hydrochlorothiazide has been researched along with Autoimmune Diabetes in 8 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This controlled clinical trial investigated the calcium channel blocker lercanidipine versus hydrochlorothiazide (HCTZ) as add-on in diabetic patients with uncontrolled hypertension on enalapril monotherapy." | 9.12 | Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension. ( Agrawal, R; Haller, H; Marx, A, 2006) |
| "Randomised, double blind, double dummy parallel study of normotensive diabetic patients with persistent microalbuminuria (30-300 mg/24 h) treated with enalapril or hydrochlorothiazide for one year after a three month, single blind placebo period." | 9.07 | Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes. ( Chatellier, G; Fressinaud, P; Gallois, Y; Hallab, M; Marre, M; Rohmer, V, 1993) |
| " This controlled clinical trial investigated the calcium channel blocker lercanidipine versus hydrochlorothiazide (HCTZ) as add-on in diabetic patients with uncontrolled hypertension on enalapril monotherapy." | 5.12 | Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension. ( Agrawal, R; Haller, H; Marx, A, 2006) |
| "Randomised, double blind, double dummy parallel study of normotensive diabetic patients with persistent microalbuminuria (30-300 mg/24 h) treated with enalapril or hydrochlorothiazide for one year after a three month, single blind placebo period." | 5.07 | Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes. ( Chatellier, G; Fressinaud, P; Gallois, Y; Hallab, M; Marre, M; Rohmer, V, 1993) |
| "Aliskiren was then force-titrated to 300 mg once daily for another 6 weeks." | 2.76 | Aliskiren as add-on therapy in the treatment of hypertensive diabetic patients inadequately controlled with valsartan/HCT combination: a placebo-controlled study. ( Baek, I; Drummond, W; Keefe, DL; Ramos, E; Sirenko, YM, 2011) |
| "Enalapril monotherapy was associated with a slight, but not significant, fall in fasting blood glucose levels and with a significant fall in hemoglobin A1c levels." | 2.66 | Metabolic effects of hydrochlorothiazide and enalapril during treatment of the hypertensive diabetic patient. Enalapril for hypertensive diabetics. ( Bandi, Z; Holland, OB; Padia, M; Prince, MJ; Stuart, CA, 1988) |
| "Captopril was well tolerated in all patients and no adverse reactions were observed." | 1.27 | Glucose metabolism during captopril mono- and combination therapy in diabetic hypertensive patients: a multiclinic trial. ( Iino, S; Inoue, S; Shionoiri, H, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sowers, JR | 1 |
| Lastra, G | 1 |
| Rocha, R | 1 |
| Seifu, Y | 1 |
| Crikelair, N | 1 |
| Levy, DG | 1 |
| Drummond, W | 1 |
| Sirenko, YM | 1 |
| Ramos, E | 1 |
| Baek, I | 1 |
| Keefe, DL | 1 |
| Agrawal, R | 1 |
| Marx, A | 1 |
| Haller, H | 1 |
| Joffe, HV | 1 |
| Kwong, RY | 1 |
| Gerhard-Herman, MD | 1 |
| Rice, C | 1 |
| Feldman, K | 1 |
| Adler, GK | 1 |
| Hallab, M | 1 |
| Gallois, Y | 1 |
| Chatellier, G | 1 |
| Rohmer, V | 1 |
| Fressinaud, P | 1 |
| Marre, M | 1 |
| McFarlane, R | 1 |
| McCredie, RJ | 1 |
| Bonney, MA | 1 |
| Molyneaux, L | 1 |
| Zilkens, R | 1 |
| Celermajer, DS | 1 |
| Yue, DK | 1 |
| Prince, MJ | 1 |
| Stuart, CA | 1 |
| Padia, M | 1 |
| Bandi, Z | 1 |
| Holland, OB | 1 |
| Shionoiri, H | 1 |
| Iino, S | 1 |
| Inoue, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 12-week, Randomized, Double-blind, Placebo Controlled, Parallel Group Study Evaluating the Efficacy & Safety of Aliskiren in Patients With Diabetes & Hypertension Not Adequately Responsive to the Combination of Valsartan 160 mg & Hydrochlorothiazide 25 [NCT00219102] | Phase 3 | 336 participants | Interventional | 2005-06-30 | Completed | ||
| Aldosterone and Vascular Disease in Diabetes Mellitus[NCT00214825] | 46 participants (Actual) | Interventional | 2003-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 trials available for hydrochlorothiazide and Autoimmune Diabetes
| Article | Year |
|---|---|
Initial combination therapy compared with monotherapy in diabetic hypertensive patients.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Glucose; Blood Pressur | 2008 |
Aliskiren as add-on therapy in the treatment of hypertensive diabetic patients inadequately controlled with valsartan/HCT combination: a placebo-controlled study.
Topics: Aged; Amides; Amlodipine; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 1; Diabet | 2011 |
Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Calcium Channel | 2006 |
Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus.
Topics: Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; Brachia | 2007 |
Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes.
Topics: Adolescent; Adult; Albuminuria; Diabetes Mellitus, Type 1; Double-Blind Method; Enalapril; Female; H | 1993 |
Angiotensin converting enzyme inhibition and arterial endothelial function in adults with Type 1 diabetes mellitus.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Cross-Over Studies; Diabetes Mellitus, Type 1; Diab | 1999 |
Metabolic effects of hydrochlorothiazide and enalapril during treatment of the hypertensive diabetic patient. Enalapril for hypertensive diabetics.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Dou | 1988 |
1 other study available for hydrochlorothiazide and Autoimmune Diabetes
| Article | Year |
|---|---|
Glucose metabolism during captopril mono- and combination therapy in diabetic hypertensive patients: a multiclinic trial.
Topics: Blood Glucose; Captopril; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Glucose Tolerance Te | 1987 |