hydrochlorothiazide has been researched along with Body Weight in 182 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both candesartan and a low dose of hydrochlorothiazide are effective and well-tolerated antihypertensive agents in isolated systolic hypertension with additive effects in combination." | 9.10 | Candesartan and hydrochlorothiazide in isolated systolic hypertension. ( Arnolda, LF; Molloy, D; Upton, J; Wing, LM, 2003) |
| "The long-term effects of indapamide or hydrochlorothiazide on blood pressure and renal function were examined in patients with impaired renal function and moderate hypertension." | 9.08 | Comparison between the effects of indapamide and hydrochlorothiazide on creatinine clearance in patients with impaired renal function and hypertension. ( Gadallah, M; Madkour, H; Massry, SG; Plante, GE; Riveline, B, 1995) |
| "Supplementation of potassium alone and in combination with magnesium was compared in 10 patients with chronic compensated heart failure receiving hydrochlorothiazide 50 mg twice daily for the whole trial." | 9.06 | Comparison of potassium alone and potassium-magnesium supplementation in patients with heart failure using hydrochlorothiazide. ( Gordin, A; Kohvakka, A; Luurila, O; Sundberg, S, 1989) |
| "Sixty-one patients (41 men, 20 women) aged 29-73 years, with moderate to severe hypertension, were enrolled in a multicentre study to compare the efficacy, safety, and tolerability of dilevalol (D) and captopril (C)." | 9.06 | Double-blind study of dilevalol and captopril, both in combination with hydrochlorothiazide, in patients with moderate to severe hypertension. ( Fraser, I; Howes, L; Kincaid-Smith, PS; Louis, W; MacDonald, G; Matthews, PG; McGrath, BP; Rallings, M; Scheinkestel, C; Whitworth, JA, 1990) |
| "Sixty patients with mild to moderate essential hypertension, uncontrolled with diuretics alone, were evaluated in a double-blind randomized study that compared the effect of indoramin plus hydrochlorothiazide with that of pindolol plus hydrochlorothiazide." | 9.06 | A double-blind comparison of indoramin and pindolol added to hydrochlorothiazide for the treatment of mild to moderate hypertension. ( Hartikainen, M; Luomanmäki, K, 1986) |
| "The efficacy and tolerance of the loop diuretic muzolimine were compared with those of a fixed combination of hydrochlorothiazide and amiloride in patients with mild to moderate hypertension." | 9.06 | Comparison of the effects of muzolimine and a fixed combination of diuretics in essential hypertension. ( Clementy, J; Wicker, P, 1986) |
| "A multicenter, double-blind, parallel-group study of 219 patients with pitting edema of various causes was undertaken to determine the efficacy and safety of indapamide, administered orally (PO) in a 2." | 9.05 | Indapamide, a new antihypertensive/diuretic agent, in the treatment of patients with edema. ( Bratnick, J; Eff, J; Neiss, E; Vukovich, RA; Zisblatt, M, 1984) |
| "Twenty-four patients with moderate to severe hypertension were treated for four weeks with captopril, an oral inhibitor of angiotensin-converting enzyme." | 9.05 | Captopril in essential hypertension; contrasting effects of adding hydrochlorothiazide or propranolol. ( Banks, RA; Bayliss, J; Jones, JC; MacGregor, GA; Markandu, ND; Roulston, JE, 1982) |
| "Forty patients completed a double-blind parallel group study comparing furosemide (FUR) and hydrochlorothiazide (HCT) when added to a stable dose of beta blocker in the treatment of mild to moderate hypertension." | 9.05 | Controlled comparison of the effects of furosemide and hydrochlorothiazide added to propranolol in the treatment of hypertension. ( Dombey, SL; Lawrence, J; Vander Elst, E; Vlassak, W, 1981) |
| " A double-blind comparison of the effect of tienylic acid and hydrochlorothiazide on blood pressure was made in patients with moderate hypertension." | 9.04 | A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension. ( Gillies, AH; Morgan, TO, 1978) |
| "The relative benefits and risks of reserpine and guanethidine were compared in patients with thiazide-treated mild to moderate hypertension (diastolic pressure 95-115 mm Hg)." | 9.04 | Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine. ( Ferguson, RK; Nies, AS; Rothenberg, RJ, 1976) |
| "The influence of hydrochlorothiazide (HCT) treatment on the plasma levels of triglycerides, total cholesterol and high density lipoprotein cholesterol (HDL-cholesterol) was studied in 10 patients with essential hypertension." | 9.04 | Influence of hydrochlorothiazide on the plasma levels of triglycerides, total cholesterol and HDL-cholesterol in patients with essential hypertension. ( Gevers Leuven, JA; van Brummelen, P; van Gent, CM, 1979) |
| "Losartan/HCTZ therapy significantly reduced not only BP but also plasma levels of BNP in patients with hypertension." | 7.78 | Effect of fixed-dose losartan/hydrochlorothiazide on brain natriuretic peptide in patients with hypertension. ( Inoue, A; Mitsutake, R; Miura, S; Saku, K; Shiga, Y; Uehara, Y, 2012) |
| "Studies were performed to determine if early treatment with an angiotensin II (Ang II) receptor blocker (ARB), olmesartan, prevents the onset of microalbuminuria by attenuating glomerular podocyte injury in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with type 2 diabetes mellitus." | 7.78 | Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. ( Hara, T; Hayden, MR; Hitomi, H; Ichimura, A; Ito, S; Kaifu, K; Kawachi, H; Kiyomoto, H; Kobori, H; Kohno, M; Matsumoto, S; Nishijima, Y; Nishiyama, A; Ohsaki, H; Sofue, T; Sowers, JR; Urushihara, M; Whaley-Connell, A, 2012) |
| "Captopril is an orally active converting enzyme inhibitor lowering blood pressure (BP) in different types of hypertension." | 7.67 | Combined captopril and hydrochlorothiazide therapy in severe hypertension: long-term haemodynamic changes at rest and during exercise. ( Lund-Johansen, P; Omvik, P, 1984) |
| "The effects of treatment with hydrochlorothiazide combined with amiloride were compared to hydrochlorothiazide treatment alone in 2 brothers with congenital nephrogenic diabetes insipidus." | 7.67 | Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. ( Alon, U; Chan, JC, 1985) |
| "To determine the influence of dietary sodium intake on the effects of hydrochlorothiazide (HCT) on blood pressure (BP), serum electrolytes, renin and aldosterone, nine male patients with uncomplicated essential hypertension were studied during the following therapeutic regimes: 1) sodium restriction alone (50 mmol/day), 2) sodium restriction combined with HCT (50 MG TWICE DAILY), 3) HCT alone, and 4) sodium restriction combined with HCT." | 7.66 | Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure, serum electrolytes, renin and aldosterone in essential hypertension. ( de Graeff, J; Schalekamp, M; van Brummelen, P, 1978) |
| "5 mg clonidine (clonidine-TTS) was investigated in 21 patients with essential hypertension over a period of 10 weeks." | 7.66 | [Clonidine transdermal therapeutic system in essential hypertension: effect and tolerance]. ( Baumgart, P; Boerlin, HJ; Groth, H; Knüsel, J; Siegenthaler, W; Vetter, H; Vetter, W; Walger, P; Wehling, M, 1983) |
| "The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension." | 7.66 | A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980) |
| "Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension." | 7.66 | Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study. ( Helgeland, A; Hjermann, I; Holme, I; Leren, P, 1978) |
| "The anti-hypertensive effect of spironolactone and thiabutazide was tested on 47 unselected patients with primary hypertension." | 7.65 | [Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)]. ( Braun, B; Klaus, D; Klump, F; Lemke, R; Zehner, J; Zöfel, P, 1975) |
| "Sibutramine treatment resulted in a significantly greater decrease in body weight, body mass index, and waist circumference and a significant increase in diastolic blood pressure during 24-hour blood pressure monitoring compared with placebo treatment." | 6.73 | Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. ( Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T, 2007) |
| "A total of 422 patients with type 2 diabetes who were hypertensive [sitting systolic blood pressure (SBP) > or = 140 mmHg and/or diastolic blood pressure (DBP) > or = 90 mmHg] and microalbuminuric [urinary albumin excretion (UAE) 30-300 mg/day] were eligible for the study." | 6.70 | Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics. ( Aznar, J; Llisterri, JL; Lozano, JV; Redon, J, 2001) |
| "Losartan (DuP 753) is a novel orally active angiotensin II antagonist that lowers blood pressure." | 6.67 | Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension. ( Carroll, J; Grossman, E; Peleg, E; Rosenthal, T; Shamiss, A, 1994) |
| "Hydrochlorothiazide treatment was accompanied by a decrease in serum potassium and an increase in serum uric acid." | 6.67 | The efficacy and tolerability of long-term felodipine treatment in hypertension. The Scandinavian Multicenter Group. ( Ibsen, H; Westberg, B, 1990) |
| " Also during treatment, fewer patients receiving hydrochlorothiazide required termination as compared with those receiving propranolol; comparative dosage requirements were lower; additional titration during long-term treatment was required less often, and BP remained lower after withdrawal of the active drugs." | 6.65 | Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents. ( , 1982) |
| "Indapamide was given in doses of 2." | 5.27 | Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983) |
| "Danazol is a semisynthetic androgen that is used in the treatment of endometriosis and hereditary angioedema." | 5.26 | Hypertension: a complication of danazol therapy. ( Bretza, JA; Novey, HS; Vaziri, ND; Warner, AS, 1980) |
| "Both candesartan and a low dose of hydrochlorothiazide are effective and well-tolerated antihypertensive agents in isolated systolic hypertension with additive effects in combination." | 5.10 | Candesartan and hydrochlorothiazide in isolated systolic hypertension. ( Arnolda, LF; Molloy, D; Upton, J; Wing, LM, 2003) |
| "The long-term effects of indapamide or hydrochlorothiazide on blood pressure and renal function were examined in patients with impaired renal function and moderate hypertension." | 5.08 | Comparison between the effects of indapamide and hydrochlorothiazide on creatinine clearance in patients with impaired renal function and hypertension. ( Gadallah, M; Madkour, H; Massry, SG; Plante, GE; Riveline, B, 1995) |
