hydrochlorothiazide and Cardiac Failure studies

Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

Research Excerpts

Excerpt	Relevance	Reference
"Due to the potential benefits of triamterene in diuretic resistance, this study was performed to assess whether triamterene add-on to the standard treatment of heart failure (HF)-related diuretic resistance improves outcomes."	9.69	Effects of Triamterene in Hospitalized Patients with Heart Failure and Diuretic Resistance: A Randomized Clinical Trial. ( Enamzadeh, E; Entezari-Maleki, T; Khani, E; Khezripour, K; Safaei, N; Taban-Sadeghi, M, 2023)
"The aim of this study was to investigate the influences of Simvastatin (Zocor) on nitric oxide (NO), calcitonin gene related peptide (CGRP) and endothelin (ET) in blood plasma of patients with coronary heart disease (CHD) complicated with congestive heart failure (CHF)."	9.17	Influences of simvastatin on vascular endothelial function of patients with coronary heart disease complicated with congestive heart failure. ( Shi, J; Wang, L; Zhang, Y, 2013)
"We studied the synergism between high-dose furosemide and hydrochlorothiazide in patients with severe congestive heart failure and impaired renal function showing diuretic resistance to a daily dose of furosemide of at least 250 mg."	9.08	Combination of high-dose furosemide and hydrochlorothiazide in the treatment of refractory congestive heart failure. ( Dormans, TP; Gerlag, PG, 1996)
"The non-sulfhydryl selective angiotensin-converting enzyme inhibitor benazepril (20 mg daily) was compared with hydrochlorothiazide (50 mg daily) in post-infarction (6-24 months) patients with symptomatic (NYHA functional class 2) mild heart failure."	9.07	A 3-month double-blind cross-over study of the effect of benazepril and hydrochlorothiazide on functional class in symptomatic mild heart failure. ( Nordrehaug, JE; Omsjø, IH; Vollset, SE, 1992)
"Because of conflicting results from studies examining the initial treatment of patients with chronic left heart failure (CHF) and sinus rhythm, the clinical efficacy and safety of digoxin and a diuretic were compared in a multicenter, randomised, open twelve-week study."	9.07	[Comparison of the clinical effect between digoxin and a diuretic in chronic left heart failure and sinus rhythm]. ( Schüren, KP; Vöhringer, HF, 1993)
"Supplementation of potassium alone and in combination with magnesium was compared in 10 patients with chronic compensated heart failure receiving hydrochlorothiazide 50 mg twice daily for the whole trial."	9.06	Comparison of potassium alone and potassium-magnesium supplementation in patients with heart failure using hydrochlorothiazide. ( Gordin, A; Kohvakka, A; Luurila, O; Sundberg, S, 1989)
"In a randomized single-blind cross-over trial, the efficacy of digoxin, angiotensin-converting enzyme (ACE) inhibition by quinapril, and their combination on exercise tolerance, heart size (echocardiography), and neurohumoral systems was investigated in 19 outpatients with congestive heart failure (CHF) New York Heart Association functional class II and sinus rhythm."	9.06	Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm. ( Elsner, D; Kromer, EP; Riegger, GA, 1990)
"This multicentre, double-blind, double-dummy, randomised parallel group study in 247 patients with mild chronic congestive heart failure compared the efficacy and tolerability of ibopamine, hydrochlorothiazide (HCTZ), ibopamine plus HCTZ and placebo during an 8-week treatment period."	9.06	Treatment of mild chronic congestive heart failure with ibopamine, hydrochlorothiazide, ibopamine plus hydrochlorothiazide or placebo. A double-blind comparative study. ( Kleber, FX; Thyroff-Friesinger, U, 1990)
"In a randomized and double-blind study of 116 patients with chronic heart failure (NYHA classes II or III) the effectiveness of captopril + hydrochlorothiazide (HCT) (group 1) and of digoxin + HCT (group 2) were compared."	9.06	[Captopril versus digoxin in the treatment of mild to moderately severe heart failure]. ( Esser, H; Heck, I; Lüderitz, B; Müller, HM, 1989)
"The fixed combination of hydrochlorothiazide 25 mg and triamterene 50 mg and the free combination of furosemide 40 mg and triamterene 50 mg were compared as maintenance treatment in patients who were in a stable condition after an episode of congestive heart failure."	9.06	Cross-over comparison of the fixed combination of hydrochlorothiazide and triamterene and the free combination of furosemide and triamterene in the maintenance treatment of congestive heart failure. ( Fintelman, H; Funke Küpper, AJ; Huige, MC; Koolen, JJ; Liem, KL; Lustermans, FA, 1986)
"The effects of piretanide and a hydrochlorothiazide (HCT)-triamterene combination were compared in an open, controlled, randomised study on two groups of 15 patients, aged 42-74 years, with congestive heart failure (NYHA II-III)."	9.05	[Diuretic monotherapy in heart failure. Comparison of piretanide and hydrochlorothiazide-triamterene]. ( Gonska, BD; Kreuzer, H, 1985)
"14 patients with congestive heart failure requiring diuretic therapy were randomly assigned to treatment with ticrynafen (TCRN) 250 mg or hydrochlorothiazide (HCTZ) 50 mg once or twice daily."	9.04	Renal function during therapy in patients with congestive cardiac failure. Ticrynafen vs. hydrochlorothiazide. ( Clements, P; Smith, JW, 1979)
"Multiclinic controlled studies have shown that enalapril alone 10 to 40 mg/day orally is effective in lowering blood pressure in patients with essential hypertension."	8.77	Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety. ( Davies, RO; Moncloa, F; Sromovsky, JA; Walker, JF, 1985)
"High doses of furosemide and spironolactone, or concomitant use of these diuretics, seem to be an important cause of hyponatremia in HF patients, particularly in combination with advanced age, diabetes and alcohol consumption."	7.96	Furosemide and spironolactone doses and hyponatremia in patients with heart failure. ( Bušić, Ž; Čulić, V; Jurić Paić, M; Velat, I, 2020)
"Our previous study indicates that hydrochlorothiazide inhibits transforming growth factor (TGF)-β/Smad signaling pathway, improves cardiac function and reduces fibrosis."	7.85	Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. ( Chen, X; Gao, X; Lu, G; Luo, C; Luo, J; Peng, L; Zuo, Z, 2017)
"Eighty-two patients hospitalized for heart failure between September 1, 2009, and August 31, 2011, who were receiving background intravenous furosemide therapy (total daily dose ≥ 160 mg); of those patients, 28 patients also received oral hydrochlorothiazide (median dose 25 mg [interquartile range 25-50 mg]), and 54 patients also received intravenous chlorothiazide (median dose 500 mg [interquartile range 250-750 mg])."	7.80	Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014)
"In a study conducted on 82 patients with a history of heart failure and hypertension who had been treated with an ARB but failed to reach the target blood pressure, ongoing oral ARB treatment was switched to a drug combination of losartan and hydrochlorothiazide (HCTZ)."	7.80	Effects of a combination of losartan and hydrochlorothiazide in patients with hypertension and a history of heart failure. ( Aizawa, T; Amino, M; Deguchi, Y; Ikari, Y; Kanda, S; Tanabe, T; Yoshioka, K, 2014)
"The EXCITE (clinical EXperienCe of amlodIpine and valsarTan in hypErtension) study was designed to evaluate the effectiveness, tolerability and adherence of amlodipine/valsartan (Aml/Val) and amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCT) single-pill combination therapies in patients with hypertension from the Middle East and Asia studied in routine clinical practice."	7.80	Real-world clinical experience of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide in hypertension: the EXCITE study. ( Assaad-Khalil, SH; Cho, B; Kitchlew, AR; Knap, D; Najem, R; Shete, A; Sison, J; Ueng, KC, 2014)
"The efficacy of flosequinan 100 mg once daily was evaluated in 15 patients with severe congestive heart failure (New York Heart Association [NYHA] class II-IV) who had not responded adequately to digoxin and diuretics."	7.68	A non-invasive evaluation of flosequinan on haemodynamics and exercise capacity in chronic congestive heart failure. ( Feinberg, MS; Freimark, D; King, C; Motro, M; Schneeweiss, A; Wynne, RD, 1993)
"Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice."	7.66	Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983)
" Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure."	7.66	Pharmacokinetics of hydrochlorothiazide in patients with congestive heart failure. ( Beermann, B; Groschinsky-Grind, M, 1979)
"Metabolic balance studies were carried out on five patients with resistant heart failure treated with spironolactone and other diuretics."	7.64	Metabolic studies on patients with resistant heart failure treated by spironolactone. ( BAYLEY, TA; FORBATH, PG; HIGGINS, HP; WILSON, JK, 1962)
" Serum uric acid levels may rise slightly, but no clinical gout was seen in this study."	7.64	TREATMENT OF CONGESTIVE HEART FAILURE WITH TRIAMTERENE. ( FRIEDMAN, R; SCHUCHER, R; WENER, J, 1965)
"Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years."	7.64	CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964)
"Arterial hypertension is an independent risk factor for cardiovascular diseases and one of the major causes for mortality worldwide."	6.45	Rational of the use of aliskiren in hypertension and beyond. ( Savvatis, K; Schultheiss, HP; Tschöpe, C; Westermann, D, 2009)
"Felodipine, a dihydropyridine calcium-channel antagonist, significantly reduces systolic and diastolic blood pressure (BP) in patients with hypertension and has been associated with beneficial hemodynamic effects in patients with chronic stable angina pectoris or congestive heart failure (CHF)."	6.16	Felodipine: a new dihydropyridine calcium-channel antagonist. ( Lopez, LM; Yedinak, KC, 1991)
"To evaluate whether the addition of hydrochlorothiazide (HCTZ) to intravenous furosemide is a safe and effective strategy for improving diuretic response in acute heart failure (AHF)."	5.69	Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. ( Carrera-Izquierdo, M; Casado, J; Cerqueiro, JM; Conde-Martel, A; Dávila-Ramos, MF; Formiga, F; Gil, P; Llácer, P; Manzano, L; Morales-Rull, JL; Pérez-Silvestre, J; Plasín, MÁ; Salamanca-Bautista, P; Sánchez-Marteles, M; Trullàs, JC, 2023)
"Due to the potential benefits of triamterene in diuretic resistance, this study was performed to assess whether triamterene add-on to the standard treatment of heart failure (HF)-related diuretic resistance improves outcomes."	5.69	Effects of Triamterene in Hospitalized Patients with Heart Failure and Diuretic Resistance: A Randomized Clinical Trial. ( Enamzadeh, E; Entezari-Maleki, T; Khani, E; Khezripour, K; Safaei, N; Taban-Sadeghi, M, 2023)
"Heart failure is a major cause of morbidity and mortality worldwide."	5.37	Effects of hydrochlorothiazide on cardiac remodeling in a rat model of myocardial infarction-induced congestive heart failure. ( Dai, G; Gao, X; Luo, J; Peng, L; Sun, H, 2011)
