hydrochlorothiazide has been researched along with Arteriosclerosis in 42 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension treatment with doxazosin or HCTZ resulted in a comparable change in arterial IMT after three years, in spite of differences in effect on plasma lipids." | 5.10 | Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study). Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands. ( Birkenhägeri, JC; de Groot, E; de Heide, LH; de Ridder, MA; Hoogerbrugge, N; Jansen, H; Stijnen, T, 2002) |
| "The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a randomized, double-blind, active-control trial to compare the effectiveness of two treatment regimens for the control of hypertension in reducing the rate of progression of early extracranial carotid artery atherosclerosis in hypertensive patients." | 5.07 | MIDAS, the Multicenter Isradipine/Diuretic Atherosclerosis Study. Design features and baseline data. ( Applegate, WB; Byington, RP, 1991) |
| "In a randomized primary prevention trial including 3,234 men with mild to moderate uncomplicated hypertension, the effect of the beta-blocker metoprolol or a thiazide diuretic as an initial antihypertensive therapy was compared regarding the risk of sudden cardiovascular death during a follow-up ranging from 2." | 5.07 | Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study. ( Barber, H; Berglund, G; Eliasson, K; Elmfeldt, D; Jastrup, B; Karatzas, N; Leer, J; Olsson, G; Tuomilehto, J; Warnold, I, 1991) |
| " The International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT) is the first, large, randomized, double-blind study undertaken exclusively in high-risk hypertensive patients, with CV events as a prospectively defined primary end-point." | 4.81 | Long-term protection in at-risk hypertensive patients--a role for nifedipine GITS? ( Ruilope, LM, 2002) |
| " To determine the effects of antihypertensive drugs on heart rate and blood velocity 15 patients with hypertension were treated with placebo, hydrochlorothiazide, nadolol, propranolol and hydralazine in sequence." | 3.66 | Effects of antihypertensive agents on blood velocity: implications for atherogenesis. ( Spence, JD, 1982) |
| "Hypertension is a risk factor for the development of atherosclerosis and its complications, which are among the major causes of morbidity and mortality." | 2.67 | The Multicenter Isradipine/Diuretic Atherosclerosis Study: a study of the antiatherogenic properties of isradipine in hypertensive patients. MIDAS Research Group. ( Bond, MG; Borhani, NO; Buckalew, V; Canossa-Terris, M; Gibbons, ME; Sowers, JR; Worthy, AJ, 1991) |
| "Isradipine is a new dihydropyridine calcium antagonist that is highly effective in lowering blood pressure." | 2.67 | A comparison of antihypertensive drug effects on the progression of extracranial carotid atherosclerosis. The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS). ( Bond, G; Brugger, S; Byington, R; Flack, JM; Grimm, RH, 1990) |
| "Insulin resistance is associated with a number of risk factors for atherosclerosis, including glucose intolerance, hypertension, and dyslipidemia." | 2.38 | Insulin resistance. An often unrecognized problem accompanying chronic medical disorders. ( Bell, DS, 1993) |
| "The treatment of both hyperlipidemia and hypertension appeared to be more effective than the treatment of hyperlipidemia, alone." | 1.26 | Aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta. ( Hollander, W; Kirkpatrick, B; Madoff, I; Paddock, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (50.00) | 18.7374 |