| "Forty patients (aged 28-66 years) with essential hypertension were randomized to 14 weeks of treatment with diltiazem or hydrochlorothiazide (HCTZ) in a double-blind, parallel study design." | 5.06 | Endocrine and vascular responses in hypertensive patients to long-term treatment with diltiazem. ( Swartz, SL, 1987) |
| "Supplementation of potassium alone and in combination with magnesium was compared in 10 patients with chronic compensated heart failure receiving hydrochlorothiazide 50 mg twice daily for the whole trial." | 5.06 | Comparison of potassium alone and potassium-magnesium supplementation in patients with heart failure using hydrochlorothiazide. ( Gordin, A; Kohvakka, A; Luurila, O; Sundberg, S, 1989) |
| " We studied 13 patients with mild essential hypertension in a randomized, double-blind design to assess the effects of indomethacin on hydrochlorothiazide's ability to lower blood pressure, alter body weight, stimulate plasma renin activity, and modulate vascular prostacyclin biosynthesis as assessed by the urinary excretion of the major enzymatically produced metabolite of prostacyclin, 2,3-dinor-6-keto-prostaglandin F1 alpha (PGF1 alpha), measured by GC/MS." | 5.06 | The antihypertensive efficacy of hydrochlorothiazide is not prostacyclin dependent. ( Byyny, RL; Gerber, JG; LoVerde, M; Nies, AS, 1990) |
| "Sixty patients with mild to moderate essential hypertension, uncontrolled with diuretics alone, were evaluated in a double-blind randomized study that compared the effect of indoramin plus hydrochlorothiazide with that of pindolol plus hydrochlorothiazide." | 5.06 | A double-blind comparison of indoramin and pindolol added to hydrochlorothiazide for the treatment of mild to moderate hypertension. ( Hartikainen, M; Luomanmäki, K, 1986) |
| "Sixty-one patients (41 men, 20 women) aged 29-73 years, with moderate to severe hypertension, were enrolled in a multicentre study to compare the efficacy, safety, and tolerability of dilevalol (D) and captopril (C)." | 5.06 | Double-blind study of dilevalol and captopril, both in combination with hydrochlorothiazide, in patients with moderate to severe hypertension. ( Fraser, I; Howes, L; Kincaid-Smith, PS; Louis, W; MacDonald, G; Matthews, PG; McGrath, BP; Rallings, M; Scheinkestel, C; Whitworth, JA, 1990) |
| "To study the effect of a combination of amiloride, 5 mg, and hydrochlorothiazide, 50 mg (Moduretic), on plasma and skeletal muscle electrolytes in patients on long-term diuretic therapy (greater than 1 year) for arterial hypertension and/or congestive heart failure, 58 patients were recruited." | 5.06 | Amiloride prevents thiazide-induced intracellular potassium and magnesium losses. ( Dyckner, T; Wester, PO; Widman, L, 1988) |
| "The efficacy and tolerance of the loop diuretic muzolimine were compared with those of a fixed combination of hydrochlorothiazide and amiloride in patients with mild to moderate hypertension." | 5.06 | Comparison of the effects of muzolimine and a fixed combination of diuretics in essential hypertension. ( Clementy, J; Wicker, P, 1986) |
| "Twenty-four patients with moderate to severe hypertension were treated for four weeks with captopril, an oral inhibitor of angiotensin-converting enzyme." | 5.05 | Captopril in essential hypertension; contrasting effects of adding hydrochlorothiazide or propranolol. ( Banks, RA; Bayliss, J; Jones, JC; MacGregor, GA; Markandu, ND; Roulston, JE, 1982) |
| "A multicenter, double-blind, parallel-group study of 219 patients with pitting edema of various causes was undertaken to determine the efficacy and safety of indapamide, administered orally (PO) in a 2." | 5.05 | Indapamide, a new antihypertensive/diuretic agent, in the treatment of patients with edema. ( Bratnick, J; Eff, J; Neiss, E; Vukovich, RA; Zisblatt, M, 1984) |
| "Blood pressure, cardiac output, plasma volume, renin, and aldosterone were measured in 13 patients with essential hypertension on placebo and after 1, 4, and 12 wk on hydrochlorothiazide 100 mg daily." | 5.05 | Hemodynamic changes during long-term thiazide treatment of essential hypertension in responders and nonresponders. ( Man in 't Veld, AJ; Schalekamp, MA; van Brummelen, P, 1980) |
| " Sixteen patients with essential hypertension were treated with guanfacine and with clonidine for 5 weeks each in a double-blind, placebo-controlled, cross-over trial." | 5.05 | Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine. ( Distler, A; Kirch, W; Lüth, B, 1980) |
| "Forty patients completed a double-blind parallel group study comparing furosemide (FUR) and hydrochlorothiazide (HCT) when added to a stable dose of beta blocker in the treatment of mild to moderate hypertension." | 5.05 | Controlled comparison of the effects of furosemide and hydrochlorothiazide added to propranolol in the treatment of hypertension. ( Dombey, SL; Lawrence, J; Vander Elst, E; Vlassak, W, 1981) |
| "Because captopril alone does not control blood pressure in all patients with essential hypertension, studies were performed to assess the effect of sodium intake and of captopril combined with hydrochlorothiazide, propranolol, and nifedipine." | 5.05 | Captopril: contrasting effects of adding hydrochlorothiazide, propranolol, or nifedipine. ( MacGregor, GA; Markandu, ND; Sagnella, GA; Smith, SJ, 1985) |
| "The relative benefits and risks of reserpine and guanethidine were compared in patients with thiazide-treated mild to moderate hypertension (diastolic pressure 95-115 mm Hg)." | 5.04 | Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine. ( Ferguson, RK; Nies, AS; Rothenberg, RJ, 1976) |
| "Sixteen patients with essential hypertension were treated with N-Amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride (BS 100--141) and clonidine for five weeks each in a double-blind cross-over trial." | 5.04 | Antihypertensive effect of N-amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride. A double-blind cross-over trial versus clonidine. ( Distler, A; Kirch, W, 1978) |
| "A crossover comparison of metoprolol and hydrochlorothiazide has been performed in 20 patients with mild hypertension." | 5.04 | Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents. ( Pedersen, OL, 1976) |
| "The influence of hydrochlorothiazide (HCT) treatment on the plasma levels of triglycerides, total cholesterol and high density lipoprotein cholesterol (HDL-cholesterol) was studied in 10 patients with essential hypertension." | 5.04 | Influence of hydrochlorothiazide on the plasma levels of triglycerides, total cholesterol and HDL-cholesterol in patients with essential hypertension. ( Gevers Leuven, JA; van Brummelen, P; van Gent, CM, 1979) |
| " A double-blind comparison of the effect of tienylic acid and hydrochlorothiazide on blood pressure was made in patients with moderate hypertension." | 5.04 | A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension. ( Gillies, AH; Morgan, TO, 1978) |
| "103 patients with arterial hypertension were treated with timolol + placebo for 7 weeks in a multicentre trial, and with timolol + hydrochlorothiazide and amiloride for a further 7-week period." | 5.04 | Individual factors influencing the response to a beta-adrenergic blocking agent given alone and in combination with a diuretic on arterial hypertension. ( Mikkelsen, E; Pedersen, OL, 1979) |
| "This study was designed to compare the effectiveness of spironolactone, hydrochlorothiazide, and combined spironolactone-hydrochlorothiazide therapy in patients with low renin and those with normal renin essential hypertension." | 5.04 | Diuretic therapies in low renin and normal renin essential hypertension. ( Brooks, CS; Johnson, CA; Kotchen, JM; Kotchen, TA, 1977) |
| "Losartan/HCTZ therapy significantly reduced not only BP but also plasma levels of BNP in patients with hypertension." | 3.78 | Effect of fixed-dose losartan/hydrochlorothiazide on brain natriuretic peptide in patients with hypertension. ( Inoue, A; Mitsutake, R; Miura, S; Saku, K; Shiga, Y; Uehara, Y, 2012) |
| "Studies were performed to determine if early treatment with an angiotensin II (Ang II) receptor blocker (ARB), olmesartan, prevents the onset of microalbuminuria by attenuating glomerular podocyte injury in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with type 2 diabetes mellitus." | 3.78 | Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. ( Hara, T; Hayden, MR; Hitomi, H; Ichimura, A; Ito, S; Kaifu, K; Kawachi, H; Kiyomoto, H; Kobori, H; Kohno, M; Matsumoto, S; Nishijima, Y; Nishiyama, A; Ohsaki, H; Sofue, T; Sowers, JR; Urushihara, M; Whaley-Connell, A, 2012) |
| " Daily measurements of body weight, urine volume, and concentration of sodium, potassium and uric acid in urine were performed for each rat." | 3.76 | Diuretic and antioxidant effects of Cacti-Nea, a dehydrated water extract from prickly pear fruit, in rats. ( Bisson, JF; Daubié, S; Guillemet, D; Hidalgo, S; Linarés, E, 2010) |
| " Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance." | 3.74 | Thiazide diuretics exacerbate fructose-induced metabolic syndrome. ( Johnson, RJ; Mu, W; Nakagawa, T; Reungjui, S; Roncal, CA; Sirivongs, D; Srinivas, TR, 2007) |
| "Hydrochlorothiazide (HCTZ) is used to manage hypertension and heart failure; however, its side effects include mild hypokalemia, metabolic abnormalities, and volume depletion, which might have deleterious effects on renal and endothelial function." | 3.74 | Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia. ( Byer, K; Croker, BP; Hu, H; Johnson, RJ; Mu, W; Nakagawa, T; Patel, JM; Reungjui, S; Roncal, CA; Simoni, J; Sitprija, V; Srinivas, T; Wesson, D, 2007) |
| "5 mL/kg of body weight (BW), PO], sucrose (2 g/kg in a 20% aqueous solution, p." | 3.70 | A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf. ( Constable, PD; Drackley, JK; Foreman, JH; Morin, DE; Thurmon, JC; Walker, PG, 1998) |
| "Twenty patients with essential hypertension aged 39-70 years, underwent 20 weeks (short-term) and 30 weeks (long-term) lipid and lipoprotein assessment following moduretic (combination of hydrochlorothiazide and amloride) therapy." | 3.68 | Effects of moduretic on plasma lipid and lipoprotein levels in hypertensive African patients. ( Agbedana, OE; Ahaneku, JE; Salako, LA; Taylor, GO; Walker, O, 1993) |
| "Captopril is an orally active converting enzyme inhibitor lowering blood pressure (BP) in different types of hypertension." | 3.67 | Combined captopril and hydrochlorothiazide therapy in severe hypertension: long-term haemodynamic changes at rest and during exercise. ( Lund-Johansen, P; Omvik, P, 1984) |