"Refractory congestive heart failure (CHF) with diuretic resistance is life-threatening and predicts a short life expectancy."	5.34	Potent diuretic effects of prednisone in heart failure patients with refractory diuretic resistance. ( Ji, Z; Liu, C; Liu, G; Liu, K; Zhen, Y; Zhou, C, 2007)
"The aim of this study was to investigate the influences of Simvastatin (Zocor) on nitric oxide (NO), calcitonin gene related peptide (CGRP) and endothelin (ET) in blood plasma of patients with coronary heart disease (CHD) complicated with congestive heart failure (CHF)."	5.17	Influences of simvastatin on vascular endothelial function of patients with coronary heart disease complicated with congestive heart failure. ( Shi, J; Wang, L; Zhang, Y, 2013)
"Hydrochlorothiazide (HCTZ) is a thiazide diuretic used for the treatment of hypertension and edema associated with fluid overload conditions such as congestive heart failure (CHF)."	5.17	Population-based meta-analysis of hydrochlorothiazide pharmacokinetics. ( Mager, DE; Mallikaarjun, S; Shoaf, SE; Van Wart, SA, 2013)
"We studied the synergism between high-dose furosemide and hydrochlorothiazide in patients with severe congestive heart failure and impaired renal function showing diuretic resistance to a daily dose of furosemide of at least 250 mg."	5.08	Combination of high-dose furosemide and hydrochlorothiazide in the treatment of refractory congestive heart failure. ( Dormans, TP; Gerlag, PG, 1996)
"Because of conflicting results from studies examining the initial treatment of patients with chronic left heart failure (CHF) and sinus rhythm, the clinical efficacy and safety of digoxin and a diuretic were compared in a multicenter, randomised, open twelve-week study."	5.07	[Comparison of the clinical effect between digoxin and a diuretic in chronic left heart failure and sinus rhythm]. ( Schüren, KP; Vöhringer, HF, 1993)
"The non-sulfhydryl selective angiotensin-converting enzyme inhibitor benazepril (20 mg daily) was compared with hydrochlorothiazide (50 mg daily) in post-infarction (6-24 months) patients with symptomatic (NYHA functional class 2) mild heart failure."	5.07	A 3-month double-blind cross-over study of the effect of benazepril and hydrochlorothiazide on functional class in symptomatic mild heart failure. ( Nordrehaug, JE; Omsjø, IH; Vollset, SE, 1992)
"In a randomized single-blind cross-over trial, the efficacy of digoxin, angiotensin-converting enzyme (ACE) inhibition by quinapril, and their combination on exercise tolerance, heart size (echocardiography), and neurohumoral systems was investigated in 19 outpatients with congestive heart failure (CHF) New York Heart Association functional class II and sinus rhythm."	5.06	Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm. ( Elsner, D; Kromer, EP; Riegger, GA, 1990)
"This multicentre, double-blind, double-dummy, randomised parallel group study in 247 patients with mild chronic congestive heart failure compared the efficacy and tolerability of ibopamine, hydrochlorothiazide (HCTZ), ibopamine plus HCTZ and placebo during an 8-week treatment period."	5.06	Treatment of mild chronic congestive heart failure with ibopamine, hydrochlorothiazide, ibopamine plus hydrochlorothiazide or placebo. A double-blind comparative study. ( Kleber, FX; Thyroff-Friesinger, U, 1990)
"In a randomized and double-blind study of 116 patients with chronic heart failure (NYHA classes II or III) the effectiveness of captopril + hydrochlorothiazide (HCT) (group 1) and of digoxin + HCT (group 2) were compared."	5.06	[Captopril versus digoxin in the treatment of mild to moderately severe heart failure]. ( Esser, H; Heck, I; Lüderitz, B; Müller, HM, 1989)
"Supplementation of potassium alone and in combination with magnesium was compared in 10 patients with chronic compensated heart failure receiving hydrochlorothiazide 50 mg twice daily for the whole trial."	5.06	Comparison of potassium alone and potassium-magnesium supplementation in patients with heart failure using hydrochlorothiazide. ( Gordin, A; Kohvakka, A; Luurila, O; Sundberg, S, 1989)
"Sixteen patients in heart failure and sinus rhythm were, after a four-week treatment-free period, randomly assigned to receive, for four to six weeks, either a diuretic combination (hydrochlorothiazide + triamterene) or a digitalis glycoside."	5.06	[Basic therapy of chronic heart failure with digitalis or diuretics?]. ( Bussmann, WD; Hopf, R; Kaltenbach, M; Offermann, T; Sievert, H, 1989)
"To study the effect of a combination of amiloride, 5 mg, and hydrochlorothiazide, 50 mg (Moduretic), on plasma and skeletal muscle electrolytes in patients on long-term diuretic therapy (greater than 1 year) for arterial hypertension and/or congestive heart failure, 58 patients were recruited."	5.06	Amiloride prevents thiazide-induced intracellular potassium and magnesium losses. ( Dyckner, T; Wester, PO; Widman, L, 1988)
"The fixed combination of hydrochlorothiazide 25 mg and triamterene 50 mg and the free combination of furosemide 40 mg and triamterene 50 mg were compared as maintenance treatment in patients who were in a stable condition after an episode of congestive heart failure."	5.06	Cross-over comparison of the fixed combination of hydrochlorothiazide and triamterene and the free combination of furosemide and triamterene in the maintenance treatment of congestive heart failure. ( Fintelman, H; Funke Küpper, AJ; Huige, MC; Koolen, JJ; Liem, KL; Lustermans, FA, 1986)
" In controlled trials, 2249 subjects, who included normal volunteers and patients with hypertension and congestive heart failure, have received enalapril alone or concomitantly with hydrochlorothiazide or other antihypertensive agents."	5.05	Overall tolerance and safety of enalapril. ( Kulaga, SF; McFate Smith, W; Moncloa, F; Pingeon, R; Walker, JF, 1984)
"The effects of piretanide and a hydrochlorothiazide (HCT)-triamterene combination were compared in an open, controlled, randomised study on two groups of 15 patients, aged 42-74 years, with congestive heart failure (NYHA II-III)."	5.05	[Diuretic monotherapy in heart failure. Comparison of piretanide and hydrochlorothiazide-triamterene]. ( Gonska, BD; Kreuzer, H, 1985)
"The efficacy and tolerability of two combinations, namely 50 mg spironolactone + 20 mg furosemide (SF) or 50 mg spironolactone + 5 mg butizide (SB), were compared in a randomised intraindividual trial in 22 patients with congestive heart failure."	5.05	[Comparative study of 2 diuretic-containing combination preparations in patients with edematous heart failure]. ( Ehrlich, E; Mauersberger, H; Rangoonwala, B, 1985)
"14 patients with congestive heart failure requiring diuretic therapy were randomly assigned to treatment with ticrynafen (TCRN) 250 mg or hydrochlorothiazide (HCTZ) 50 mg once or twice daily."	5.04	Renal function during therapy in patients with congestive cardiac failure. Ticrynafen vs. hydrochlorothiazide. ( Clements, P; Smith, JW, 1979)
"526 patients with essential hypertension or congestive cardiac failure were treated with ticrynafen (250--500 mg/day) or hydrochlorothiazide (50--100 mg/day) for 6 weeks to 6 months."	5.04	Renal function during ticrynafen therapy. ( Beg, MA; Donikian, MA; Ragland, R; Ziv, DS; Zuccarello, W, 1979)
" These initial studies demonstrate that tienilic acid is safe and effective in the treatment of mild to moderate essential hypertension, salt and water retention states, including oedema associated with congestive cardiac failure or mild to moderate renal dysfunction, and in the management of elevated serum uric acid levels associated with gout."	5.04	Safety of tienilic acid. ( Beg, MA; Ragland, R, 1979)
"Multiclinic controlled studies have shown that enalapril alone 10 to 40 mg/day orally is effective in lowering blood pressure in patients with essential hypertension."	4.77	Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety. ( Davies, RO; Moncloa, F; Sromovsky, JA; Walker, JF, 1985)
" Alcohol consumption, female sex, n-terminal pro-brain natriuretic peptide (NT-proBNP), hydrochlorothiazide (HCT), and mineralocorticoid receptor antagonist (MRA) use, or angiotensin II receptor I blocker (ARB) non-use were associated with hyponatremia in patients with normal renal function (p ≤ 0."	4.12	Clinical predictors of hyponatremia in patients with heart failure according to severity of chronic kidney disease. ( Bušić, Ž; Čulić, V; Velat, I, 2022)
"High doses of furosemide and spironolactone, or concomitant use of these diuretics, seem to be an important cause of hyponatremia in HF patients, particularly in combination with advanced age, diabetes and alcohol consumption."	3.96	Furosemide and spironolactone doses and hyponatremia in patients with heart failure. ( Bušić, Ž; Čulić, V; Jurić Paić, M; Velat, I, 2020)
"Our previous study indicates that hydrochlorothiazide inhibits transforming growth factor (TGF)-β/Smad signaling pathway, improves cardiac function and reduces fibrosis."	3.85	Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. ( Chen, X; Gao, X; Lu, G; Luo, C; Luo, J; Peng, L; Zuo, Z, 2017)
"The EXCITE (clinical EXperienCe of amlodIpine and valsarTan in hypErtension) study was designed to evaluate the effectiveness, tolerability and adherence of amlodipine/valsartan (Aml/Val) and amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCT) single-pill combination therapies in patients with hypertension from the Middle East and Asia studied in routine clinical practice."	3.80	Real-world clinical experience of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide in hypertension: the EXCITE study. ( Assaad-Khalil, SH; Cho, B; Kitchlew, AR; Knap, D; Najem, R; Shete, A; Sison, J; Ueng, KC, 2014)
"In a study conducted on 82 patients with a history of heart failure and hypertension who had been treated with an ARB but failed to reach the target blood pressure, ongoing oral ARB treatment was switched to a drug combination of losartan and hydrochlorothiazide (HCTZ)."	3.80	Effects of a combination of losartan and hydrochlorothiazide in patients with hypertension and a history of heart failure. ( Aizawa, T; Amino, M; Deguchi, Y; Ikari, Y; Kanda, S; Tanabe, T; Yoshioka, K, 2014)
"Eighty-two patients hospitalized for heart failure between September 1, 2009, and August 31, 2011, who were receiving background intravenous furosemide therapy (total daily dose ≥ 160 mg); of those patients, 28 patients also received oral hydrochlorothiazide (median dose 25 mg [interquartile range 25-50 mg]), and 54 patients also received intravenous chlorothiazide (median dose 500 mg [interquartile range 250-750 mg])."	3.80	Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014)
"There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management."	3.77	Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. ( Bleske, BE; Dorsch, MP; Erickson, SR; Gillespie, BW; Weder, AB, 2011)
" To control hypertension and chronic heart failure he had been treated with 5 mg ramipril and 12."	3.73	[A patient with severe hyperkalaemia -- an emergency after RALES]. ( Daul, A; Nürnberger, J; Philipp, T, 2005)
