hydrochlorothiazide has been researched along with Brain Vascular Disorders in 30 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of the present exploratory study was to determine whether blood pressure-lowering therapy with the combination of the angiotensin receptor blocker losartan plus hydrochlorothiazide (LPH) worsens brain perfusion in patients with both hypertension and cerebral hemodynamic impairment due to symptomatic chronic major cerebral artery steno-occlusive disease." | 7.78 | Effect of combination therapy with the angiotensin receptor blocker losartan plus hydrochlorothiazide on brain perfusion in patients with both hypertension and cerebral hemodynamic impairment due to symptomatic chronic major cerebral artery steno-occlusiv ( Kobayashi, M; Kuroda, H; Ogasawara, K; Ogawa, A; Saura, H; Suzuki, T; Terasaki, K; Yamashita, T, 2012) |
| "The primary objective of this study was to determine whether combination therapy with valsartan 160 mg plus hydrochlorothiazide (HCTZ) 25 mg OD would be more effective than monotherapy with amlodipine 10 mg OD in reducing systolic blood pressure (SBP) in patients with moderate (stage II) hypertension and > or =1 other cardiovascular risk factor or concomitant condition." | 5.11 | Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: the VAST study. ( Bönner, G; Heintz, D; Kandra, A; Khder, Y; Malacco, E; Ruilope, LM, 2005) |
| "Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications." | 5.08 | Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. ( Arabidze, GG; Birkenhäger, WH; Bulpitt, CJ; Celis, H; de Leeuw, PW; Dollery, CT; Fagard, R; Fletcher, AE; Forette, F; Leonetti, G; Nachev, C; O'Brien, ET; Rodicio, JL; Rosenfeld, J; Staessen, JA; Thijs, L; Tuomilehto, J; Zanchetti, A, 1997) |
| " The purpose of the present exploratory study was to determine whether blood pressure-lowering therapy with the combination of the angiotensin receptor blocker losartan plus hydrochlorothiazide (LPH) worsens brain perfusion in patients with both hypertension and cerebral hemodynamic impairment due to symptomatic chronic major cerebral artery steno-occlusive disease." | 3.78 | Effect of combination therapy with the angiotensin receptor blocker losartan plus hydrochlorothiazide on brain perfusion in patients with both hypertension and cerebral hemodynamic impairment due to symptomatic chronic major cerebral artery steno-occlusiv ( Kobayashi, M; Kuroda, H; Ogasawara, K; Ogawa, A; Saura, H; Suzuki, T; Terasaki, K; Yamashita, T, 2012) |
| "Effects of benidipine hydrochloride or triple therapy (hydralazine, reserpine, and hydrochlorothiazide) on renal cortical and medullary intrinsic antioxidant enzyme (AOE) activity were evaluated in stroke-prone spontaneously hypertensive rats (SHR-SP) as an animal model for human essential hypertension with cerebral stroke." | 3.69 | Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP). ( Fukui, M; Shou, I; Takahashi, Y; Tomino, Y; Wang, LN, 1997) |
| "In stroke-prone spontaneously hypertensive rats, oral long-term treatment with verapamil, propranolol, hydrochlorothiazide, and dihydralazine attenuated the development of hypertension." | 3.67 | Development of hypertension and life span in stroke-prone spontaneously hypertensive rats during oral long-term treatment with various antihypertensive drugs. ( Gries, J; Kretzschmar, R; Neumann, BW, 1989) |
| "Hyperlipidemia is a widely acknowledged side effect of thiazide diuretic therapy, but it is often dismissed as a short-term effect of high-dose therapy." | 2.40 | Hyperlipidemia of diuretic therapy. ( Ames, R, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (63.33) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saura, H | 1 |
