hydrochlorothiazide has been researched along with Arrhythmia in 41 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized single-blind cross-over trial, the efficacy of digoxin, angiotensin-converting enzyme (ACE) inhibition by quinapril, and their combination on exercise tolerance, heart size (echocardiography), and neurohumoral systems was investigated in 19 outpatients with congestive heart failure (CHF) New York Heart Association functional class II and sinus rhythm." | 9.06 | Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm. ( Elsner, D; Kromer, EP; Riegger, GA, 1990) |
| "The purpose of this study was to determine if chronic administration of the diuretics hydrochlorothiazide and amiloride alters the response to catecholamine-induced ventricular arrhythmias." | 7.67 | Effect of chronic diuretics on epinephrine-induced ventricular arrhythmias: a comparison of hydrochlorothiazide and amiloride in the rat. ( Rabkin, SW; Roob, O, 1987) |
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 7.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| " To evaluate the effect of antihypertensive treatment on cardiac arrhythmias (CA) and transient episodes of myocardial ischemia (TEMI), we studied 46 hypertensive patients with LVH, divided into four groups randomly treated with enalapril, hydrochlorothiazide (HCTZ), atenolol, or verapamil (SR-V) for 6 months." | 5.09 | Effects of drug therapy on cardiac arrhythmias and ischemia in hypertensives with LVH. ( Abrignani, MG; Barbagallo, M; Dominguez, LJ; Nardi, E; Novo, G; Novo, S; Strano, A, 2001) |
| "In the majority of hypertensive patients, treatment with 50 mg/d of hydrochlorothiazide does not cause marked hypokalemia or ventricular arrhythmias." | 5.07 | Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. ( Black, DM; Cheitlin, MD; Fine, R; Hearst, N; Hulley, SB; Sebastian, A; Seeley, DG; Siegel, D, 1992) |
| "In a randomized single-blind cross-over trial, the efficacy of digoxin, angiotensin-converting enzyme (ACE) inhibition by quinapril, and their combination on exercise tolerance, heart size (echocardiography), and neurohumoral systems was investigated in 19 outpatients with congestive heart failure (CHF) New York Heart Association functional class II and sinus rhythm." | 5.06 | Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm. ( Elsner, D; Kromer, EP; Riegger, GA, 1990) |
| "Twenty patients with uncomplicated systemic hypertension underwent treadmill testing twice during placebo treatment and twice during hydrochlorothiazide treatment." | 5.06 | Diuretic therapy and exercise in patients with systemic hypertension. ( Freis, ED; Notargiacomo, A; Papademetriou, V, 1989) |
| "Nineteen men with mild to moderate hypertension and without a history of cardiac arrhythmias were randomized (double-blind) into groups to receive hydrochlorothiazide (HCTZ) at a dose of 25 mg/day, HCTZ at 50 mg/day, or HCTZ (25 mg) plus triamterene (50 mg) for a six-month period after a three-week (single-blind) placebo period." | 5.06 | Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension. ( Hamilton, BP; Hamilton, J; Peters, RW, 1989) |
| "Twenty patients aged 33 to 69 years with uncomplicated hypertension, no heart disease, and normal stress test results underwent ambulatory ECG monitoring a month after receiving placebo and two and four weeks after hydrochlorothiazide therapy." | 5.05 | Nonarrhythmogenicity of diuretic-induced hypokalemia. Its evidence in patients with uncomplicated hypertension. ( Gavras, HP; Madias, JE; Madias, NE, 1984) |
| " In the first case, the drugs venlafaxine, amiodarone and domperidone may have contributed to QT interval prolongation in a patient with hypokalemia and hypomagnesaemia." | 3.76 | Multifactorial QT interval prolongation. ( Baranchuk, A; Digby, G; Machaalany, J; Malik, P; Methot, M; Redfearn, D; Simpson, CS, 2010) |
| "To assess whether therapy with hydrochlorothiazide (HCTZ) or the calcium antagonist nitrendipine influences silent ischemia or arrhythmias, we studied 10 asymptomatic hypertensive male patients with positive Tl-201 scintigraphy in a double-blind, crossover protocol." | 3.68 | Influence of therapy on silent ischemia and ventricular arrhythmias in hypertensive patients. ( Ammon, S; Massie, BM; O'Kelly, B; Szlachcic, J; Tubau, JF, 1991) |