| "The effect of short-term diuretic treatment on the action of clonidine was evaluated in eight subjects with mild, uncomplicated hypertension." | 3.67 | Diuretic treatment alters clonidine suppression of plasma norepinephrine. ( Felton, K; Hui, TP; Krakoff, LR; Yeager, K, 1986) |
| "5 mmoles per day), hydrochlorothiazide (10 milligrams per kilogram body weight per day), or both NaHCO3 and hydrochlorothiazide." | 3.67 | Effects of sodium bicarbonate and hydrochlorothiazide on the hypercalciuric action of 1,25(OH)2D3 in the rat. ( Campbell, DR; Goulding, A, 1984) |
| "The effects of treatment with hydrochlorothiazide combined with amiloride were compared to hydrochlorothiazide treatment alone in 2 brothers with congenital nephrogenic diabetes insipidus." | 3.67 | Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. ( Alon, U; Chan, JC, 1985) |
| "Hydrochlorothiazide, a drug which is often initially prescribed for mild to moderate hypertension, failed to lower blood pressures in 9 of 43 patients but concomitantly elevated plasma norepinephrine (NE) levels in all patients with hypertension." | 3.66 | Fenfluramine potentiation of antihypertensive effects of thiazides. ( Coleman, MD; Kopin, IJ; Lake, CR; Ziegler, MG, 1980) |
| "Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension." | 3.66 | Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study. ( Helgeland, A; Hjermann, I; Holme, I; Leren, P, 1978) |
| "The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension." | 3.66 | A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension. ( Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L, 1980) |
| "To determine the influence of dietary sodium intake on the effects of hydrochlorothiazide (HCT) on blood pressure (BP), serum electrolytes, renin and aldosterone, nine male patients with uncomplicated essential hypertension were studied during the following therapeutic regimes: 1) sodium restriction alone (50 mmol/day), 2) sodium restriction combined with HCT (50 MG TWICE DAILY), 3) HCT alone, and 4) sodium restriction combined with HCT." | 3.66 | Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure, serum electrolytes, renin and aldosterone in essential hypertension. ( de Graeff, J; Schalekamp, M; van Brummelen, P, 1978) |
| "The interrelationship between PRA, urinary aldosterone excretion, and blood pressure was studied in 11 patients with essential hypertension while receiving a diuretic (1st week) and subsequently a diuretic + oxprenolol (2nd week)." | 3.66 | The renin-angiotensin-aldosterone system and blood pressure during oxprenolol treatment in hypertensive patients pretreated with diuretics. ( Pedrinelli, R; Salvetti, A; Simonini, N, 1982) |
| "5 mg clonidine (clonidine-TTS) was investigated in 21 patients with essential hypertension over a period of 10 weeks." | 3.66 | [Clonidine transdermal therapeutic system in essential hypertension: effect and tolerance]. ( Baumgart, P; Boerlin, HJ; Groth, H; Knüsel, J; Siegenthaler, W; Vetter, H; Vetter, W; Walger, P; Wehling, M, 1983) |
| "M-mode echocardiography was used in 12 patients with essential hypertension to study changes in cardiac anatomy during long-term therapy with hydrochlorothiazide (50 to 100 mg) and alpha-methyldopa (500 to 1,750 mg)." | 3.66 | Effect of long-term antihypertensive therapy on cardiac anatomy in patients with essential hypertension. ( Drayer, JI; Gardin, JM; Lipson, JL; Weber, MA, 1983) |
| "The anti-hypertensive effect of spironolactone and thiabutazide was tested on 47 unselected patients with primary hypertension." | 3.65 | [Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)]. ( Braun, B; Klaus, D; Klump, F; Lemke, R; Zehner, J; Zöfel, P, 1975) |
| "Sibutramine treatment resulted in a significantly greater decrease in body weight, body mass index, and waist circumference and a significant increase in diastolic blood pressure during 24-hour blood pressure monitoring compared with placebo treatment." | 2.73 | Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. ( Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T, 2007) |
| "A total of 422 patients with type 2 diabetes who were hypertensive [sitting systolic blood pressure (SBP) > or = 140 mmHg and/or diastolic blood pressure (DBP) > or = 90 mmHg] and microalbuminuric [urinary albumin excretion (UAE) 30-300 mg/day] were eligible for the study." | 2.70 | Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics. ( Aznar, J; Llisterri, JL; Lozano, JV; Redon, J, 2001) |
| "Losartan (DuP 753) is a novel orally active angiotensin II antagonist that lowers blood pressure." | 2.67 | Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension. ( Carroll, J; Grossman, E; Peleg, E; Rosenthal, T; Shamiss, A, 1994) |
| " If seated DBP was > or = 90 mm Hg at any visit, daily dosage of felodipine was doubled to a maximum of 20 mg." | 2.67 | Antihypertensive effect and tolerability of felodipine extended release (ER) tablets in comparison with felodipine plain tablets (PT) and placebo in hypertensives on a diuretic. Canadian Study Group. ( Carruthers, SG; Vint-Reed, C, 1993) |
| "Hydrochlorothiazide treatment was accompanied by a decrease in serum potassium and an increase in serum uric acid." | 2.67 | The efficacy and tolerability of long-term felodipine treatment in hypertension. The Scandinavian Multicenter Group. ( Ibsen, H; Westberg, B, 1990) |
| "Pinacidil is a direct vasodilator with good absorption, a half-life of 2 to 4 hours, and side effects similar to those of other vasodilators." | 2.66 | A double-blind, randomized, controlled trial comparing pinacidil to hydralazine in essential hypertension. ( Byyny, RL; LoVerde, ME; Mitchell, WD; Nies, AS, 1987) |
| "When indomethacin was added to hydrochlorothiazide, body weight and plasma potassium levels increased and PRA decreased." | 2.66 | Effects of indomethacin and sulindac on hydrochlorothiazide kinetics. ( Gribnau, FW; Kateman, WG; Koopmans, PP; Tan, Y; van Ginneken, CA, 1985) |
| " Also during treatment, fewer patients receiving hydrochlorothiazide required termination as compared with those receiving propranolol; comparative dosage requirements were lower; additional titration during long-term treatment was required less often, and BP remained lower after withdrawal of the active drugs." | 2.65 | Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents. ( , 1982) |
| "5 mg, 25 mg, and 50 mg hydrochlorothiazide combined with 400 mg acebutolol was assessed." | 2.65 | Lack of effect of beta-blocker on flat dose response to thiazide in hypertension: efficacy of low dose thiazide combined with beta-blocker. ( Banks, RA; Bayliss, J; MacGregor, GA; Markandu, ND; Roulston, J, 1983) |
| " Blood pressure was significantly reduced with both medications, although most patients required an increase in dosage from 250 to 500 mg ticrynafen daily." | 2.64 | Clinical study of ticrynafen. A new diuretic, antihypertensive, and uricosuric agent. ( Freis, ED; Kyle, MC; Nemati, M, 1977) |
| "Treatment with furosemide or HCTZ did not have relevant effects on measured parameters." | 1.43 | The Effects of Early Postnatal Diuretics Treatment on Kidney Development and Long-Term Kidney Function in Wistar Rats. ( Bueters, RR; Florquin, S; Jeronimus-Klaasen, A; Maicas, N; Schreuder, MF; van den Heuvel, LP, 2016) |
| "Hydrochlorothiazide treatment was associated with hypokalemia, which was not present in losartan or indapamide treatment." | 1.36 | Comparative study of hydrochlorothiazide and indapamide on the anti-atherogenic potential of losartan in cholesterol fed rat. ( Islam, MZ; Rahman, MS, 2010) |
| "Treatment with losartan, captopril, and the TRx prevented the rhEPO-induced increased in systolic BP." | 1.33 | Antihypertensive and renal protective effects of renin-angiotensin system blockade in uremic rats treated with erythropoietin. ( Agharazii, M; Larivière, R; Lebel, M; Rodrigue, ME, 2006) |
| "5 mg/kg/day) combined with indapamide (0." | 1.31 | Protective effects of delapril combined with indapamide or hydrochlorothiazide in spontaneously hypertensive stroke-prone rats: a comparative dose-response analysis. ( Agnati, LF; Biagini, G; Boschi, S; Torri, C; Vantaggiato, G; Zini, I; Zoli, M, 2000) |
| " Here, we evaluated whether chronic administration of an NO donor, molsidomine, controlled systemic blood pressure and renal disease progression and prolonged survival in rats with renal mass reduction (RMR)." | 1.30 | Renoprotection by nitric oxide donor and lisinopril in the remnant kidney model. ( Benedetti, G; Benigni, A; Bruzzi, I; Corna, D; Noris, M; Remuzzi, G; Todeschini, M; Zoja, C, 1999) |
| "In the present study we induced chronic renal failure by administration of lithium for 16 weeks to new-born rats, and examined the spontaneous course of this nephropathy and the effects of antihypertensive treatment with either perindopril (12 mg/kg diet) or hydrochlorothiazide (500-1000 mg/kg diet) during a 24 weeks follow up period without lithium." | 1.30 | Effects of perindopril and hydrochlorothiazide on the long-term progression of lithium-induced chronic renal failure in rats. ( Christensen, S; Hansen, AK; Marcussen, N; Shalmi, M, 1997) |
| "Treatment with hydrochlorothiazide also lowered blood pressure but had no significant effect on left ventricular weight to body weight ratio [2." | 1.28 | Effects of antihypertensive drugs on heart and resistance vessels. ( Fouad-Tarazi, FM; Kobayashi, H; Sano, T; Tarazi, RC, 1990) |
| " In 2-year studies using dietary concentrations of 0, 250, 500 and 2000 ppm in rats and 0, 2500 and 5000 ppm in mice, survival of dosed and control groups of rats and mice was similar, as were body weights of mice." | 1.28 | Toxicology and carcinogenicity studies of diuretics in F344 rats and B6C3F1 mice. 1. Hydrochlorothiazide. ( Bucher, JR; Davis, WE; Elwell, MR; Eustis, SL; Haseman, JK; Huff, J; Meierhenry, EF, 1990) |
| " Diuretic agents allow dosing rate flexibilities because the temporal profile of diuretic action can vary considerably as long as the total diuretic effect per day is the same." | 1.28 | Optimization of the therapeutic index by adjustment of the rate of drug administration or use of drug combinations: exploratory studies of diuretics. ( Levy, G; Zhi, J, 1990) |
| "Hydralazine tended to lower LV MCVR per 100 g in both strains despite its tendency to increase ventricular mass." | 1.28 | Role of lowering arterial pressure on maximal coronary flow with and without regression of cardiac hypertrophy. ( Canby, CA; Tomanek, RJ, 1989) |
