hydrochlorothiazide has been researched along with Cardiomegaly in 46 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thiazides are one of the most common antihypertensive drugs used for hypertension treatment and hydrochlorothiazide (HCTZ) is the most frequently used diuretic for hypertension treatment." | 8.02 | Hydrochlorothiazide Reduces Cardiac Hypertrophy, Fibrosis and Rho-Kinase Activation in DOCA-Salt Induced Hypertension. ( Araos, P; Jalil, JE; Mondaca-Ruff, D; Mora, IG; Novoa, UF; Ocaranza, MP; Yañez, CE, 2021) |
| "Compared with untreated controls, omapatrilat and I + H significantly attenuated hypertension [male control, 198." | 7.72 | Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. ( Beattie, E; Dominiczak, AF; Graham, D; Hamilton, C; Spiers, A, 2004) |
| " In the present study the effects of the angiotensin converting enzyme inhibitor (ACEI) enalapril and the thiazide-type diuretic, hydrochlorothiazide, on the development of the salt-induced left ventricular and kidney hypertrophy were examined in normotensive Wistar-Kyoto and Wistar rats." | 7.69 | Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats. ( Karppanen, H; Laakso, J; Mervaala, EM; Vapaatalo, H, 1994) |
| "Hydrochlorothiazide was administered from 8 weeks, and LV mass and function were measured at 16 weeks after surgery to induce hypertension." | 5.29 | Hydrochlorothiazide improves ventricular compliance and thus performance without reducing hypertrophy in renal artery stenosis in rats. ( Norton, GR; Tsotetsi, OJ; Woodiwiss, AJ, 1993) |
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 5.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| "To compare clinical efficacy and tolerance of fixed combinations of perindopril and indapamide (noliprel), capoten+hydrochlorotiaside (caposide) in arterial hypertension stage I-II of high and very high risk which failed prior monotherapy." | 5.11 | [Comparison of noliprel and caposide efficacy in patients with arterial hypertension of high risk]. ( Brel', UA; Chaliabi, TA; Kapustin, IO; Marchenko, IV; Nedogoda, SV; Prokhorova, EA; Tsoma, VA, 2005) |
| "Forty-four patients with uncomplicated systemic hypertension underwent 48-hour electrocardiographic monitoring before and after four weeks of treatment with hydrochlorothiazide, 100 mg daily." | 5.06 | Thiazide therapy is not a cause of arrhythmia in patients with systemic hypertension. ( Burris, JF; Fletcher, RD; Freis, ED; Notargiacomo, A; Papademetriou, V, 1988) |
| "Twenty patients with uncomplicated systemic hypertension underwent treadmill testing twice during placebo treatment and twice during hydrochlorothiazide treatment." | 5.06 | Diuretic therapy and exercise in patients with systemic hypertension. ( Freis, ED; Notargiacomo, A; Papademetriou, V, 1989) |
| "Thiazides are one of the most common antihypertensive drugs used for hypertension treatment and hydrochlorothiazide (HCTZ) is the most frequently used diuretic for hypertension treatment." | 4.02 | Hydrochlorothiazide Reduces Cardiac Hypertrophy, Fibrosis and Rho-Kinase Activation in DOCA-Salt Induced Hypertension. ( Araos, P; Jalil, JE; Mondaca-Ruff, D; Mora, IG; Novoa, UF; Ocaranza, MP; Yañez, CE, 2021) |
| "Compared with untreated controls, omapatrilat and I + H significantly attenuated hypertension [male control, 198." | 3.72 | Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. ( Beattie, E; Dominiczak, AF; Graham, D; Hamilton, C; Spiers, A, 2004) |