| " Thirty-eight patients (22 low renin, 16 normal renin) with moderate diastolic hypertension were treated with hydrochlorothiazide administered twice a day." | 3.67 | Potassium and magnesium abnormalities: diuretics and arrhythmias in hypertension. ( Hollifield, JW, 1984) |
| " Thirty-one patients with uncomplicated hypertension underwent 48-hour ambulatory ECG monitoring both before any treatment and after 4 weeks of hydrochlorothiazide, (HCTZ), 100 mg daily." | 3.67 | Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or without left ventricular hypertrophy. ( Fletcher, RD; Freis, ED; Gottdiener, J; Notargiacomo, A; Papademetriou, V; Price, M, 1985) |
| "The purpose of this study was to determine if chronic administration of the diuretics hydrochlorothiazide and amiloride alters the response to catecholamine-induced ventricular arrhythmias." | 3.67 | Effect of chronic diuretics on epinephrine-induced ventricular arrhythmias: a comparison of hydrochlorothiazide and amiloride in the rat. ( Rabkin, SW; Roob, O, 1987) |
| " We treated 38 patients (22 low renin, 16 normal renin) with moderate diastolic hypertension with hydrochlorothiazide (HCTC) administered on a twice daily schedule." | 3.66 | Thiazide diuretics, hypokalemia and cardiac arrhythmias. ( Hollifield, JW; Slaton, PE, 1981) |
| "Triamterene therapy was evaluated in 35 patients with congestive heart failure over a period of two and one-half years." | 3.64 | CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE. ( LAUFER, ST; MAHABIR, RN, 1964) |
| "Serious ventricular arrhythmias occurred in 13 of 37 patients receiving hydrochlorothiazide compared with 15 of 37 receiving placebo and 9 of 37 receiving hydrochlorothiazide + amiloride." | 2.67 | Diuretic therapy and ventricular arrhythmias in persons 65 years of age and older. ( Myers, MG, 1990) |
| "The patients with complex arrhythmias were older (p less than 0." | 2.66 | Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker. ( Hardarson, T; Ragnarsson, J; Snorrason, SP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (75.61) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 1 (2.44) | 29.6817 |
| 2010's | 1 (2.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Digby, G | 1 |
| Machaalany, J | 1 |
| Malik, P | 1 |
| Methot, M | 1 |
| Simpson, CS | 1 |
| Redfearn, D | 1 |
| Baranchuk, A | 1 |
| SOKOLOV-PONOMAREVA, OD | 1 |
| BEREZHKOV, LF | 1 |
| LAUFER, ST | 2 |
| MAHABIR, RN | 2 |
| Papademetriou, V | 4 |
| Fletcher, R | 1 |
| Khatri, IM | 1 |
| Freis, ED | 4 |
| Hancock, EW | 1 |
| Hollifield, JW | 3 |
| Madias, JE | 1 |
| Madias, NE | 1 |
| Gavras, HP | 1 |
| Slaton, PE | 1 |
| Holland, OB | 2 |
| Nixon, JV | 1 |
| Kuhnert, L | 2 |
| Millar, RS | 1 |
| Pertoldi, F | 1 |
| D'Orlando, L | 1 |
| Mercante, WP | 1 |
| Novo, S | 1 |
| Abrignani, MG | 1 |
| Novo, G | 1 |
| Nardi, E | 1 |
| Dominguez, LJ | 1 |
| Strano, A | 1 |
| Barbagallo, M | 1 |
| Chazov, EI | 1 |
| Whiting, GF | 1 |
| McLaran, CJ | 1 |
| Bochner, F | 1 |
| Clarfield, AM | 1 |
| Friedman, R | 1 |
| Bergman, H | 1 |
| Myers, MG | 1 |
| Kromer, EP | 1 |
| Elsner, D | 1 |
| Riegger, GA | 1 |
| Szlachcic, J | 1 |
| Tubau, JF | 1 |
| O'Kelly, B | 1 |
| Ammon, S | 1 |
| Massie, BM | 1 |
| Siegel, D | 1 |
| Hulley, SB | 2 |
| Black, DM | 1 |
| Cheitlin, MD | 1 |
| Sebastian, A | 1 |
| Seeley, DG | 1 |
| Hearst, N | 1 |
| Fine, R | 1 |
| Price, M | 1 |
| Notargiacomo, A | 2 |
| Gottdiener, J | 1 |
| Fletcher, RD | 1 |
| Kuller, LH | 1 |
| Cohen, JD | 1 |
| Neaton, J | 1 |
| Rabkin, SW | 1 |
| Roob, O | 1 |
| Sideris, DA | 1 |
| Messerli, FH | 1 |
| Nunez, BD | 1 |
| Nunez, MM | 1 |
| Garavaglia, GE | 1 |
| Schmieder, RE | 1 |
| Ventura, HO | 1 |
| Peters, RW | 1 |
| Hamilton, J | 1 |
| Hamilton, BP | 1 |
| Pollard, J | 1 |
| Padia, M | 1 |
| Anderson, RJ | 1 |
| Blomqvist, G | 1 |
| Alexander, BS | 1 |
| Ragnarsson, J | 1 |
| Hardarson, T | 1 |
| Snorrason, SP | 1 |
| Zahid, M | 1 |
| Krumlovsky, FA | 1 |
| Roxe, D | 1 |