"The efficacy of flosequinan 100 mg once daily was evaluated in 15 patients with severe congestive heart failure (New York Heart Association [NYHA] class II-IV) who had not responded adequately to digoxin and diuretics."	3.68	A non-invasive evaluation of flosequinan on haemodynamics and exercise capacity in chronic congestive heart failure. ( Feinberg, MS; Freimark, D; King, C; Motro, M; Schneeweiss, A; Wynne, RD, 1993)
"Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice."	3.66	Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983)
" Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure."	3.66	Pharmacokinetics of hydrochlorothiazide in patients with congestive heart failure. ( Beermann, B; Groschinsky-Grind, M, 1979)
" Serum uric acid levels may rise slightly, but no clinical gout was seen in this study."	3.64	TREATMENT OF CONGESTIVE HEART FAILURE WITH TRIAMTERENE. ( FRIEDMAN, R; SCHUCHER, R; WENER, J, 1965)
"Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years."	3.64	CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964)
"Metabolic balance studies were carried out on five patients with resistant heart failure treated with spironolactone and other diuretics."	3.64	Metabolic studies on patients with resistant heart failure treated by spironolactone. ( BAYLEY, TA; FORBATH, PG; HIGGINS, HP; WILSON, JK, 1962)
"CLOROTIC is the first large-scale trial to evaluate whether the addition of a thiazide diuretic (hydrochlorothiazide) to a loop diuretic (furosemide) is a safe and effective strategy for improving congestive symptoms resulting from HF."	2.82	Rationale and Design of the "Safety and Efficacy of the Combination of Loop with Thiazide-type Diuretics in Patients with Decompensated Heart Failure (CLOROTIC) Trial:" A Double-Blind, Randomized, Placebo-Controlled Study to Determine the Effect of Combin ( Casado, J; Formiga, F; Freitas Ramírez, A; Manzano, L; Morales-Rull, JL; Trullàs, JC, 2016)
"Hypertension is associated with an increased risk of diastolic dysfunction."	2.77	Adding thiazide to a renin-angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension. ( Fukuda, S; Ishii, K; Ito, H; Iwakura, K; Kasayuki, N; Kihara, H; Nakamura, F; Shimada, K; Yoshikawa, J, 2012)
"This study was performed to compare the effect of one month's treatment with hydrochlorothiazide (25 mg) in combination with either amiloride (2."	2.67	A study of plasma sodium levels in elderly people taking amiloride or triamterene in combination with hydrochlorothiazide. ( Bielawska, CA; Fidler, HM; Goldman, J; Hoffbrand, BI; Rai, GS, 1993)
"In the long-term therapy of congestive heart failure hydrochlorothiazide together with potassium-sparing amiloride is a pleasant and effective therapy for patients with normal renal function, but the risk of hypokalaemia must be kept in mind also when using this combination."	2.65	The effect of amiloride/hydrochlorothiazide combination vs furosemide plus potassium supplementation in the treatment of oedema of cardiac origin. ( Huikko, M; Varjoranta, K; Viherkoski, M, 1981)
"Ten patients with congestive heart failure, on full digitalis treatment, were given TA (dose range 250-1000 mg/die): in each patient a prompt diuretic effect was observed, associated to a significant reduction of body weight and to a marked improvement of the clinical signs of heart failure."	2.65	[Tienilic acid in the treatment of arterial hypertension and congestive cardiac insufficiency]. ( Agabiti-Rosei, E; Alicandri, C; Corea, L; Fariello, R; Muiesan, G; Oldoni, T, 1979)
"Arterial hypertension is an independent risk factor for cardiovascular diseases and one of the major causes for mortality worldwide."	2.45	Rational of the use of aliskiren in hypertension and beyond. ( Savvatis, K; Schultheiss, HP; Tschöpe, C; Westermann, D, 2009)
"Valsartan is a nonpeptide angiotensin receptor antagonist that selectively blocks the binding of angiotensin II to the angiotensin II type 1 receptor."	2.45	Valsartan: more than a decade of experience. ( Bailey, J; Black, HR; Samuel, R; Zappe, D, 2009)
"Hyperlipidemia is a widely acknowledged side effect of thiazide diuretic therapy, but it is often dismissed as a short-term effect of high-dose therapy."	2.40	Hyperlipidemia of diuretic therapy. ( Ames, R, 1998)
" On the fourth day of once-daily dosing with hydrochlorothiazide 25 mg, 24-hour natriuresis and chloriuresis are no longer augmented, but the elevation in 24-hour kaliuresis that follows the first dose remains unchanged."	2.38	Renal excretory responses to single and repeated administration of diuretics in healthy subjects: clinical connotations. ( Leary, WP; Reyes, AJ, 1993)
"Enalapril maleate is a prodrug which when administered orally is hydrolysed to release the active converting enzyme inhibitor enalaprilat."	2.37	An overview of the clinical pharmacology of enalapril. ( Davies, RO; Gomez, HJ; Irvin, JD; Walker, JF, 1984)
"Heart failure is a major cause of morbidity and mortality worldwide."	1.37	Effects of hydrochlorothiazide on cardiac remodeling in a rat model of myocardial infarction-induced congestive heart failure. ( Dai, G; Gao, X; Luo, J; Peng, L; Sun, H, 2011)
"Refractory congestive heart failure (CHF) with diuretic resistance is life-threatening and predicts a short life expectancy."	1.34	Potent diuretic effects of prednisone in heart failure patients with refractory diuretic resistance. ( Ji, Z; Liu, C; Liu, G; Liu, K; Zhen, Y; Zhou, C, 2007)
"Treatment with triamterene (100 mg/d; n = 10) over a period of 3 weeks led to an increase of serum potassium (from 4."	1.26	[Serum and total body potassium during treatment with chlortalidone and hydrochlorothiazide. Influence of triamterene (author's transl)]. ( Kaltenbach, M; Kober, G; Schäfer, GE; Werner, E, 1977)
"In 50 patients with congestive heart failure a compound diuretic drug aldactone--saltucine was used."	1.25	[Use of aldactone-saltucine for patients with chronic circulatory insufficiency]. ( Evsikov, EM; Kharchenko, VI; Savenkov, PM; Sidorenko, BA, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	156 (77.23)	18.7374
1990's	17 (8.42)	18.2507
2000's	8 (3.96)	29.6817
2010's	13 (6.44)	24.3611
2020's	8 (3.96)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Safety and Efficacy of the Combination of Loop Diuretics With Thiazide-type Diuretics in Patients With Decompensated Heart Failure: a Double-blind, Randomized, Placebo-controlled Trial (CLOROTIC Trial).[NCT01647932]	Phase 3	232 participants (Actual)	Interventional	2014-10-31	Completed
Stroke Prediction Study Using a Model Based on Internet Search Queries[NCT04755959]		450 participants (Anticipated)	Observational	2021-02-28	Not yet recruiting
Long-term Prednisone Use in Patients With Advanced Heart Failure (ACCF/AHA Stage D) and Hyperuricemia[NCT02282683]	Phase 2/Phase 3	90 participants (Anticipated)	Interventional	2013-12-31	Recruiting
Effect of Short-Term Prednisone Therapy on C-reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers[NCT05916586]		120 participants (Anticipated)	Interventional	2023-08-11	Recruiting
Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT)[NCT02832973]	Phase 4	72 participants (Actual)	Interventional	2015-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Diuretics in pediatrics. European journal of pediatrics, 2023, Volume: 182, Issue:5 Topics: Adult; Child; Diuretics; Heart Failure; Humans; Hydrochlorothiazide; Sodium; Sodium Potassium Chlori	2023
Valsartan: more than a decade of experience. Drugs, 2009, Volume: 69, Issue:17 Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihyperte	2009
Rational of the use of aliskiren in hypertension and beyond. Minerva cardioangiologica, 2009, Volume: 57, Issue:6 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl C	2009
An overview of the clinical pharmacology of enalapril. British journal of clinical pharmacology, 1984, Volume: 18 Suppl 2 Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Di	1984
Renal excretory responses to single and repeated administration of diuretics in healthy subjects: clinical connotations. Cardiovascular drugs and therapy, 1993, Volume: 7 Suppl 1 Topics: Calcium; Chlorides; Diuretics; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Natriuresis	1993
Hyperlipidemia of diuretic therapy. Archives des maladies du coeur et des vaisseaux, 1998, Volume: 91 Suppl Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cere	1998
Hydrochlorothiazide-induced relapsing fever. Israel journal of medical sciences, 1992, Volume: 28, Issue:12 Topics: Adverse Drug Reaction Reporting Systems; Aged; Cell Migration Inhibition; Female; Heart Failure; Hum	1992
Felodipine: a new dihydropyridine calcium-channel antagonist. DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:11 Topics: Angina Pectoris; Animals; Blood Pressure; Double-Blind Method; Felodipine; Heart Failure; Humans; Hy	1991
Enalapril in hypertension and congestive heart failure. Overall review of efficacy and safety. Drugs, 1985, Volume: 30 Suppl 1 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Enalapril; Female	1985
Effectiveness of drug therapy in hypertension: present status. A review. Circulation research, 1971, Volume: 28, Issue:5 Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block	1971

Article	Year
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. European heart journal, 2023, 02-01, Volume: 44, Issue:5 Topics: Diuretics; Dyspnea; Female; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Pro	2023
Effects of Triamterene in Hospitalized Patients with Heart Failure and Diuretic Resistance: A Randomized Clinical Trial. Journal of clinical pharmacology, 2023, Volume: 63, Issue:12 Topics: Diuretics; Heart Failure; Humans; Hydrochlorothiazide; Potassium; Triamterene	2023
Effect of adding hydrochlorothiazide to usual treatment of patients with acute decompensated heart failure: a randomized clinical trial. Scientific reports, 2021, 08-13, Volume: 11, Issue:1 Topics: Creatinine; Diuretics; Double-Blind Method; Female; Furosemide; Heart Failure; Humans; Hydrochloroth	2021
Influences of simvastatin on vascular endothelial function of patients with coronary heart disease complicated with congestive heart failure. European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:12 Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Coronary Disease; Digoxin; Drug Therapy, Combination;	2013
Population-based meta-analysis of hydrochlorothiazide pharmacokinetics. Biopharmaceutics & drug disposition, 2013, Volume: 34, Issue:9 Topics: Adult; Antihypertensive Agents; Benzazepines; Diuretics; Heart Failure; Humans; Hydrochlorothiazide;	2013
Rationale and Design of the "Safety and Efficacy of the Combination of Loop with Thiazide-type Diuretics in Patients with Decompensated Heart Failure (CLOROTIC) Trial:" A Double-Blind, Randomized, Placebo-Controlled Study to Determine the Effect of Combin Journal of cardiac failure, 2016, Volume: 22, Issue:7 Topics: Chronic Disease; Diuretics; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Furosemi	2016