| 1990's | 16 (38.10) | 18.2507 |
| 2000's | 4 (9.52) | 29.6817 |
| 2010's | 1 (2.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kolos, I | 1 |
| Troitskiy, A | 1 |
| Balakhonova, T | 1 |
| Shariya, M | 1 |
| Skrypnik, D | 1 |
| Tvorogova, T | 1 |
| Deev, A | 1 |
| Boytsov, S | 1 |
| Simon, A | 1 |
| Levenson, J | 1 |
| Hoogerbrugge, N | 1 |
| de Groot, E | 1 |
| de Heide, LH | 1 |
| de Ridder, MA | 1 |
| Birkenhägeri, JC | 1 |
| Stijnen, T | 1 |
| Jansen, H | 1 |
| SANCHETTI, P | 1 |
| FAVERO, S | 1 |
| LONGARETTI, A | 1 |
| BELSITO, F | 1 |
| QUAN, KC | 1 |
| KAHANA, L | 1 |
| GIRALDI, A | 1 |
| CHERIELIGNIERE, EL | 1 |
| DIMARCO, N | 1 |
| BOETTIGER, LE | 1 |
| MALMBORG, RO | 1 |
| MICHAELI, EW | 1 |
| MARANGONI, R | 1 |
| MELLONI, G | 1 |
| SETTEL, E | 1 |
| Fonseca, FA | 1 |
| Ihara, SS | 1 |
| Izar, MC | 1 |
| Silva, EP | 1 |
| Kasinski, N | 1 |
| Lopes, IE | 1 |
| Pinto, LE | 1 |
| Paiva, TB | 1 |
| Tufik, S | 1 |
| de Paola, AA | 1 |
| Carvalho, AC | 1 |
| Spence, JD | 1 |
| Lebrillant, E | 1 |
| Roulet, MJ | 1 |
| Robert, R | 1 |
| Schiavi, P | 1 |
| Guez, D | 1 |
| Jean, T | 1 |
| Hansson, L | 1 |
| Zanchetti, A | 2 |
| Bell, DS | 1 |
| Borhani, NO | 6 |
| Prisant, LM | 1 |
| Zemel, PC | 1 |
| Nichols, FT | 1 |
| Zemel, MB | 1 |
| Sowers, JR | 4 |
| Carr, AA | 2 |
| Thompson, WO | 1 |
| Bond, MG | 5 |
| Furberg, CD | 3 |
| Byington, RP | 5 |
| Gibbons, ME | 2 |
| Mercuri, M | 1 |
| Borhani, PA | 1 |
| Buckalew, VM | 1 |
| Canossa-Terris, M | 2 |
| Kappagoda, T | 1 |
| Rocco, MV | 1 |
| Schnaper, HW | 2 |
| Craven, TE | 2 |
| Pahor, M | 1 |
| Ruilope, LM | 1 |
| Hollander, W | 1 |
| Madoff, I | 1 |
| Paddock, J | 1 |
| Kirkpatrick, B | 1 |
| Smith, A | 1 |
| Rawlins, MD | 1 |
| Miller, ST | 1 |
| Brugger, SB | 2 |
| Khoury, S | 1 |
| Flack, J | 1 |
| Buckalew, V | 1 |
| Worthy, AJ | 1 |
| Applegate, WB | 1 |
| Olsson, G | 1 |
| Tuomilehto, J | 1 |
| Berglund, G | 1 |
| Elmfeldt, D | 1 |
| Warnold, I | 1 |
| Barber, H | 1 |
| Eliasson, K | 1 |
| Jastrup, B | 1 |
| Karatzas, N | 1 |
| Leer, J | 1 |
| Grimm, RH | 1 |
| Flack, JM | 1 |
| Byington, R | 1 |
| Bond, G | 1 |
| Brugger, S | 1 |
| Shishkina, OS | 1 |
| Wilmoth, SK | 1 |
| Enevold, GL | 1 |
| Strickland, HL | 1 |
| Borhani, NA | 1 |
| Sweet, RL | 1 |
| Sheffield, LT | 1 |
| Freis, ED | 1 |
| Chasis, H | 1 |
| Sidorenko, BA | 1 |
| Kharchenko, VI | 1 |
| Titov, VN | 1 |
| Lotova, EV | 1 |
| Mel'nichenko, GA | 1 |
| Senft, G | 1 |
| Pavesi, V | 1 |
| Campus, G | 1 |
| Tolva, D | 1 |
| Benati, E | 1 |
| Colombo, G | 1 |
| Tretenhahn, W | 1 |
| Anfossi, F | 1 |
| Guaraggi, A | 1 |
| Rossi, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Preoperative Identification of the Histologically Vulnerable Plaque Using Non-invasive Imaging, Biomechanical Assessment and Baroreflex Evaluation in Patients With Severe Carotid Stenosis"[NCT05566080] | 100 participants (Actual) | Observational | 2021-03-15 | Completed | |||
| Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis[NCT00805311] | Phase 4 | 400 participants (Actual) | Interventional | 2009-04-30 | Terminated (stopped due to Due to the clear advantage of carotid endarterectomy) | ||
| Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction)[NCT02428374] | Phase 4 | 300 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for hydrochlorothiazide and Arteriosclerosis
| Article | Year |
|---|---|
Effects of calcium channel blockers on atherosclerosis: new insights.