| del Greco, F | 1 |
| Mistovich, M | 1 |
| Lumme, JA | 1 |
| Jounela, AJ | 1 |
| Roux, M | 1 |
| Herne, N | 1 |
| Gilly, R | 1 |
| Michaud, J | 1 |
| Le Gall, F | 1 |
| Poblete, PF | 1 |
| Kyle, MC | 1 |
| Pipberger, HV | 1 |
| Leemhuis, MP | 1 |
| Struyvenberg, A | 1 |
| Chung, EK | 2 |
| Redleaf, PD | 1 |
| Lerner, IJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Once Versus Twice Daily Electrolyte Monitoring in CHF; a Study Monitoring Electrolytes in Congestive Heart Failure Patients Being Actively Diuresed in Hospital[NCT02497742] | 96 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| [NCT00000525] | Phase 3 | 233 participants (Actual) | Interventional | 1986-07-31 | Completed | ||
| [NCT00000487] | Phase 3 | 0 participants | Interventional | 1972-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydrochlorothiazide and Arrhythmia
| Article | Year |
|---|---|
Significance of hypokalaemia due to diuretics.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorothiazide; Diuretics; Ethacrynic Acid; Extracellular Space; Fu | 1973 |
11 trials available for hydrochlorothiazide and Arrhythmia
| Article | Year |
|---|---|
Nonarrhythmogenicity of diuretic-induced hypokalemia. Its evidence in patients with uncomplicated hypertension.
Topics: Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Hydrochlorothiazide; Hyperte | 1984 |
Effects of drug therapy on cardiac arrhythmias and ischemia in hypertensives with LVH.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Atenolol; Blood | 2001 |
Diuretic therapy and ventricular arrhythmias in persons 65 years of age and older.
Topics: Aged; Aged, 80 and over; Amiloride; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Double-Blind | 1990 |
Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm.
Topics: Adult; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Arrhythmias, Cardiac; Digoxin; Drug Th | 1990 |
Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Chlorthalidone; Double-Blind Method; Electrocardi | 1992 |
Diuretic therapy and exercise in patients with systemic hypertension.
Topics: Arrhythmias, Cardiac; Cardiomegaly; Catecholamines; Combined Modality Therapy; Double-Blind Method; | 1989 |
Incidence of cardiac arrhythmias associated with mild hypokalemia induced by low-dose diuretic therapy for hypertension.
Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Drug Administratio | 1989 |
Ventricular ectopic activity with diuretic therapy.
Topics: Adult; Amiloride; Arrhythmias, Cardiac; Clinical Trials as Topic; Death, Sudden; Drug Combinations; | 1988 |
Ventricular dysrhythmias in middle-aged hypertensive men treated either with a diuretic agent or a beta-blocker.
Topics: Aged; Amiloride; Arrhythmias, Cardiac; Bendroflumethiazide; Clinical Trials as Topic; Drug Combinati | 1987 |
Cardiac arrhythmias in hypertensive outpatients on various diuretics. Correlation between incidence and serum potassium and magnesium levels.
Topics: Adult; Arrhythmias, Cardiac; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hype | 1986 |
Effect of treatment on morbidity in hypertension. Veterans Administration Cooperative Study on Antihypertensive Agents. Effect on the electrocardiogram.
Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiomegaly; Clinical Trials as Topi | 1973 |
29 other studies available for hydrochlorothiazide and Arrhythmia
| Article | Year |
|---|---|
Multifactorial QT interval prolongation.
Topics: Alcoholism; Amiodarone; Antipsychotic Agents; Arrhythmias, Cardiac; Biomarkers; Citalopram; Cyclohex | 2010 |
[SOME NEW DRUGS IN THE TREATMENT OF RHEUMATIC CHILDREN].
Topics: Adolescent; Alkaloids; Anabolic Agents; Antithyroid Agents; Arrhythmias, Cardiac; Cardiovascular Dis | 1964 |
CLINICAL EXPERIENCE WITH A NEW DIURETIC, TRIAMTERENE, IN CONJESTIVE HEART FAILURE.
Topics: Arrhythmias, Cardiac; Canada; Chlorides; Digitalis Glycosides; Diuretics; Edema; Heart Failure; Hydr | 1964 |
Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias.
Topics: Adult; Aged; Ambulatory Care; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Complexes, Prem | 1983 |
Bigeminal rhythm on multiple cardiac drug therapy.
