Page last updated: 2024-10-28

hydrochlorothiazide and Coronary Disease

hydrochlorothiazide has been researched along with Coronary Disease in 60 studies

Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to investigate the influences of Simvastatin (Zocor) on nitric oxide (NO), calcitonin gene related peptide (CGRP) and endothelin (ET) in blood plasma of patients with coronary heart disease (CHD) complicated with congestive heart failure (CHF)."9.17Influences of simvastatin on vascular endothelial function of patients with coronary heart disease complicated with congestive heart failure. ( Shi, J; Wang, L; Zhang, Y, 2013)
"In 78 patients with mild or moderate hypertension, effect of acebutolol and hydrochlorothiazide on plasma lipids, lipoproteins, fibrinogen and plasma fibrinolysis time were investigated."7.68[Does chronic therapy of hypertension with acebutolol or hydrochlorothiazide effect coronary risk factors?]. ( Karolko, B; Kopel, E; Kübler, G; Witkowska, M, 1991)
"In 59 patients with mild or moderate essential hypertension effects of propranolol and hydrochlorothiazide on serum lipids, fibrynogen, glucose and uric acid concentrations as well as serum euglobulins fibrynolysis time were studied."7.67[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension]. ( Karolko, B; Kawecka, M; Lukasik, S; Moszczyńska, J; Witkowska, M, 1989)
"The impact of treating hypertension on coronary artery disease has been less than anticipated from epidemiologic studies of cardiovascular risk factors."6.67Comparative trial of doxazosin and atenolol on cardiovascular risk reduction in systemic hypertension. The Alpha Beta Canada Trial Group. ( Carruthers, G; Dessain, P; Fodor, G; Newman, C; Palmer, W; Sim, D, 1993)
"The aim of this study was to investigate the influences of Simvastatin (Zocor) on nitric oxide (NO), calcitonin gene related peptide (CGRP) and endothelin (ET) in blood plasma of patients with coronary heart disease (CHD) complicated with congestive heart failure (CHF)."5.17Influences of simvastatin on vascular endothelial function of patients with coronary heart disease complicated with congestive heart failure. ( Shi, J; Wang, L; Zhang, Y, 2013)
"The ACCOMPLISH (Avoiding Cardiovascular Events Through COMbination Therapy in Patients Living With Systolic Hypertension) trial compared the outcomes effects of a renin-angiotensin system blocker, benazepril, combined with amlodipine (B+A) or hydrochlorothiazide (B+H)."5.14Cardiovascular events during differing hypertension therapies in patients with diabetes. ( Bakris, GL; Dahlöf, B; Devereux, RB; Hester, A; Hua, TA; Jamerson, K; Kelly, RY; Kjeldsen, SE; Pitt, B; Velazquez, EJ; Weber, MA; Weir, M, 2010)
"To understand the effects of single- and multiple-drug combinations for hypertension on the risk of adverse clinical outcomes, the authors analyzed data from the International Verapamil SR/Trandolapril Study (INVEST)."3.73A drug dose model for predicting clinical outcomes in hypertensive coronary disease patients. ( Cooper-DeHoff, R; Elliott, WJ; Hewkin, AC; Kupfer, S; Pepine, CJ, 2005)
