hydrochlorothiazide has been researched along with Alloxan Diabetes in 15 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that compared with hydrochlorothiazide (HCTZ), the renin inhibitor aliskiren (ALISK) or amlodipine (AMLO) and their combination reduce albuminuria via reduction in renal inflammation, independent of blood pressure (BP) changes." | 7.78 | Combined aliskiren and amlodipine reduce albuminuria via reduction in renal inflammation in diabetic rats. ( Huang, J; Matavelli, LC; Siragy, HM, 2012) |
| "We hypothesized that compared with hydrochlorothiazide (HCTZ), the renin inhibitor aliskiren (ALISK) or amlodipine (AMLO) and their combination reduce albuminuria via reduction in renal inflammation, independent of blood pressure (BP) changes." | 3.78 | Combined aliskiren and amlodipine reduce albuminuria via reduction in renal inflammation in diabetic rats. ( Huang, J; Matavelli, LC; Siragy, HM, 2012) |
| "We have compared the effects of the angiotensin converting enzyme inhibitor, perindopril, and a conventional antihypertensive regimen (triple therapy: hydralazine, reserpine and hydrochlorothiazide) on kidney function and albuminuria in hypertensive diabetic rats." | 3.68 | Antihypertensive therapy in a model combining spontaneous hypertension with diabetes. ( Allen, TJ; Cooper, ME; Doyle, AE; Jerums, G; O'Brien, RC; Rumble, JR, 1992) |
| "Perindopril was associated with significantly lower AER than lacidipine, whereas lacidipine was more potent in preventing increases in ocular AVC." | 1.29 | Organ specificity of antihypertensive therapy on ocular albumin vascular clearance and albuminuria in the hypertensive diabetic rat. ( Cooper, M; Gin, T; Jerums, G; Joon, TL; Panagiotopoulos, S; Taylor, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matavelli, LC | 1 |
| Huang, J | 1 |
| Siragy, HM | 1 |
| KENNEDY, GC | 1 |
| CRAWFORD, JD | 1 |
| O'Brien, RC | 2 |
| Cooper, ME | 2 |
| Jerums, G | 3 |
| Doyle, AE | 2 |
| Gin, T | 1 |
| Joon, TL | 1 |
| Panagiotopoulos, S | 1 |
| Cooper, M | 1 |
| Taylor, H | 1 |
| A-Rahim, YI | 1 |
| Beyer, KH | 2 |
| Vesell, ES | 2 |
| Tang, Z | 1 |
| Shou, I | 1 |
| Wang, LN | 1 |
| Fukui, M | 1 |
| Tomino, Y | 1 |
| Follansbee, MH | 1 |
| Griffith, JW | 1 |
| Hnatyszyn, O | 1 |
| Miño, J | 1 |
| Gorzalczany, S | 1 |
| Opezzo, J | 1 |
| Ferraro, G | 1 |
| Coussio, J | 1 |
| Acevedo, C | 1 |
| Minker, E | 1 |
| Koltai, M | 1 |
| Blazsó, G | 1 |
| Rumble, JR | 1 |
| Allen, TJ | 1 |
| Atef, M | 1 |
| Hanafy, MS | 1 |
| Arbid, MS | 1 |
| Foy, JM | 1 |
| Furman, BL | 1 |
| Creutzfeldt, W | 1 |
| Guidoux, R | 1 |
| Staquet, M | 1 |
| Nabwangu, J | 1 |
| Wolff, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Evidence Base Study on the Clinical Effects of Integrated Western Medicine and Traditional Chinese Medicine for Diabetic Foot Ulcer Treatment[NCT00393510] | Phase 2 | 80 participants (Actual) | Interventional | 2000-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The number of successful limb rescued (without amputation). (NCT00393510)
Timeframe: 24 weeks
| Intervention | Participants (Number) |
|---|---|
| Traditional Chinese Medicine | 37 |
| Placebo | 31 |
Time taken for maturation of granulation to enable skin grafting. (NCT00393510)
Timeframe: 24 week
| Intervention | Weeks (Mean) |
|---|---|
| Traditional Chinese Medicine | 5.9 |
| Placebo | 9.2 |
The state of inflammation at baseline and at 4 weeks after treatment. TNF-alpha are in value of serum level. (NCT00393510)
Timeframe: Baseline and 4 week
| Intervention | pg/mL (Mean) | |
|---|---|---|
| Baseline | Week 4 | |
| Placebo | 44 | 39 |
| Traditional Chinese Medicine | 48 | 28 |
1 review available for hydrochlorothiazide and Alloxan Diabetes
| Article | Year |
|---|---|
[Current views on the mode of action of hypoglycemic sulfonamides].
Topics: Amino Acids; Animals; Blood Glucose; Chlorpropamide; Diabetes Insipidus; Diabetes Mellitus, Experime | 1969 |
14 other studies available for hydrochlorothiazide and Alloxan Diabetes
| Article | Year |
|---|---|
Combined aliskiren and amlodipine reduce albuminuria via reduction in renal inflammation in diabetic rats.
Topics: Albuminuria; Amides; Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus | 2012 |
Treatment of diabetes insipidus with hydrochlorothiazide.
Topics: Acetazolamide; Diabetes Insipidus; Diabetes Mellitus; Diabetes Mellitus, Experimental; Hydrochloroth | 1959 |
The effects of perindopril and triple therapy in a normotensive model of diabetic nephropathy.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressu | 1993 |
Organ specificity of antihypertensive therapy on ocular albumin vascular clearance and albuminuria in the hypertensive diabetic rat.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Press | 1996 |
Studies on pyrazinoylguanidine. 1. Characterization of metabolic effects in diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Blood Glucose; Choles | 1996 |
Effects of antihypertensive drugs or glycemic control on antioxidant enzyme activities in spontaneously hypertensive rats with diabetes.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Glucose; Captopril; Catalase; Diabetes Mellitu | 1997 |
Studies on pyrazinoylguanidine. 5. Temporal effects over 24 weeks demonstrating attenuation of diabetic nephropathy in STZ-diabetic rats.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Ca | 1997 |
Diuretic activity of an aqueous extract of Phyllanthus sellowianus.
Topics: Animals; Diabetes Mellitus, Experimental; Diuretics; Electrolytes; Euphorbiaceae; Female; Hydrochlor | 1999 |
Diabetes-induced alterations of autonomic nerve function in the cat.
Topics: Animals; Cat Diseases; Cats; Cholinesterases; Cortisone; Diabetes Mellitus; Diabetes Mellitus, Exper | 1978 |
Antihypertensive therapy in a model combining spontaneous hypertension with diabetes.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Gluco | 1992 |
Enhanced diabetogenic effects of combined treatment with hydrochlorothiazide and prednisone in adjuvant arthritic rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Blood Glucose; Blo | 1991 |
Effect of single dose administration of diuretics on the blood sugar of alloxan-diabetic mice or mice made hyperglycaemic by the acute administration of diazoxide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Diuresis; Diuretics; Drug Intera | 1973 |
[Diabetogenic effects of thiazide diuretics and the solvent N-monomethyl-acetamide in rats].
Topics: Acetates; Amides; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucos | 1969 |
The effect of thiazides on the blood sugar of alloxanized and suballoxanized rats.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Glucose | 1965 |