Adding thiazide to a renin-angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzy	2012
Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial. Journal of hypertension, 2004, Volume: 22, Issue:4 Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus; Dihydrop	2004
[A clinical study on manshuailing oral liquid in treating elder patients with congestive heart failure of type heart and kidney yang deficiency]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2003, Volume: 28, Issue:11 Topics: Administration, Oral; Adult; Aged; Cardiotonic Agents; Combined Modality Therapy; Diagnosis, Differe	2003
The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects. European journal of clinical pharmacology, 2006, Volume: 62, Issue:11 Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting	2006
Overall tolerance and safety of enalapril. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1984, Volume: 2, Issue:2 Topics: Captopril; Clinical Trials as Topic; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Com	1984
[Treatment of cardiac failure with diuretics. A double-blind study comparing a fixed combination of hydrochlorothiazide/amiloride and furosemide plus potassium substitution]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1983, May-20, Volume: 103, Issue:14 Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fu	1983
The effect of amiloride/hydrochlorothiazide combination vs furosemide plus potassium supplementation in the treatment of oedema of cardiac origin. Annals of clinical research, 1981, Volume: 13, Issue:1 Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Edema, Car	1981
[Moduretic in the treatment of cardiac failure]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1981, Jun-10, Volume: 101, Issue:16 Topics: Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Female; Follow-Up Studies; Heart Failu	1981
[Current state of the treatment of arterial hypertension]. Cardiology, 1980, Volume: 66 Suppl 2 Topics: Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Heart Failure; Humans; Hydralazine	1980
[Clinical aspects and therapy of hydropic heart insufficiency. Results of a multicenter field study]. Fortschritte der Medizin, 1981, Dec-03, Volume: 99, Issue:45 Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Edema, Cardiac;	1981
Reduction of exercise-induced ventricular arrhythmias in mild symptomatic heart failure by benazepril. American heart journal, 1993, Volume: 125, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Cardiac Complexes, Premature; Double-Blind M	1993
A study of plasma sodium levels in elderly people taking amiloride or triamterene in combination with hydrochlorothiazide. Postgraduate medical journal, 1993, Volume: 69, Issue:816 Topics: Aged; Aged, 80 and over; Amiloride; Drug Therapy, Combination; Female; Heart Failure; Humans; Hydroc	1993
[Comparison of the clinical effect between digoxin and a diuretic in chronic left heart failure and sinus rhythm]. Medizinische Klinik (Munich, Germany : 1983), 1993, Jul-15, Volume: 88, Issue:7 Topics: Aged; Digoxin; Drug Therapy, Combination; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; H	1993
Combination of high-dose furosemide and hydrochlorothiazide in the treatment of refractory congestive heart failure. European heart journal, 1996, Volume: 17, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Diuretics; Dose-Response Relationship, Drug; Drug S	1996
The efficacy and safety of furosemide and a combination of spironolactone and hydrochlorothiazide in congestive heart failure. Journal of clinical pharmacology, 1977, Volume: 17, Issue:7 Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug Evaluation; Elec	1977
Renal function during therapy in patients with congestive cardiac failure. Ticrynafen vs. hydrochlorothiazide. Nephron, 1979, Volume: 23 Suppl 1 Topics: Clinical Trials as Topic; Diuretics; Female; Heart Failure; Humans; Hydrochlorothiazide; Male; Middl	1979
Renal function during ticrynafen therapy. Nephron, 1979, Volume: 23 Suppl 1 Topics: Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Heart Failure; Humans; Hydrochlorothia	1979
Safety of tienilic acid. Postgraduate medical journal, 1979, Volume: 55 Suppl 3 Topics: Clinical Trials as Topic; Glycolates; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Kidn	1979
Tienilic acid, a uricosuric diuretic, in the treatment of heart failure. Postgraduate medical journal, 1979, Volume: 55 Suppl 3 Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Glycolates; Heart Failure; Human	1979
[Tienilic acid in the treatment of arterial hypertension and congestive cardiac insufficiency]. Giornale italiano di cardiologia, 1979, Volume: 9, Issue:12 Topics: Adult; Aged; Diuresis; Drug Evaluation; Female; Glycolates; Heart Failure; Humans; Hydrochlorothiazi	1979
[Potassium-saving saluretic treatment of hypertension and edematous heart decompensation with Moduretik]. ZFA. Zeitschrift fur Allgemeinmedizin, 1976, Jun-30, Volume: 52, Issue:18 Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Edema, Cardiac; Female; Heart F	1976
[Effect of combined treatment with hydrochlorothiazide and amiloride on serum and urinary potassium]. Harefuah, 1975, Nov-02, Volume: 89, Issue:9 Topics: Amiloride; Clinical Trials as Topic; Drug Therapy, Combination; Heart Failure; Humans; Hydrochloroth	1975
Triamterene may preserve lymphocyte magnesium and potassium in patients with congestive heart failure. Magnesium research, 1992, Volume: 5, Issue:1 Topics: Aged; Aged, 80 and over; Digoxin; Double-Blind Method; Drug Therapy, Combination; Erythrocytes; Furo	1992
A 3-month double-blind cross-over study of the effect of benazepril and hydrochlorothiazide on functional class in symptomatic mild heart failure. Journal of internal medicine, 1992, Volume: 231, Issue:6 Topics: Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Blood Pressure; Double-Blind Method; Female;	1992
Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:1 Topics: Adult; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Arrhythmias, Cardiac; Digoxin; Drug Th	1990
Felodipine: a new dihydropyridine calcium-channel antagonist. DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:11 Topics: Angina Pectoris; Animals; Blood Pressure; Double-Blind Method; Felodipine; Heart Failure; Humans; Hy	1991
[Ibopamine in treatment of mild heart failure, a comparison with hydrochlorothiazide]. Zeitschrift fur Kardiologie, 1991, Volume: 80 Suppl 8 Topics: Aged; Cardiotonic Agents; Deoxyepinephrine; Double-Blind Method; Drug Therapy, Combination; Female;	1991
Treatment of mild chronic congestive heart failure with ibopamine, hydrochlorothiazide, ibopamine plus hydrochlorothiazide or placebo. A double-blind comparative study. Cardiology, 1990, Volume: 77 Suppl 5 Topics: Adult; Aged; Aged, 80 and over; Cardiotonic Agents; Deoxyepinephrine; Double-Blind Method; Female; H	1990
Ibopamine versus hydrochlorothiazide/amiloride in patients with mild congestive heart failure. SK & F Ibopamine Working Group. Cardiovascular drugs and therapy, 1989, Volume: 3, Issue:6 Topics: Amiloride; Body Weight; Cardiotonic Agents; Deoxyepinephrine; Double-Blind Method; Drug Combinations	1989
[Captopril versus digoxin in the treatment of mild to moderately severe heart failure]. Deutsche medizinische Wochenschrift (1946), 1989, May-05, Volume: 114, Issue:18 Topics: Blood Pressure; Captopril; Chronic Disease; Clinical Trials as Topic; Digoxin; Double-Blind Method;	1989
Comparison of potassium alone and potassium-magnesium supplementation in patients with heart failure using hydrochlorothiazide. Magnesium, 1989, Volume: 8, Issue:2 Topics: Aged; Blood Pressure; Body Weight; Double-Blind Method; Female; Heart Failure; Heart Rate; Humans; H	1989
[Basic therapy of chronic heart failure with digitalis or diuretics?]. Deutsche medizinische Wochenschrift (1946), 1989, Mar-10, Volume: 114, Issue:10 Topics: Aged; Chronic Disease; Digitalis Glycosides; Digitoxin; Digoxin; Drug Combinations; Drug Evaluation;	1989
Amiloride prevents thiazide-induced intracellular potassium and magnesium losses. Acta medica Scandinavica, 1988, Volume: 224, Issue:1 Topics: Aged; Amiloride; Blood Pressure; Body Water; Body Weight; Drug Combinations; Female; Heart Failure;	1988
A single-blind, comparative study of hydrochlorothiazide/amiloride ('Moduret' 25) and hydrochlorothiazide/triamterene ('dyazide') in elderly patients with congestive heart failure. Current medical research and opinion, 1987, Volume: 10, Issue:9 Topics: Aged; Aged, 80 and over; Amiloride; Antihypertensive Agents; Body Weight; Drug Combinations; Female;	1987
Cross-over comparison of the fixed combination of hydrochlorothiazide and triamterene and the free combination of furosemide and triamterene in the maintenance treatment of congestive heart failure. European journal of clinical pharmacology, 1986, Volume: 30, Issue:3 Topics: Adult; Aged; Drug Therapy, Combination; Heart Failure; Humans; Hydrochlorothiazide; Middle Aged; Ran	1986
[Diuretic monotherapy in heart failure. Comparison of piretanide and hydrochlorothiazide-triamterene]. Deutsche medizinische Wochenschrift (1946), 1985, Nov-22, Volume: 110, Issue:47 Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Drug Combinations; Female	1985
[Comparative study of 2 diuretic-containing combination preparations in patients with edematous heart failure]. Wiener medizinische Wochenschrift (1946), 1985, Apr-30, Volume: 135, Issue:8 Topics: Aged; Diuretics; Drug Combinations; Edema, Cardiac; Female; Furosemide; Heart Failure; Humans; Hydro	1985
[Effect of amiloride on potassium loss induced by hydrochlorothiazide]. La Nouvelle presse medicale, 1974, Sep-21, Volume: 3, Issue:31 Topics: Amiloride; Chlorides; Diuresis; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure;	1974
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects. Circulation, 1972, Volume: 45, Issue:5 Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu	1972
The effect of alprenolol in elderly patients with raised blood pressure. Acta medica Scandinavica. Supplementum, 1974, Volume: 554 Topics: Aged; Alprenolol; Ambulatory Care; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparat	1974
[Clinical amd metabolic results of a particular combination thiazide-antialdosterone in heart failure]. La Clinica terapeutica, 1974, Mar-15, Volume: 68, Issue:5 Topics: Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Synergism; Ethacrynic Acid; Heart Failu	1974
[Treatment of cardiac edema with a new diuretic (combination of amiloride hydrochlorate and hydrochlorothiazide)]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1974, Volume: 19, Issue:2 Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Heart Failur	1974
Hypertension: a challenge in preventive medicine. Journal of the Royal College of Physicians of London, 1974, Volume: 9, Issue:1 Topics: Age Factors; Attitude to Health; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disea	1974
A controlled clinical trial comparing the diuretic furosemide and hydrochlorothiazide. The Journal of the Association of Physicians of India, 1968, Volume: 16, Issue:2 Topics: Clinical Trials as Topic; Furosemide; Heart Failure; Humans; Hydrochlorothiazide; Liver Cirrhosis; N	1968
