hydrochlorothiazide has been researched along with Adverse Drug Event in 31 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of telmisartan/HCTZ is an effective and well-tolerated treatment option for patients with hypertension." | 8.86 | Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension. ( Kjeldsen, SE; Mancia, G; Schmieder, RE; Unger, T, 2010) |
| " Safety was assessed by monitoring and recording adverse events (AEs)." | 6.75 | Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension. ( Chrysant, SG; Dattani, D; Hoppe, UC; Murray, AV; Patel, S; Ritter, S; Zhang, J, 2010) |
| " Safety and tolerability were assessed by the incidence rate of adverse events (AEs) and discontinuation." | 5.56 | Real-World Effectiveness and Safety of a Single-Pill Combination of Olmesartan/Amlodipine/Hydrochlorothiazide in Korean Patients with Essential Hypertension (RESOLVE): A Large, Observational, Retrospective, Cohort Study. ( Park, SJ; Rhee, SJ, 2020) |
| "The aim of this randomized, double-blind, multicenter 12-week study was to compare the efficacy, safety, and tolerability of a combination of olmesartan medoxomil/hydrochlorothiazide (HCTZ) with that of benazepril plus amlodipine besylate in patients with stage 2 hypertension." | 5.12 | Efficacy and safety of olmesartan medoxomil and hydrochlorothiazide compared with benazepril and amlodipine besylate. ( Dubiel, R; Kereiakes, DJ; Lipka, LJ; Neutel, JM; Punzi, HA; Xu, J, 2007) |
| "The combination of telmisartan/HCTZ is an effective and well-tolerated treatment option for patients with hypertension." | 4.86 | Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension. ( Kjeldsen, SE; Mancia, G; Schmieder, RE; Unger, T, 2010) |
| "This cohort study found that among older adults, chlorthalidone use was associated with a higher risk of eGFR decline, cardiovascular events, and hypokalemia compared with hydrochlorothiazide use." | 4.02 | Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function. ( Bugeja, A; Burns, K; Canney, M; Edwards, C; Hundemer, GL; Knoll, G; Petrcich, W; Sood, MM, 2021) |
| " Serious adverse events were more frequent in E (2." | 2.76 | Efficacy and safety of early versus late titration of fixed-dose irbesartan/hydrochlorothiazide: ACTUAL study. ( Aoun, J; Girerd, X; Rosenbaum, D, 2011) |
| " Safety was assessed by monitoring and recording adverse events (AEs)." | 2.75 | Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension. ( Chrysant, SG; Dattani, D; Hoppe, UC; Murray, AV; Patel, S; Ritter, S; Zhang, J, 2010) |
| " Safety and tolerability were assessed by the incidence rate of adverse events (AEs) and discontinuation." | 1.56 | Real-World Effectiveness and Safety of a Single-Pill Combination of Olmesartan/Amlodipine/Hydrochlorothiazide in Korean Patients with Essential Hypertension (RESOLVE): A Large, Observational, Retrospective, Cohort Study. ( Park, SJ; Rhee, SJ, 2020) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (29.03) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 12 (38.71) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Edwards, C | 1 |
| Hundemer, GL | 1 |
| Petrcich, W | 1 |
| Canney, M | 1 |
| Knoll, G | 1 |
| Burns, K | 1 |
| Bugeja, A | 1 |
| Sood, MM | 1 |
| Park, SJ | 1 |
| Rhee, SJ | 1 |
| Chadalavada, P | 1 |
| Simons-Linares, CR | 1 |
| Chahal, P | 1 |
| Pease, DR | 1 |
| Martinez-Escala, ME | 1 |
| Jimenez, J | 1 |
| Guitart, J | 1 |
| West, DP | 1 |
| Nardone, B | 1 |
| Ayyagari, R | 1 |
| Xie, J | 1 |
| Cheng, D | 1 |
| Wu, EQ | 1 |
| Huang, XY | 1 |
| Chen, S | 1 |
| Reap, LE | 1 |
| Rodd, C | 1 |
| Larios, J | 1 |
| Marshall, M | 1 |
| Nasr, SH | 1 |
| Milliner, DS | 1 |
| Wooldridge, TD | 1 |
| Sethi, S | 1 |
| Corominas, M | 1 |
| Andrés-López, B | 1 |
| Lleonart, R | 1 |
| Handler, J | 1 |
| Kjeldsen, SE | 1 |
| Schmieder, RE | 1 |
| Unger, T | 2 |
| Mancia, G | 1 |
| Schröder, S | 1 |
| Surmann, P | 1 |
| van der Linden, CM | 1 |
| Jansen, PA | 1 |
| van Marum, RJ | 1 |
| Grouls, RJ | 1 |
| Korsten, EH | 1 |
| Egberts, AC | 1 |
| Callen, JP | 1 |