Topics: Arteriosclerosis; Calcium Channel Blockers; Diuretics; Humans; Hydrochlorothiazide; Nifedipine; Sodi | 2002 |
Insulin resistance. An often unrecognized problem accompanying chronic medical disorders.
Topics: Acanthosis Nigricans; Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arteri | 1993 |
The hypertensive patient with multiple risk factors: is treatment really so difficult?
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticholesteremic Agents; Antihypertensive | 1997 |
Long-term protection in at-risk hypertensive patients--a role for nifedipine GITS?
Topics: Amiloride; Arteriosclerosis; Calcium Channel Blockers; Cardiovascular Diseases; Diuretics; Drug Comb | 2002 |
The treatment of hypertension. Why, when and how.
Topics: Arteriosclerosis; Cardiovascular Diseases; Diuretics; Female; Guanethidine; Humans; Hydralazine; Hyd | 1972 |
17 trials available for hydrochlorothiazide and Arteriosclerosis
| Article | Year |
|---|---|
Modern medical treatment with or without carotid endarterectomy for severe asymptomatic carotid atherosclerosis.
Topics: Aged; Amlodipine; Arteriosclerosis; Atorvastatin; Carotid Artery Diseases; Endarterectomy, Carotid; | 2015 |
Modern medical treatment with or without carotid endarterectomy for severe asymptomatic carotid atherosclerosis.
Topics: Aged; Amlodipine; Arteriosclerosis; Atorvastatin; Carotid Artery Diseases; Endarterectomy, Carotid; | 2015 |
Modern medical treatment with or without carotid endarterectomy for severe asymptomatic carotid atherosclerosis.
Topics: Aged; Amlodipine; Arteriosclerosis; Atorvastatin; Carotid Artery Diseases; Endarterectomy, Carotid; | 2015 |
Modern medical treatment with or without carotid endarterectomy for severe asymptomatic carotid atherosclerosis.
Topics: Aged; Amlodipine; Arteriosclerosis; Atorvastatin; Carotid Artery Diseases; Endarterectomy, Carotid; | 2015 |
Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study). Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands.
Topics: Aged; Antihypertensive Agents; Arteriosclerosis; Carotid Arteries; Disease Progression; Diuretics; D | 2002 |
The antiatherosclerotic effect of calcium antagonists in man--what did MIDAS actually show? Multicenter Isradipine Diuretic Atherosclerosis Study.
Topics: Arteriosclerosis; Carotid Arteries; Controlled Clinical Trials as Topic; Humans; Hydrochlorothiazide | 1995 |
MIDAS: rationale, design and descriptive data of trial patients. The MIDAS Research Group.
Topics: Adult; Aged; Arteriosclerosis; Carotid Arteries; Double-Blind Method; Female; Humans; Hydrochlorothi | 1994 |
Carotid plaque associations among hypertensive patients.
Topics: Aged; Arteriosclerosis; Carotid Stenosis; Female; Georgia; Humans; Hydrochlorothiazide; Hypertension | 1993 |
Calcium antagonists and atherosclerosis. The Multicenter Isradipine/Diuretic Atherosclerosis Study.
