hydrochlorothiazide has been researched along with Dementia in 8 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As arterial hypertension is the most important risk factor for ischemic stroke, the relevant guidelines recommend rigorous treatment to normalize blood pressure." | 6.73 | [Effects of long-term antihypertensive therapy with losartan on blood pressure and cognitive function in patients with essential hypertension and other cerebrovascular risk factors (AWARE observational study)]. ( Bestehorn, K; Diener, HC; Haller, H; Jung, C; Lüders, S; Schmieder, RE; Schrader, J; Smolka, W; Wahle, K, 2008) |
| "To assess whether candesartan-based antihypertensive treatment in elderly patients with mildly to moderately elevated blood pressure confers a reduction in cardiovascular events, cognitive decline and dementia." | 5.10 | The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. ( Elmfeldt, D; Hansson, L; Hofman, A; Lithell, H; Olofsson, B; Skoog, I; Trenkwalder, P; Zanchetti, A, 2003) |
| "As arterial hypertension is the most important risk factor for ischemic stroke, the relevant guidelines recommend rigorous treatment to normalize blood pressure." | 2.73 | [Effects of long-term antihypertensive therapy with losartan on blood pressure and cognitive function in patients with essential hypertension and other cerebrovascular risk factors (AWARE observational study)]. ( Bestehorn, K; Diener, HC; Haller, H; Jung, C; Lüders, S; Schmieder, RE; Schrader, J; Smolka, W; Wahle, K, 2008) |
| "Hypertension is a risk factor for dementia, particularly vascular dementia." | 2.69 | [Antihypertensive treatment and prevention of dementia]. ( Seux, ML, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schrader, J | 1 |
| Lüders, S | 1 |
| Diener, HC | 1 |
| Haller, H | 1 |
| Schmieder, RE | 1 |
| Wahle, K | 1 |
| Smolka, W | 1 |
| Jung, C | 1 |
| Bestehorn, K | 1 |
| Forette, F | 1 |
| Seux, ML | 2 |
| Staessen, JA | 1 |
| Thijs, L | 1 |
| Babarskiene, MR | 1 |
| Babeanu, S | 1 |
| Bossini, A | 1 |
| Fagard, R | 1 |
| Gil-Extremera, B | 1 |
| Laks, T | 1 |
| Kobalava, Z | 1 |
| Sarti, C | 1 |
| Tuomilehto, J | 1 |
| Vanhanen, H | 1 |
| Webster, J | 1 |
| Yodfat, Y | 1 |
| Birkenhäger, WH | 1 |
| Lithell, H | 1 |
| Hansson, L | 1 |
| Skoog, I | 1 |
| Elmfeldt, D | 1 |
| Hofman, A | 1 |
| Olofsson, B | 1 |
| Trenkwalder, P | 2 |
| Zanchetti, A | 1 |
| Williams, B | 1 |
| Prince, M | 1 |
| Lewis, G | 1 |
| Bird, A | 1 |
| Blizard, R | 1 |
| Mann, A | 1 |
| Lehrl, S | 1 |
| Grässel, E | 1 |
| Eicke, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A European Multicentre Double-blind Placebo-controlled Phase III Trial of Nilvadipine in Mild to Moderate Alzheimer's Disease[NCT02017340] | Phase 3 | 511 participants (Actual) | Interventional | 2013-04-24 | Completed | ||
| Prevention of Hypertension Incidence and Diabetes Italian Assessment Study. Therapeutic Strategies of Prevention of Diabetes and Hypertension in Subjects With Metabolic Syndrome and High-Normal Blood Pressure.[NCT00456963] | Phase 4 | 3,000 participants (Anticipated) | Interventional | 2007-09-30 | Terminated (stopped due to Because of delay in approval of the protocol by a number of Ethics Commitees the trial was terminated on March 4, 2010. No patient had received any study drug.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydrochlorothiazide and Dementia
| Article | Year |
|---|---|
Protection against stroke and dementia: an update on the latest clinical trial evidence.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl | 2004 |
7 trials available for hydrochlorothiazide and Dementia
| Article | Year |
|---|---|
[Effects of long-term antihypertensive therapy with losartan on blood pressure and cognitive function in patients with essential hypertension and other cerebrovascular risk factors (AWARE observational study)].
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; C-Reactive P | 2008 |
The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study.
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Dementia; Double-Blind Method; Drug Therapy | 2002 |
[Antihypertensive treatment and prevention of dementia].
Topics: Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Dementia; Diur | 1999 |
The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Bl | 2003 |
A longitudinal study of factors predicting change in cognitive test scores over time, in an older hypertensive population.
Topics: Aged; Amiloride; Antihypertensive Agents; Atenolol; Cognition Disorders; Dementia; Drug Combinations | 1996 |
[Effectiveness of felodipine in hypertensive patients with mild cerebral cognition disorders in a randomized double-blind study].
Topics: Aged; Amiloride; Blood Viscosity; Brain; Cognition Disorders; Dementia; Double-Blind Method; Drug Th | 2000 |
[Cognition disorders and dementia--new end-organ damage in hypertension].
Topics: Aged; Amiloride; Cognition Disorders; Dementia; Double-Blind Method; Felodipine; Humans; Hydrochloro | 2000 |