The combination of guanethidine and hydrochlorothiazide in the treatment of arterial hypertension with and without renal failure. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1968, Volume: 1, Issue:6 Topics: Adult; Analysis of Variance; Blood Pressure; Clinical Trials as Topic; Creatine; Drug Synergism; Fem	1968
High doses of spironolactone (Aldactone, SC-14266, Verospirone) alone and in combination with triamterene and-or diuretics in the treatment of refractory edema associated with secondary hyperaldosteronism. Endokrinologie, 1970, Volume: 57, Issue:1 Topics: Adult; Aged; Body Weight; Chlorides; Clinical Trials as Topic; Clopamide; Creatinine; Diet, Sodium-R	1970

Article	Year
Clinical predictors of hyponatremia in patients with heart failure according to severity of chronic kidney disease. Wiener klinische Wochenschrift, 2022, Volume: 134, Issue:17-18 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Calcium Chan	2022
Photodermatitis caused by torasemide. Contact dermatitis, 2021, Volume: 84, Issue:1 Topics: Aged; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Female; Heart Failure; Humans;	2021
Furosemide and spironolactone doses and hyponatremia in patients with heart failure. BMC pharmacology & toxicology, 2020, 08-03, Volume: 21, Issue:1 Topics: Aged; Aged, 80 and over; Diuretics; Female; Furosemide; Heart Failure; Hospitalization; Humans; Hydr	2020
Intravenous Mineralocorticoid Receptor Antagonist Use in Acutely Decompensated Heart Failure with Diuretic Resistance. International heart journal, 2021, Jan-30, Volume: 62, Issue:1 Topics: Administration, Intravenous; Aged; Aged, 80 and over; Bumetanide; Canrenoic Acid; Creatinine; Diures	2021
Cognitive deficits and self-care behaviors in elderly adults with heart failure. Clinical interventions in aging, 2017, Volume: 12 Topics: Age Factors; Aged; Aged, 80 and over; Cognition Disorders; Cross-Sectional Studies; Disability Evalu	2017
Effects of a combination of losartan and hydrochlorothiazide in patients with hypertension and a history of heart failure. The Tokai journal of experimental and clinical medicine, 2014, Mar-20, Volume: 39, Issue:1 Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Blood Pressure;	2014
Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. Pharmacotherapy, 2014, Volume: 34, Issue:8 Topics: Administration, Intravenous; Administration, Oral; Aged; Chlorothiazide; Diuretics; Drug Therapy, Co	2014
Real-world clinical experience of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide in hypertension: the EXCITE study. Current medical research and opinion, 2014, Volume: 30, Issue:10 Topics: Adult; Aged; Amlodipine; Amlodipine, Valsartan Drug Combination; Antihypertensive Agents; Asia; Bloo	2014
Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovascular therapeutics, 2017, Volume: 35, Issue:2 Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Cel	2017
Determinants of masked hypertension in hypertensive patients treated in a primary care setting. Internal medicine journal, 2012, Volume: 42, Issue:3 Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents	2012
Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4 Topics: Adult; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Cholesterol; Heart	2011
Effects of hydrochlorothiazide on cardiac remodeling in a rat model of myocardial infarction-induced congestive heart failure. European journal of pharmacology, 2011, Sep-30, Volume: 667, Issue:1-3 Topics: Animals; Collagen; Cytokines; Disease Models, Animal; Electrolytes; Gene Expression Regulation; Hear	2011
Effects of an angiotensin 2 receptor blocker plus diuretic combination drug in chronic heart failure complicated by hypertension. The Journal of international medical research, 2011, Volume: 39, Issue:4 Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds;	2011
The effects of Su-5879 (esidrix) in congestive heart failure and hypertension: a clinical evaluation. American heart journal, 1959, Volume: 57, Issue:4 Topics: Acetazolamide; Heart Failure; Humans; Hydrochlorothiazide; Hypertension	1959
Hydrochlorothiazide in the treatment of congestive heart failure. The American journal of cardiology, 1959, Volume: 3, Issue:2 Topics: Acetazolamide; Heart Failure; Humans; Hydrochlorothiazide	1959
The diuretic effects of hydrochlorothiazide in congestive heart failure, cirrhosis, chronic renal disease and hypertension: preliminary report based on a study of 28 cases. The American journal of the medical sciences, 1959, Volume: 237, Issue:5 Topics: Acetazolamide; Diuretics; Edema; Heart Failure; Hydrochlorothiazide; Hypertension; Kidney Failure, C	1959
Clinical studies on hydrochlorothiazide; antihypertensive and metabolic effects. Journal of the American Medical Association, 1959, Jul-11, Volume: 170, Issue:11 Topics: Acetazolamide; Antihypertensive Agents; Biomedical Research; Heart Failure; Hydrochlorothiazide; Hyp	1959
The use of chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure. International record of medicine and general practice clinics, 1959, Volume: 172, Issue:8 Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hydrochlorothiazide	1959
Chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure. International record of medicine and general practice clinics, 1959, Volume: 172, Issue:8 Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hydrochlorothiazide	1959
[Studies of diuresis caused by hydrochlorothiazide]. La Riforma medica, 1959, Jun-13, Volume: 73, Issue:24 Topics: Acetazolamide; Ascites; Diuresis; Diuretics; Heart Failure; Humans; Hydrochlorothiazide; Liver Cirrh	1959
A note on hydrochlorothiazide as a therapeutic agent. Southern medical journal, 1959, Volume: 52, Issue:8 Topics: Acetazolamide; Heart Failure; Hydrochlorothiazide	1959
[The clinical use of hydrochlorothiazide in the therapy of cardiocirculatory insufficiency]. Minerva medica, 1960, Nov-10, Volume: 51 Topics: Chlorothiazide; Heart Failure; Humans; Hydrochlorothiazide	1960
Hydrochlorothiazide used alone in congestive heart failure and in combination with prednisone and other diuretics in cirrhosis and nephrosis. The American journal of the medical sciences, 1960, Volume: 240 Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Liver Cirrhosis; Nephrosis; Prednison	1960
Some effects of diuresis with hydrochlorothiazide. New York state journal of medicine, 1960, Nov-01, Volume: 60 Topics: Chlorothiazide; Diuresis; Heart Failure; Hydrochlorothiazide; Liver Diseases; Organic Chemicals	1960
Combined spironolactone-hydrochlorothiazide (Aldactazide) treatment in refractory congestive failure. Current therapeutic research, clinical and experimental, 1961, Volume: 3 Topics: Chlorothiazide; Drug Combinations; Heart Failure; Hydrochlorothiazide; Lactones; Spironolactone	1961
[Hydrochlorothiazide in the treatment of cardiac edema and of its effects on electrolyte metabolism]. Srpski arhiv za celokupno lekarstvo, 1960, Volume: 88 Topics: Chlorothiazide; Edema, Cardiac; Electrolytes; Heart Failure; Hydrochlorothiazide	1960
[Comparative study of the acute effects of hydrochlorothiazide in relation to chlorothiazide and other mercurial diuretics]. Arquivos brasileiros de cardiologia, 1961, Volume: 14 Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide	1961
Hydrochlorothiazide in severe congestive heart failure. Clinical experience in the treatment. Virginia medical monthly, 1959, Volume: 86 Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide	1959
Hydrochlorothiazide as a diuretic agent. Preliminary report of our clinical trials. Indian journal of medical sciences, 1960, Volume: 14 Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide	1960
Treatment of congestive heart failure and hypertension: clinical experience with hydrochlorothiazide. American practitioner and digest of treatment, 1960, Volume: 11 Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide; Hypertension	1960
Hydrochlorothiazide (hydrodiuril) in the management of cardiac oedema. Canadian Medical Association journal, 1959, Aug-15, Volume: 81 Topics: Chlorothiazide; Disease Management; Edema, Cardiac; Heart Failure; Hydrochlorothiazide	1959
[Our experience with hydrochlorothiazide in the treatment of cardiac insufficiency]. Actualites cardiologiques et angeiologiques internationales, 1961, Volume: 10 Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide	1961
[Magnesium, calcium and phosphorus balances in essential hypertension and heart insufficiency in the treatment with hydrochlorothiazide]. Klinische Wochenschrift, 1962, Feb-01, Volume: 40 Topics: Calcium, Dietary; Chlorothiazide; Essential Hypertension; Heart Failure; Humans; Hydrochlorothiazide	1962
[Comparative evaluation of diuretic action of novurit, hypothiazide, diacarb in circulatory insufficiency]. Meditsinskii zhurnal Uzbekistana, 1961, Volume: 8 Topics: Acetazolamide; Alkylmercury Compounds; Chlorothiazide; Diuretics; Drug Combinations; Heart Failure;	1961
Comparison of short term metabolic effects of hydroflumethiazide and hydrochlorothiazide. Journal of chronic diseases, 1962, Volume: 15 Topics: Chlorothiazide; Heart Failure; Humans; Hydrochlorothiazide; Hydroflumethiazide; Hypertension; Ions;	1962
A comparative study of diuretic agents, methyclothiazide and dihydrochlorothiazide, in patients with chronic edema. Current therapeutic research, clinical and experimental, 1963, Volume: 5 Topics: Benzothiadiazines; Diuretics; Edema; Heart Failure; Hydrochlorothiazide; Liver Cirrhosis; Methycloth	1963
Metabolic studies on patients with resistant heart failure treated by spironolactone. Canadian Medical Association journal, 1962, Dec-15, Volume: 87 Topics: Diuresis; Diuretics; Heart Failure; Humans; Hydrochlorothiazide; Potassium; Spironolactone	1962
[EXPERIMENTAL STUDIES AND CLINICAL TRIALS OF A NEW DIURETIC]. Deutsche medizinische Wochenschrift (1946), 1963, Aug-30, Volume: 88 Topics: Diuretics; Heart Failure; Humans; Hydrochlorothiazide; Liver Cirrhosis; ortho-Aminobenzoates; Resear	1963
[USE OF SPIRONOLACTONE IN THE THERAPY OF CONGESTIVE HEART FAILURE]. Sbornik lekarsky, 1963, Volume: 65 Topics: Body Fluids; Heart Failure; Humans; Hydrochlorothiazide; Potassium; Sodium; Sodium, Dietary; Spirono	1963
[CONSIDERATIONS ON TREATMENT WITH SALURETIC SULFONAMIDES IN CARDIAC INSUFFICIENCY]. Studii si cercetari de medicina interna, 1963, Volume: 91 Topics: Benzothiadiazines; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Organomercury Comp	1963
RED BLOOD CELL POTASSIUM; THERAPEUTIC IMPLICATIONS. JAMA, 1964, Jan-04, Volume: 187 Topics: Anemia; Anemia, Hypochromic; Blood Platelets; Digitalis Glycosides; Diuretics; Erythrocytes; Fludroc	1964
[GUSTATORY ACUITY FOR SALTY FLAVOR AND SALIVARY ELECTROLYTE CONCENTRATION]. Rassegna di neurologia vegetativa, 1963, Feb-28, Volume: 17 Topics: Addison Disease; Cerebrovascular Disorders; Chlorides; Cushing Syndrome; Flavoring Agents; Heart Fai	1963
