS AND DIABETES.
Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose | 1964 |
[SECONDARY ASPECIFIC EFFECTS OF BENZOTHIAZINIC DIURETICS].
Topics: Agranulocytosis; Amylases; Blood Glucose; Chlorothiazide; Diabetes Mellitus; Diuretics; Drug Eruptio | 1964 |
ETIOLOGICAL FACTORS IN THIAZIDE-INDUCED OR AGGRAVATED DIABETES MELLITUS.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Amylases; Blood Chemical Analysis; Blood Urea Nitrogen; | 1965 |
HYDROCHLOROTHIAZIDE AND SALIVA. AN EXPERIMENTAL INVESTIGATION OF THE EFFECT OF HYDROCHLOROTHIAZIDE ON THE SALIVARY SECRETION IN MAN.
Topics: Diabetes Mellitus; Humans; Hydrochlorothiazide; Male; Saliva | 1964 |
LIFE: losartan versus atenolol.
Topics: Antihypertensive Agents; Atenolol; Comorbidity; Death, Sudden, Cardiac; Diabetes Mellitus; Drug Ther | 2003 |
Diabetes mellitus following oral diuretics.
Topics: Diabetes Mellitus; Female; Furosemide; Humans; Hydrochlorothiazide; Middle Aged | 1967 |
Elevated hemoglobin A1c and low-density lipoprotein cholesterol levels in thiazide-treated diabetic patients.
Topics: Cholesterol; Diabetes Mellitus; Female; Furosemide; Hemoglobin A; Humans; Hydrochlorothiazide; Lipop | 1984 |
Indomethacin- and Moduretic--induced hyperkalemia.
Topics: Aged; Amiloride; Diabetes Complications; Diabetes Mellitus; Drug Combinations; Drug Interactions; Fe | 1983 |
[Comparison of the effects of 2 different diuretics in the treatment of hypertension in diabetics].
Topics: Acetazolamide; Aged; Blood Glucose; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Femal | 1983 |
Metoprolol in diabetes mellitus: effect on glucose homeostasis.
Topics: Aged; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Female; Glucagon; Homeostasis; Human | 1980 |
The glucose tolerance test in hypertensive patients treated long term with thiazide diuretics.
Topics: Diabetes Mellitus; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypertension; Risk | 1981 |
[On the question of endocrine side effects in patients on medication for renal calcium stone disease (author's transl)].
Topics: Calcium; Cellulose; Diabetes Mellitus; Female; Glucose Tolerance Test; Humans; Hydrochlorothiazide; | 1980 |
[Relevance of general practitioner's prescriptions for hospital pharmacotherapy. A survey of hospital physicians].
Topics: Aged; Attitude of Health Personnel; Captopril; Data Interpretation, Statistical; Diabetes Mellitus; | 1996 |
Diabetes-induced alterations of autonomic nerve function in the cat.
Topics: Animals; Cat Diseases; Cats; Cholinesterases; Cortisone; Diabetes Mellitus; Diabetes Mellitus, Exper | 1978 |
[Indications and results of an additional differentiated pharmacotherapy of obesity].
Topics: Adolescent; Adult; Aged; Biguanides; Diabetes Mellitus; Diet, Reducing; Female; Furosemide; Humans; | 1978 |
A new method for the production of experimental diabetes in rabbits.
Topics: Administration, Oral; Animals; Chlorpropamide; Diabetes Mellitus; Disease Models, Animal; Drug Syner | 1975 |
[The connection between Moduretic and diabetes mellitus. A case report].
Topics: Aged; Amiloride; Diabetes Mellitus; Female; Humans; Hydrochlorothiazide; Pyrazines | 1975 |
Diabetogenic effect of oral diuretics in asymptomatic diabetes.
Topics: Adult; Aged; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Furosemide; Glucose Tolerance Test; Huma | 1975 |
[Effect of long-term administration of hydrochlorothiazide on glycide tolerance in diabetic patients].
Topics: Aged; Carbohydrate Metabolism; Diabetes Mellitus; Energy Metabolism; Female; Humans; Hydrochlorothia | 1975 |
A comparison of steroid and thiazide diabetes.
Topics: Aged; Diabetes Mellitus; Female; Humans; Hydrochlorothiazide; Male; Middle Aged; Prednisone | 1986 |
[Chlorpropamide, thiazides and congestive heart failure].
