hydrochlorothiazide has been researched along with Bone Loss, Osteoclastic in 10 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies were undertaken in man to evaluate the roles of volume depletion and of the parathyroid glands in mediating the changes in serum and urinary calcium which follow the administration of hydrochlorothiazide, 100 mg twice daily, for 4 days, 42 studies were carried out in 16 normal subjects, 9 patients with hyperparathyroidism, and 7 vitamin D-treated subjects with hypoparathyroidism." | 5.03 | changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms. ( Brickman, AS; Coburn, JW; Massry, SG, 1972) |
| "We hypothesized that aldosteronism is accompanied by hypercalciuria and hypermagnesuria that lead to bone loss, which could be rescued by hydrochlorothiazide and spironolactone." | 3.73 | Bone loss in rats with aldosteronism. ( Bhattacharya, SK; Chhokar, VS; Runyan, AL; Runyan, JW; Sun, Y; Weber, KT, 2005) |
| "That the in vitro effect of HCTZ on bone resorption may be due to inhibition of osteoclast carbonic anhydrase is discussed." | 1.29 | Hydrochlorothiazide inhibits osteoclastic bone resorption in vitro. ( Hall, TJ; Schaueblin, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Runyan, AL | 1 |
| Chhokar, VS | 1 |
| Sun, Y | 1 |
| Bhattacharya, SK | 1 |
| Runyan, JW | 1 |
| Weber, KT | 1 |
| Bolland, MJ | 1 |
| Ames, RW | 1 |
| Horne, AM | 1 |
| Orr-Walker, BJ | 1 |
| Gamble, GD | 1 |
| Reid, IR | 1 |
| Ott, SM | 1 |
| LaCroix, AZ | 1 |
| Scholes, D | 1 |
| Ichikawa, LE | 1 |
| Wu, K | 1 |
| Christoffersen, J | 1 |
| Christoffersen, MR | 1 |
| Jeantet, A | 1 |
| Giachino, G | 1 |
| Rossi, P | 1 |
| Tetta, C | 1 |
| Thea, A | 1 |
| Squiccimarro, G | 1 |
| Calitri, V | 1 |
| Vercellone, A | 1 |
| Hall, TJ | 1 |
| Schaueblin, M | 1 |
| Gasińska, T | 1 |
| Rozek-Lesiak, K | 1 |
| Harbut-Gryłka, A | 1 |
| Broulik, PD | 1 |
| Pacovský, V | 1 |
| Lemann, J | 1 |
| Gray, RW | 1 |
| Maierhofer, WJ | 1 |
| Cheung, HS | 1 |
| Brickman, AS | 1 |
| Massry, SG | 1 |
| Coburn, JW | 1 |
4 trials available for hydrochlorothiazide and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
The effect of treatment with a thiazide diuretic for 4 years on bone density in normal postmenopausal women.
Topics: Blood Chemical Analysis; Bone Density; Bone Resorption; Calcium; Double-Blind Method; Female; Fractu | 2007 |
Effects of three years of low-dose thiazides on mineral metabolism in healthy elderly persons.
Topics: Aged; Bicarbonates; Bone and Bones; Bone Density; Bone Resorption; Calcium; Calcium, Dietary; Dose-R | 2008 |
Hydrochlorothiazide inhibits bone resorption in men despite experimentally elevated serum 1,25-dihydroxyvitamin D concentrations.
Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Body Weight; Bone Resorption; Calcitriol; Calcium; Creat | 1985 |
changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms.
Topics: Adult; Aged; Blood Proteins; Bone Resorption; Calcium; Clinical Trials as Topic; Ergocalciferols; Ex | 1972 |
6 other studies available for hydrochlorothiazide and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Bone loss in rats with aldosteronism.
Topics: Animals; Bone Resorption; Calcium; Hydrochlorothiazide; Hyperaldosteronism; Magnesium; Male; Parathy | 2005 |
The effect of bendroflumethiazide and hydrochlorothiazide on the rate of dissolution of calcium hydroxyapatite.
Topics: Bendroflumethiazide; Bone Resorption; Durapatite; Humans; Hydrochlorothiazide; Hydrolysis; Hydroxyap | 1984 |
Immobilization: a cause of resorptive hypercalciuria.
Topics: Adult; Alkaline Phosphatase; Bone Resorption; Calcitonin; Calcium; Creatine; Humans; Hydrochlorothia | 1984 |
Hydrochlorothiazide inhibits osteoclastic bone resorption in vitro.
Topics: Animals; Animals, Newborn; Bone Density; Bone Resorption; Calcium; Cell Division; Cell Line; Cell Su | 1994 |
[Effect of hydrochlorothiazide on various parameters of calcium and phosphate metabolism in patients with increased bone resorption caused by malignant metastases to the skeleton].
Topics: Adult; Aged; Bone Resorption; Calcium; Female; Humans; Hydrochlorothiazide; Hypercalcemia; Male; Mid | 1979 |
Hydrochlorothiazide inhibits parathormone-stimulated increase in plasma tartrate-resistant acid phosphatase in mice.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcium; Creatinine; Hydrochlorothiazide | 1991 |