TREATMENT OF EDEMA BY THE COMBINED ADMINISTRATION OF CHEMICALLY DIFFERENT DIURETIC AGENTS. The American journal of cardiology, 1963, Volume: 12 Topics: Ascites; Chlorthalidone; Diuretics; Edema; Heart Failure; Humans; Hydrochlorothiazide; Organomercury	1963
[RESEARCH ON THE DIURETIC AND SALURETIC ACTIVITY OF TRIAMTERENE IN THE THERAPY OF EDEMATIGENOUS SYNDROMES]. La Clinica terapeutica, 1963, Sep-30, Volume: 26 Topics: Diuretics; Edema; Glomerulonephritis; Heart Diseases; Heart Failure; Hydrochlorothiazide; Liver Cirr	1963
ALDOSTERONE ANTAGONISTS IN DIURETIC THERAPY: THEIR EFFECT ON THE REFRACTORY PHASE. Archives of internal medicine, 1964, Volume: 113 Topics: Blood Chemical Analysis; Body Weight; Edema; Heart Failure; Hematocrit; Hydrochlorothiazide; Mineral	1964
S35-LABELED BENDROFLUMETHIAZIDE IN HUMAN BEINGS: CLINICAL STUDIES. Archives of internal medicine, 1964, Volume: 113 Topics: Adolescent; Bendroflumethiazide; Chlorothiazide; Geriatrics; Heart Failure; Humans; Hydrochlorothiaz	1964
[ON ION TRANSPORT BEFORE AND AFTER TREATMENT OF CONGESTIVE HEART FAILURE]. Turk Tip Cemiyeti mecmuasi, 1963, Volume: 29 Topics: Chlorthalidone; Coronary Disease; Digitalis Glycosides; Diuretics; Electrolytes; Heart Failure; Huma	1963
CLINICAL EXPERIENCE WITH THE DIURETIC EFFECTS OF TRIAMTERENE ALONE AND COMBINED WITH HYDROCHLOROTHIAZIDE. Current therapeutic research, clinical and experimental, 1964, Volume: 6 Topics: Arteriosclerosis; Body Weight; Diuretics; Heart Failure; Hydrochlorothiazide; Hypertension; Potassiu	1964
[ON THE ACTION OF TRIAMTERENE ON SALIDIURESIS CAUSED BY HYDROCHLOROTHIAZIDE]. Gazzetta medica italiana, 1963, Volume: 122 Topics: Ascites; Diuresis; Diuretics; Edema; Heart Failure; Hepatitis; Hydrochlorothiazide; Hypertension; Hy	1963
[NATRIURETIC DRUGS]. Revista medica de Chile, 1963, Volume: 91 Topics: Acetazolamide; Aldosterone; Ascites; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Diuresis; Di	1963
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS]. Vie medicale (Paris, France : 1920), 1964, Volume: 45 Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics;	1964
[OBSERVATIONS ON ELECTROLYTE CHANGES IN CONGESTIVE HEART FAILURE DURING CARDIOKINETIC OR DEPLETIVE TREATMENT]. Atti della Societa italiana di cardiologia, 1964, Volume: 25 Topics: Aortic Diseases; Arteriosclerosis; Blood Chemical Analysis; Diuretics; Electrolytes; Heart Failure;	1964
CARDIAC AND METABOLIC DISEASE, AND INFECTIONS IN THE OBSTETRIC PATIENT. Clinical obstetrics and gynecology, 1964, Volume: 13 Topics: Acetazolamide; Acid-Base Equilibrium; Blood Circulation; Chlorothiazide; Chlorthalidone; Diet, Sodiu	1964
[CLINICAL AND BIOCHEMICAL EVALUATION OF THE DIURETIC ACTION OF HYPOTHIAZIDE]. Klinicheskaia meditsina, 1964, Volume: 42 Topics: Biomedical Research; Blood; Chlorine; Chlorothiazide; Diuretics; Drug Therapy; Edema; Heart Failure;	1964
IDIOPATHIC PULMONARY HEMOSIDEROSIS. Wisconsin medical journal, 1964, Volume: 63 Topics: Arteritis; Child; Digitoxin; Endocardial Fibroelastosis; Heart Failure; Hemoptysis; Hemosiderosis; H	1964
CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. Canadian Medical Association journal, 1964, Aug-15, Volume: 91 Topics: Arrhythmias, Cardiac; Canada; Chlorides; Digitalis Glycosides; Diuretics; Edema; Heart Failure; Hydr	1964
A NEW EFFECTIVE DIURETIC--LASIX. British medical journal, 1964, Oct-10, Volume: 2, Issue:5414 Topics: Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiazide; Hypokalemia	1964
[CONSIDERATIONS ON VARIOUS FORMS OF EDEMA AND ON THEIR TREATMENT WITH TRIAMTERENE-HYDROCHLOROTHIAZIDE]. La Clinica terapeutica, 1964, Jul-31, Volume: 30 Topics: Drug Combinations; Drug Therapy; Edema; Geriatrics; Heart Failure; Hydrochlorothiazide; Liver Cirrho	1964
DIURETIC AND PHARMACOLOGICAL STUDY OF R-37 (2-AMINO-4-META-CHLOROANILINO-S-TRIAZINE)--A TRIAZINE DERIVATIVE. Archives internationales de pharmacodynamie et de therapie, 1964, Sep-01, Volume: 151 Topics: Acidosis; Alkalosis; Anemia; Blood Urea Nitrogen; Diuretics; Dogs; Heart Failure; Hydrochlorothiazid	1964
THE DIURETIC RESPONSE TO FRUSEMIDE. Lancet (London, England), 1964, Nov-21, Volume: 2, Issue:7369 Topics: Chlorides; Diuretics; Fluids and Secretions; Furosemide; Heart Failure; Humans; Hydrochlorothiazide;	1964
A CLINICAL TRIAL OF FRUSEMIDE. Lancet (London, England), 1964, Nov-21, Volume: 2, Issue:7369 Topics: Biomedical Research; Blood Chemical Analysis; Chlorides; Chlorthalidone; Diuretics; Fluids and Secre	1964
ETHACRYNIC ACID IN PATHOLOGICAL FLUID RETENTION. JAMA, 1965, Mar-01, Volume: 191 Topics: Digoxin; Diuretics; Drug Therapy; Ethacrynic Acid; Geriatrics; Heart Failure; Humans; Hydrochlorothi	1965
[CLINICAL RESEARCH ON A NEW DRUG COMBINATION WITH DIURETIC ACTION]. La Clinica terapeutica, 1964, Oct-31, Volume: 31 Topics: Ascites; Biomedical Research; Diuretics; Drug Combinations; Drug Therapy; Edema; Heart Failure; Hydr	1964
TREATMENT OF CONGESTIVE HEART FAILURE WITH TRIAMTERENE. Canadian Medical Association journal, 1965, Feb-27, Volume: 92 Topics: Blood; Diuresis; Diuretics; Drug Therapy; Gout; Heart Failure; Humans; Hydrochlorothiazide; Potassiu	1965
[USE OF HYPOTHIAZIDE IN RHEUMATIC CHILDREN WITH CIRCULATORY INSUFFICIENCY]. Voprosy okhrany materinstva i detstva, 1964, Volume: 9 Topics: Adolescent; Child; Diuretics; Drug Therapy; Heart Failure; Humans; Hydrochlorothiazide; Rheumatic He	1964
TREATING DIFFICULT-TO-MANAGE EDEMATOUS HYPERTENSIVE PATIENTS WITH HYDROCHLOROTHIAZIDE. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1965, Volume: 117 Topics: Disease Management; Drug Therapy; Edema; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; T	1965
ETHACRYNIC ACID: A NEW POTENT DIURETIC. The American journal of the medical sciences, 1965, Volume: 249 Topics: Alkalosis; Blood Chemical Analysis; Blood Urea Nitrogen; Body Weight; Digitalis Glycosides; Diuresis	1965
FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA. Journal of the American Geriatrics Society, 1965, Volume: 13 Topics: Arteriosclerosis; Chlorothiazide; Coronary Disease; Drug Combinations; Drug Therapy; Edema; Edema, C	1965
[EFFECT OF HYPOTHIAZIDE ON THE WATER-ELECTROLYTE METABOLISM IN CIRCULATORY INSUFFICIENCY]. Zhurnal eksperimental'noi i klinicheskoi meditsiny, 1964, Volume: 4 Topics: Electrolytes; Heart Failure; Humans; Hydrochlorothiazide; Water; Water-Electrolyte Balance	1964
FUROSEMIDE (LASIX) AS A DIURETIC. Acta medica Scandinavica, 1965, Volume: 177 Topics: Chlorothiazide; Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiaz	1965
[ON THERAPY OF WATER-SALT RETENTION WITH TRIAMTERENE ALONE OR ASSOCIATED WITH HYDROCHLOROTHIAZIDE]. Minerva medica, 1965, Jun-27, Volume: 56 Topics: Edema; Heart Failure; Humans; Hydrochlorothiazide; Triamterene; Water; Water-Electrolyte Balance	1965
Hydrochlorothiazide in the treatment of congestive heart failure. Henry Ford Hospital medical bulletin, 1959, Volume: 7 Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide	1959
[Treatment of cardiac edema by hydrochlorothiazide]. Jornal do medico, 1959, Dec-05, Volume: 40 Topics: Chlorothiazide; Edema, Cardiac; Heart Failure; Hydrochlorothiazide	1959
[A new diuretic: hydrochlorothiazide in the treatment of cardiac insufficiency]. Lyon medical, 1959, Nov-29, Volume: 91 Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide	1959
[Hydrochlorothiazide. A new diuretic in the treatment of cardiac insufficiency]. La Presse medicale, 1959, Nov-21, Volume: 67 Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide	1959
[Clinical study of the diuretic action of hydrochlorothiazide]. Arquivos brasileiros de cardiologia, 1959, Volume: 12 Topics: Biomedical Research; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Nephrotic Syndro	1959
[Clinical experimentation on a new oral saldiuretic, the potassium salt of trichloromethyl hydrochlorothiazide (PS-207) in cardiac insufficiency]. La Presse medicale, 1962, May-19, Volume: 70 Topics: Chlorothiazide; Empirical Research; Heart Failure; Hydrochlorothiazide; Potassium; Potassium Compoun	1962
Hydrochlorothiazide in congestive heart failure and in toxemia of pregnancy. The Journal of the Medical Society of New Jersey, 1962, Volume: 59 Topics: Chlorothiazide; Female; Heart Failure; Hydrochlorothiazide; Pre-Eclampsia; Pregnancy	1962
[On the diuretic action of hypothiazide]. Zdravookhranenie Belorussii, 1962, Volume: 8 Topics: Cardiovascular Diseases; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide	1962
Clinical trials with hydrochlorothiazide. Indian journal of medical sciences, 1962, Volume: 16 Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide; Hypertension	1962
[A patient with severe hyperkalaemia -- an emergency after RALES]. Deutsche medizinische Wochenschrift (1946), 2005, Sep-09, Volume: 130, Issue:36 Topics: Acute Kidney Injury; Adrenergic beta-Agonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-	2005
Potent diuretic effects of prednisone in heart failure patients with refractory diuretic resistance. The Canadian journal of cardiology, 2007, Volume: 23, Issue:11 Topics: Creatinine; Diuresis; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Glucocorticoids; He	2007
Potent diuretic effects of prednisone in heart failure patients with refractory diuretic resistance. The Canadian journal of cardiology, 2007, Volume: 23, Issue:11 Topics: Creatinine; Diuresis; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Glucocorticoids; He	2007
Potent diuretic effects of prednisone in heart failure patients with refractory diuretic resistance. The Canadian journal of cardiology, 2007, Volume: 23, Issue:11 Topics: Creatinine; Diuresis; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Glucocorticoids; He	2007
Potent diuretic effects of prednisone in heart failure patients with refractory diuretic resistance. The Canadian journal of cardiology, 2007, Volume: 23, Issue:11 Topics: Creatinine; Diuresis; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Glucocorticoids; He	2007
[The hemodynamic action of diuretics]. Munchener medizinische Wochenschrift (1950), 1966, Dec-23, Volume: 108, Issue:51 Topics: Blood Volume; Cardiac Output; Digitalis Glycosides; Diuretics; Ethacrynic Acid; Furosemide; Glomerul	1966
Polythiazide as a diuretic. A clinical trial. Journal of the Indian Medical Association, 1967, Jan-01, Volume: 48, Issue:1 Topics: Adolescent; Adult; Aged; Edema; Female; Heart Failure; Humans; Hydrochlorothiazide; Liver Cirrhosis;	1967
[Behavior of protein in the 24-hour urine after administration of certain diuretics]. Polskie Archiwum Medycyny Wewnetrznej, 1967, Volume: 39, Issue:2 Topics: Acetazolamide; Adolescent; Adult; Aged; Heart Failure; Humans; Hydrochlorothiazide; Middle Aged; Org	1967
Hemodynamic effects of captopril in essential hypertension, renovascular hypertension and cardiac failure: correlations with short- and long-term effects on plasma renin. The American journal of cardiology, 1982, Apr-21, Volume: 49, Issue:6 Topics: Blood Pressure; Captopril; Drug Therapy, Combination; Female; Heart Failure; Hemodynamics; Humans; H	1982