| "In spite of more than three decades of wide use of hydrochlorothiazide as a diuretic, its mean biological half-life (t1/2) and apparent volume of distribution (Vdarea) in normal subjects were found to vary greatly among 11 studies reported between 1976 and 1986." | 1.28 | Large differences in the biological half-life and volume of distribution of hydrochlorothiazide in normal subjects from eleven studies. Correlation with their last blood sampling times. ( Chen, TM; Chiou, WL, 1992) |
| "Hydrochlorothiazide did not produce a statistically significant increase in urinary amylase excretion but did reduce the ratio of salivary amylase/creatinine clearance in a two-hour urine collection." | 1.27 | The influence of hydrochlorothiazide and tripamide on serum and urinary amylase. ( Conrad, KA; Fagan, TC; Simons, JA, 1988) |
| "Indapamide was given in doses of 2." | 1.27 | Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983) |
| "Renal hypertrophy was also decreased significantly by cicletanine at a dose of 100 mg/kg." | 1.27 | Comparison of cicletanine with other antihypertensive drugs in SHR-SP models. ( Braquet, P; Clostre, F; Le Hegarat, M; Malherbe, E, 1988) |
| " No differences between the dose-response curves of furosemide, bumetanide, or piretanide could be demonstrated." | 1.27 | Effect of diuretics on the tubuloglomerular feedback response. ( Brunkhorst, R; Franke, H; Gutsche, HU; Müller-Ott, K; Niedermayer, W, 1984) |
| "Hydrochlorothiazide was administered at two doses to Long-Evans rats for 7-10 days." | 1.27 | The effect of chronic hydrochlorothiazide administration on renal function in the rat. ( Shirley, DG; Walter, SJ, 1986) |
| "Trichlormethiazide treatment and continued sodium deprivation caused marked losses of body weight and food intake and promotions of urine output and water intake." | 1.27 | [Decreased renal excretory capacity of uric acid in rats fed a low sodium diet under consecutive administration of thiazide diuretics]. ( Iwaki, K; Yonetani, Y, 1985) |
| "Danazol is a semisynthetic androgen that is used in the treatment of endometriosis and hereditary angioedema." | 1.26 | Hypertension: a complication of danazol therapy. ( Bretza, JA; Novey, HS; Vaziri, ND; Warner, AS, 1980) |
| "The treatment of both hyperlipidemia and hypertension appeared to be more effective than the treatment of hyperlipidemia, alone." | 1.26 | Aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta. ( Hollander, W; Kirkpatrick, B; Madoff, I; Paddock, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 132 (72.53) | 18.7374 |
| 1990's | 27 (14.84) | 18.2507 |
| 2000's | 16 (8.79) | 29.6817 |
| 2010's | 7 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bueters, RR | 1 |
| Jeronimus-Klaasen, A | 1 |
| Maicas, N | 1 |
| Florquin, S | 1 |
| van den Heuvel, LP | 1 |
| Schreuder, MF | 1 |
| Damian, DJ | 1 |
| McNamee, R | 1 |
| Carr, M | 1 |
| Lewin, AJ | 1 |
| Weir, MR | 2 |
| Bisson, JF | 1 |
| Daubié, S | 1 |
| Hidalgo, S | 1 |
| Guillemet, D | 1 |
| Linarés, E | 1 |
| Islam, MZ | 1 |
| Rahman, MS | 1 |
| Shiga, Y | 1 |
| Miura, S | 1 |
| Mitsutake, R | 1 |
| Uehara, Y | 2 |
| Inoue, A | 1 |
| Saku, K | 1 |
| Sofue, T | 1 |
| Kiyomoto, H | 1 |
| Kobori, H | 1 |
| Urushihara, M | 1 |
| Nishijima, Y | 1 |
| Kaifu, K | 1 |
| Hara, T | 1 |
| Matsumoto, S | 1 |
| Ichimura, A | 1 |
| Ohsaki, H | 1 |
| Hitomi, H | 1 |
| Kawachi, H | 1 |
| Hayden, MR | 1 |
| Whaley-Connell, A | 1 |
| Sowers, JR | 1 |
| Ito, S | 1 |
| Kohno, M | 1 |
| Nishiyama, A | 1 |
| Weber, MA | 4 |
| Jamerson, K | 1 |
| Bakris, GL | 1 |
| Zappe, D | 1 |
| Zhang, Y | 1 |
| Dahlof, B | 1 |
| Velazquez, EJ | 1 |
| Pitt, B | 1 |
| SELLER, RH | 1 |
| SWARTZ, CD | 1 |
| RAMIREZ-MUXO, O | 1 |
| BREST, AH | 1 |
| MOYER, JH | 1 |
| QUAN, KC | 1 |
| KAHANA, L | 1 |
| TATUM, HJ | 1 |
| URANGAIMAZ, FA | 1 |
| TONNELIER, E | 1 |
| KLAUER, D | 1 |
| CHEKHERDEMIAN, M | 1 |
| WOLFF, FW | 1 |
| LANGDON, RG | 1 |
| ARSTILA, A | 1 |
| MAEKINEN, E | 1 |
| VANHA-PERTTULA, T | 1 |
| BERNSTEIN, A | 1 |
| ODZE, M | 1 |
| CREWS, A | 1 |
| SIMON, F | 1 |
| Wing, LM | 1 |
| Arnolda, LF | 1 |
| Upton, J | 1 |
| Molloy, D | 1 |
| Gröholm, T | 1 |
| Finckenberg, P | 1 |
| Palojoki, E | 1 |
| Saraste, A | 1 |
| Bäcklund, T | 1 |
| Eriksson, A | 1 |
| Laine, M | 1 |
| Mervaala, E | 1 |
| Tikkanen, I | 1 |
| Zhou, X | 1 |
| Matavelli, LC | 1 |
| Ono, H | 1 |
| Frohlich, ED | 2 |
| Zhao, Y | 1 |
| Bell, D | 1 |
| Smith, LR | 1 |
| Zhao, L | 1 |
| Devine, AB | 1 |
| McHenry, EM | 1 |
| Nicholls, DP | 1 |
| McDermott, BJ | 1 |
| Lebel, M | 1 |
| Rodrigue, ME | 1 |
| Agharazii, M | 1 |
| Larivière, R | 1 |
| Scholze, J | 1 |
| Grimm, E | 1 |
| Herrmann, D | 1 |
| Unger, T | 1 |
| Kintscher, U | 1 |
| Sládková, M | 1 |
| Kojsová, S | 1 |
| Jendeková, L | 1 |
| Pechánová, O | 1 |
| Reungjui, S | 2 |
| Roncal, CA | 2 |
| Mu, W | 2 |
| Srinivas, TR | 1 |
| Sirivongs, D | 1 |
| Johnson, RJ | 2 |
| Nakagawa, T | 2 |
| Hu, H | 1 |
| Croker, BP | 1 |
| Patel, JM | 1 |
| Srinivas, T | 1 |
| Byer, K | 1 |
| Simoni, J | 1 |
| Wesson, D | 1 |
| Sitprija, V | 1 |
| Hall, CE | 2 |
| Holland, OB | 1 |
| Hall, O | 1 |
| McCarron, DA | 1 |
| Drayer, JI | 3 |
| Lund-Johansen, P | 5 |
| Omvik, P | 2 |
| Idikio, H | 1 |
| Fernandez, PG | 1 |
| Triggle, CR | 1 |
| Kim, BK | 1 |
| Gardin, JM | 2 |
| Lipson, JL | 1 |
| Goulding, A | 2 |
| Campbell, DR | 1 |
| MacGregor, GA | 3 |
| Banks, RA | 2 |
| Markandu, ND | 3 |
| Bayliss, J | 2 |
| Roulston, J | 1 |
| Brooks, BA | 1 |
| Lant, AF | 1 |
| McNabb, WR | 1 |
| Noormohamed, FH | 1 |
| Eastell, R | 1 |
| Edmonds, CJ | 1 |
| Papademetriou, V | 1 |
| Price, M | 1 |
| Johnson, E | 1 |
| Smith, M | 1 |
| Freis, ED | 5 |
| Eff, J | 1 |
| Bratnick, J | 1 |
| Zisblatt, M | 1 |
| Vukovich, RA | 1 |
| Neiss, E | 1 |
| Groth, H | 1 |
| Vetter, H | 1 |
| Knüsel, J | 1 |
| Boerlin, HJ | 1 |
| Walger, P | 1 |
| Baumgart, P | 1 |
| Wehling, M | 1 |
| Siegenthaler, W | 1 |
| Vetter, W | 1 |
| Helgeland, A | 2 |
| Leren, P | 2 |
| Foss, OP | 1 |
| Hjermann, I | 2 |
| Holme, I | 2 |
| Lund-Larsen, PG | 1 |
| Gutsche, HU | 1 |
| Brunkhorst, R | 1 |
| Müller-Ott, K | 1 |
| Franke, H | 1 |
| Niedermayer, W | 1 |
| Salvetti, A | 1 |
| Pedrinelli, R | 1 |
| Simonini, N | 1 |
| Roulston, JE | 1 |
| Jones, JC | 1 |
| Slotkoff, L | 1 |
| Walter, SJ | 2 |
| Shirley, DG | 2 |
| van Brummelen, P | 4 |
| Man in 't Veld, AJ | 1 |
| Schalekamp, MA | 2 |
| Distler, A | 2 |
| Kirch, W | 2 |
| Lüth, B | 1 |
| Walker, BR | 2 |
| Hare, LE | 1 |
| Deitch, MW | 2 |
| Wollam, GL | 1 |
| Tarazi, RC | 3 |
| Bravo, EL | 2 |
| Dustan, HP | 2 |
| Gold, JA | 1 |
| Levey, BA | 1 |
| Olesen, OV | 1 |
| Jaffé, G | 1 |
| Grimshaw, JJ | 1 |
| Vallé-Jones, JC | 1 |
| Warnock, JM | 1 |
| Aronow, WS | 1 |
| Moser, M | 1 |
| Lunn, J | 1 |
| Vander Elst, E | 1 |
| Dombey, SL | 1 |
| Lawrence, J | 1 |
| Vlassak, W | 1 |
| Lake, CR | 1 |
| Ziegler, MG | 1 |
| Coleman, MD | 1 |
| Kopin, IJ | 1 |
| Ruilope, L | 1 |
| Alcazar, JM | 1 |
| Diaz, VP | 1 |
| Jarillo, MD | 1 |
| Millet, VG | 1 |
| Rodicio, JL | 1 |
| Bretza, JA | 1 |
| Novey, HS | 1 |
| Vaziri, ND | 1 |
| Warner, AS | 1 |
| Lebrillant, E | 1 |
| Roulet, MJ | 1 |
| Robert, R | 1 |
| Schiavi, P | 1 |
| Guez, D | 1 |
| Jean, T | 1 |
| Schraeger, JA | 1 |
| Canby, CA | 2 |
| Rongish, BJ | 1 |
| Kawai, M | 1 |
| Tomanek, RJ | 2 |
| Madkour, H | 1 |
| Gadallah, M | 1 |
| Riveline, B | 1 |
| Plante, GE | 1 |
| Massry, SG | 1 |
| Ahaneku, JE | 1 |
| Taylor, GO | 1 |
| Agbedana, OE | 1 |
| Walker, O | 1 |
| Salako, LA | 1 |
| Grossman, E | 1 |
| Peleg, E | 1 |
| Carroll, J | 1 |
| Shamiss, A | 1 |
| Rosenthal, T | 1 |
| Hasselgren, B | 1 |
| Johansson, P | 1 |
| Carruthers, SG | 1 |
| Vint-Reed, C | 1 |
| O'Brien, RC | 1 |
| Cooper, ME | 1 |
| Jerums, G | 1 |
| Doyle, AE | 1 |
| Numabe, A | 1 |
| Hirawa, N | 1 |
| Kawabata, Y | 1 |
| Nagoshi, H | 1 |
| Kaneko, H | 1 |
| Gomi, T | 1 |
| Goto, A | 1 |
| Toyo-oka, T | 1 |
| Omata, M | 1 |
| Christensen, S | 1 |
| Shalmi, M | 1 |
| Hansen, AK | 1 |
| Marcussen, N | 1 |
| Walker, PG | 1 |
| Constable, PD | 1 |
| Morin, DE | 1 |
| Drackley, JK | 1 |
| Foreman, JH | 1 |
| Thurmon, JC | 1 |
| Benigni, A | 1 |
| Zoja, C | 1 |
| Noris, M | 1 |
| Corna, D | 1 |
| Benedetti, G | 1 |
| Bruzzi, I | 1 |
| Todeschini, M | 1 |
| Remuzzi, G | 1 |
| Boschi, S | 1 |
| Vantaggiato, G | 1 |
| Torri, C | 1 |
| Zini, I | 1 |
| Agnati, LF | 1 |
| Zoli, M | 1 |
| Biagini, G | 1 |
| Goto, K | 1 |
| Fujii, K | 1 |
| Onaka, U | 1 |
| Abe, I | 2 |
| Fujishima, M | 1 |
| Lin, Y | 1 |
| Tsuchihashi, T | 1 |
| Kagiyama, S | 1 |
| Matsumura, K | 1 |
| Campbell, M | 1 |
| Sonkodi, S | 1 |
| Soucek, M | 1 |
| Wiecek, A | 1 |
| Lozano, JV | 1 |
| Llisterri, JL | 1 |
| Aznar, J | 1 |
| Redon, J | 1 |
| Crespo, MJ | 1 |
| De Mello, WC | 1 |
| Gevers Leuven, JA | 1 |
| van Gent, CM | 1 |
| Pinals, RS | 1 |
| Dalakos, TG | 1 |
| Streeten, DH | 1 |
| Rengo, F | 1 |
| Trimarco, B | 1 |
| Bonaduce, D | 1 |
| Petretta, M | 1 |
| Ferrara, N | 1 |
| D'Ascia, C | 1 |
| Saccá, L | 1 |
| Cade, R | 1 |
| Juncos, L | 1 |
| Tarrant, D | 1 |
| Mahoney, J | 1 |
| Raulerson, D | 1 |
| Nemati, M | 1 |
| Kyle, MC | 1 |
| Brooks, CS | 1 |
| Johnson, CA | 1 |
| Kotchen, JM | 1 |
| Kotchen, TA | 1 |
| Amery, A | 3 |
| Berthaux, P | 3 |
| Birkenhäger, W | 3 |
| Bulpitt, C | 3 |
| Clement, D | 3 |
| De Shaepdryver, A | 1 |
| Dollery, C | 3 |
| Ernould, H | 1 |
| Fagard, R | 3 |
| Forette, F | 3 |
| Hellemans, J | 3 |
| Kho, T | 1 |
| Meurice, J | 1 |
| Pierquin, L | 1 |
| Mills, JN | 1 |
| Waterhouse, JM | 1 |
| Minors, DS | 1 |
| Dziewanowska, ZE | 1 |
| de Carvalho, JG | 1 |
| Dunn, FG | 1 |
| Chrysant, SG | 1 |
| Boel, A | 2 |
| Brixko, P | 2 |
| Deruyttere, M | 2 |
| de Schaepdryver, A | 2 |
| Henry, JF | 2 |
| Laaser, U | 2 |
| MacFarlane, J | 2 |
| Maling, T | 1 |
| Mutsers, A | 2 |
| Nissinen, A | 2 |
| Ohn, OH | 1 |
| Pelemans, J | 1 |
| Suchettkaye, AI | 1 |
| Tuomilehto, J | 2 |
| Willems, J | 2 |
| Araoye, MA | 1 |
| Chang, MY | 1 |
| Khatri, IM | 1 |
| Gillies, AH | 1 |
| Morgan, TO | 1 |
| De Padua, F | 1 |
| Forte, J | 1 |
| Koistinen, A | 1 |
| Miguel, P | 1 |
| Ohm, OT | 1 |
| Pelemans, W | 1 |
| Suchett-Kaye, AI | 1 |
| Willemse, P | 1 |
| Pedersen, OL | 3 |
| Mikkelsen, E | 1 |
| Woerlee, M | 1 |
| Lemieux, G | 1 |
| Gougoux, A | 1 |
| Vinay, P | 1 |
| Kiss, A | 1 |
| Baverel, G | 1 |
| Shah, S | 1 |
| Khatri, I | 1 |
| Schalekamp, M | 1 |
| de Graeff, J | 1 |
| Ferguson, RK | 1 |
| Rothenberg, RJ | 1 |
| Nies, AS | 3 |
| Valmin, K | 1 |
| Hansen, T | 1 |
| Dunn, MI | 1 |