| " In the present study the effects of the angiotensin converting enzyme inhibitor (ACEI) enalapril and the thiazide-type diuretic, hydrochlorothiazide, on the development of the salt-induced left ventricular and kidney hypertrophy were examined in normotensive Wistar-Kyoto and Wistar rats." | 3.69 | Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats. ( Karppanen, H; Laakso, J; Mervaala, EM; Vapaatalo, H, 1994) |
| "The aim was to compare the effects of two diuretics, indapamide and hydrochlorothiazide, on cardiac hypertrophy in stroke prone spontaneously hypertensive rats (SHR-SP)." | 3.68 | Diuretic effects on cardiac hypertrophy in the stroke prone spontaneously hypertensive rat. ( Contard, F; Glukhova, M; Guez, D; Marotte, F; Narcisse, G; Rappaport, L; Samuel, JL; Schatz, C; Swynghedauw, B, 1993) |
| " Enalapril maleate (MK421) and hydrochlorothiazide (HTZ) were used to assess the control of hypertension, and reversal of left ventricular hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl), or a low (0." | 3.67 | The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension. ( Fernandez, D; Fernandez, PG; Idikio, H; Kim, BK; Snedden, W; Triggle, CR, 1984) |
| "The effect of a single daily dose of 500 mg of methyldopa with 50 mg of hydrochlorothiazide and 5 mg of amiloride hydrochloride was studied in 21 patients with mild to moderate hypertension." | 3.67 | The effect of single-dose methyldopa and diuretic on BP and left ventricular mass. ( Hilewitz, H; Rogel, S; Weinstein, M, 1984) |
| " Thirty-one patients with uncomplicated hypertension underwent 48-hour ambulatory ECG monitoring both before any treatment and after 4 weeks of hydrochlorothiazide, (HCTZ), 100 mg daily." | 3.67 | Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or without left ventricular hypertrophy. ( Fletcher, RD; Freis, ED; Gottdiener, J; Notargiacomo, A; Papademetriou, V; Price, M, 1985) |
| "Enalapril maleate (MK 421), and hydrochlorothiazide were used to evaluate the control of hypertension and reversal of myocardial hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl) or a low salt (0." | 3.66 | Cardiac regression and blood pressure control in the Dahl rat treated with either enalapril maleate (MK 421, an angiotensin converting enzyme inhibitor) or hydrochlorothiazide. ( Fernandez, PG; Idikio, H; Kim, BK; Sharma, JN; Triggle, CR, 1983) |
| "During 12-week hydrochlorothiazide treatment 16 men suffering from uncomplicated essential hypertension were examined." | 3.66 | [Hemodynamic mechanism of the hypotensive action of diuretics and their effect on myocardial hypertrophy in the process of long-term treatment of hypertension]. ( D'iakonova, EG; Iurenev, AP, 1982) |
| "M-mode echocardiography was used in 12 patients with essential hypertension to study changes in cardiac anatomy during long-term therapy with hydrochlorothiazide (50 to 100 mg) and alpha-methyldopa (500 to 1,750 mg)." | 3.66 | Effect of long-term antihypertensive therapy on cardiac anatomy in patients with essential hypertension. ( Drayer, JI; Gardin, JM; Lipson, JL; Weber, MA, 1983) |