| Chrysant, SG | 1 |
| Murray, AV | 1 |
| Hoppe, UC | 1 |
| Dattani, D | 1 |
| Patel, S | 1 |
| Ritter, S | 1 |
| Zhang, J | 1 |
| Girerd, X | 1 |
| Rosenbaum, D | 1 |
| Aoun, J | 1 |
| Goebel, M | 1 |
| Clemenz, M | 1 |
| Kereiakes, DJ | 1 |
| Neutel, JM | 1 |
| Punzi, HA | 1 |
| Xu, J | 1 |
| Lipka, LJ | 1 |
| Dubiel, R | 1 |
| Audia, P | 1 |
| Feinfeld, DA | 1 |
| Dubrow, A | 1 |
| Winchester, JF | 1 |
| Burns, JR | 1 |
| Finlayson, B | 1 |
| Rambaldi, M | 1 |
| Russo, R | 1 |
| Iaquinto, G | 1 |
| Agozzino, L | 1 |
| De Cristofano, R | 1 |
| Levine, L | 1 |
| Langohr, HD | 1 |
| White, JP | 1 |
| Ward, MJ | 1 |
| Hurwitz, MM | 1 |
| Brettner, A | 1 |
| Heitzman, ER | 1 |
| Woodin, WG | 1 |
| Schulte-Steinberg, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 54-week, Open-label, Multicenter Study to Assess the Long-term Safety and Tolerability of the Combination of Aliskiren 300 mg /Valsartan 320 mg in Patients With Essential Hypertension Followed by a 26 Week Open-label Extension to Assess the Long-term Sa[NCT00386607] | Phase 3 | 601 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| Efficacy and Safety of Irbesartan/Hydrochlorothiazide Combination: A Comparison of Active and Usual Titration Regimen in the Treatment of Hypertensive Patients Insufficiently Controlled by Monotherapy[NCT00708344] | Phase 4 | 832 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00386607)
Timeframe: Baseline and Month 18
| Intervention | mmHg (Mean) |
|---|---|
| Extension Treatment | -18.3 |
(NCT00386607)
Timeframe: Baseline and Month 18
| Intervention | mmHg (Mean) |
|---|---|
| Extension Treatment | -28.8 |
(NCT00386607)
Timeframe: Month 12
| Intervention | percentage of patients (Number) |
|---|---|
| Core Treatment- Aliskiren/Valsartan & Aliskiren/Valsartan/HCTZ | 76.2 |
adverse event data obtained from both the core study and the 6 month extension study. (NCT00386607)
Timeframe: Month 18
| Intervention | percentage of patients (Number) |
|---|---|
| Core and Extension Treatment - Aliskiren/Valsartan/HCTZ | 61.6 |
(NCT00386607)
Timeframe: Month 18
| Intervention | Percentage of patients (Number) |
|---|---|
| Extension Treatment | 86.6 |
(NCT00386607)
Timeframe: Baseline and Weeks 2, 4, 6, 10, 14, 18, 28, 41, and 54
| Intervention | mmHg (Mean) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Week 2 (Visit 5) | Week 4 (Visit 6) | Week 6 (Visit 7) | Week 10 (Visit 8) | Week 14 (Visit 9) | Week 18 (Visit 10) | Week 28 (Visit 11) | Week 41 (Visit 12) | Week 54 (Visit 13) | Endpoint (value at week 54 or LOCF) | |
| Core Treatment | -7.9 | -10.8 | -11.8 | -12.5 | -13.7 | -15.0 | -15.2 | -15.2 | -14.2 | -13.4 |
(NCT00386607)
Timeframe: Baseline and Weeks 2, 4, 6, 10, 14, 18, 28, 41 and 54
| Intervention | mmHg (Mean) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Week 2 (Visit 5) | Week 4 (Visit 6) | Week 6 (Visit 7) | Week 10 (Visit 8) | Week 14 (Visit 9) | Week 18 (Visit 10) | Week 28 (Visit 11) | Week 41 (Visit 12) | Week 54 (Visit 13) | Endpoint (value at week 54 or LOCF) | |
| Core Treatment | -11.0 | -15.0 | -17.6 | -18.4 | -20.7 | -22.6 | -24.3 | -24.3 | -22.3 | -20.5 |
(NCT00386607)
Timeframe: .Weeks 2, 4, 6, 10, 14, 18, 28, 41, and 54
| Intervention | Percentage of patients (Number) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Week 2 (Visit 5) | Week 4 (Visit 6) | Week 6 (Visit 7) | Week 10 (Visit 8) | Week 14 (Visit 9) | Week 18 (Visit 10) | Week 28 (Visit 11) | Week 41 (Visit 12) | Week 54 (Visit 13) | Endpoint (value at week 54 or LOCF) | |
| Core Treatment | 32.8 | 45.9 | 52.4 | 60.8 | 68.7 | 76.4 | 77.9 | 78.2 | 71.7 | 66.9 |
6 reviews available for hydrochlorothiazide and Adverse Drug Event
| Article | Year |
|---|---|
Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; B | 2010 |
Drug-induced subacute cutaneous lupus erythematosus.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hydrochlorothiazide; Lupus Erythematosus, C | 2010 |
Effective treatment of hypertension by AT(1) receptor antagonism: the past and future of telmisartan.