Topics: Adult; Aged; Arteriosclerosis; Carotid Arteries; Double-Blind Method; Female; Humans; Hydrochlorothi | 1993 |
Final outcome results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS). A randomized controlled trial.
Topics: Aged; Antihypertensive Agents; Arteriosclerosis; Carotid Arteries; Diastole; Disease Progression; Di | 1996 |
The hypertensive patient with multiple risk factors: is treatment really so difficult?
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Animals; Anticholesteremic Agents; Antihypertensive | 1997 |
Isradipine, raised glycosylated haemoglobin, and risk of cardiovascular events.
Topics: Arteriosclerosis; Blood Glucose; Calcium Channel Blockers; Cardiovascular Diseases; Carotid Artery D | 1997 |
MIDAS: hypertension and atherosclerosis. A trial of the effects of antihypertensive drug treatment on atherosclerosis. MIDAS Research Group.
Topics: Antihypertensive Agents; Arteriosclerosis; Dihydropyridines; Double-Blind Method; Female; Humans; Hy | 1992 |
Multicenter study with isradipine and diuretics against atherosclerosis. US MIDAS Research Group.
Topics: Arteriosclerosis; Calcium Channel Blockers; Carotid Artery Diseases; Coronary Artery Disease; Diuret | 1990 |
The Multicenter Isradipine/Diuretic Atherosclerosis Study: a study of the antiatherogenic properties of isradipine in hypertensive patients. MIDAS Research Group.
Topics: Adult; Aged; Arteriosclerosis; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Double- | 1991 |
MIDAS, the Multicenter Isradipine/Diuretic Atherosclerosis Study. Design features and baseline data.
Topics: Adult; Aged; Antihypertensive Agents; Arteriosclerosis; Blood Pressure; Carotid Arteries; Diuretics; | 1991 |
Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the MAPHY Study.
Topics: Adult; Arteriosclerosis; Bendroflumethiazide; Death, Sudden; Diuretics; Follow-Up Studies; Humans; H | 1991 |
A comparison of antihypertensive drug effects on the progression of extracranial carotid atherosclerosis. The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS).
Topics: Adult; Antihypertensive Agents; Arteriosclerosis; Carotid Artery Diseases; Double-Blind Method; Fema | 1990 |
Multicenter isradipine diuretic atherosclerosis study (MIDAS). Design features. The Midas Research Group.
Topics: Adult; Antihypertensive Agents; Arteriosclerosis; Calcium Channel Blockers; Clinical Trials as Topic | 1989 |
Appraisal of antihypertensive drug therapy.
Topics: Antihypertensive Agents; Arteriosclerosis; Clinical Trials as Topic; Coronary Disease; Diabetes Comp | 1974 |
21 other studies available for hydrochlorothiazide and Arteriosclerosis
| Article | Year |
|---|---|
[CLINICAL STUDY OF A NEW COMPLEX HYPOTENSIVE DRUG COMBINATION].
Topics: Antihypertensive Agents; Arteriosclerosis; Carbamates; Cerebrovascular Disorders; Coronary Disease; | 1963 |
[CLINICAL RESEARCH WITH A COMPOUND HYPOTENSIVE PREPARATION (MEBUTAMATE + 1-4 DIHYDRAZINOPHTHALAZINE + DIHYDROCHLOROTHIAZIDE + POTASSIUM)].
Topics: Antihypertensive Agents; Arteriosclerosis; Carbamates; Humans; Hydralazine; Hydrochlorothiazide; Hyp | 1963 |
CLINICAL EXPERIENCE WITH THE DIURETIC EFFECTS OF TRIAMTERENE ALONE AND COMBINED WITH HYDROCHLOROTHIAZIDE.
Topics: Arteriosclerosis; Body Weight; Diuretics; Heart Failure; Hydrochlorothiazide; Hypertension; Potassiu | 1964 |
[ACTION OF ALPHA-METHYLDOPA IN COMBINATION WITH DIHYDROCHLOROTHIAZIDE ON RENAL HEMODYNAMICS IN HYPERTENSIVE SUBJECTS].