"To assess whether therapy with hydrochlorothiazide (HCTZ) or the calcium antagonist nitrendipine influences silent ischemia or arrhythmias, we studied 10 asymptomatic hypertensive male patients with positive Tl-201 scintigraphy in a double-blind, crossover protocol."3.68Influence of therapy on silent ischemia and ventricular arrhythmias in hypertensive patients. ( Ammon, S; Massie, BM; O'Kelly, B; Szlachcic, J; Tubau, JF, 1991)
"In 78 patients with mild or moderate hypertension, effect of acebutolol and hydrochlorothiazide on plasma lipids, lipoproteins, fibrinogen and plasma fibrinolysis time were investigated."3.68[Does chronic therapy of hypertension with acebutolol or hydrochlorothiazide effect coronary risk factors?]. ( Karolko, B; Kopel, E; Kübler, G; Witkowska, M, 1991)
"In 59 patients with mild or moderate essential hypertension effects of propranolol and hydrochlorothiazide on serum lipids, fibrynogen, glucose and uric acid concentrations as well as serum euglobulins fibrynolysis time were studied."3.67[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension]. ( Karolko, B; Kawecka, M; Lukasik, S; Moszczyńska, J; Witkowska, M, 1989)
"Patients with high blood pressure are often overweight or even obese."2.71[Arterial hypertension in obese patients. Rationale for a prospective medical care study in the family doctor's practice]. ( Bramlage, P; Kirch, W; Sharma, AM, 2004)
"The impact of treating hypertension on coronary artery disease has been less than anticipated from epidemiologic studies of cardiovascular risk factors."2.67Comparative trial of doxazosin and atenolol on cardiovascular risk reduction in systemic hypertension. The Alpha Beta Canada Trial Group. ( Carruthers, G; Dessain, P; Fodor, G; Newman, C; Palmer, W; Sim, D, 1993)
"More metoprolol-treated patients withdrew because of depression (6 vs less than 1%; p = 0."2.66Influence of beta 2 agonism and beta 1 and beta 2 antagonism on adverse effects and plasma lipoproteins: results of a multicenter comparison of dilevalol and metoprolol. ( Ahmad, S; Glasser, SP; Lucas, C; Lutz, LJ; Materson, BJ; Morledge, JH; Ramanathan, KB; Saunders, E; Schnaper, HW; Vlachakis, ND, 1989)
"Hydrochlorothiazide was used alone in 36 percent of patients, in combination with propranolol in 26 percent, and with methyldopa in 20 percent."2.66Coronary heart disease and treatment of hypertension. Some Oslo Study data. ( Helgeland, A; Leren, P, 1986)
"Hyperlipidemia is a widely acknowledged side effect of thiazide diuretic therapy, but it is often dismissed as a short-term effect of high-dose therapy."2.40Hyperlipidemia of diuretic therapy. ( Ames, R, 1998)
"The treatment of both hyperlipidemia and hypertension appeared to be more effective than the treatment of hyperlipidemia, alone."1.26Aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta. ( Hollander, W; Kirkpatrick, B; Madoff, I; Paddock, J, 1976)