| Freeman, J | 1 |
| Hollander, W | 1 |
| Madoff, I | 1 |
| Paddock, J | 1 |
| Kirkpatrick, B | 1 |
| Ferrari, L | 1 |
| Bobkova, VI | 1 |
| Kartitskií, VS | 1 |
| Lapkes, TG | 1 |
| Mazurova, SV | 1 |
| Carney, S | 2 |
| Morgan, T | 2 |
| Wilson, M | 2 |
| Matthews, G | 1 |
| Roberts, R | 1 |
| Klump, F | 1 |
| Braun, B | 1 |
| Klaus, D | 1 |
| Lemke, R | 1 |
| Zehner, J | 1 |
| Zöfel, P | 1 |
| Ratheiser, K | 1 |
| Dusleag, J | 1 |
| Seitl, K | 1 |
| Titscher, G | 1 |
| Klein, W | 1 |
| Chillon, JM | 1 |
| Capdeville-Atkinson, C | 1 |
| Lartaud, I | 1 |
| Guillou, J | 1 |
| Mertès, PM | 1 |
| Atkinson, J | 1 |
| Chen, TM | 1 |
| Chiou, WL | 1 |
| Weissel, M | 1 |
| Stanek, B | 1 |
| Flygt, G | 1 |
| McGrath, BP | 1 |
| Matthews, PG | 1 |
| Louis, W | 1 |
| Howes, L | 1 |
| Whitworth, JA | 1 |
| Kincaid-Smith, PS | 1 |
| Fraser, I | 1 |
| Scheinkestel, C | 1 |
| MacDonald, G | 1 |
| Rallings, M | 1 |
| Brørs, O | 1 |
| Elliott, WJ | 1 |
| Weber, RR | 1 |
| Murphy, MB | 1 |
| Hagino, K | 1 |
| Oshige, H | 1 |
| Ozawa, K | 1 |
| Kudo, K | 1 |
| Koide, M | 1 |
| Sugita, R | 1 |
| Adachi, K | 1 |
| Koike, H | 1 |
| Ibsen, H | 1 |
| Westberg, B | 1 |
| Kobayashi, H | 1 |
| Sano, T | 1 |
| Fouad-Tarazi, FM | 1 |
| Gerber, JG | 1 |
| LoVerde, M | 1 |
| Byyny, RL | 2 |
| Bucher, JR | 1 |
| Huff, J | 1 |
| Haseman, JK | 1 |
| Eustis, SL | 1 |
| Elwell, MR | 1 |
| Davis, WE | 1 |
| Meierhenry, EF | 1 |
| Simpson, FO | 1 |
| Ledingham, JM | 1 |
| Knoers, N | 1 |
| Monnens, LA | 1 |
| Zhi, J | 1 |
| Levy, G | 1 |
| Luomanmäki, K | 1 |
| Hartikainen, M | 1 |
| Swartz, SL | 1 |
| Conrad, KA | 1 |
| Fagan, TC | 1 |
| Simons, JA | 1 |
| Poulsen, L | 1 |
| Friberg, M | 1 |
| Noer, I | 1 |
| Krusell, L | 1 |
| Smith, SJ | 1 |
| Sagnella, GA | 1 |
| Maroko, PR | 1 |
| McDevitt, JT | 1 |
| Fox, MJ | 1 |
| Silber, SA | 1 |
| Young, MD | 1 |
| Beg, M | 1 |
| Rockhold, FW | 1 |
| Free, SM | 1 |
| Herron, JR | 1 |
| Gray, JM | 1 |
| Kohvakka, A | 1 |
| Luurila, O | 1 |
| Gordin, A | 1 |
| Sundberg, S | 1 |
| Jansen, RW | 1 |
| Van Lier, HJ | 1 |
| Hoefnagels, WH | 1 |
| Malherbe, E | 1 |
| Le Hegarat, M | 1 |
| Clostre, F | 1 |
| Braquet, P | 1 |
| Lemann, J | 1 |
| Gray, RW | 1 |
| Maierhofer, WJ | 1 |
| Cheung, HS | 1 |
| LoVerde, ME | 1 |
| Mitchell, WD | 1 |
| Dyckner, T | 1 |
| Wester, PO | 1 |
| Widman, L | 1 |
| Ghosh, AK | 1 |
| Mankikar, G | 1 |
| Strouthidis, T | 1 |
| Windsor, A | 1 |
| Long, C | 1 |
| Glover, DR | 1 |
| Hui, TP | 1 |
| Krakoff, LR | 1 |
| Felton, K | 1 |
| Yeager, K | 1 |
| Wicker, P | 1 |
| Clementy, J | 1 |
| Johnson, BF | 1 |
| Saunders, R | 1 |
| Hickler, R | 1 |
| Marwaha, R | 1 |
| Johnson, J | 1 |
| Larochelle, P | 1 |
| Logan, AG | 1 |
| Koopmans, PP | 1 |
| Kateman, WG | 1 |
| Tan, Y | 1 |
| van Ginneken, CA | 1 |
| Gribnau, FW | 1 |
| Alon, U | 1 |
| Chan, JC | 1 |
| Riechers, G | 1 |
| Futerova, M | 1 |
| Hanisch, M | 1 |
| Ritter, W | 1 |
| Kühn, K | 1 |
| Iwaki, K | 1 |
| Yonetani, Y | 1 |
| Hovell, MF | 1 |
| Geary, DC | 1 |
| Black, DR | 1 |
| Kamachi, K | 1 |
| Kirk, R | 1 |
| Elder, J | 1 |
| Kohner, EM | 1 |
| Dollery, CT | 2 |
| Lowy, C | 1 |
| Schumer, B | 1 |
| George, CF | 1 |
| Breckenridge, AM | 1 |
| Gaunt, R | 2 |
| Gisoldi, E | 2 |
| Herkner, J | 1 |
| Howie, N | 1 |
| Renzi, AA | 1 |
| Kochar, MS | 1 |
| Itskovitz, HD | 1 |
| McMahon, FG | 1 |
| Cole, PA | 1 |
| Boyles, PW | 1 |
| Vanov, SK | 1 |
| Whight, C | 1 |
| O'Steen, WK | 1 |
| Hall, OS | 1 |
| Nash, DT | 1 |
| Gottlieb, TB | 1 |
| Katz, FH | 1 |
| Chidsey, CA | 1 |
| Sharefkin, JB | 1 |
| Silen, W | 1 |
| Weinstein, SF | 1 |
| Allan, DM | 1 |
| Mendoza, SA | 1 |
| Fukuchi, S | 1 |
| Nakajima, K | 1 |
| Takenouchi, T | 1 |
| Nishisato, K | 1 |
| Parijs, J | 1 |
| Joossens, JV | 1 |
| Van der Linden, L | 1 |
| Verstreken, G | 1 |
| Amery, AK | 1 |
| Hicks, BH | 1 |
| Ward, JD | 1 |
| Jarrett, RJ | 1 |
| Keen, H | 1 |
| Wise, P | 1 |
| Vetter, G | 1 |
| Jukes, C | 1 |
| Irvine, RO | 2 |
| Jandhyala, BS | 1 |
| Cavero, I | 1 |
| Smookler, HH | 1 |
| Buckley, JP | 1 |
| Kusus, T | 1 |
| Lydtin, H | 1 |
| Zöllner, N | 1 |
| Radó, JP | 1 |
| Marosi, J | 1 |
| Takó, J | 1 |
| Dean, G | 1 |
| Louw, S | 1 |
| Hersch, C | 1 |
| Kirsten, HO | 1 |
| Brereton, DN | 1 |
| Finnemore, L | 1 |
| Dewar, J | 1 |
| Wigger, W | 1 |
| Scheler, F | 1 |
| Creutzfeldt, W | 1 |
| Adlin, EV | 1 |
| Marks, AD | 1 |
| Channick, BJ | 1 |
| Spalding, CT | 1 |
| Jones, VD | 1 |
| Solomon, S | 1 |
| Mouzet, MT | 1 |
| Balsan, S | 1 |
| Royer, P | 1 |
| McKean, WI | 1 |
| Ronnov-Jessen, V | 1 |
| Hansen, J | 2 |
| Smith, N | 1 |
| Gros, G | 1 |
| Weller, JM | 1 |
| Hoobler, SW | 1 |
| Doll, R | 1 |
| Langman, MJ | 1 |
| Shawdon, HH | 1 |
| Russell, RP | 1 |
| Lindeman, RD | 1 |
| Prescott, LF | 1 |
| Schneider, PJ | 1 |
| Eytel, CS | 1 |
| Fregly, MJ | 1 |
| Kim, KJ | 1 |
| Helbig, D | 1 |
| Sappington, RF | 1 |
| Kasper, H | 1 |
| Hölscher, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Multinational, Multicenter Trial to Compare the Effects of Amlodipine/Benazepril to Benazepril and Hydrochlorothiazide Combined on the Reduction of Cardiovascular Morbidity and Mortality in Patients With High Risk Hypertension[NCT00170950] | Phase 3 | 11,506 participants (Actual) | Interventional | 2003-10-31 | Terminated (stopped due to The study was terminated early because of significant efficacy results for the primary endpoint in favor of benazepril/amlodipine treatment.) | ||
| Uric Acid and Hypertension in African Americans[NCT00241839] | Phase 3 | 150 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933] | Phase 2 | 34 participants (Actual) | Interventional | 2019-06-18 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CV mortality was defined as death due to sudden cardiac death, fatal MI, fatal stroke, coronary intervention, congestive heart failure (CHF), or other CV causes. (NCT00170950)
Timeframe: For each patient, baseline to time of first CV mortality event, MI (non-fatal), or stroke (non-fatal) (or last exposure if no event occurred). (Median duration of exposure was 33.4 months. [25th to 75th percentiles: 21 to 41 months.])
| Intervention | Percentage of Patients with an Event (Number) |
|---|---|
| Benazepril/Amlodipine | 5.0 |
| Benazepril/Hydrochlorothiazide | 6.3 |
Cardiovascular morbidity was defined as including any of the following events: non-fatal MI, non-fatal stroke, hospitalization for unstable angina, resuscitated sudden death, or coronary revascularization procedure (PCI or CABG). (NCT00170950)
Timeframe: For each patient, baseline to time of first CV morbidity event (or last exposure if no event occurred). (Median duration of exposure was 33.4 months. [25th to 75th percentiles: 21 to 41 months.])]
| Intervention | Percentage of Patients with an Event (Number) |
|---|---|
| Benazepril/Amlodipine | 8.6 |
| Benazepril/Hydrochlorothiazide | 10.3 |
CV morbidity was defined as non-fatal myocardial infarction (MI), non-fatal stroke, hospitalization for unstable angina, resuscitated sudden death, or coronary revascularization procedure. CV mortality was defined as death due to MI, stroke, coronary intervention, congestive heart failure (CHF), sudden cardiac death, or other CV causes. (NCT00170950)
Timeframe: For each patient, baseline to time of first CV morbidity or mortality event (or last exposure if no event occurred). (Median duration of exposure was 33.4 months. [25th to 75th percentiles: 21 to 41 months.])
| Intervention | Percentage of Patients with an event (Number) |
|---|---|
| Benazepril/Amlodipine | 9.6 |
| Benazepril/Hydrochlorothiazide | 11.8 |
"The Diastolic BP was taken at Baseline and after 8-10 weeks of treatment or placebo while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol / placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 3.44 |
| B (Placebo) | -0.83 |
Subjects had 24 hr blood pressure monitoring (ABPM) at baseline and treatment end. The readings were averaged and the changes from baseline to treatment end were compared. (NCT00241839)
Timeframe: Baseline and end of treatment (8-10 weeks on allopurinol / placebo)
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | -5.9 |
| B (Placebo) | 0.90 |
"The systolic BP was taken at Baseline and after 8-10 weeks of treatment on placebo, while on chlorthalidone and potassium chloride. The blood pressure was measured according to Shared Care protocol: 15 minutes of quiet, undisturbed rest with three BP measurements obtained subsequently at 5 minute intervals.~The mean of the second and third reading was the value used for analysis for both the Baseline measurement and the measurement after 8 - 10 weeks of treatment. The dependent variable is baseline value minus ending value.~Measures are in millimeters of mercury (mm hg)" (NCT00241839)
Timeframe: Measured at 8-10 weeks on allopurinol or placebo
| Intervention | mm Hg (Mean) |
|---|---|
| A (Allopurinol) | 0.21 |
| B (Placebo) | -0.95 |
Subjects on allopurinol are expected to lower their uric acid levels relative to placebo. (NCT00241839)
Timeframe: Baseline UA levels compared to end of treatment levels (8-10 weeks on allopurinol / placebo)
| Intervention | mg/dl (Mean) |
|---|---|
| A (Allopurinol) | 2.29 |
| B (Placebo) | 0.14 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -3.4 |
| Treatment Grup | -13.5 |
Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.15 |
| Treatment Grup | 2.55 |
Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of ECW/TBW (Mean) |
|---|---|
| Placebo | -0.24 |
| Treatment Grup | -2.92 |
decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -5.4 |
| Treatment Grup | -18.1 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -10 |
| Treatment Grup | -26.1 |
Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of sodium excreted (Mean) |
|---|---|
| Placebo | -0.348 |
| Treatment Grup | 0.598 |
Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.075 |
| Treatment Grup | -4.36 |
77 trials available for hydrochlorothiazide and Body Weight
| Article | Year |
|---|---|
Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Age Factors; Aged; Amiloride; Antihypertensive Agents; Ateno | 2016 |
Antihypertensive efficacy and tolerability of irbesartan/hydrochlorothiazide in hypertensive patients stratified by body mass index and type 2 diabetes mellitus status: a post hoc subgroup analysis of the Irbesartan/HCTZ Blood Pressure Reductions in Diver
Topics: Aged; Antihypertensive Agents; Biphenyl Compounds; Body Mass Index; Body Weight; Cluster Analysis; D | 2008 |
Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial.