Topics: Antihypertensive Agents; Arteriosclerosis; Blood Circulation; Diuresis; Hemodynamics; Humans; Hydroc | 1963 |
[SEVERE NEUROLOGICAL SIDE-EFFECTS IN HYPOTENSION THERAPY].
Topics: Amobarbital; Antihypertensive Agents; Arteriosclerosis; Chlorothiazide; Chlorthalidone; Guanethidine | 1964 |
[OBSERVATIONS ON ELECTROLYTE CHANGES IN CONGESTIVE HEART FAILURE DURING CARDIOKINETIC OR DEPLETIVE TREATMENT].
Topics: Aortic Diseases; Arteriosclerosis; Blood Chemical Analysis; Diuretics; Electrolytes; Heart Failure; | 1964 |
FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA.
Topics: Arteriosclerosis; Chlorothiazide; Coronary Disease; Drug Combinations; Drug Therapy; Edema; Edema, C | 1965 |
Hydrochlorothiazide abolishes the anti-atherosclerotic effect of quinapril.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Drug Interactions; Hydrochlorothiazide; In | 2003 |
Effects of antihypertensive agents on blood velocity: implications for atherogenesis.
Topics: Adult; Aged; Antihypertensive Agents; Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Female; | 1982 |
Study of antiatherogenic properties of indapamide in a pharmacologic model.
Topics: Animals; Arteriosclerosis; Basement Membrane; Body Weight; Carotid Arteries; Cell Division; Choleste | 1993 |
Aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta.
Topics: Animals; Aortic Coarctation; Arteriosclerosis; Blood Pressure; Body Weight; Cholesterol, Dietary; Co | 1976 |
Widespread atheromatous arterial disease.
Topics: Adult; Arteriosclerosis; Humans; Hydrochlorothiazide; Male; Propranolol | 1977 |
[The effect of visken and hypothiazide on the indices of the central and renal hemodynamics in patients with atherosclerotic hypertension].
Topics: Aged; Arteriosclerosis; Drug Evaluation; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hyperten | 1990 |
Detection and monitoring of asymptomatic atherosclerosis in clinical trials.
Topics: Antihypertensive Agents; Arteriosclerosis; Calcium Channel Blockers; Carotid Arteries; Humans; Hydro | 1989 |
Myocardial infarction after exercise-induced electrocardiographic changes in a patient with variant angina pectoris.
Topics: Amitriptyline; Angina Pectoris; Arteriosclerosis; Catheterization; Diabetes Complications; Electroca | 1974 |
[Comparison of the effectiveness and mechanism of action of the saluretic preparations triamterene and hypothiazide and their combination (triampur) in circulatory insufficiency].
Topics: Acid-Base Equilibrium; Adult; Aged; Arteriosclerosis; Circadian Rhythm; Coronary Disease; Creatinine | 1973 |
[Disorders of carbohydrate metabolism following diuretically effective agents].
Topics: Arteriosclerosis; Carbohydrate Metabolism; Chlorothiazide; Diabetes Mellitus; Diazoxide; Furosemide; | 1967 |
[Results of hypotensive treatment in a hospital environment].
Topics: Adult; Aged; Arteriosclerosis; Carbamates; Female; Humans; Hydralazine; Hydrochlorothiazide; Hyperte | 1968 |
[Hypotensive activity of alpha-methyl-dopa alone and combined with dihydrochloro-thiazide].
Topics: Adult; Aged; Arteriosclerosis; Drug Synergism; Female; Humans; Hydrochlorothiazide; Hypertension; Ma | 1965 |
[The treatment of hypertension].
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Arteriosclerosis; Child; Child, Preschool; Coronar | 1966 |
[On the antihypertensive activity of some drugs alone or in various associations].
Topics: Adult; Aged; Antihypertensive Agents; Arteriosclerosis; Carbamates; Female; Humans; Hydrazines; Hydr | 1966 |