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-199044 (73.33)18.7374
1990's8 (13.33)18.2507
2000's6 (10.00)29.6817
2010's2 (3.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, L1
Shi, J1
Zhang, Y1
Krikken, JA1
Waanders, F1
Dallinga-Thie, GM1
Dikkeschei, LD1
Vogt, L1
Navis, GJ1
Dullaart, RP1
Weingärtner, O1
Böhm, M1
Laufs, U1
Weber, MA1
Bakris, GL1
Jamerson, K1
Weir, M1
Kjeldsen, SE1
Devereux, RB1
Velazquez, EJ1
Dahlöf, B1
Kelly, RY1
Hua, TA1
Hester, A1
Pitt, B1
Reese, AM1
Talbert, RL1
Bussey, HI1
SCHWARTZ, G1
STECHEL, GH1
FISHMAN, SI1
FANKHAUSER, A1
BUZZI, RM1
SAMMARTINO, F1
MAS, FR1
LA ROSA, C1
SANCHETTI, P1
FAVERO, S1
OZDOGAN, E1
SCHWARTZ, W1
COHEN, MH1
ROSEN, RJ1
SETTEL, E1
Rollins, G1
Elliott, WJ1
Hewkin, AC1
Kupfer, S1
Cooper-DeHoff, R1
Pepine, CJ1
Bramlage, P1
Sharma, AM1
Kirch, W1
Cressman, MD1
Gifford, RW1
Schmieder, R2
Friedrich, G2
Neus, H2
Rüdel, H1
von Eiff, AW2
Strec, V1
Brdová, L1
Petrovicová, J1
Brugger, P1
Klein, G1
Helgeland, A3
Angelkort, B1
Letzel, H1
Rüddel, H1
Morgan, DB1
Davidson, C1
Carruthers, G1
Dessain, P1
Fodor, G1
Newman, C1
Palmer, W1
Sim, D1
Zanchetti, A1
Ames, R1
Byington, RP1
Furberg, CD2
Craven, TE1
Pahor, M1
Sowers, JR1
de Pasquale, C1
Currò, F1
Amadeo, A1
Hollander, W1
Madoff, I1
Paddock, J1
Kirkpatrick, B1
Cohen, JD2
Szlachcic, J1
Tubau, JF1
O'Kelly, B1
Ammon, S1
Massie, BM1
Witkowska, M2
Kübler, G1
Kopel, E1
Karolko, B2
Kuller, LH1
Hulley, SB1
Neaton, J1
Materson, BJ1
Vlachakis, ND1
Glasser, SP1
Lucas, C1
Ramanathan, KB1
Ahmad, S1
Morledge, JH1
Saunders, E1
Lutz, LJ1
Schnaper, HW1
Lukasik, S1
Kawecka, M1
Moszczyńska, J1
Rockhold, FW1
Goldberg, MR1
Thompson, WL1
Leren, P2
Kaplan, NM1
Löllgen, H1
Schmidt, A1
Upmeyer, HJ1
Samuelsson, O1
Berglund, G1
Elmfeldt, D1
Wilhelmsen, L1
Wikstrand, J1
Houston, MC1
Johnston, PE1
Cutler, JA1
Schiffl, H1
Schollmeyer, P1
Kuller, L1
Farrier, N1
Caggiula, A1
Borhani, N1
Dunkle, S1
Ryvkin, IA1
Korsunskiĭ, AA1
Pribylova, LP1
Lobanova, LS1
Raĭskaia, AM1
Teichmann, G1
Löper, W1
Freis, ED1
Chasis, H1
Laidlaw, JC1
Sidorenko, BA1
Kharchenko, VI1
Titov, VN1
Lotova, EV1
Mel'nichenko, GA1
Smolenskiĭ, VS1
Mazel', GS1
Pisano, G1
Ghia, G1
Yasui, H1
Ira, TS1
Zinner, EN1
Tretenhahn, W1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Multinational, Multicenter Trial to Compare the Effects of Amlodipine/Benazepril to Benazepril and Hydrochlorothiazide Combined on the Reduction of Cardiovascular Morbidity and Mortality in Patients With High Risk Hypertension[NCT00170950]Phase 311,506 participants (Actual)Interventional2003-10-31Terminated (stopped due to The study was terminated early because of significant efficacy results for the primary endpoint in favor of benazepril/amlodipine treatment.)
INternational VErapamil SR Trandolapril STudy[NCT00133692]Phase 422,000 participants Interventional1997-09-30Completed
[NCT00000487]Phase 30 participants Interventional1972-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Time-to-event Analysis of Percentage of Patients With a Cardiovascular (CV) Mortality Event, Non-fatal Myocardial Infarction (MI), or Non-fatal Stroke