Indomethacin- and Moduretic--induced hyperkalemia. Israel journal of medical sciences, 1983, Volume: 19, Issue:6 Topics: Aged; Amiloride; Diabetes Complications; Diabetes Mellitus; Drug Combinations; Drug Interactions; Fe	1983
Potassium and magnesium balance in thiazide-treated cardiac patients with special reference to diet. Acta medica Scandinavica. Supplementum, 1982, Volume: 668 Topics: Adult; Aged; Diet; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypokalemia; Magnesium; Male;	1982
Clinical use of captopril. Illustrative cases. JAMA, 1982, Apr-16, Volume: 247, Issue:15 Topics: Adult; Aged; Blood Pressure; Captopril; Drug Therapy, Combination; Female; Heart Failure; Humans; Hy	1982
[Acute kidney failure caused by triamterene and hydrochlorothiazide]. Deutsche medizinische Wochenschrift (1946), 1982, May-28, Volume: 107, Issue:21 Topics: Acute Kidney Injury; Adult; Heart Failure; Heart Valve Diseases; Humans; Hydrochlorothiazide; Male;	1982
[Tienilic acid, hyperuricemia and kidney function]. Schweizerische medizinische Wochenschrift, 1981, Mar-14, Volume: 111, Issue:11 Topics: Aged; Creatinine; Female; Furosemide; Glycolates; Heart Failure; Humans; Hydrochlorothiazide; Kidney	1981
A patient compliance comparative study of three diuretics in the treatment of oedema. The Journal of international medical research, 1980, Volume: 8, Issue:5 Topics: Adult; Aged; Amiloride; Cyclopenthiazide; Diuretics; Edema, Cardiac; Female; Heart Failure; Humans;	1980
[Comparative analysis of several treatment methods for severe congestive heart failure]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1993, Volume: 13, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Captopril; Digoxin; Drugs, Chinese Herbal; Female; Heart Failure; Hu	1993
A non-invasive evaluation of flosequinan on haemodynamics and exercise capacity in chronic congestive heart failure. International journal of clinical pharmacology research, 1993, Volume: 13, Issue:3 Topics: Aged; Amiloride; Cardiac Output; Chronic Disease; Echocardiography; Exercise; Exercise Test; Female;	1993
Sequential nephron blockade breaks resistance to diuretics in edematous states. Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:3 Topics: Acetazolamide; Adult; Ascites; Diuresis; Diuretics; Edema; Female; Furosemide; Heart Failure; Humans	1997
Renin-angiotensin system mediated mechanisms: cardioreparation and cardioprotection. Heart (British Cardiac Society), 2000, Volume: 84 Suppl 1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diuretics; Female; Fibrosis; Heart Failure; Human	2000
Pharmacokinetics of hydrochlorothiazide in patients with congestive heart failure. British journal of clinical pharmacology, 1979, Volume: 7, Issue:6 Topics: Aged; Female; Heart Failure; Humans; Hydrochlorothiazide; Kinetics; Male; Middle Aged; Time Factors	1979
[Serum and total body potassium during treatment with chlortalidone and hydrochlorothiazide. Influence of triamterene (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1977, Dec-16, Volume: 102, Issue:50 Topics: Adult; Aged; Chlorthalidone; Drug Therapy, Combination; Female; Heart Failure; Humans; Hydrochloroth	1977
[Hyperkalemia caused by hyporeninism: role of the hydrochlorothiazide-amiloride combination]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1977, Volume: 22, Issue:10 Topics: Aged; Aldosterone; Amiloride; Diabetes Complications; Female; Heart Failure; Humans; Hydrochlorothia	1977
[Change in rheographic properties of blood in congestive circulatory insufficiency treated with diuretics]. Kardiologiia, 1977, Volume: 17, Issue:5 Topics: Adult; Aged; Blood Circulation; Blood Viscosity; Diuretics; Erythrocyte Aggregation; Ethacrynic Acid	1977
[Changes in electrolytes in urine, blood and edema fluid after administration of some diuretics]. Minerva medica, 1975, Mar-31, Volume: 66, Issue:24 Topics: Adult; Aged; Calcium; Diuretics; Ethacrynic Acid; Female; Furosemide; Heart Failure; Humans; Hydroch	1975
Diuretic effect of combined thiazide and amiloride. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1975, Volume: 58, Issue:4 Topics: Adult; Amiloride; Diuretics; Drug Combinations; Drug Therapy, Combination; Heart Failure; Humans; Hy	1975
[Use of aldactone-saltucine for patients with chronic circulatory insufficiency]. Kardiologiia, 1975, Volume: 15, Issue:5 Topics: Adult; Aged; Butanes; Creatinine; Diuresis; Diuretics; Drug Combinations; Drug Evaluation; Female; F	1975
[Use of aldactone-saltucine in patients with heart failure]. Kardiologiia, 1975, Volume: 15, Issue:5 Topics: Adult; Aged; Aldosterone; Body Weight; Butanes; Chlorides; Diuretics; Drug Combinations; Drug Evalua	1975
[Combination therapy in chronic heart failure. Hemodynamic effects with a calcium antagonist-diuretic combination]. Fortschritte der Medizin, 1991, Jun-30, Volume: 109, Issue:19 Topics: Adult; Aged; Chronic Disease; Drug Combinations; Heart Failure; Hemodynamics; Humans; Hydrochlorothi	1991
Thiazide-induced dilutional hyponatraemia masquerading as subarachnoid haemorrhage. Lancet (London, England), 1986, Sep-13, Volume: 2, Issue:8507 Topics: Aged; Amiloride; Bendroflumethiazide; Diagnosis, Differential; Drug Combinations; Female; Heart Fail	1986
Multiple drug use in an elderly man. Hospital practice (Office ed.), 1987, Jul-15, Volume: 22, Issue:7 Topics: Aged; Atrial Fibrillation; Diazepam; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; D	1987
[Digitalis therapy in chronic heart failure. Digitoxin in patients in sinus rhythm pretreated with diuretics]. Deutsche medizinische Wochenschrift (1946), 1988, Mar-25, Volume: 113, Issue:12 Topics: Adult; Aged; Digitoxin; Diuretics; Drug Evaluation; Drug Therapy, Combination; Echocardiography; Fem	1988
Whipple's disease with cardiac and renal abnormalities. Archives of internal medicine, 1969, Volume: 123, Issue:6 Topics: Biopsy; Glomerulonephritis; Heart Failure; Humans; Hydrochlorothiazide; Kidney Glomerulus; Male; Mid	1969
[Clinical study of amiloride hydrochloride, a diuretic with low potassium loss]. La Presse medicale, 1970, Jan-03, Volume: 78, Issue:1 Topics: Arrhythmias, Cardiac; Blood Urea Nitrogen; Cardiac Complexes, Premature; Diuretics; Drug Synergism;	1970
[Therapy of cardiac edema with a combination of hydrochlorthiazide and amiloride-HCl (author's transl)]. Wiener klinische Wochenschrift, 1973, Dec-28, Volume: 85, Issue:52 Topics: Alkalosis; Diuretics; Drug Combinations; Electrolytes; Heart Failure; Hydrochlorothiazide; Hypokalem	1973
[Chlorpropamide, thiazides and congestive heart failure]. Harefuah, 1974, Feb-15, Volume: 86, Issue:4 Topics: Aged; Chlorpropamide; Diabetes Mellitus; Diuresis; Diuretics; Glyburide; Heart Failure; Humans; Hydr	1974
Diuretics, cardiac failure and potassium depletion: a rational approach. The Medical journal of Australia, 1974, Dec-07, Volume: 2, Issue:23 Topics: Aged; Amiloride; Body Weight; Diet, Sodium-Restricted; Diuretics; Edema; Furosemide; Heart Failure;	1974
A clinical study of Co-hydroDiuril a combination of an antikaliuretic (amiloride) and hydrochlorothiazide. Current therapeutic research, clinical and experimental, 1972, Volume: 14, Issue:9 Topics: Adult; Aged; Amiloride; Blood Pressure; Blood Urea Nitrogen; Body Weight; Diuretics; Drug Combinatio	1972
Effect of furosemide and hydrochlorothiazide on plasma renin activity in man. Annales medicinae experimentalis et biologiae Fenniae, 1970, Volume: 48, Issue:2 Topics: Administration, Oral; Aldosterone; Angiotensin II; Furosemide; Heart Failure; Humans; Hydrochlorothi	1970
Diuretic agents: inciting factor in nonocclusive mesenteric infarction? JAMA, 1974, Sep-09, Volume: 229, Issue:11 Topics: Aged; Blood Urea Nitrogen; Body Weight; Digitalis; Diuretics; Female; Furosemide; Heart Failure; Hem	1974
Idiopathic edema. Virginia medical monthly, 1974, Volume: 101, Issue:11 Topics: Adult; Age Factors; Aldosterone; Edema; Female; Heart Failure; Humans; Hydrochlorothiazide; Hydrosta	1974
[The treatment of cardiac edemas with a new diuretic (combination of amiloride and hydrochlorothiazide)]. Acta cardiologica, 1973, Volume: 28, Issue:3 Topics: Adult; Aged; Amiloride; Diuretics; Female; Heart Failure; Humans; Hydrochlorothiazide; Male; Middle	1973
[Comparison of the combination of hydrochlorothiazide and amiloride (Moduretic) and furosemide in the treatment of cardiac edema]. Acta cardiologica, 1973, Volume: 28, Issue:3 Topics: Aged; Amiloride; Diuretics; Drug Combinations; Female; Furosemide; Heart Failure; Humans; Hydrochlor	1973
Clinical experience with amiloride in the elderly. Acta cardiologica, 1973, Volume: 28, Issue:3 Topics: Age Factors; Aged; Amiloride; Calcium; Creatinine; Diuretics; Edema; Heart Failure; Humans; Hydrazin	1973
Effect of amiloride and hydrochlorothiazide on body fluids and electrolytes in geriatric patients with congestive cardiac failure. Gerontologia clinica, 1974, Volume: 16, Issue:1 Topics: Aged; Amiloride; Body Fluids; Diuretics; Electrolytes; Heart Failure; Humans; Hydrochlorothiazide; P	1974
Serum calcium and phosphorus in patients treated with thiazides and furosemide. Acta medica Scandinavica, 1973, Volume: 194, Issue:4 Topics: Adult; Aged; Calcium; Chlorothiazide; Depression, Chemical; Female; Furosemide; Heart Failure; Human	1973
[Effects of hydrochlorothiazide, furosemide and ethacrynic acid on the electrolyte composition of the urine, plasma and edema fluid]. Bollettino della Societa italiana di biologia sperimentale, 1973, Jul-30, Volume: 49, Issue:12 Topics: Adult; Aged; Body Fluids; Edema; Electrolytes; Ethacrynic Acid; Female; Furosemide; Heart Failure; H	1973
Hypertension: challenge in preventive medicine. Preventive medicine, 1973, Volume: 2, Issue:1 Topics: Aged; Aneurysm; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebrovascular Disorders; Drug Therap	1973
[Comparative study of the diuretic action of hydrochlorothiazide, mersalyl, and ethacrynic acid in congestive heart insufficiency]. Prensa medica argentina, 1971, Dec-10, Volume: 58, Issue:41 Topics: Diuresis; Ethacrynic Acid; Heart Failure; Humans; Hydrochlorothiazide; Natriuresis; Organomercury Co	1971
Evaluation of amiloride combined with hydrochlorothiazide in the treatment of congestive heart failure. The New Zealand medical journal, 1970, Volume: 72, Issue:459 Topics: Aged; Amidines; Body Weight; Diuretics; Drug Synergism; Female; Heart Failure; Humans; Hydrochloroth	1970
Digitalis-induced double atrioventricular nodal rhythm associated with electrical alternans. Japanese heart journal, 1968, Volume: 9, Issue:5 Topics: Aged; Arrhythmias, Cardiac; Digoxin; Electrocardiography; Heart Failure; Humans; Hydrochlorothiazide	1968
Clinical evaluations of a combined application of amiloride (MK-870) and thiazide. Japanese heart journal, 1969, Volume: 10, Issue:4 Topics: Adult; Blood Pressure; Diuretics; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypertension;	1969
[Maximum consumption of oxygen and physical work capacity in patients with chronic (congestive) cardiac insufficiency after treatment with digoxin and hydrochlorothiazide (Nefrix)]. Studii si cercetari de medicina interna, 1969, Volume: 10, Issue:5 Topics: Digoxin; Disability Evaluation; Exercise Test; Heart; Heart Failure; Heart Function Tests; Humans; H	1969