| "Vascular and cardiac hypertrophy were significantly attenuated with losartan or perindopril, but were unchanged with other treatments." | 1.30 | Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis. ( Anderson, NH; Devlin, AM; Dominiczak, AF; Graham, D; Hamilton, CA; Morton, JJ; Reid, JL; Schork, NJ, 1999) |
| "Perindopril treatment also effectively prevented the development of vascular hypertrophy; however, treatment with hydralazine and hydrochlorothiazide was not as effective despite equivalent blood pressure reduction." | 1.30 | Different effects of antihypertensive agents on cardiac and vascular hypertrophy in the transgenic rat line TGR(mRen2)27. ( Brosnan, MJ; Clark, JS; Devlin, AM; Dominiczak, AF; Mullins, JJ, 1999) |
| "Hydrochlorothiazide was administered from 8 weeks, and LV mass and function were measured at 16 weeks after surgery to induce hypertension." | 1.29 | Hydrochlorothiazide improves ventricular compliance and thus performance without reducing hypertrophy in renal artery stenosis in rats. ( Norton, GR; Tsotetsi, OJ; Woodiwiss, AJ, 1993) |
| " Therefore, after 4 weeks of washout with placebo (phase 1), doxazosin (dosage range from 1 to 16 mg, plus hydrochlorothiazide when necessary) was given to 11 essential hypertensive patients (6 M, 5 F, age range 34-63 years) for 8 weeks (phase 2) in order to achieve diastolic blood pressure values less than 90 mmHg; this dosage was then maintained for a further 20 weeks up to the end of the study (phase 3)." | 1.28 | Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin. ( Agabiti-Rosei, E; Beschi, M; Calebich, S; Castellano, M; Muiesan, G; Muiesan, ML; Rizzoni, D; Zulli, R, 1992) |
| " It was found that in a part of patients the long-term administration of antihypertensive drugs led to an increased accumulation of kynurenine as a manifestation of pyridoxal-5-phosphate deficiency." | 1.28 | Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. ( Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV, 1990) |
| "Hydralazine tended to lower LV MCVR per 100 g in both strains despite its tendency to increase ventricular mass." | 1.28 | Role of lowering arterial pressure on maximal coronary flow with and without regression of cardiac hypertrophy. ( Canby, CA; Tomanek, RJ, 1989) |
| "Renal hypertrophy was also decreased significantly by cicletanine at a dose of 100 mg/kg." | 1.27 | Comparison of cicletanine with other antihypertensive drugs in SHR-SP models. ( Braquet, P; Clostre, F; Le Hegarat, M; Malherbe, E, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (56.52) | 18.7374 |
| 1990's | 15 (32.61) | 18.2507 |
| 2000's | 3 (6.52) | 29.6817 |
| 2010's | 1 (2.17) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Mondaca-Ruff, D | 1 |
| Araos, P | 1 |
| Yañez, CE | 1 |
| Novoa, UF | 1 |
| Mora, IG | 1 |
| Ocaranza, MP | 1 |
| Jalil, JE | 1 |
| Kujal, P | 1 |
| Chábová, VČ | 1 |
| Vernerová, Z | 1 |
| Walkowska, A | 1 |
| Kompanowska-Jezierska, E | 1 |
| Sadowski, J | 1 |
| Vaňourková, Z | 1 |
| Husková, Z | 1 |
| Opočenský, M | 1 |
| Skaroupková, P | 1 |
| Schejbalová, S | 1 |
| Kramer, HJ | 1 |
| Rakušan, D | 1 |
| Malý, J | 1 |
| Netuka, I | 1 |
| Vaněčková, I | 1 |
| Kopkan, L | 1 |
| Cervenka, L | 1 |
| Graham, D | 2 |
| Hamilton, C | 1 |
| Beattie, E | 1 |
| Spiers, A | 1 |
| Dominiczak, AF | 3 |
| Nedogoda, SV | 1 |
| Marchenko, IV | 1 |
| Chaliabi, TA | 1 |
| Tsoma, VA | 1 |
| Brel', UA | 1 |
| Prokhorova, EA | 1 |
| Kapustin, IO | 1 |
| Fernandez, PG | 5 |
| Kim, BK | 5 |