Topics: Aged; Chlorpropamide; Diabetes Mellitus; Diuresis; Diuretics; Glyburide; Heart Failure; Humans; Hydr | 1974 |
Effect of thiazides on blood sugar level in oedematous and non oedematous states.
Topics: Adult; Bendroflumethiazide; Benzothiadiazines; Blood Glucose; Diabetes Mellitus; Diuretics; Edema; F | 1972 |
Effect of hydrochlorothiazides on blood sugar level in diabetics and nondiabetics.
Topics: Diabetes Mellitus; Humans; Hydrochlorothiazide; Hyperglycemia | 1969 |
[Diabetogenic effects of thiazide diuretics and the solvent N-monomethyl-acetamide in rats].
Topics: Acetates; Amides; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucos | 1969 |
[Impairment of carbohydrate tolerance by saluretics in diabetics treated with insulin].
Topics: Blood Glucose; Diabetes Mellitus; Female; Humans; Hydrochlorothiazide; Insulin; Male; Middle Aged | 1969 |
[Experience with the administration of hydrochlorothiazide in diabetics].
Topics: Aged; Diabetes Mellitus; Diet Therapy; Female; Humans; Hydrochlorothiazide; Male; Middle Aged | 1970 |
[Disorders of carbohydrate metabolism following diuretically effective agents].
Topics: Arteriosclerosis; Carbohydrate Metabolism; Chlorothiazide; Diabetes Mellitus; Diazoxide; Furosemide; | 1967 |
["Therapy with saluretics and insulin resistance in diabetes mellitus"].
Topics: Diabetes Mellitus; Diabetic Coma; Diuretics; Humans; Hydrochlorothiazide; Insulin; Insulin Resistanc | 1967 |
[Research on hyperglycemia caused by saluretics].
Topics: Diabetes Mellitus; Diuresis; Diuretics; Electrolytes; Female; Furosemide; Heart Diseases; Humans; Hy | 1967 |
[Studies on the question of an interrelationship between saluretic acting thiazide derivatives and thiamine in diabetes].
Topics: Blood Glucose; Diabetes Mellitus; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Natriuresis; | 1968 |
[Studies on the influrence of saluretic thiazide derivatives and thiamine on carbohydrate metabolism].
Topics: Carbohydrate Metabolism; Diabetes Mellitus; Diuretics; Furosemide; Glucose Tolerance Test; Humans; H | 1968 |
[Carbohydrate metabolism disorders due to saluretic drugs. A contribution to the genesis of so-called "thiazide diabetes"].
Topics: Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Diuretics; Erythrocytes; Ethacrynic Acid; | 1968 |
[Diabetic acidosis during hydrochlorothiazide treatment].
Topics: Acidosis; Aged; Diabetes Mellitus; Female; Humans; Hydrochlorothiazide | 1968 |
[Contribution to the problem of the diabetogenic effect of thiazide diuretics].
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Female; Humans; Hydrochlorothiazide; Middle Aged; Obe | 1969 |
Diuretics. I--Benzothiadiazines and related drugs.
Topics: Benzothiadiazines; Calcium; Chlorothiazide; Diabetes Mellitus; Diuretics; Edema; Gout; Humans; Hydro | 1969 |
Hyperuricaemic and hyperglycaemic effects of thiazides in non-prediabetics.
Topics: Blood; Diabetes Mellitus; Heart Failure; Humans; Hydrochlorothiazide; Polythiazide; Prediabetic Stat | 1965 |
[Thiazide diuretics and changes in carbohydrate metabolism. Clinical study of 30 cases].
Topics: Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Glucose Tolerance Test; Humans; Hydrochlo | 1966 |
[Contribution to the effect of thiazide compounds on the development of diabetes mellitus].
Topics: Adult; Aged; Chlorothiazide; Czechoslovakia; Diabetes Mellitus; Female; Health Surveys; Humans; Hydr | 1966 |
[Effects of triamterene and the association of triamterene and hydrochlorothiazide on carbohydrate metabolism in senile subjects].
Topics: Aged; Carbohydrate Metabolism; Diabetes Mellitus; Humans; Hydrochlorothiazide; Triamterene | 1966 |
[On the diabetogenic action of hypothiazide].
Topics: Adult; Diabetes Mellitus; Female; Humans; Hydrochlorothiazide | 1966 |