Diuretics in cardiac edema. Canadian Medical Association journal, 1970, Jan-31, Volume: 102, Issue:2 Topics: Diuretics; Furosemide; Heart Failure; Humans; Hydrochlorothiazide	1970
Report of the panels on cardiovascular drugs from the drug efficacy study. Circulation, 1970, Volume: 41, Issue:1 Topics: Angina Pectoris; Cardiovascular Diseases; Chlorothiazide; Digitalis Glycosides; Drug Industry; Drug	1970
[Some aspects of renal metabolism of citric acid]. Minerva medica, 1970, Sep-01, Volume: 61, Issue:70 Topics: Adult; Age Factors; Aged; Chlorthalidone; Citrates; Heart Failure; Humans; Hydrochlorothiazide; Hype	1970
[Plasma renin activity in hypertensive and non-hypertensive patients and its clinical significance]. Japanese circulation journal, 1970, Volume: 34, Issue:12 Topics: Addison Disease; Adolescent; Adult; Aged; Aortic Diseases; Biological Assay; Blood Pressure; Blood U	1970
[Prevention of potassium metabolism disorders arising during the treatment of cardiac insufficiency with diuretics]. Kardiologiia, 1967, Volume: 7, Issue:5 Topics: Adult; Digitalis Glycosides; Diuretics; Drug Synergism; Female; Furosemide; Heart Failure; Humans; H	1967
[Clinical observations on the diuretic action of the association of triamterene with hydrochlorothiazide]. Minerva cardioangiologica, 1967, Volume: 15, Issue:7 Topics: Adult; Aged; Coronary Disease; Diuresis; Edema; Heart Diseases; Heart Failure; Humans; Hydrochloroth	1967
Medical and pacemaker therapy of complete heart block and congestive heart failure in a dog. Journal of the American Veterinary Medical Association, 1968, Apr-15, Volume: 152, Issue:8 Topics: Animals; Digoxin; Dog Diseases; Dogs; Electrocardiography; Ethacrynic Acid; Heart Block; Heart Failu	1968
The role of catecholamines in circulatory regulation on the chronic congestive heart failure. Clinical study of the urinary catecholamine excretion in the patients with chronic congestive heart failure. Japanese circulation journal, 1968, Volume: 32, Issue:4 Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiomyopathies; Catecholamines; Coronary Disease; Digital	1968
Clinical evaluation of diuretics in congestive heart failure. A detailed study in four patients. Archives of internal medicine, 1969, Volume: 124, Issue:1 Topics: Aged; Arrhythmias, Cardiac; Chlorides; Diuretics; Drug Synergism; Furosemide; Heart Failure; Humans;	1969
Hyperuricaemic and hyperglycaemic effects of thiazides in non-prediabetics. The Journal of the Egyptian Medical Association, 1965, Volume: 48, Issue:7 Topics: Blood; Diabetes Mellitus; Heart Failure; Humans; Hydrochlorothiazide; Polythiazide; Prediabetic Stat	1965
The pharmacology of an oral diuretic ("Doburil") in congestive cardiac failure: a comparison with hydrochlorothiazide. The Medical journal of Australia, 1966, Oct-01, Volume: 2, Issue:14 Topics: Adult; Aged; Benzothiadiazines; Chlorides; Diuretics; Female; Heart Failure; Humans; Hydrochlorothia	1966
[The behavior of the electrolytes in cardiac insufficiency under the Administration of diuretics and thiazides and under sodium and potassium loading]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1966, Jul-01, Volume: 21, Issue:13 Topics: Digitalis Glycosides; Diuretics; Heart Failure; Humans; Hydrochlorothiazide; Potassium; Potassium Ch	1966

hydrochlorothiazide and Cardiac Failure

Research Excerpts

Research

Studies (202)

Authors

Clinical Trials (5)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Velat, I	2
Bušić, Ž	2
Čulić, V	2
Trullàs, JC	4
Morales-Rull, JL	4
Casado, J	4
Carrera-Izquierdo, M	3
Sánchez-Marteles, M	3
Conde-Martel, A	3
Dávila-Ramos, MF	3
Llácer, P	3
Salamanca-Bautista, P	3
Pérez-Silvestre, J	3
Plasín, MÁ	3
Cerqueiro, JM	3
Gil, P	3
Formiga, F	4
Manzano, L	4
Lava, SAG	1
Zollinger, C	1
Chehade, H	1
Schaffner, D	1
Sekarski, N	1
Di Bernardo, S	1
Taban-Sadeghi, M	1
Khani, E	1
Khezripour, K	1
Enamzadeh, E	1
Safaei, N	1
Entezari-Maleki, T	1
Haeberle, M	1
Karle, CA	1
Jurić Paić, M	1
Girerd, N	1
Aubry, M	1
Lantelme, P	1
Huttin, O	1
Rossignol, P	1
Piardi, DS	1
Butzke, M	1
Mazzuca, ACM	1
Gomes, BS	1
Alves, SG	1
Kotzian, BJ	1
Ghisleni, EC	1
Giaretta, V	1
Bellaver, P	1
Varaschin, GA	1
Garbin, AP	1
Beck-da-Silva, L	1
Uchmanowicz, I	1
Jankowska-Polańska, B	1
Mazur, G	1
Sivarajan Froelicher, E	1
Wang, L	1
Shi, J	1
Zhang, Y	1
Van Wart, SA	1
Shoaf, SE	1
Mallikaarjun, S	1
Mager, DE	1
Kanda, S	1
Yoshioka, K	1
Amino, M	1
Deguchi, Y	1
Aizawa, T	1
Tanabe, T	1
Ikari, Y	1
Kissling, KT	1
Pickworth, KK	1
Sison, J	1
Assaad-Khalil, SH	1
Najem, R	1
Kitchlew, AR	1
Cho, B	1
Ueng, KC	1
Shete, A	1
Knap, D	1
Freitas Ramírez, A	1
Luo, J	2
Chen, X	1
Luo, C	1
Lu, G	1
Peng, L	2
Gao, X	2
Zuo, Z	1
Black, HR	1
Bailey, J	1
Zappe, D	1
Samuel, R	1
Westermann, D	1
Savvatis, K	1
Schultheiss, HP	1
Tschöpe, C	1
Andalib, A	1
Akhtari, S	1
Rigal, R	1
Curnew, G	1
Leclerc, JM	1
Vaillancourt, M	1
Tardif, JC	1
Dorsch, MP	1
Gillespie, BW	1
Erickson, SR	1
Bleske, BE	1
Weder, AB	1
Sun, H	1
Dai, G	1
Suzuki, O	1
Ishii, H	1
Kobayashi, S	1
Ito, H	1
Ishii, K	1
Kihara, H	1
Kasayuki, N	1
Nakamura, F	1
Shimada, K	1
Fukuda, S	1
Iwakura, K	1
Yoshikawa, J	1
HEJTMANCIK, MR	1
HERRMANN, GR	1
KROETZ, FW	1
BREST, AN	3
LIKOFF, W	1
SACKNER, MA	1
WALLACK, AA	1
BELLET, S	1
VERTES, V	2
SOPHER, M	1
KEYES, JW	2
BRENEMAN, GM	2
ALVAREZ, H	2
CASSANO, A	1
CONTI, F	1
COSTA, C	1
CORDOVA, C	1
SPIES, TD	1
NIEDERMEIER, W	1
STONE, RE	1
FANCINI, P	1
PORTER, GA	1
DAVID, NA	1
ROSENBLUM, MA	1
SETTEL, E	2
KOVACEVIC, M	1
BRCELJ, S	1
PERISIC, Z	1
LICHTIG, C	1
YOUNES, A	1
AJZEN, H	1
de MELLO, H	1
CAVELL, GF	1
WYSO, EM	1
RICHARDSON, DW	1
DATEY, KK	1
SHAH, PM	1
KURIEN, J	1
WEINER, AA	1
LEVINE, J	1
RUSSO, JL	1
ZAGALA, J	1
WENER, J	2
FRIEDMAN, R	3
MAYMAN, A	1
SCHUCHER, R	2
DJORDJEVIC, BS	1
LAMBIE, I	1
BUDIMIR, M	1
GLAUBITT, D	1
RAUSCH-STROOMANN, JG	1
SHARAPOV, UB	1
KATZ, JB	1
ROBINOW, SH	1
PATEL, N	1
MOCK, DC	1
BAYLEY, TA	1
FORBATH, PG	1
WILSON, JK	1
HIGGINS, HP	1
KLEINFELDER, H	1
HORKY, K	1
KUECHEL, O	1
HARNAGEA, P	1
DOBREANU-ENESCU, V	1
TEODORINI, S	1
VLADESCU, C	1
SINGER, MM	2
HOFF, HR	1
FISCH, S	2
DEGRAFF, AC	2
DIGIESI, V	1
MORACE, G	1
SELLER, RH	2
FUCHS, M	1
SWARTZ, C	1
MOYER, JH	2
AMERIO, A	1
LEONDEFF, I	1
CORATELLI, P	1
CURATOLI, L	1
SWARTZ, CD	1
RAMIREZ-MUXO, O	1
BREST, AH	1
BRETTELL, HR	1
SMITH, JG	1
AIKAWA, JK	1
OZDOGAN, E	1
QUAN, KC	1
KAHANA, L	1
CASIROLA, G	1
TARTARA, A	1
CHERIE LIGNIERE, E	1
ARMASCRUZ, R	1
GOMEZ, R	1
MARDONES, J	1
PLAZADELOSREYES, M	1
BAGROS, P	1
MARANGONI, R	1
MELLONI, G	1
PLATT, MA	1
MERZON, AK	1
KASIANOVA, TN	1
IRVIN, JM	1
LAUFER, ST	2
MAHABIR, RN	2
STOKES, W	1
ANFOSSI, F	1
GUARRAGGI, A	1
MODI, KN	1
DELIWALA, CV	1
SHETH, UK	2
ROBSON, AO	1
KERR, DN	1
ASHCROFT, R	1
TEASDALE, G	1
VEREL, D	1
STENTIFORD, NH	1
RAHMAN, F	1
SAYNOR, R	1
SPERBER, RJ	1
DIRE, LB	1
BELLUSCHI, A	1
ZELENETSKAIA, SS	1
CHURAKOVA, TP	1
GAL, R	1
BERNSTEIN, A	1
ODZE, M	1
CREWS, A	1
SIMON, F	1
SIMONIAN, ZN	1
PELTOLA, P	2
BARBI, G	1
MALTEZ, JS	1
PERRIN, A	2
FATH, A	2
DESCROIX, M	2
DUPORTET, B	2
SABBAGA, E	1
SALDANHA, RV	1
de FARIA, C	1
NUSSENZVEIG, I	1
KARTUN, P	1
AZERAD, E	1
KHAJAVI, A	1
KRAVCHENKO, GT	1
PINTO, IJ	1
DIVEKAR, MV	1
RAGHAVAN, P	1
MEHTA, DJ	1
Staessen, JA	1
Thijisq, L	1
Fagard, R	1
Celis, H	1
Birkenhäger, WH	1
Bulpitt, CJ	1
de Leeuw, PW	1
Fletcher, AE	1
Forette, F	1
Leonetti, G	1
McCormack, P	1
Nachev, C	1
O'Brien, E	1
Rodicio, JL	1
Rosenfeld, J	2
Sarti, C	1
Tuomilehto, J	1
Webster, J	1
Yodfat, Y	1
Zanchetti, A	1
Yang, DY	1
Wu, XL	1
Xu, H	1
Duan, XZ	1
Wang, SW	1
Lu, ZZ	1
Nürnberger, J	1
Daul, A	1
Philipp, T	1
Knauf, H	2
Bailey, MA	1
Hasenfuss, G	1
Mutschler, E	2
Liu, C	1
Liu, G	1
Zhou, C	1
Ji, Z	1
Zhen, Y	1
Liu, K	1
Schneider, KW	1
Kaur, J	1
Wahi, PL	1
Proniewska, W	1
Davies, RO	2
Gomez, HJ	1
Irvin, JD	1
Walker, JF	3
McFate Smith, W	1
Kulaga, SF	1
Moncloa, F	2
Pingeon, R	1
Kremer, D	1
Wenting, GJ	1
de Bruyn, JH	1
Man in't Veld, AJ	1
Woittiez, AJ	1
Derkx, FH	1
Schalekamp, MA	1
Mor, R	1
Pitlik, S	2
Rosenfeld, JB	1
Kohvakka, A	2
Heinonen, L	1
Pietinen, P	1
Salo, H	1
Eisalo, A	2
Viherkoski, M	1
Huikko, M	1
Varjoranta, K	1
Nordlie, KE	1
Søiland, C	1
Freis, E	1
Angelkort, B	1
Letzel, H	1
Ferguson, RK	1
Rotmensch, HH	1
Vlasses, PH	1
Heitmann, D	1
Rumpf, KW	1
Scheler, F	1
de Torrenté, A	1
Wade, AG	1
Nordrehaug, JE	2
Vollset, SE	2
Lou, ZJ	1
Zhu, GL	1
Sun, XL	1
Motro, M	1
Freimark, D	1
Feinberg, MS	1
Wynne, RD	1
King, C	1
Schneeweiss, A	1
Fidler, HM	1
Goldman, J	1
Bielawska, CA	1
Rai, GS	1
Hoffbrand, BI	1
Vöhringer, HF	1
Schüren, KP	1
Reyes, AJ	1
Leary, WP	1
Dormans, TP	1
Gerlag, PG	1
Ames, R	1
Brilla, CG	1
Levy, B	1
Smith, JW	1
Clements, P	1
Beg, MA	2
Zuccarello, W	1
Donikian, MA	1
Ragland, R	2
Ziv, DS	1
Weber, KT	1
Fishman, AP	1
Beermann, B	1
Groschinsky-Grind, M	1
Fariello, R	1
Agabiti-Rosei, E	1
Alicandri, C	1
Corea, L	1
Oldoni, T	1
Muiesan, G	2
Schäfer, GE	1
Werner, E	1
Kober, G	1
Kaltenbach, M	3
Heim, J	1
Dewailly, P	1
Jaillard, J	1
Baumann, JC	1
Braun, HD	1
Savenkov, MP	1
Kitzes, R	1
Cohen, L	1
Borrello, G	2
Stianrapapongs, P	1
Sitprija, V	1
Sidorenko, BA	1
Savenkov, PM	1
Kharchenko, VI	1
Evsikov, EM	1
Bobkova, VI	1
Kartitskií, VS	1
Lapkes, TG	1
Mazurova, SV	1
Huminer, D	1
Hardy, B	1
Schwinger, RH	1
Antoni, DH	1
Omsjø, IH	1
Kromer, EP	1
Elsner, D	1
Riegger, GA	1
Yedinak, KC	1
Lopez, LM	1
Kleber, FX	2
Thyroff-Friesinger, U	2
Podszus, Th	1
Peter, JH	1
Völger, KD	1
Zilles, P	1
Heck, I	1
Müller, HM	1
Esser, H	1
Lüderitz, B	1
Luurila, O	1
Gordin, A	1
Sundberg, S	1
Sromovsky, JA	1
Bain, PG	1
Egner, W	1
Walker, PR	1
Sievert, H	2
Offermann, T	2
Hopf, R	2
Bussmann, WD	2
Bressler, R	1
Dyckner, T	1
Wester, PO	1
Widman, L	1
Ghosh, AK	1
Mankikar, G	1
Strouthidis, T	1
Windsor, A	1
Long, C	1
Glover, DR	1
Funke Küpper, AJ	1
Fintelman, H	1
Huige, MC	1
Koolen, JJ	1
Liem, KL	1
Lustermans, FA	1
Gonska, BD	1
Kreuzer, H	1
Mauersberger, H	1
Rangoonwala, B	1
Ehrlich, E	1
Kraunz, RF	1
Roux, M	1
Herne, N	1
Gilly, R	1
Michaud, J	1
Le Gall, F	1
Hitzenberger, G	1
Ravina, A	1
Kain, T	1
Whight, C	1
Morgan, T	1
Carney, S	1
Wilson, M	1
Nash, DT	1
Lahovaara, S	1
Paasonen, MK	1
Freis, ED	2
Sharefkin, JB	1
Silen, W	1
Carey, RM	1
Wooster, LD	1
Hook, EW	1
Scebat, L	1
Renais, J	1
Hiltgen, M	1
Gerbaux, A	1
Warembourg, H	2
Bertrand, ME	2
Hubert, C	1
Sevens-Rocmans, C	1
Demanet, JC	1
Macfarlane, JP	1
Kennedy, RD	1
Heino, A	1
Munter, J	1
Miraglia, G	1
Nava, A	1
Dalla Volta, S	1
Ginestet, A	1
Cox, JR	1
Porthouse, A	1
Laidlaw, JC	1
Lindy, S	1
Tarssanen, L	1
Cesari, L	1
Vattimo, A	1
Nardi, P	1
Chaudhury, RR	1
Chugh, KS	1
Gupta, GS	1
Sodhi, P	1
Gupta, KK	1
Motolese, M	1
Petz, E	1
Todisco, T	1
Radó, JP	1
Marosi, J	1
Takó, J	1
Alonso, HO	1
Gaspary, F	1
Tverde, P	1
McKean, WI	1
Irvine, RO	1
Chung, EK	1
Koshikawa, S	1
Sasaoka, T	1
Enescu, I	1
Tacu, V	1
Babei, E	1
Malo, RA	1
Gastaldi, L	1
Buccianti, G	1
Rizzato, G	1
Marazzini, L	1
Eto, M	1
Vinogradov, AV	1
Matveev, LN	1
Pisano, G	1
Ghia, G	1
Buchanan, JW	1
Dear, MG	1
Pyle, RL	1
Berg, P	1
Yasui, H	1
el-Ebrashy, N	1
el-Danasoury, M	1
Higazi, AM	1
Wooster, AG	1
Lockett, MF	1
Curnow, DH	1
Joske, RA	1
Teodoresco, P	1
Lilis, M	1
Stefan, I	1
Tzincou, S	1
Coucou, N	1