| Snedden, W | 3 |
| Nolan, R | 1 |
| Ko, P | 1 |
| Idikio, H | 4 |
| Fernandez, D | 2 |
| Triggle, CR | 4 |
| Sharma, JN | 1 |
| Reichek, N | 1 |
| Franklin, BB | 1 |
| Chandler, T | 1 |
| Muhammad, A | 1 |
| Plappert, T | 1 |
| St John Sutton, M | 1 |
| Shkhvatsabaia, IK | 2 |
| D'iakonova, EG | 1 |
| Iurenev, AP | 1 |
| Drayer, JI | 1 |
| Weber, MA | 1 |
| Gardin, JM | 1 |
| Lipson, JL | 1 |
| Wollam, GL | 1 |
| Hall, WD | 1 |
| Porter, VD | 1 |
| Douglas, MB | 1 |
| Unger, DJ | 1 |
| Blumenstein, BA | 1 |
| Cotsonis, GA | 1 |
| Knudtson, ML | 1 |
| Felner, JM | 1 |
| Schlant, RC | 1 |
| Weinstein, M | 1 |
| Hilewitz, H | 1 |
| Rogel, S | 1 |
| Giudicelli, JF | 1 |
| Freslon, JL | 1 |
| Richer, C | 1 |
| Contard, F | 2 |
| Glukhova, M | 2 |
| Sabri, A | 1 |
| Marotte, F | 2 |
| Sartore, S | 1 |
| Narcisse, G | 2 |
| Schatz, C | 2 |
| Guez, D | 2 |
| Rappaport, L | 2 |
| Samuel, JL | 2 |
| Schraeger, JA | 1 |
| Canby, CA | 2 |
| Rongish, BJ | 1 |
| Kawai, M | 1 |
| Tomanek, RJ | 2 |
| Norton, GR | 1 |
| Tsotetsi, OJ | 1 |
| Woodiwiss, AJ | 1 |
| Mervaala, EM | 1 |
| Laakso, J | 1 |
| Vapaatalo, H | 1 |
| Karppanen, H | 1 |
| Tsoporis, J | 2 |
| Fields, N | 2 |
| Lee, RM | 2 |
| Leenen, FH | 2 |
| Swynghedauw, B | 1 |
| Anderson, NH | 1 |
| Devlin, AM | 2 |
| Morton, JJ | 1 |
| Hamilton, CA | 1 |
| Reid, JL | 1 |
| Schork, NJ | 1 |
| Brosnan, MJ | 1 |
| Clark, JS | 1 |
| Mullins, JJ | 1 |
| Mervaala, E | 1 |
| Müller, DN | 1 |
| Schmidt, F | 1 |
| Park, JK | 1 |
| Gross, V | 1 |
| Bader, M | 1 |
| Breu, V | 1 |
| Ganten, D | 1 |
| Haller, H | 1 |
| Luft, FC | 1 |
| Agabiti-Rosei, E | 1 |
| Muiesan, ML | 1 |
| Rizzoni, D | 1 |
| Zulli, R | 1 |
| Calebich, S | 1 |
| Beschi, M | 1 |
| Castellano, M | 1 |
| Muiesan, G | 1 |
| Foster, E | 1 |
| Plehn, JF | 1 |
| Bernard, SA | 1 |
| Battinelli, NJ | 1 |
| Huntington-Coats, M | 1 |
| Apstein, CS | 1 |
| Otterstad, JE | 1 |
| Froeland, G | 1 |
| Wasenius Soeyland, AK | 1 |
| Knutsen, KM | 1 |
| Ekeli, T | 1 |
| Van Hoof, R | 1 |
| Leonetti, G | 1 |
| Fogari, R | 1 |
| Mazzola, C | 1 |
| Mangiameli, S | 1 |
| Castello, C | 1 |
| Rudzite, VK | 1 |
| Vitols, AV | 1 |
| Liepinja, DJ | 1 |
| Silava, AK | 1 |
| Papademetriou, V | 3 |
| Price, M | 1 |
| Notargiacomo, A | 3 |
| Gottdiener, J | 1 |
| Fletcher, RD | 2 |
| Freis, ED | 4 |
| Kuller, LH | 1 |
| Hulley, SB | 1 |
| Cohen, JD | 1 |
| Neaton, J | 1 |
| Burris, JF | 1 |
| Ferder, L | 1 |
| Inserra, F | 1 |
| Medina, F | 1 |
| Glasser, SP | 1 |
| Koehn, DK | 1 |
| Messerli, FH | 1 |
| Nunez, BD | 1 |
| Nunez, MM | 1 |
| Garavaglia, GE | 1 |
| Schmieder, RE | 1 |
| Ventura, HO | 1 |
| Franz, IW | 1 |
| Tönnesmann, U | 1 |
| Behr, U | 1 |
| Ketelhut, R | 1 |
| De Quattro, V | 1 |
| Iureneva, AP | 1 |
| Salenko, BB | 1 |
| Khramelashvili, VV | 1 |
| Samuelsson, O | 1 |
| Berglund, G | 1 |
| Elmfeldt, D | 1 |
| Wilhelmsen, L | 1 |
| Wikstrand, J | 1 |
| Malherbe, E | 1 |
| Le Hegarat, M | 1 |
| Clostre, F | 1 |
| Braquet, P | 1 |
| Lee, CC | 1 |
| O'Steen, WK | 1 |
| Hall, CE | 1 |
| Hall, OS | 1 |
| Poblete, PF | 1 |
| Kyle, MC | 1 |
| Pipberger, HV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000487] | Phase 3 | 0 participants | Interventional | 1972-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydrochlorothiazide and Cardiomegaly
| Article | Year |
|---|---|
[The heart and arterial hypertension].