Topics: Aged; Amlodipine; Antihypertensive Agents; Benzazepines; Body Mass Index; Body Size; Body Weight; Ca | 2013 |
Candesartan and hydrochlorothiazide in isolated systolic hypertension.
Topics: Aged; Aged, 80 and over; Australia; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Pressu | 2003 |
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.
Topics: Adult; Aged; Antihypertensive Agents; Appetite Depressants; Blood Pressure; Body Weight; Cyclobutane | 2007 |
Step-one antihypertensive therapy: a comparison of a centrally acting agent and a diuretic.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Diureti | 1984 |
Lack of effect of beta-blocker on flat dose response to thiazide in hypertension: efficacy of low dose thiazide combined with beta-blocker.
Topics: Acebutolol; Adult; Body Weight; Chlorides; Clinical Trials as Topic; Dose-Response Relationship, Dru | 1983 |
Indapamide, a new antihypertensive/diuretic agent, in the treatment of patients with edema.
Topics: Antihypertensive Agents; Body Weight; Diuretics; Drug Evaluation; Edema; Humans; Hydrochlorothiazide | 1984 |
Serum glucose levels during long-term observation of treated and untreated men with mild hypertension. The Oslo study.
Topics: Adult; Antihypertensive Agents; Blood Glucose; Body Weight; Drug Therapy, Combination; Fasting; Huma | 1984 |
Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. II. Results of long-term therapy. Veterans Administration Cooperative Study Group on Antihypertensive Agents.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Heart Rate; | 1982 |
Captopril in essential hypertension; contrasting effects of adding hydrochlorothiazide or propranolol.
Topics: Adult; Aged; Aldosterone; Body Weight; Captopril; Clinical Trials as Topic; Drug Therapy, Combinatio | 1982 |
Hemodynamic changes during long-term thiazide treatment of essential hypertension in responders and nonresponders.
Topics: Adult; Aldosterone; Blood Volume; Body Weight; Diuresis; Hemodynamics; Humans; Hydrochlorothiazide; | 1980 |
Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as To | 1980 |
Comparative antihypertensive effects of guanabenz and clonidine.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidi | 1982 |
Diuretic potency of combined hydrochlorothiazide and furosemide therapy in patients with azotemia.
Topics: Adult; Body Weight; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Furosemide; Huma | 1982 |
Evaluation of guanabenz added to hydrochlorothiazide therapy in hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Therap | 1982 |
Comparative effects of pindolol and hydrochlorothiazide in black hypertensive patients.
Topics: Black People; Blood Glucose; Blood Pressure; Body Weight; Humans; Hydrochlorothiazide; Hypertension; | 1981 |
Controlled comparison of the effects of furosemide and hydrochlorothiazide added to propranolol in the treatment of hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Drug Therapy, Combination; Female; Furosemide; Heart Rate; | 1981 |
Comparison between the effects of indapamide and hydrochlorothiazide on creatinine clearance in patients with impaired renal function and hypertension.
Topics: Body Weight; Creatinine; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertensi | 1995 |
Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Bod | 1994 |
Natriuretic and diuretic effects of felodipine and hydrochlorothiazide after single and repeated doses.
Topics: Adult; Blood Pressure; Body Weight; Cross-Over Studies; Diuresis; Double-Blind Method; Felodipine; H | 1995 |
Antihypertensive effect and tolerability of felodipine extended release (ER) tablets in comparison with felodipine plain tablets (PT) and placebo in hypertensives on a diuretic. Canadian Study Group.
Topics: Adult; Aged; Blood Pressure; Body Weight; Canada; Delayed-Action Preparations; Double-Blind Method; | 1993 |
A candesartan cilexetil/hydrochlorothiazide combination tablet provides effective blood pressure control in hypertensive patients inadequately controlled on monotherapy.
Topics: Adult; Aged; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weigh | 2001 |
Losartan reduces microalbuminuria in hypertensive microalbuminuric type 2 diabetics.
Topics: Albuminuria; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, | 2001 |
Influence of hydrochlorothiazide on the plasma levels of triglycerides, total cholesterol and HDL-cholesterol in patients with essential hypertension.
Topics: Adult; Blood Pressure; Body Weight; Cholesterol; Clinical Trials as Topic; Humans; Hydrochlorothiazi | 1979 |
Renal physiology and the treatment of hypertension.
Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Depression, Chemical; Drug Therapy, Combinati | 1977 |
Clinical study of ticrynafen. A new diuretic, antihypertensive, and uricosuric agent.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Diureti | 1977 |
Diuretic therapies in low renin and normal renin essential hypertension.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Combinations | 1977 |
Antihypertensive therapy in elderly patients. Pilot trial of the European Working Party on High Blood Pressure in the Elderly.
Topics: Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Female; Humans; Hydrochloro | 1977 |
A chronopharmacological study on hydrochlorthiazide.
Topics: Adolescent; Adult; Blood Pressure; Body Weight; Calcium; Chlorides; Circadian Rhythm; Clinical Trial | 1977 |
Ticrynafen: a novel uricosuric antihypertensive natriuretic agent.
Topics: Blood Pressure; Blood Urea Nitrogen; Blood Volume; Body Weight; Clinical Trials as Topic; Creatinine | 1978 |
Antihypertensive effect of N-amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride. A double-blind cross-over trial versus clonidine.
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; C | 1978 |
Antihypertensive therapy in patients above age 60. Third interim report of the European Working Party on High blood pressure in Elderly (EWPHE).
Topics: Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Double-Blind Method; Europe | 1978 |
Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension.
Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Furosemide; Humans; Hydrochlorothiazide; Hype | 1978 |
A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension.
Topics: Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Chlorides; Clinical T | 1978 |
Antihypertensive therapy in patients above age 60 years (Fourth Interim report of the European Working Party on High Blood pressure in Elderly: EWPHE).
Topics: Aged; Aging; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Doubl | 1978 |
Individual factors influencing the response to a beta-adrenergic blocking agent given alone and in combination with a diuretic on arterial hypertension.
Topics: Adult; Aging; Amiloride; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Heart Rat | 1979 |
Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine.
Topics: Body Weight; Clinical Trials as Topic; Drug Resistance; Evaluation Studies as Topic; Female; Guaneth | 1976 |
Treatment of benign essential hypertension: comparison of furosemide and hydrochlorothiazide.
Topics: Adult; Bicarbonates; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuresis; Dose-Response | 1975 |
Comparison of metoprolol as hydrochlorothiazide and antihypertensive agents.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Heart | 1976 |
Moderate hypertension: treatment with guanethidine and methyldopa.
Topics: Adult; Body Weight; Clinical Trials as Topic; Drug Administration Schedule; Female; Guanethidine; Hu | 1975 |
A "lipo-protective" effect of a fixed combination of captopril and hydrochlorothiazide in antihypertensive therapy.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Cho | 1992 |
Felodipine is more effective than hydrochlorothiazide when added to a beta-blocker in treating elderly hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Body Weight; Double-Blind Method; Drug Therapy, C | 1990 |
Double-blind study of dilevalol and captopril, both in combination with hydrochlorothiazide, in patients with moderate to severe hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Captopril; Double-Blind Method; Drug Therapy, Combination; | 1990 |
A double-blind, randomized, placebo-controlled comparison of the metabolic effects of low-dose hydrochlorothiazide and indapamide.
Topics: Blood Pressure; Body Weight; Double-Blind Method; Female; Heart Rate; Humans; Hydrochlorothiazide; H | 1991 |
The efficacy and tolerability of long-term felodipine treatment in hypertension. The Scandinavian Multicenter Group.
Topics: Adrenergic beta-Antagonists; Adult; Ankle; Blood Pressure; Body Weight; Double-Blind Method; Drug Ad | 1990 |
The antihypertensive efficacy of hydrochlorothiazide is not prostacyclin dependent.
Topics: Adult; Aged; Blood Pressure; Body Weight; Double-Blind Method; Epoprostenol; Female; Humans; Hydroch | 1990 |
A double-blind comparison of indoramin and pindolol added to hydrochlorothiazide for the treatment of mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Therap | 1986 |
Endocrine and vascular responses in hypertensive patients to long-term treatment with diltiazem.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Body Weight; Diltiazem; Dinoprostone; Endocrine Glands; | 1987 |
Comparison of indapamide and hydrochlorothiazide plus amiloride as a third drug in the treatment of arterial hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Double-Blind Method; Female; Heart Rate; Humans | 1989 |
Ibopamine versus hydrochlorothiazide/amiloride in patients with mild congestive heart failure. SK & F Ibopamine Working Group.
Topics: Amiloride; Body Weight; Cardiotonic Agents; Deoxyepinephrine; Double-Blind Method; Drug Combinations | 1989 |
Captopril: contrasting effects of adding hydrochlorothiazide, propranolol, or nifedipine.
Topics: Blood Pressure; Body Weight; Captopril; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hype | 1985 |
Antihypertensive effectiveness of very low doses of hydrochlorothiazide: results of the PHICOG Trial.
Topics: Adolescent; Adult; Age Factors; Aged; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Body Weigh | 1989 |
Comparison of potassium alone and potassium-magnesium supplementation in patients with heart failure using hydrochlorothiazide.
Topics: Aged; Blood Pressure; Body Weight; Double-Blind Method; Female; Heart Failure; Heart Rate; Humans; H | 1989 |
Nitrendipine versus hydrochlorothiazide in hypertensive patients over 70 years of age.
Topics: Aged; Body Weight; Double-Blind Method; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazid | 1989 |
Hydrochlorothiazide inhibits bone resorption in men despite experimentally elevated serum 1,25-dihydroxyvitamin D concentrations.
Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Body Weight; Bone Resorption; Calcitriol; Calcium; Creat | 1985 |
A double-blind, randomized, controlled trial comparing pinacidil to hydralazine in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Dou | 1987 |
Amiloride prevents thiazide-induced intracellular potassium and magnesium losses.
Topics: Aged; Amiloride; Blood Pressure; Body Water; Body Weight; Drug Combinations; Female; Heart Failure; | 1988 |
A single-blind, comparative study of hydrochlorothiazide/amiloride ('Moduret' 25) and hydrochlorothiazide/triamterene ('dyazide') in elderly patients with congestive heart failure.
Topics: Aged; Aged, 80 and over; Amiloride; Antihypertensive Agents; Body Weight; Drug Combinations; Female; | 1987 |
Comparison of the effects of muzolimine and a fixed combination of diuretics in essential hypertension.
Topics: Administration, Oral; Aged; Amiloride; Analysis of Variance; Blood Glucose; Blood Pressure; Body Wei | 1986 |
The effects of thiazide diuretics upon plasma lipoproteins.
Topics: Adult; Blood Glucose; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLD | 1986 |
Hydrochlorothiazide-amiloride versus hydrochlorothiazide alone for essential hypertension: effects on blood pressure and serum potassium level.
Topics: Adolescent; Adult; Age Factors; Aged; Amiloride; Blood Pressure; Body Weight; Clinical Trials as Top | 1985 |
Effects of indomethacin and sulindac on hydrochlorothiazide kinetics.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Drug Interactions; Female; Humans; Hyd | 1985 |
Effects of muzolimine and of a combination of hydrochlorothiazide/triamterene in healthy subjects and in nephrotic patients.
Topics: Adolescent; Adult; Aged; Body Weight; Creatinine; Drug Therapy, Combination; Electrolytes; Female; H | 1985 |
Effect of diuretic therapy on glucose tolerance in hypertensive patients.
