hydrochlorothiazide has been researched along with Carcinoma, Squamous Cell in 23 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrochlorothiazide is associated with an increased risk for NMSC (especially SCC) and melanoma in non-Asian countries, whereas bendroflumethiazide and indapamide are not associated with a meaningful risk for skin cancers." | 5.22 | Associations of thiazide use with skin cancers: a systematic review and meta-analysis. ( Chen, YH; Chi, CC; Hung, MJ; Lai, CC; Lai, EC; Shao, SC, 2022) |
| "The mean age for cutaneous and lip squamous cell carcinoma development was 73." | 2.82 | Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis. ( Barboza, CAG; de Castro, RD; de Lisboa Lopes Costa, A; de Macedo Andrade, AC; Felix, FA; França, GM; Ribeiro, ILA, 2022) |
| " These results do not modify the benefit/risk ratio but should lead to propose preventive mesures: identification of high risk population, avoidance of this drug if possible in immunocompromised patients or with previous skin cancer, regular skin examination in case of long term use of hydrochlorothiazide." | 2.61 | [Hydrochlorothiazide use and risk of skin cancers: A systematic review]. ( Becquart, O; Bourrain, JL; Du-Thanh, A; Duflos, C; Guillot, B, 2019) |
| "Hydrochlorothiazide (HCTZ) is a frequently prescribed diuretic that exhibits photosensitizing properties." | 1.91 | Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice? ( Al-Chaer, RN; Lerche, CM; Wulf, HC, 2023) |
| " The aim of this study was to investigate the association between hydrochlorothiazide use and incidence of skin cancer in a cohort of unselected Caucasian adults, taking dosing into account." | 1.91 | Chronic Use of Hydrochlorothiazide and Risk of Skin Cancer in Caucasian Adults: A PharmLines Initiative Inception Cohort Study. ( Bos, J; De Bock, GH; De Vos, S; Greven, N; Haisma, MS; Hak, E; Horváth, B; Logendran, M; Rácz, E; van der Vegt, B, 2023) |
| "BCC recurrences were statistically significant with age, longer follow-up, and positive margins after excision in HCTZ users (p = 0." | 1.91 | The effect of hydrochlorothiazide on the recurrence of nonmelanoma skin cancer: a 7-year retrospective study comprising 300 patients. ( Akıncı, K; Albayati, A; Özkan, B; Savran, S; Uysal, AÇ; Uysal, Pİ, 2023) |
| " We found clear dose-response relationships between hydrochlorothiazide use and both BCC and SCC; the highest cumulative dose category (≥200,000 mg of HCTZ) had ORs of 1." | 1.48 | Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark. ( Friis, S; Gaist, D; Hölmich, LR; Pedersen, SA; Pottegård, A; Schmidt, SAJ, 2018) |
| " There was a clear dose-response effect (P < 0." | 1.46 | Hydrochlorothiazide use is strongly associated with risk of lip cancer. ( Friedman, GD; Friis, S; Habel, LA; Hallas, J; Olesen, M; Pottegård, A; Svendsen, MT, 2017) |
| "A woman with unresectable squamous cell carcinoma of the thymus was treated with combination chemotherapy consisting of cyclophosphamide, adriamycin, cisplatin, and prednisone." | 1.27 | Squamous cell carcinoma of the thymus: a case report of rapid response to cyclophosphamide, doxorubicin, cisplatin, and prednisone. ( Barkley, HT; Chiuten, DF; Chong, C; McKenna, RJ; Umsawasdi, T; Weedn, VW, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 17 (73.91) | 2.80 |