Topics: Blood Pressure; Cardiac Output; Cardiac Volume; Cardiomegaly; Heart; Heart Rate; Hemodynamics; Human | 1982 |
11 trials available for hydrochlorothiazide and Cardiomegaly
| Article | Year |
|---|---|
[Comparison of noliprel and caposide efficacy in patients with arterial hypertension of high risk].
Topics: Antihypertensive Agents; Captopril; Cardiomegaly; Female; Heart Ventricles; Humans; Hydrochlorothiaz | 2005 |
Left ventricular changes after chronic therapy with enalapril maleate in moderate to severe hypertensive patients.
Topics: Adult; Blood Pressure; Cardiomegaly; Chlorides; Creatinine; Diastole; Dipeptides; Double-Blind Metho | 1984 |
Time course of regression of left ventricular hypertrophy in treated hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Drug Therapy, Combination; Echo | 1983 |
Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year's treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double-blind, randomized study.
Topics: Adult; Aged; Atenolol; Cardiomegaly; Double-Blind Method; Echocardiography; Humans; Hydrochlorothiaz | 1992 |
Left ventricular hypertrophy in elderly hypertensive patients: a report from the European Working Party on High Blood Pressure in the Elderly trial.
Topics: Aged; Cardiomegaly; Cardiovascular Diseases; Double-Blind Method; Drug Therapy, Combination; Electro | 1991 |
Comparison of the effects on blood pressure and left ventricular hypertrophy of lacidipine and hydrochlorothiazide in hypertensive patients.
Topics: Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Double-Blind Method; Heart | 1991 |
Thiazide therapy is not a cause of arrhythmia in patients with systemic hypertension.
Topics: Cardiac Complexes, Premature; Cardiomegaly; Clinical Trials as Topic; Electrocardiography; Humans; H | 1988 |
Diuretic therapy and exercise in patients with systemic hypertension.
Topics: Arrhythmias, Cardiac; Cardiomegaly; Catecholamines; Combined Modality Therapy; Double-Blind Method; | 1989 |
[Regression of left heart hypertrophy in hypertensive patients as a result of antihypertensive therapy].
Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiac Output; Cardiac Volume; Cardiomegaly; | 1989 |
QRS-amplitudes during antihypertensive treatment: a comparison between beta-blocker and thiazide diuretic regimens.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Electrocardio | 1986 |
Effect of treatment on morbidity in hypertension. Veterans Administration Cooperative Study on Antihypertensive Agents. Effect on the electrocardiogram.
Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiomegaly; Clinical Trials as Topi | 1973 |
34 other studies available for hydrochlorothiazide and Cardiomegaly
| Article | Year |
|---|---|
Hydrochlorothiazide Reduces Cardiac Hypertrophy, Fibrosis and Rho-Kinase Activation in DOCA-Salt Induced Hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Connective Tissue Growth Factor; Fib | 2021 |
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme | 2010 |
Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences.
Topics: Animals; Antihypertensive Agents; Biological Availability; Biphenyl Compounds; Blood Pressure; Carba | 2004 |
The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Diet, Sodium-Restricted; Dipeptides; | 1984 |
Cardiac regression and blood pressure control in the Dahl rat treated with either enalapril maleate (MK 421, an angiotensin converting enzyme inhibitor) or hydrochlorothiazide.
Topics: Animals; Blood Pressure; Cardiomegaly; Diet, Sodium-Restricted; Dipeptides; Enalapril; Hydrochloroth | 1983 |
Reversal of left ventricular hypertrophy by antihypertensive therapy.
Topics: Antihypertensive Agents; Cardiomegaly; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazid | 1982 |
[Hemodynamic mechanism of the hypotensive action of diuretics and their effect on myocardial hypertrophy in the process of long-term treatment of hypertension].
Topics: Adult; Antihypertensive Agents; Cardiomegaly; Diuretics; Drug Evaluation; Furosemide; Heart; Hemodyn | 1982 |
Regression of left ventricular hypertrophy and control of hypertension in the spontaneously hypertensive rat (SHR): oxprenolol versus hydrochlorothiazide.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Heart Ventricles; Hydrochlorothiazide; Hypertens | 1983 |
Effect of long-term antihypertensive therapy on cardiac anatomy in patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Drug Therapy, Combi | 1983 |
The effect of single-dose methyldopa and diuretic on BP and left ventricular mass.