CV mortality was defined as death due to sudden cardiac death, fatal MI, fatal stroke, coronary intervention, congestive heart failure (CHF), or other CV causes. (NCT00170950)
Timeframe: For each patient, baseline to time of first CV mortality event, MI (non-fatal), or stroke (non-fatal) (or last exposure if no event occurred). (Median duration of exposure was 33.4 months. [25th to 75th percentiles: 21 to 41 months.])

InterventionPercentage of Patients with an Event (Number)
Benazepril/Amlodipine5.0
Benazepril/Hydrochlorothiazide6.3

Time-to-event Analysis of Percentage of Patients With a Composite Cardiovascular (CV) Morbidity Event

Cardiovascular morbidity was defined as including any of the following events: non-fatal MI, non-fatal stroke, hospitalization for unstable angina, resuscitated sudden death, or coronary revascularization procedure (PCI or CABG). (NCT00170950)
Timeframe: For each patient, baseline to time of first CV morbidity event (or last exposure if no event occurred). (Median duration of exposure was 33.4 months. [25th to 75th percentiles: 21 to 41 months.])]

InterventionPercentage of Patients with an Event (Number)
Benazepril/Amlodipine8.6
Benazepril/Hydrochlorothiazide10.3

Time-to-event Analysis of Percentage of Patients With a Composite Cardiovascular (CV) Morbidity or Mortality Event

CV morbidity was defined as non-fatal myocardial infarction (MI), non-fatal stroke, hospitalization for unstable angina, resuscitated sudden death, or coronary revascularization procedure. CV mortality was defined as death due to MI, stroke, coronary intervention, congestive heart failure (CHF), sudden cardiac death, or other CV causes. (NCT00170950)
Timeframe: For each patient, baseline to time of first CV morbidity or mortality event (or last exposure if no event occurred). (Median duration of exposure was 33.4 months. [25th to 75th percentiles: 21 to 41 months.])

InterventionPercentage of Patients with an event (Number)
Benazepril/Amlodipine9.6
Benazepril/Hydrochlorothiazide11.8

Reviews

6 reviews available for hydrochlorothiazide and Coronary Disease

ArticleYear
[Exertion hypertension in coronary disease and its importance in prevention and rehabilitation].
    Wiener medizinische Wochenschrift (1946), 1982, Nov-30, Volume: 132, Issue:22

    Topics: Adult; Coronary Disease; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle

1982
The hypertensive patient with multiple risk factors: is treatment really so difficult?
    American journal of hypertension, 1997, Volume: 10, Issue:10 Pt 2

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticholesteremic Agents; Antihypertensive

1997
Hyperlipidemia of diuretic therapy.
    Archives des maladies du coeur et des vaisseaux, 1998, Volume: 91 Suppl

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cere

1998
[Importance of the continuity of anti-hypertension treatment in prevention of ischemic cardiovascular diseases: preliminary note. Controlled study of hypertensive patients treated with amiloride associated with hydrochlorothiazide and chlorthalidone].
    Minerva medica, 1978, Jun-23, Volume: 69, Issue:31

    Topics: Adult; Aged; Amiloride; Chlorthalidone; Coronary Disease; Drug Therapy, Combination; Female; Humans;

1978
Essential hypertension: new insights and controversies in treatment with diuretics.
    Southern medical journal, 1986, Volume: 79, Issue:8

    Topics: Amiloride; Antihypertensive Agents; Blood Pressure; Coronary Disease; Diuretics; Dose-Response Relat

1986
Effectiveness of drug therapy in hypertension: present status. A review.
    Circulation research, 1971, Volume: 28, Issue:5

    Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block

1971

Trials

24 trials available for hydrochlorothiazide and Coronary Disease

ArticleYear
Influences of simvastatin on vascular endothelial function of patients with coronary heart disease complicated with congestive heart failure.
    European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:12

    Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Coronary Disease; Digoxin; Drug Therapy, Combination;

2013
Antiproteinuric therapy decreases LDL-cholesterol as well as HDL-cholesterol in non-diabetic proteinuric patients: relationships with cholesteryl ester transfer protein mass and adiponectin.
    Expert opinion on therapeutic targets, 2009, Volume: 13, Issue:5

    Topics: Adiponectin; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Cholesterol Ester Transfer Protei

2009
Cardiovascular events during differing hypertension therapies in patients with diabetes.
    Journal of the American College of Cardiology, 2010, Jun-29, Volume: 56, Issue:1

    Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzazepines; B

2010
[Arterial hypertension in obese patients. Rationale for a prospective medical care study in the family doctor's practice].
    MMW Fortschritte der Medizin, 2004, Aug-05, Volume: 146 Suppl 2

    Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; C

2004
Controversies in hypertension: mild hypertension, isolated systolic hypertension, and the choice of a step one drug.
    Clinical cardiology, 1983, Volume: 6, Issue:1

    Topics: Adult; Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Clinical Trials as Topic;

1983
The influence of beta blockers on cardiovascular reactivity and Type A behavior pattern in hypertensives.
    Psychosomatic medicine, 1983, Volume: 45, Issue:5

    Topics: Amiloride; Atenolol; Blood Pressure; Coronary Disease; Drug Therapy, Combination; Heart Rate; Humans

1983
Treatment of mild hypertension: a five year controlled drug trial. The Oslo study.
    The American journal of medicine, 1980, Volume: 69, Issue:5

    Topics: Adult; Blood Pressure; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disease; Drug T

1980
[Clinical aspects and therapy of hydropic heart insufficiency. Results of a multicenter field study].
    Fortschritte der Medizin, 1981, Dec-03, Volume: 99, Issue:45

    Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Edema, Cardiac;

1981
Effects of beta-blockers on type-A coronary-prone behaviour.
    Klinische Wochenschrift, 1982, Oct-15, Volume: 60, Issue:20

    Topics: Amiloride; Atenolol; Blood Pressure; Coronary Disease; Humans; Hydrochlorothiazide; Hypertension; Ma

1982
Comparative trial of doxazosin and atenolol on cardiovascular risk reduction in systemic hypertension. The Alpha Beta Canada Trial Group.
    The American journal of cardiology, 1993, Mar-01, Volume: 71, Issue:7

    Topics: Adult; Aged; Atenolol; Cholesterol; Cholesterol, HDL; Coronary Disease; Double-Blind Method; Doxazos

1993
The hypertensive patient with multiple risk factors: is treatment really so difficult?
    American journal of hypertension, 1997, Volume: 10, Issue:10 Pt 2

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticholesteremic Agents; Antihypertensive

1997
Isradipine in prediabetic hypertensive subjects.
    Diabetes care, 1998, Volume: 21, Issue:12

    Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Cardiovascular Dis

1998
Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party.
    BMJ (Clinical research ed.), 1992, Feb-15, Volume: 304, Issue:6824

    Topics: Aged; Amiloride; Atenolol; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease; Diu

1992
Influence of beta 2 agonism and beta 1 and beta 2 antagonism on adverse effects and plasma lipoproteins: results of a multicenter comparison of dilevalol and metoprolol.
    The American journal of cardiology, 1989, Jun-05, Volume: 63, Issue:19

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Cholesterol; Coronary Disease; Double-B

1989
Beneficial effects of pinacidil on blood lipids: comparisons with prazosin and placebo in patients with hypertension. Pinacidil-Prazosin and Pinacidil-Placebo Research Groups, Lilly Research Laboratories.
    The Journal of laboratory and clinical medicine, 1989, Volume: 114, Issue:6

    Topics: Antihypertensive Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic;

1989
Coronary heart disease and treatment of hypertension. Some Oslo Study data.
    The American journal of medicine, 1986, Feb-14, Volume: 80, Issue:2A

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Blood Glucose; Carbohydrate

1986
Oslo Hypertension Study.
    Drugs, 1986, Volume: 31 Suppl 1

    Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Cholesterol, HDL; Coronary Disease; Follow-Up Stu

1986
[Double-blind comparison of fixed combination preparations of a beta blocker and a diuretic and beta blocker, a diuretic and hydralazine in patients with coronary heart disease and arterial hypertension].
    Medizinische Klinik (Munich, Germany : 1983), 1986, Nov-11, Volume: 81, Issue:23

    Topics: Adrenergic beta-Antagonists; Aged; Amiloride; Clinical Trials as Topic; Coronary Disease; Double-Bli

1986
QRS-amplitudes during antihypertensive treatment: a comparison between beta-blocker and thiazide diuretic regimens.
    European heart journal, 1986, Volume: 7, Issue:3

    Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Electrocardio

1986
Drug treatment trials in hypertension: a review.
    Preventive medicine, 1985, Volume: 14, Issue:4

    Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Coro

1985
Metabolic consequences of long-term thiazide-based antihypertensive treatment of renal hypertension.
    Cardiology, 1985, Volume: 72 Suppl 1

    Topics: Adolescent; Adult; Aged; Amiloride; Blood Glucose; Blood Pressure; Cholesterol; Coronary Disease; Dr

1985
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.
    Circulation, 1972, Volume: 45, Issue:5

    Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu

1972
Appraisal of antihypertensive drug therapy.
    Circulation, 1974, Volume: 50, Issue:1

    Topics: Antihypertensive Agents; Arteriosclerosis; Clinical Trials as Topic; Coronary Disease; Diabetes Comp

1974
Hypertension: a challenge in preventive medicine.
    Journal of the Royal College of Physicians of London, 1974, Volume: 9, Issue:1

    Topics: Age Factors; Attitude to Health; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disea

1974

Other Studies

31 other studies available for hydrochlorothiazide and Coronary Disease

ArticleYear
[67-year-old patient with abdominal pain and pronounced peritonitis].
    Deutsche medizinische Wochenschrift (1946), 2009, Volume: 134, Issue:22