| Authors | Studies |
|---|---|
| de Haan-Du, J | 1 |
| Landman, GWD | 1 |
| Groenier, KH | 1 |
| Vissers, PAJ | 1 |
| Louwman, MWJ | 1 |
| Kleefstra, N | 1 |
| de Bock, GH | 2 |
| de Macedo Andrade, AC | 1 |
| Felix, FA | 1 |
| França, GM | 1 |
| Ribeiro, ILA | 1 |
| Barboza, CAG | 1 |
| de Castro, RD | 1 |
| de Lisboa Lopes Costa, A | 1 |
| Shao, SC | 1 |
| Lai, CC | 1 |
| Chen, YH | 1 |
| Lai, EC | 1 |
| Hung, MJ | 1 |
| Chi, CC | 1 |
| Lerche, CM | 1 |
| Al-Chaer, RN | 1 |
| Wulf, HC | 1 |
| Haisma, MS | 1 |
| Greven, N | 1 |
| Logendran, M | 1 |
| Bos, J | 1 |
| van der Vegt, B | 1 |
| Horváth, B | 1 |
| De Vos, S | 1 |
| Hak, E | 1 |
| Rácz, E | 1 |
| Özkan, B | 1 |
| Savran, S | 1 |
| Akıncı, K | 1 |
| Albayati, A | 1 |
| Uysal, Pİ | 1 |
| Uysal, AÇ | 1 |
| Tchernev, G | 1 |
| O'Neill, B | 1 |
| Moe, S | 1 |
| Korownyk, C | 1 |
| Randhawa, A | 1 |
| Wylie, G | 1 |
| Daniels, B | 1 |
| Pearson, SA | 1 |
| Vajdic, CM | 1 |
| Pottegård, A | 4 |
| Buckley, NA | 1 |
| Zoega, H | 1 |
| Freeman, C | 1 |
| Hull, C | 1 |
| Sontheimer, R | 1 |
| Curtis, J | 1 |
| Adalsteinsson, JA | 1 |
| Muzumdar, S | 1 |
| Waldman, R | 1 |
| Hu, C | 1 |
| Wu, R | 1 |
| Ratner, D | 1 |
| Ungar, J | 1 |
| Silverberg, JI | 1 |
| Olafsdottir, GH | 1 |
| Kristjansson, AK | 1 |
| Tryggvadottir, L | 1 |
| Jonasson, JG | 1 |
| Letellier, T | 1 |
| Leborgne, F | 1 |
| Kerleau, C | 1 |
| Gaultier, A | 1 |
| Dantal, J | 1 |
| Ville, S | 1 |
| Eworuke, E | 1 |
| Haug, N | 1 |
| Bradley, M | 1 |
| Cosgrove, A | 1 |
| Zhang, T | 1 |
| Dee, EC | 1 |
| Adimadhyam, S | 1 |
| Petrone, A | 1 |
| Lee, H | 1 |
| Woodworth, T | 1 |
| Toh, S | 1 |
| Hollestein, LM | 1 |
| Arnspang Pedersen, S | 1 |
| Hallas, J | 1 |
| Olesen, M | 1 |
| Svendsen, MT | 1 |
| Habel, LA | 1 |
| Friedman, GD | 1 |
| Friis, S | 2 |
| Pedersen, SA | 2 |
| Gaist, D | 2 |
| Schmidt, SAJ | 1 |
| Hölmich, LR | 1 |
| Han, S | 1 |
| Wolfe, CM | 2 |
| Angnardo, L | 1 |
| Cognetta, AB | 2 |
| Becquart, O | 1 |
| Guillot, B | 1 |
| Bourrain, JL | 1 |
| Duflos, C | 1 |
| Du-Thanh, A | 1 |
| Heinrichs, E | 1 |
| Leslie, MD | 1 |
| Glaser, MG | 1 |
| Umsawasdi, T | 1 |
| Chong, C | 1 |
| Weedn, VW | 1 |
| McKenna, RJ | 1 |
| Barkley, HT | 1 |
| Chiuten, DF | 1 |
5 reviews available for hydrochlorothiazide and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis.
Topics: Aged; Carcinoma, Squamous Cell; Female; Humans; Hydrochlorothiazide; Lip; Lip Neoplasms; Male; Skin | 2022 |
Associations of thiazide use with skin cancers: a systematic review and meta-analysis.
Topics: Bendroflumethiazide; Carcinoma, Squamous Cell; Humans; Hydrochlorothiazide; Indapamide; Melanoma; Sk | 2022 |
Hydrochlorothiazide and squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Diuretics; Humans; Hydrochlorothiazide; Hypertension | 2020 |
[Hydrochlorothiazide use and risk of skin cancers: A systematic review].
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Hydrochlorothiazide; Melanoma; Risk Assessm | 2019 |
Hydrochlorothiazide Use and Skin Cancer: A Mohs Surgeon's Concern.