Topics: Adult; Aged; Amiloride; Blood Pressure; Cardiomegaly; Drug Therapy, Combination; Echocardiography; F | 1984 |
[Antihypertensives and the prevention of development of genetic hypertension in the hypertensive SHR rat].
Topics: Animals; Antihypertensive Agents; Atenolol; Captopril; Cardiomegaly; Dihydralazine; Dose-Response Re | 1980 |
Comparative effects of indapamide and hydrochlorothiazide on cardiac hypertrophy and vascular smooth-muscle phenotype in the stroke-prone, spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Vessels; Hydrochlorothiazide; Hypertension; Indapami | 1993 |
Normal left ventricular diastolic compliance after regression of hypertrophy.
Topics: Aging; Animals; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Collagen; Diastole; Elasticity | 1994 |
Hydrochlorothiazide improves ventricular compliance and thus performance without reducing hypertrophy in renal artery stenosis in rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Compliance; Coronary Circulation; Dextrans; Heart; Heart Vent | 1993 |
Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Calcium; Cardiomegaly; Dose-Response Relationship, Dr | 1994 |
Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Blood Volume; Cardiomegaly; Heart; Heart Ventricles; Hydrochlorothiazide; H | 1993 |
Diuretic effects on cardiac hypertrophy in the stroke prone spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Vessels; Drug Evaluation, Preclinical; Fibrosis; Hyd | 1993 |
Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiomegaly; Cell Nucleus; Diastole; DNA; | 1999 |
Different effects of antihypertensive agents on cardiac and vascular hypertrophy in the transgenic rat line TGR(mRen2)27.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive A | 1999 |
Blood pressure-independent effects in rats with human renin and angiotensinogen genes.
Topics: Albuminuria; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Antihypertensi | 2000 |
Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Aldosterone; Antihypertensive Agents; Blood Pressure; Cardiomeg | 1992 |
Regression of left ventricular hypertrophy in "previously untreated" hypertensive blacks after 6 months of blood pressure reduction with alpha- and beta-adrenergic blockade and thiazide therapy.
Topics: Adult; Aged; Black People; Blood Pressure; Cardiomegaly; Drug Therapy, Combination; Echocardiography | 1992 |
Arterial vasodilation and cardiovascular structural changes in normotensive rats.
Topics: Animals; Arteries; Blood Volume; Cardiomegaly; Cardiovascular Physiological Phenomena; Cardiovascula | 1991 |
Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Volume; Cardiomegaly; Clonidine; Drug Therap | 1990 |
Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or without left ventricular hypertrophy.
Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Diuretics; Echocardio | 1985 |
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid | 1986 |
Safety aspects of long-term antihypertensive therapy (10 years) with clonidine.
Topics: Adult; Blood Pressure; Cardiomegaly; Cholesterol; Clonidine; Drug Therapy, Combination; Electrocardi | 1987 |
Predictors of left ventricular hypertrophy in patients with essential hypertension.
Topics: Blood Pressure; Cardiomegaly; Echocardiography; Electrocardiography; Female; Humans; Hydrochlorothia | 1989 |
Hypertension and sudden death. Disparate effects of calcium entry blocker and diuretic therapy on cardiac dysrhythmias.
Topics: Adult; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiomegaly; Death, Sudden; Electrocardiogra | 1989 |
Role of lowering arterial pressure on maximal coronary flow with and without regression of cardiac hypertrophy.
Topics: Animals; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Coronary Circulation; Heart; Hydralaz | 1989 |
[Left ventricular hypertrophy and neural tonus in hypertension: differences in the action of diuretics and relaxation therapy].
Topics: Adult; Aged; Blood Pressure; California; Cardiomegaly; Diuretics; Drug Therapy, Combination; Epineph | 1986 |
Comparison of cicletanine with other antihypertensive drugs in SHR-SP models.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Diuresis; Di | 1988 |
Modulation of right and left ventricular wall thicknesses in experimental hypertension.
Topics: Animals; Cardiomegaly; Enalapril; Hydrochlorothiazide; Hypertension; Rats; Sodium Chloride | 1985 |
Hormone influenced hypertension in the male rat. Effect of hydrochlorothiazide.
Topics: 5-Hydroxytryptophan; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Ce | 1969 |