| Ogasawara, K | 1 |
| Suzuki, T | 1 |
| Kuroda, H | 1 |
| Yamashita, T | 1 |
| Kobayashi, M | 1 |
| Terasaki, K | 1 |
| Ogawa, A | 1 |
| DIGIESI, V | 1 |
| MORACE, G | 1 |
| SANCHETTI, P | 1 |
| FAVERO, S | 1 |
| DRACHEVA, ZN | 2 |
| TIAZHKOROB, AM | 1 |
| KUCHEROVA, LL | 1 |
| KANDRUSINA, GA | 1 |
| MANKOVSKII, NB | 1 |
| VAINSHTOK, IB | 1 |
| Ruilope, LM | 1 |
| Malacco, E | 1 |
| Khder, Y | 1 |
| Kandra, A | 1 |
| Bönner, G | 1 |
| Heintz, D | 1 |
| Dorigotti, L | 1 |
| Carpi, C | 1 |
| Bertoli, G | 1 |
| Mariani, PL | 1 |
| Eninia, GI | 1 |
| Smeltere, ES | 1 |
| Godlevska, MA | 1 |
| Uzulinia, IP | 1 |
| Helgeland, A | 1 |
| Freis, E | 1 |
| Vakaliuk, PM | 1 |
| Shvedenko, LA | 1 |
| Iurkevich, ST | 1 |
| Nikulin, KE | 1 |
| Ilika, VG | 1 |
| Gold, G | 1 |
| Fishman, P | 1 |
| Contard, F | 1 |
| Sabri, A | 1 |
| Glukhova, M | 1 |
| Sartore, S | 1 |
| Marotte, F | 1 |
| Pomies, JP | 1 |
| Schiavi, P | 1 |
| Guez, D | 1 |
| Samuel, JL | 1 |
| Rappaport, L | 1 |
| Shou, I | 1 |
| Wang, LN | 1 |
| Takahashi, Y | 1 |
| Fukui, M | 1 |
| Tomino, Y | 1 |
| Staessen, JA | 2 |
| Fagard, R | 2 |
| Thijs, L | 1 |
| Celis, H | 1 |
| Arabidze, GG | 1 |
| Birkenhäger, WH | 1 |
| Bulpitt, CJ | 2 |
| de Leeuw, PW | 1 |
| Dollery, CT | 1 |
| Fletcher, AE | 1 |
| Forette, F | 2 |
| Leonetti, G | 1 |
| Nachev, C | 1 |
| O'Brien, ET | 1 |
| Rosenfeld, J | 1 |
| Rodicio, JL | 1 |
| Tuomilehto, J | 1 |
| Zanchetti, A | 2 |
| Black, HR | 1 |
| Elliott, WJ | 1 |
| Neaton, JD | 1 |
| Grandits, G | 1 |
| Grambsch, P | 1 |
| Grimm, RH | 1 |
| Hansson, L | 1 |
| Lacoucière, Y | 1 |
| Muller, J | 1 |
| Sleight, P | 1 |
| Weber, MA | 1 |
| White, WB | 1 |
| Williams, G | 1 |
| Wittes, J | 1 |
| Fakouhi, TD | 1 |
| Ames, R | 1 |
| Liu, L | 1 |
| Wang, JG | 1 |
| Gong, L | 1 |
| Liu, G | 1 |
| Spotnitz, HM | 1 |
| Staessen, J | 1 |
| Amery, A | 1 |
| Birkenhäger, W | 1 |
| Cox, J | 1 |
| de Leeuw, P | 1 |
| De Cort, P | 1 |
| Fletcher, A | 1 |
| Gries, J | 1 |
| Kretzschmar, R | 1 |
| Neumann, BW | 1 |
| Soltis, EE | 1 |
| Bohr, DF | 1 |
| Mohr, JP | 1 |
| O'Steen, WK | 1 |
| Hall, CE | 1 |
| Hall, OS | 1 |
| Freis, ED | 2 |
| Laidlaw, JC | 1 |
| Hidaka, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Estudio RioplateNsE Sobre Telemonitoreo en hIpertensos No-controlAdos[NCT02730052] | 0 participants (Actual) | Interventional | 2016-12-31 | Withdrawn (stopped due to Centers recruited poorly) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydrochlorothiazide and Brain Vascular Disorders
| Article | Year |
|---|---|
Hyperlipidemia of diuretic therapy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cere | 1998 |
Elderly hypertensive patient. Epidemiologic review.
Topics: Adult; Age Factors; Aged; Cerebrovascular Disorders; Female; Humans; Hydrochlorothiazide; Hypertensi | 1978 |
Effectiveness of drug therapy in hypertension: present status. A review.
Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block | 1971 |
10 trials available for hydrochlorothiazide and Brain Vascular Disorders
| Article | Year |
|---|---|
Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: the VAST study.
Topics: Age Factors; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; D | 2005 |
Treatment of mild hypertension: a five year controlled drug trial. The Oslo study.
Topics: Adult; Blood Pressure; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disease; Drug T | 1980 |
[Current state of the treatment of arterial hypertension].