Topics: Antihypertensive Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Hydrochlorothiazid | 2016 |
18 other studies available for hydrochlorothiazide and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
The Risk of Cutaneous Squamous Cell Carcinoma Among Patients with Type 2 Diabetes Receiving Hydrochlorothiazide: A Cohort Study.
Topics: Aged; Carcinoma, Squamous Cell; Diabetes Mellitus, Type 2; Diuretics; Dose-Response Relationship, Dr | 2021 |
Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?
Topics: Animals; Carcinoma, Squamous Cell; Hydrochlorothiazide; Mice; Mice, Hairless; Neoplasms, Radiation-I | 2023 |
Chronic Use of Hydrochlorothiazide and Risk of Skin Cancer in Caucasian Adults: A PharmLines Initiative Inception Cohort Study.
Topics: Adult; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Humans; Hydrochlorothiazide; | 2023 |
The effect of hydrochlorothiazide on the recurrence of nonmelanoma skin cancer: a 7-year retrospective study comprising 300 patients.
Topics: Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Hydrochlorothiazide; Recurrence; Retr | 2023 |
NITROSOGENESIS LESSONS FROM DERMATOLOGISTS-NITROSAMINES/ NDSRIS CONTAMINATION OF THE POLIMEDICATION IN POLIMORBID PATIENTS AS THE MOST POWERFUL SKIN CANCER INDUCTOR: DOUBLE HATCHET FLAP FOR SCC OF THE SCALP OCCURRING DURING TREATMENT WITH VALSARTAN/ HYDRO
Topics: Aged, 80 and over; Carcinogens; Carcinoma, Squamous Cell; Dermatologists; Humans; Hydrochlorothiazid | 2023 |
Severe widespread actinic damage and squamous cell carcinoma: could hydrochlorothiazide be implicated? A report of two cases.
Topics: Aged, 80 and over; Carcinoma, Squamous Cell; Diuretics; Female; Humans; Hydrochlorothiazide; Middle | 2020 |
Risk of squamous cell carcinoma of the lip and cutaneous melanoma in older Australians using hydrochlorothiazide: A population-based case-control study.
Topics: Aged; Aged, 80 and over; Australia; Carcinoma, Squamous Cell; Case-Control Studies; Cohort Studies; | 2020 |
Squamous cell carcinoma of the dorsal hands and feet after repeated exposure to ultraviolet nail lamps.
Topics: Aged; Beauty Culture; Carcinoma, Squamous Cell; Female; Foot; Hand; Humans; Hydrochlorothiazide; Men | 2020 |
Association between hydrochlorothiazide and the risk of in situ and invasive squamous cell skin carcinoma and basal cell carcinoma: A population-based case-control study.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Carcinogenesis; Carcinoma, Basal Cell; Carcinoma, | 2021 |
Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients.
Topics: Adult; Age Factors; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Databases, Factual; Diuretics; | 2020 |
In Brief: Hydrochlorothiazide and skin cancer.
Topics: Antihypertensive Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Drug Labeling; Humans; Hyd | 2020 |
Risk of Nonmelanoma Skin Cancer in Association With Use of Hydrochlorothiazide-Containing Products in the United States.
Topics: Adult; Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Carcino | 2021 |
Increased cutaneous squamous cell carcinoma risk with hydrochlorothiazide use: is there a safe alternative?
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Case-Control Studies; Humans; Hydrochlorothiazide; | 2021 |
Hydrochlorothiazide use is strongly associated with risk of lip cancer.
Topics: Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Case-Control Studies; Denmark; Diuretics; Dose-Re | 2017 |
Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; C | 2018 |
Hydrochlorothiazide Use and Increased Squamous Cell Carcinoma Burden in a High-Risk Mohs Population: A Cross-Sectional Study.
Topics: Aged; Carcinoma, Squamous Cell; Cross-Sectional Studies; Diuretics; Female; Florida; Humans; Hydroch | 2020 |
Impaired salivary gland function after radiotherapy compounded by commonly prescribed medications.
Topics: Aged; Amiloride; Amitriptyline; Carcinoma, Squamous Cell; Cisplatin; Drug Combinations; Female; Huma | 1993 |
Squamous cell carcinoma of the thymus: a case report of rapid response to cyclophosphamide, doxorubicin, cisplatin, and prednisone.
Topics: Amiloride; Antineoplastic Combined Chemotherapy Protocols; Blood Urea Nitrogen; Carcinoma, Squamous | 1986 |