Topics: Age Factors; Blood Glucose; Body Weight; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Fasting; Fat | 1971 |
Comparison of the potassium- retaining effects of amiloride and spironolactone in hypertensive patients with thiazide-induced hypokalaemia.
Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Therapy, Combination; Female; H | 1973 |
Effects of hydrochlorothiazide in hypertensive patients and the need for potassium supplementation.
Topics: Adult; Aged; Blood Pressure; Body Weight; Carbon Dioxide; Chlorides; Clinical Trials as Topic; Human | 1973 |
Study of a new antihypertensive (guanabenz).
Topics: Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Drug Evaluation; Ele | 1974 |
Moderate sodium restriction and diuretics in the treatment of hypertension.
Topics: Adult; Body Weight; Clinical Trials as Topic; Diet, Sodium-Restricted; Female; Humans; Hydrochloroth | 1973 |
A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics.
Topics: Adult; Aged; Amides; Blood Glucose; Blood Pressure; Body Weight; Clinical Trials as Topic; Clopamide | 1973 |
[Clinical testing of a new potassium-saving diuretic for the treatment of hypertension].
Topics: Aged; Amiloride; Blood Pressure; Body Weight; Clinical Trials as Topic; Creatinine; Diuretics; Drug | 1973 |
[Saluretic treatment of hypertension and uric acid level in serum. Clinical test of a combination of hydrochlorothiazide and probenecid].
Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Blood Protein Electrophoresis; Bod | 1969 |
High doses of spironolactone (Aldactone, SC-14266, Verospirone) alone and in combination with triamterene and-or diuretics in the treatment of refractory edema associated with secondary hyperaldosteronism.
Topics: Adult; Aged; Body Weight; Chlorides; Clinical Trials as Topic; Clopamide; Creatinine; Diet, Sodium-R | 1970 |
A double-blind trial in hypertension comparing Baycaron (FBA 1500), hydrochlorothiazide and placebo.
Topics: Black People; Blood Pressure; Blood Urea Nitrogen; Body Weight; Clinical Trials as Topic; Furans; Hu | 1971 |
Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone.
Topics: Adult; Aged; Body Weight; Female; Glycyrrhiza; Humans; Hydrochlorothiazide; Hypertension; Male; Midd | 1968 |
Metabolic and hypotensive effects of ethacrynic acid. Comparative study with hydrochlorothiazide.
Topics: Analysis of Variance; Aspartate Aminotransferases; Blood Glucose; Blood Pressure; Blood Urea Nitroge | 1968 |
Long-term effect of probenecid on diuretic-induced hyperuricemia.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure Determination; Body Weight; Chlorthalidone; Hum | 1966 |
105 other studies available for hydrochlorothiazide and Body Weight
| Article | Year |
|---|---|
The Effects of Early Postnatal Diuretics Treatment on Kidney Development and Long-Term Kidney Function in Wistar Rats.
Topics: Acute-Phase Proteins; Aging; Animals; Apoptosis; Blood Pressure; Body Weight; Cell Proliferation; Di | 2016 |
Diuretic and antioxidant effects of Cacti-Nea, a dehydrated water extract from prickly pear fruit, in rats.
Topics: Administration, Oral; Animals; Antioxidants; Body Weight; Diuretics; Drinking; Drug Evaluation, Prec | 2010 |
Comparative study of hydrochlorothiazide and indapamide on the anti-atherogenic potential of losartan in cholesterol fed rat.
Topics: Animals; Antihypertensive Agents; Atherosclerosis; Body Weight; Cholesterol, Dietary; Diuretics; Hyd | 2010 |
Effect of fixed-dose losartan/hydrochlorothiazide on brain natriuretic peptide in patients with hypertension.
Topics: Aged; Blood Pressure; Body Weight; Diastole; Dose-Response Relationship, Drug; Female; Follow-Up Stu | 2012 |
Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Glucos | 2012 |
ALDOSTERONE ANTAGONISTS IN DIURETIC THERAPY: THEIR EFFECT ON THE REFRACTORY PHASE.
Topics: Blood Chemical Analysis; Body Weight; Edema; Heart Failure; Hematocrit; Hydrochlorothiazide; Mineral | 1964 |
CLINICAL EXPERIENCE WITH THE DIURETIC EFFECTS OF TRIAMTERENE ALONE AND COMBINED WITH HYDROCHLOROTHIAZIDE.
Topics: Arteriosclerosis; Body Weight; Diuretics; Heart Failure; Hydrochlorothiazide; Hypertension; Potassiu | 1964 |
THE OBSTETRIC PATIENT WITH TOXEMIA.
Topics: Adrenal Insufficiency; Body Weight; Chlorides; Delivery, Obstetric; Diet, Sodium-Restricted; Diureti | 1964 |
[DIURETIC DRUGS IN THE EDEMAS OF PREGNANCY].
Topics: Acetazolamide; Benzothiadiazines; Blood Pressure; Body Weight; Chlorothiazide; Diuretics; Edema; Fem | 1964 |
CONJOINT CLINIC ON DRUGS AND DIABETES.
Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose | 1964 |
THE EFFECT OF DIURETICS ON THE ADRENAL CORTEX OF THE RAT.
Topics: Acetazolamide; Adrenal Cortex; Adrenal Glands; Ascorbic Acid; Body Weight; Cholesterol; Diuretics; H | 1964 |
ETHACRYNIC ACID: A NEW POTENT DIURETIC.
Topics: Alkalosis; Blood Chemical Analysis; Blood Urea Nitrogen; Body Weight; Digitalis Glycosides; Diuresis | 1965 |
Cardioprotective effects of vasopeptidase inhibition vs. angiotensin type 1-receptor blockade in spontaneously hypertensive rats on a high salt diet.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; A | 2004 |
Superiority of combination of thiazide with angiotensin-converting enzyme inhibitor or AT1-receptor blocker over thiazide alone on renoprotection in L-NAME/SHR.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pr | 2005 |
Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure reduction in nitric oxide-deficient hypertension.
Topics: Adrenomedullin; Animals; Body Weight; Hydralazine; Hydrochlorothiazide; Hypertension; Intracellular | 2006 |
Antihypertensive and renal protective effects of renin-angiotensin system blockade in uremic rats treated with erythropoietin.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihype | 2006 |
Chronic and acute effects of different antihypertensive drugs on femoral artery relaxation of L-NAME hypertensive rats.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pre | 2007 |
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Diuretics; Fructose; Gout Suppressants; Hydrochlo | 2007 |
Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Diuretics; Hydrochlorothiazide; Hypertension, Ren | 2007 |
Evolution of adrenal regeneration hypertension in rats with actively regenerating or fully regenerated glands.
Topics: Adrenal Glands; Aging; Animals; Blood Pressure; Body Weight; Diet; Drinking; Female; Heart; Hydrochl | 1967 |
The calcium channel blocker nitrendipine in single- and multiple-agent antihypertensive regimens: preliminary report of a multicenter study.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Body Weight; Calcium Channel Blockers; Drug Therapy, Combi | 1984 |
Long-term haemodynamic effects of enalapril (alone and in combination with hydrochlorothiazide) at rest and during exercise in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Body Fluids; Body Weight; Cardiac Output; Drug Therapy, Combination; En | 1984 |
Regression of left ventricular hypertrophy and control of hypertension in the spontaneously hypertensive rat (SHR): oxprenolol versus hydrochlorothiazide.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Heart Ventricles; Hydrochlorothiazide; Hypertens | 1983 |
Effect of long-term antihypertensive therapy on cardiac anatomy in patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Drug Therapy, Combi | 1983 |
Effects of sodium bicarbonate and hydrochlorothiazide on the hypercalciuric action of 1,25(OH)2D3 in the rat.
Topics: Animals; Bicarbonates; Body Weight; Calcitriol; Calcium; Diet; Drug Interactions; Hydrochlorothiazid | 1984 |
Combined captopril and hydrochlorothiazide therapy in severe hypertension: long-term haemodynamic changes at rest and during exercise.
Topics: Adult; Aged; Blood Glucose; Body Weight; Captopril; Cardiac Output; Creatinine; Diastole; Drug Thera | 1984 |
Renal actions of a uricosuric diuretic, racemic indacrinone, in man: comparison with ethacrynic acid and hydrochlorothiazide.
Topics: Body Weight; Diuretics; Ethacrynic Acid; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hy | 1984 |
Hyponatraemia associated with trimethoprim and a diuretic.
Topics: Aged; Amiloride; Body Weight; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydrochl | 1984 |
Early changes in plasma and urinary potassium in diuretic-treated patients with systemic hypertension.
Topics: Blood Pressure; Body Weight; Creatinine; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Mid | 1984 |
[Clonidine transdermal therapeutic system in essential hypertension: effect and tolerance].
Topics: Adult; Body Weight; Clonidine; Dermatitis, Contact; Drug Tolerance; Female; Heart Rate; Humans; Hydr | 1983 |
Effect of diuretics on the tubuloglomerular feedback response.
Topics: Animals; Body Weight; Bumetanide; Diuretics; Feedback; Furosemide; Hydrochlorothiazide; Kidney Glome | 1984 |
The renin-angiotensin-aldosterone system and blood pressure during oxprenolol treatment in hypertensive patients pretreated with diuretics.
Topics: Adult; Aldosterone; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Combinations; Female; Hu | 1982 |
Clinical efficacy and safety of indapamide in the treatment of edema.
Topics: Body Weight; Diuretics; Double-Blind Method; Edema; Electrolytes; Female; Humans; Hydrochlorothiazid | 1983 |
Sodium balance and antidiuresis in thiazide-treated rats with diabetes insipidus.
Topics: Animals; Body Weight; Diabetes Insipidus; Diet, Sodium-Restricted; Diuresis; Hydrochlorothiazide; Ma | 1983 |
Influence of the dietary potassium intake on the natriuretic effect of hydrochlorothiazide in rats.
Topics: Animals; Body Weight; Diet; Diuretics; Drug Interactions; Hydrochlorothiazide; Kidney; Male; Natriur | 1982 |
A comparative study of Moducren and Moduretic and their effect on plasma potassium in essential hypertension.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Body Weight; Drug Combinations; Female; Heart Rate; | 1982 |
Changes in ventricular septal thickness during diuretic therapy.
Topics: Adult; Aged; Blood Pressure; Body Weight; Diuretics; Echocardiography; Heart Rate; Heart Septum; Hea | 1982 |
Fenfluramine potentiation of antihypertensive effects of thiazides.
Topics: Antihypertensive Agents; Blood Pressure; Body Weight; Drug Synergism; Drug Therapy, Combination; Fen | 1980 |
A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension.
Topics: Adolescent; Adult; Aged; Amiloride; Blood Chemical Analysis; Blood Pressure; Body Weight; Drug Thera | 1980 |
Hypertension: a complication of danazol therapy.
Topics: Adult; Blood Pressure; Body Weight; Danazol; Humans; Hydrochlorothiazide; Hypertension; Male; Pregna | 1980 |
Study of antiatherogenic properties of indapamide in a pharmacologic model.
Topics: Animals; Arteriosclerosis; Basement Membrane; Body Weight; Carotid Arteries; Cell Division; Choleste | 1993 |
Normal left ventricular diastolic compliance after regression of hypertrophy.
Topics: Aging; Animals; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Collagen; Diastole; Elasticity | 1994 |
Effects of moduretic on plasma lipid and lipoprotein levels in hypertensive African patients.
Topics: Aged; Amiloride; Blood Pressure; Body Weight; Diet; Drug Combinations; Female; Humans; Hydrochloroth | 1993 |
The effects of perindopril and triple therapy in a normotensive model of diabetic nephropathy.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressu | 1993 |
A new adenosine subtype-1 receptor antagonist, FK-838, attenuates salt-induced hypertension in Dahl salt-sensitive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Creatinine; Eicosanoids; Hydrochlorot | 1995 |
Effects of perindopril and hydrochlorothiazide on the long-term progression of lithium-induced chronic renal failure in rats.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blood Pressure; Body Weight; Creatinine; Disease | 1997 |
A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf.