Topics: Arrhythmias, Cardiac; Cardiovascular Agents; Digoxin; Drug Therapy, Combination; Electrocardiography | 1984 |
Potassium and magnesium abnormalities: diuretics and arrhythmias in hypertension.
Topics: Adult; Arrhythmias, Cardiac; Blood Pressure; Humans; Hydrochlorothiazide; Hypertension; Magnesium; M | 1984 |
Thiazide diuretics, hypokalemia and cardiac arrhythmias.
Topics: Adult; Arrhythmias, Cardiac; Diuretics; Female; Heart Ventricles; Humans; Hydrochlorothiazide; Hyper | 1981 |
Diuretic-induced ventricular ectopic activity.
Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Exercise Test; Heart Ventricles; Humans; Hydrochlo | 1981 |
Discontinuation of Sotazide.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Contraindications; Drug Combi | 1996 |
Electromechanical dissociation 48 hours after atenolol overdose: usefulness of calcium chloride.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Arrhythmias, Cardiac; Atenolol; Blood P | 1998 |
[Treatment of rhythm and conduction disorders].
Topics: Adrenergic beta-Antagonists; Ajmaline; Arrhythmias, Cardiac; Atropine; Drug Therapy, Combination; Hu | 1975 |
Severe hyperkalaemia with Moduretic.
Topics: Aged; Amiloride; Arrhythmias, Cardiac; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyper | 1979 |
Diuretics, potassium, and ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Diuretics; Humans; Hydrochlorothiazide; Hypokalemia; Hypotension; | 1992 |
Diuretics, potassium, and ventricular arrhythmias.
Topics: Adolescent; Aged; Arrhythmias, Cardiac; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hypoka | 1992 |
Influence of therapy on silent ischemia and ventricular arrhythmias in hypertensive patients.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Electrocardiography, Ambulatory | 1991 |
Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or without left ventricular hypertrophy.
Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Diuretics; Echocardio | 1985 |
Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomegaly; Catecholamines; Chlorthalid | 1986 |
Effect of chronic diuretics on epinephrine-induced ventricular arrhythmias: a comparison of hydrochlorothiazide and amiloride in the rat.
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Blood Pressure; Diuretics; Dose-Response Relationship, Dru | 1987 |
The importance of blood pressure in the emergence of arrhythmias.
Topics: Amiloride; Animals; Arrhythmias, Cardiac; Biomechanical Phenomena; Blood Pressure; Cardiac Complexes | 1987 |
Hypertension and sudden death. Disparate effects of calcium entry blocker and diuretic therapy on cardiac dysrhythmias.
Topics: Adult; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiomegaly; Death, Sudden; Electrocardiogra | 1989 |
Diuretic-induced CNS magnesium alteration and digoxin intoxication.
Topics: Animals; Arrhythmias, Cardiac; Bendroflumethiazide; Brain Chemistry; Digoxin; Diuretics; Electrocard | 1988 |
Central nervous system and cardiac manifestations of hydrochlorothiazide overdosage; treatment with hemodialysis.
Topics: Aged; Arrhythmias, Cardiac; Central Nervous System; Heart; Humans; Hydrochlorothiazide; Kidney Failu | 1988 |
Thiazide treatment of hypertension. Effects of thiazide diuretics on serum potassium, magnesium, and ventricular ectopy.
Topics: Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Heart Ventricles; Humans; Hydrochlorothiazid | 1986 |
[Clinical study of amiloride hydrochloride, a diuretic with low potassium loss].
Topics: Arrhythmias, Cardiac; Blood Urea Nitrogen; Cardiac Complexes, Premature; Diuretics; Drug Synergism; | 1970 |
When a drug is the culprit.
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Clofibrate; Depression; Drug-Related Side Effect | 1973 |
Digitalis-induced A-V nodal tachycardia.
Topics: Aged; Arrhythmias, Cardiac; Digoxin; Humans; Hydrochlorothiazide; Male; Tachycardia | 1969 |
Digitalis-induced double atrioventricular nodal rhythm associated with electrical alternans.
Topics: Aged; Arrhythmias, Cardiac; Digoxin; Electrocardiography; Heart Failure; Humans; Hydrochlorothiazide | 1968 |
Thiazide-induced hypokalemia with associated major ventricular arrhythmias. Report of a case and comment on therapeutic use of bretylium.
Topics: Arrhythmias, Cardiac; Bretylium Compounds; Electrocardiography; Female; Humans; Hydrochlorothiazide; | 1968 |
Clinical evaluation of diuretics in congestive heart failure. A detailed study in four patients.
Topics: Aged; Arrhythmias, Cardiac; Chlorides; Diuretics; Drug Synergism; Furosemide; Heart Failure; Humans; | 1969 |