    Topics: Abdominal Pain; Aged; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents;

2009
Angiotensin-converting-enzyme inhibitors and diuretics for hypertension.
    The New England journal of medicine, 2003, Jul-03, Volume: 349, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Chlorthalidone; Coronary Disease;

2003
Clinical therapeutic evaluation of hydrochlorothiazide (hydrodiuril).
    Journal of the American Medical Association, 1959, Aug-22, Volume: 170, Issue:17

    Topics: Acetazolamide; Coronary Disease; Diuretics; Heart Diseases; Humans; Hydrochlorothiazide; Hypertensio

1959
[Hydrochlorothiazide in clinical practice].
    Prensa medica argentina, 1960, Nov-04, Volume: 47

    Topics: Chlorothiazide; Coronary Disease; Diuretics; Hydrochlorothiazide; Hypertension; Kidney Diseases; Liv

1960
[CLINICAL STUDY OF A NEW COMPLEX HYPOTENSIVE DRUG COMBINATION].
    Gazzetta medica italiana, 1963, Volume: 122

    Topics: Antihypertensive Agents; Arteriosclerosis; Carbamates; Cerebrovascular Disorders; Coronary Disease;

1963
[ON ION TRANSPORT BEFORE AND AFTER TREATMENT OF CONGESTIVE HEART FAILURE].
    Turk Tip Cemiyeti mecmuasi, 1963, Volume: 29

    Topics: Chlorthalidone; Coronary Disease; Digitalis Glycosides; Diuretics; Electrolytes; Heart Failure; Huma

1963
MEBUTAMATE AND HYDROCHLOROTHIAZIDE IN HYPERTENSION.
    Journal of the American Geriatrics Society, 1964, Volume: 12

    Topics: Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure Determination; Carbamates;

1964
PROLONGED CARDIOGENIC SHOCK WITH RECOVERY.
    The Journal of the American Osteopathic Association, 1964, Volume: 63

    Topics: Angina Pectoris; Coronary Disease; Digoxin; Electrocardiography; Hydrochlorothiazide; Hypercholester

1964
SMALL-BOWEL ULCERS WITH THAIZIDE AND POTASSIUM.
    JAMA, 1965, Feb-01, Volume: 191

    Topics: Coronary Disease; Diuretics; Hydrochlorothiazide; Hypertension; Ileum; Intestinal Diseases; Potassiu

1965
FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA.
    Journal of the American Geriatrics Society, 1965, Volume: 13

    Topics: Arteriosclerosis; Chlorothiazide; Coronary Disease; Drug Combinations; Drug Therapy; Edema; Edema, C

1965
Calcium antagonist and beta blocker regimens found equally effective in hypertensive patients with coronary artery disease.
    Report on medical guidelines & outcomes research, 2004, Jan-23, Volume: 15, Issue:2

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Coronary Disease; Di

2004
A drug dose model for predicting clinical outcomes in hypertensive coronary disease patients.
    Journal of clinical hypertension (Greenwich, Conn.), 2005, Volume: 7, Issue:11

    Topics: Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Chi-Square Distribution; Coronary Disea

2005
[Effective pharmacotherapy with diuretics in spa therapy].
    Fysiatricky a reumatologicky vestnik, 1983, Volume: 61, Issue:2

    Topics: Adult; Balneology; Coronary Disease; Diuresis; Humans; Hydrochlorothiazide; Male; Middle Aged; Risk

1983
Hypokalaemia and diuretics: an analysis of publications.
    British medical journal, 1980, Mar-29, Volume: 280, Issue:6218

    Topics: Chlorothiazide; Chlorthalidone; Coronary Disease; Diuretics; Dose-Response Relationship, Drug; Furos

1980
Aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta.
    Circulation research, 1976, Volume: 38, Issue:6 Suppl 2

    Topics: Animals; Aortic Coarctation; Arteriosclerosis; Blood Pressure; Body Weight; Cholesterol, Dietary; Co

1976
Abnormal electrocardiograms and cardiovascular risk: role of silent myocardial ischemia. Evidence from MRFIT.
    The American journal of cardiology, 1992, Nov-16, Volume: 70, Issue:16