Topics: Animals; Animals, Newborn; Blood Glucose; Blood Proteins; Body Temperature; Body Weight; Cattle; Col | 1998 |
Renoprotection by nitric oxide donor and lisinopril in the remnant kidney model.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Creatinine; Disease | 1999 |
Protective effects of delapril combined with indapamide or hydrochlorothiazide in spontaneously hypertensive stroke-prone rats: a comparative dose-response analysis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Diuretics; Dose-Resp | 2000 |
Angiotensin-converting enzyme inhibitor prevents age-related endothelial dysfunction.
Topics: Acetylcholine; Administration, Oral; Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors | 2000 |
The influence of chronic antihypertensive treatment on the central pressor response in SHR.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl | 2001 |
Chronic administration of losartan plus hydrochlorothiazide improves vascular status in young cardiomyopathic hamsters.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta, Thoracic; Body Weight; Cardiomyopathies; Cri | 2001 |
Idiopathic edema as a cause of nonarticular rheumatism.
Topics: Adult; Body Weight; Capillary Permeability; Chlorthalidone; Dextroamphetamine; Edema; Female; Humans | 1979 |
Potassium sparing effect of amiloride in patients receiving diuretics: a quantitative study.
Topics: Adult; Amiloride; Body Weight; Diuretics; Female; Humans; Hydrochlorothiazide; Male; Middle Aged; Po | 1979 |
Long-term versus short-term effects of hydrochlorothiazide on renal haemodynamics in essential hypertension.
Topics: Adult; Blood Pressure; Blood Volume; Body Weight; Glomerular Filtration Rate; Hemodynamics; Humans; | 1979 |
Metabolic effects in man of tienilic acid, a new diuretic with uricosuric properties.
Topics: Acid-Base Equilibrium; Adult; Body Weight; Diuretics; Electrolytes; Glycolates; Humans; Hydrochlorot | 1978 |
Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study.
Topics: Adult; Blood Pressure; Body Weight; Cholesterol; Drug Therapy, Combination; Humans; Hydrochlorothiaz | 1978 |
Mechanism of antihypertensive effect of thiazide diuretics.
Topics: Antihypertensive Agents; Body Weight; Diuretics; Extracellular Space; Hematocrit; Hemodynamics; Huma | 1978 |
Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure, serum electrolytes, renin and aldosterone in essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Humans; Hydrochlorothiazid | 1978 |
Aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta.
Topics: Animals; Aortic Coarctation; Arteriosclerosis; Blood Pressure; Body Weight; Cholesterol, Dietary; Co | 1976 |
[Association of proteolytic enzymes with a new synthetic diurectic. III. Toxicological research].
Topics: Animals; Blood Cell Count; Blood Cells; Body Weight; Chymotrypsin; Drug Combinations; Hydrochlorothi | 1975 |
[Use of aldactone-saltucine in patients with heart failure].
Topics: Adult; Aged; Aldosterone; Body Weight; Butanes; Chlorides; Diuretics; Drug Combinations; Drug Evalua | 1975 |
Sodium restriction and thiazide diuretics in the treatment of hypertension.
Topics: Amiloride; Bicarbonates; Body Weight; Chlorothiazide; Diet, Sodium-Restricted; Diuretics; Humans; Hy | 1975 |
[Spironolactone and thiabutazide in the treatment of essential hypertension (author's transl)].
Topics: Aldosterone; Antihypertensive Agents; Blood Pressure; Body Weight; Butanes; Female; Furosemide; Huma | 1975 |
Chronic antihypertensive treatment with captopril plus hydrochlorothiazide improves aortic distensibility in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Body Weight; Captopril; Decerebra | 1992 |
Large differences in the biological half-life and volume of distribution of hydrochlorothiazide in normal subjects from eleven studies. Correlation with their last blood sampling times.
Topics: Blood Volume; Body Weight; Half-Life; Humans; Hydrochlorothiazide; Reference Values | 1992 |
Effect of furosemide, hydrochlorothiazide and sodium restriction on rat adrenoceptors.
Topics: Animals; Binding, Competitive; Body Weight; Diet, Sodium-Restricted; Furosemide; Hydrochlorothiazide | 1991 |
[Effect of XKJ-001, a crude drug preparation, on body water distribution and water excretion in mice].
Topics: Animals; Body Water; Body Weight; Diuretics; Drugs, Chinese Herbal; Hematocrit; Hydrochlorothiazide; | 1991 |
Effects of antihypertensive drugs on heart and resistance vessels.
Topics: Animals; Blood Pressure; Body Weight; Captopril; Heart; Hindlimb; Hydrochlorothiazide; Male; Organ S | 1990 |
Toxicology and carcinogenicity studies of diuretics in F344 rats and B6C3F1 mice. 1. Hydrochlorothiazide.
Topics: Adenofibroma; Animals; Body Weight; Carcinogens; Chronic Kidney Disease-Mineral and Bone Disorder; D | 1990 |
Surfeit and deficit of sodium: evidence from studies of body sodium in rats.
Topics: Animals; Body Composition; Body Weight; Furosemide; Hydrochlorothiazide; Male; Natriuresis; Rats; Ra | 1990 |
Amiloride-hydrochlorothiazide versus indomethacin-hydrochlorothiazide in the treatment of nephrogenic diabetes insipidus.
Topics: Adolescent; Amiloride; Body Weight; Child; Child, Preschool; Diabetes Insipidus; Drug Evaluation; Hu | 1990 |
Optimization of the therapeutic index by adjustment of the rate of drug administration or use of drug combinations: exploratory studies of diuretics.
Topics: Animals; Body Weight; Diuretics; Drug Combinations; Furosemide; Hydrochlorothiazide; Male; Models, B | 1990 |
The influence of hydrochlorothiazide and tripamide on serum and urinary amylase.
Topics: Adult; Amylases; Body Weight; Creatinine; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Indo | 1988 |
Role of lowering arterial pressure on maximal coronary flow with and without regression of cardiac hypertrophy.
Topics: Animals; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Coronary Circulation; Heart; Hydralaz | 1989 |
Comparison of cicletanine with other antihypertensive drugs in SHR-SP models.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Diuresis; Di | 1988 |
Diuretic treatment alters clonidine suppression of plasma norepinephrine.
Topics: Administration, Oral; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Clonidine; Drug Interac | 1986 |
The effect of chronic hydrochlorothiazide administration on renal function in the rat.
Topics: Animals; Body Water; Body Weight; Hydrochlorothiazide; Kidney; Male; Potassium; Rats; Sodium; Tissue | 1986 |
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus.
Topics: Adult; Alkalosis; Amiloride; Body Weight; Child; Diabetes Insipidus; Drug Therapy, Combination; Foll | 1985 |
[Decreased renal excretory capacity of uric acid in rats fed a low sodium diet under consecutive administration of thiazide diuretics].
Topics: Animals; Body Weight; Diuretics; Feeding Behavior; Hematocrit; Hydrochlorothiazide; Kidney; Male; Po | 1985 |
Experimental analysis of adherence counseling: implications for hypertension management.
Topics: Adult; Behavior Therapy; Blood Pressure; Body Weight; Counseling; Follow-Up Studies; Humans; Hydroch | 1985 |
Sodium retention after adrenal enucleation: drug and salt appetite studies.
Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Aminoglutethimide; Animals; Appetite; Body Weight; D | 1968 |
Diuretics, cardiac failure and potassium depletion: a rational approach.
Topics: Aged; Amiloride; Body Weight; Diet, Sodium-Restricted; Diuretics; Edema; Furosemide; Heart Failure; | 1974 |
Hormone influenced hypertension in the male rat. Effect of hydrochlorothiazide.
Topics: 5-Hydroxytryptophan; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Ce | 1969 |
A clinical study of Co-hydroDiuril a combination of an antikaliuretic (amiloride) and hydrochlorothiazide.
Topics: Adult; Aged; Amiloride; Blood Pressure; Blood Urea Nitrogen; Body Weight; Diuretics; Drug Combinatio | 1972 |
Combined therapy with vasodilator drugs and beta-adrenergic blockade in hypertension. A comparative study of minoxidil and hydralazine.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Body Weight; Cardiac Output; Female; Fu | 1972 |
Diuretic agents: inciting factor in nonocclusive mesenteric infarction?
Topics: Aged; Blood Urea Nitrogen; Body Weight; Digitalis; Diuretics; Female; Furosemide; Heart Failure; Hem | 1974 |
Hyperkalemia, acidosis, and short stature associated with a defect in renal potassium excretion.
Topics: Acidosis; Administration, Oral; Ammonium Chloride; Bicarbonates; Blood; Body Height; Body Weight; Ca | 1974 |
Plasma aldosterone in essential hypertension with low renin activity.
Topics: Aldosterone; Body Weight; Corticosterone; Cushing Syndrome; Furosemide; Humans; Hydrochlorothiazide; | 1974 |
Spironolactone as a nonspecific treatment for primary aldosteronism.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Urea Nitrogen; Body Weight; Carbon Dioxide; Creatini | 1973 |
Effects of hydrochlorothiazide and amiloride on potassium distribution in skeletal muscle of the rat.
Topics: Amiloride; Animals; Body Weight; Chlorides; Diuretics; Extracellular Space; Hydrochlorothiazide; Mal | 1973 |
Prolonged administration of hydrochlorothiazide on cardiac function in beagle dogs.
Topics: Administration, Oral; Animals; Blood Pressure; Blood Volume; Body Weight; Cardiac Output; Dogs; Elec | 1973 |
[ADH-like mechanism of action of chlorpropamide in diabetes insipidus (a comparison with the antidiuretic effect of other blood glucose decreasing sulfonamides and hydrochlorothiazide)].
Topics: Aged; Blood Glucose; Body Weight; Chlorpropamide; Depression, Chemical; Diabetes Insipidus; Diuresis | 1970 |
Spironolactone and hydrochlorothiazide in essential hypertension. Blood pressure response and plasma renin activity.
Topics: Adult; Blood Pressure; Body Weight; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle | 1972 |
The effect of hydrochlorothiazide and triamterene on the tissue content of sodium and potassium in the rat.
Topics: Animals; Blood Chemical Analysis; Body Weight; Drinking; Drug Interactions; Feeding Behavior; Female | 1971 |
[Effect of 1-beta-oxyethyl-2-phenyl-methyl-piperidine in 6 cases of diabetes insipidus in children].
Topics: Biopsy; Body Temperature; Body Weight; Brain Diseases; Calcium; Child; Child, Preschool; Chlorides; | 1968 |
Evaluation of amiloride combined with hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Aged; Amidines; Body Weight; Diuretics; Drug Synergism; Female; Heart Failure; Humans; Hydrochloroth | 1970 |
Blood volume and exchangeable sodium during treatment of hypertension with guanethidine and hydrochlorothiazide.
Topics: Adult; Aged; Blood Volume; Body Weight; Chromium Isotopes; Extracellular Space; Female; Guanethidine | 1969 |
Refractoriness to renal effects of aldosterone in the golden hamster.
Topics: Adrenalectomy; Aldosterone; Animals; Body Weight; Cricetinae; Diet, Sodium-Restricted; Hydrochloroth | 1971 |
Relationship of sodium and potassium intake to blood pressure.
Topics: Blood Pressure; Body Weight; Edema; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Potassiu | 1971 |
Hydrochlorothiazide in the treatment of hypertension. The effects on blood volume, exchangeable sodium and blood pressure.
Topics: Aged; Albumins; Blood Pressure; Blood Pressure Determination; Blood Volume; Blood Volume Determinati | 1968 |
The nephrotic syndrome in an elderly woman. An unusual association with an unusual response to therapy.
Topics: Aged; Biopsy; Body Weight; Chronic Disease; Diagnosis, Differential; Edema; Female; Humans; Hydrochl | 1969 |
The salt appetite of adrenalectomized rats as influenced by deoxycorticosterone and hydrochlorothizide.
Topics: Adrenalectomy; Analysis of Variance; Animals; Appetite; Body Weight; Depression, Chemical; Desoxycor | 1969 |
[Special problems of burns in childhood].
Topics: Acetazolamide; Acidosis, Respiratory; Bandages; Body Weight; Burns; Child; Child, Preschool; Chlorpr | 1966 |
[Influence of hydrochlorothiazide on urine thiamine excretion].
Topics: Animals; Body Weight; Female; Humans; Hydrochlorothiazide; Liver Cirrhosis; Male; Middle Aged; Rats; | 1966 |