Topics: Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Heart Failure; Humans; Hydralazine | 1980 |
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; | 1997 |
Rationale and design for the Controlled ONset Verapamil INvestigation of Cardiovascular Endpoints (CONVINCE) Trial.
Topics: Aged; Antihypertensive Agents; Atenolol; Cardiovascular Diseases; Cerebrovascular Disorders; Double- | 1998 |
Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; | 1998 |
Syst-Eur--a multicenter trial on the treatment of isolated systolic hypertension in the elderly: first interim report.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Double- | 1992 |
Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party.
Topics: Aged; Amiloride; Atenolol; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease; Diu | 1992 |
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.
Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu | 1972 |
Hypertension: a challenge in preventive medicine.
Topics: Age Factors; Attitude to Health; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disea | 1974 |
17 other studies available for hydrochlorothiazide and Brain Vascular Disorders
| Article | Year |
|---|---|
Effect of combination therapy with the angiotensin receptor blocker losartan plus hydrochlorothiazide on brain perfusion in patients with both hypertension and cerebral hemodynamic impairment due to symptomatic chronic major cerebral artery steno-occlusiv
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Arterial Occlusive Di | 2012 |
[GUSTATORY ACUITY FOR SALTY FLAVOR AND SALIVARY ELECTROLYTE CONCENTRATION].
Topics: Addison Disease; Cerebrovascular Disorders; Chlorides; Cushing Syndrome; Flavoring Agents; Heart Fai | 1963 |
[CLINICAL STUDY OF A NEW COMPLEX HYPOTENSIVE DRUG COMBINATION].
Topics: Antihypertensive Agents; Arteriosclerosis; Carbamates; Cerebrovascular Disorders; Coronary Disease; | 1963 |
[USE OF RESERPINE ASSCIATED WITH HYPOTHIAZIDE IN THE TREATMENT OF CEREBRAL FORMS OF HYPERTENSION].
Topics: Cerebrovascular Disorders; Drug Therapy; Humans; Hydrochlorothiazide; Hypertension; Reserpine | 1964 |
[TREATMENT OF AGED PATIENTS WITH CEREBRAL FORMS OF HYPERTENSION WITH HYPOTHIAZIDE AND RESERPINE].
Topics: Cerebrovascular Disorders; Humans; Hydrochlorothiazide; Hypertension; Reserpine | 1965 |
Effects of pildralazine alone and in combination on severe hypertension and cerebrovascular lesions in saline-drinking spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cerebrovascular Disorders; Drug Therapy, Combination; Female; Hydrochloroth | 1984 |
[Characteristics of the action of gemiton, adelfan and dopegit on cerebral circulation in arterial hypertension].
Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disea | 1984 |
[Changes In myocardial contractile function and microcirculation in hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Conjunctiva; Drug Combinations; Dru | 1982 |
Hypertension: special concerns in managing the older patient.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Body Mass Index; Cerebrovascular D | 1995 |
Arterial smooth muscle cell phenotype in stroke-prone spontaneously hypertensive rats.
Topics: Actins; Animals; Aorta, Thoracic; Cerebral Cortex; Cerebrovascular Disorders; Fibronectins; Hydrochl | 1993 |
Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP).
Topics: Animals; Antioxidants; Blood Pressure; Calcium Channel Blockers; Catalase; Cerebrovascular Disorders | 1997 |
Development of hypertension and life span in stroke-prone spontaneously hypertensive rats during oral long-term treatment with various antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Dihydralazine; Heart; H | 1989 |
Vascular reactivity in the spontaneously hypertensive stroke-prone rat. Effect of antihypertensive treatment.
Topics: Animals; Blood Pressure; Calcium; Cerebrovascular Disorders; Female; Femoral Artery; Hydralazine; Hy | 1987 |
Lacunar stroke.
Topics: Adult; Blood Pressure; Brain; Cerebrovascular Disorders; Diagnosis, Differential; Hemiplegia; Humans | 1986 |
Hormone influenced hypertension in the male rat. Effect of hydrochlorothiazide.
Topics: 5-Hydroxytryptophan; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Ce | 1969 |
Hypertension: challenge in preventive medicine.
Topics: Aged; Aneurysm; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebrovascular Disorders; Drug Therap | 1973 |
[Effects of various therapeutic agents on hemorrhagic diathesis and blood clotting factors in aged patients with cerebrovascular disorders].
Topics: Adrenochrome; Aged; Blood Coagulation; Blood Coagulation Tests; Cerebrovascular Disorders; Female; H | 1972 |