    Topics: Adult; Antihypertensive Agents; Chlorthalidone; Cholesterol, Dietary; Coronary Disease; Electrocardi

1992
Influence of therapy on silent ischemia and ventricular arrhythmias in hypertensive patients.
    Journal of cardiovascular pharmacology, 1991, Volume: 18 Suppl 1

    Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Electrocardiography, Ambulatory

1991
[Does chronic therapy of hypertension with acebutolol or hydrochlorothiazide effect coronary risk factors?].
    Kardiologia polska, 1991, Volume: 34, Issue:3

    Topics: Acebutolol; Adult; Coronary Disease; Female; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male

1991
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis.
    Circulation, 1986, Volume: 73, Issue:1

    Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid

1986
[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension].
    Kardiologia polska, 1989, Volume: 32 Suppl 2

    Topics: Adult; Coronary Disease; Dose-Response Relationship, Drug; Female; Humans; Hydrochlorothiazide; Hype

1989
Problems with the use of diuretics in the treatment of hypertension.
    American journal of nephrology, 1986, Volume: 6, Issue:1

    Topics: Adrenergic beta-Antagonists; Blood Pressure; Coronary Disease; Diuretics; Female; Humans; Hydrochlor

1986
Relationship of diuretic therapy and serum magnesium levels among participants in the Multiple Risk Factor Intervention Trial.
    American journal of epidemiology, 1985, Volume: 122, Issue:6

    Topics: Adult; Blood Pressure; California; Chlorthalidone; Coronary Disease; Diet; Epidemiologic Methods; Hu

1985
Results of treatment of hypertension.
    Lancet (London, England), 1971, Jan-30, Volume: 1, Issue:7692

    Topics: Acute Kidney Injury; Antihypertensive Agents; Cardiovascular Diseases; Coronary Disease; Female; Hum

1971
[Initial results of the activity of the Angiocardiological Center in Kolomna].
    Kardiologiia, 1971, Volume: 11, Issue:10

    Topics: Adolescent; Adult; Coronary Disease; Diabetes Complications; Female; Heparin; Humans; Hydrochlorothi

1971
[Use, association and contraindications of hypotensive drugs].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1969, Jun-15, Volume: 24, Issue:12

    Topics: Antihypertensive Agents; Blood Pressure; Coronary Disease; Diuretics; Furosemide; Ganglionic Blocker

1969
[Comparison of the effectiveness and mechanism of action of the saluretic preparations triamterene and hypothiazide and their combination (triampur) in circulatory insufficiency].
    Kardiologiia, 1973, Volume: 13, Issue:4

    Topics: Acid-Base Equilibrium; Adult; Aged; Arteriosclerosis; Circadian Rhythm; Coronary Disease; Creatinine

1973
[Origin and treatment of arterial hypertension in middle and old age].
    Sovetskaia meditsina, 1972, Volume: 35, Issue:1

    Topics: Aged; Benzimidazoles; Coronary Disease; Humans; Hydrochlorothiazide; Hypertension; Intracranial Arte

1972
[Clinical observations on the diuretic action of the association of triamterene with hydrochlorothiazide].
    Minerva cardioangiologica, 1967, Volume: 15, Issue:7

    Topics: Adult; Aged; Coronary Disease; Diuresis; Edema; Heart Diseases; Heart Failure; Humans; Hydrochloroth

1967
The role of catecholamines in circulatory regulation on the chronic congestive heart failure. Clinical study of the urinary catecholamine excretion in the patients with chronic congestive heart failure.
    Japanese circulation journal, 1968, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiomyopathies; Catecholamines; Coronary Disease; Digital

1968
Small bowel ulceration.
    The American journal of gastroenterology, 1966, Volume: 46, Issue:5

    Topics: Aged; Coronary Disease; Diagnosis, Differential; Female; Humans; Hydrochlorothiazide; Ileum; Intesti

1966
[The treatment of hypertension].
    Wiener medizinische Wochenschrift (1946), 1966, May-21, Volume: 116, Issue:21

    Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Arteriosclerosis; Child; Child, Preschool; Coronar

1966