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Diuretics; Drug Therapy, Combina | 2006 |
[Pancreatitis caused by drugs].
Topics: Adult; Azathioprine; Chlorothiazide; Contraceptives, Oral; Drug-Related Side Effects and Adverse Rea | 1977 |
Reported ocular side effects of the ten most frequently prescribed drugs.
Topics: Acetaminophen; Ampicillin; Brompheniramine; Codeine; Diazepam; Digoxin; Drug Prescriptions; Drug-Rel | 1979 |
Drug-induced adverse pulmonary reactions.
Topics: Amiodarone; Asthma; Bleomycin; Carmustine; Drug-Related Side Effects and Adverse Reactions; Gold; Hu | 1985 |
3 trials available for hydrochlorothiazide and Adverse Drug Event
| Article | Year |
|---|---|
Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Amides; Antihypertensive Agents; Drug Combinations; Drug | 2010 |
Efficacy and safety of early versus late titration of fixed-dose irbesartan/hydrochlorothiazide: ACTUAL study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Drug Combinations; Drug-Related Side Effects and Adve | 2011 |
Efficacy and safety of olmesartan medoxomil and hydrochlorothiazide compared with benazepril and amlodipine besylate.
Topics: Amlodipine; Antihypertensive Agents; Benzazepines; Blood Pressure; Diastole; Drug-Related Side Effec | 2007 |
22 other studies available for hydrochlorothiazide and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function.
Topics: Aged; Chlorthalidone; Drug-Related Side Effects and Adverse Reactions; Female; Glomerular Filtration | 2021 |
Real-World Effectiveness and Safety of a Single-Pill Combination of Olmesartan/Amlodipine/Hydrochlorothiazide in Korean Patients with Essential Hypertension (RESOLVE): A Large, Observational, Retrospective, Cohort Study.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Asian People; Cohort Studies; D | 2020 |
Drug-induced acute pancreatitis: Prevalence, Causative agents, and Outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Doxycycline; Drug-Related Side Effects and | 2020 |
Cutaneous T-cell lymphoma after chronic exposure to hydrochlorothiazide: pharmacovigilance analysis from the RADAR (Research on Adverse Drug events And Reports) Program.
Topics: Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Hydrochlorothiazide; Ly | 2021 |
A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions; F | 2018 |
Hydrochlorothizide-induced acute generalised exanthematous pustulosis presenting with bilateral periorbital impetigo.
Topics: Acute Generalized Exanthematous Pustulosis; Administration, Topical; Aged, 80 and over; Anti-Infecti | 2019 |
Triamterene crystalline nephropathy.
Topics: Antihypertensive Agents; Biopsy; Creatinine; Diagnostic Errors; Drug Combinations; Drug-Related Side | 2014 |
Severe adverse drug reactions induced by hydrochlorothiazide: A persistent old problem.
Topics: Aged; Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydr | 2016 |
Lithium and antihypertensive medication: a potentially dangerous interaction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Antimanic Agents; Bipolar Disorde | 2009 |
Photoallergenic potential testing by online irradiation and HPLC.
Topics: Anti-Allergic Agents; Chromatography, High Pressure Liquid; Dipeptides; Diuretics; Drug Evaluation, | 2010 |
Recurrence of adverse drug reactions following inappropriate re-prescription: better documentation, availability of information and monitoring are needed.
Topics: Adverse Drug Reaction Reporting Systems; Aged, 80 and over; Diclofenac; Drug Prescriptions; Drug-Rel | 2010 |
Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction.
Topics: Acidosis, Lactic; Acute Disease; Acute Kidney Injury; Angiotensin II Type 1 Receptor Blockers; Benzi | 2008 |
Management of the stone former.
Topics: Allopurinol; Calcium; Cellulose; Cystinuria; Diet; Drug-Related Side Effects and Adverse Reactions; | 1984 |
[Myopathies under drug influence].
Topics: Chlorothiazide; Diuretics; Drug-Related Side Effects and Adverse Reactions; Hemorrhage; Humans; Hydr | 1975 |
When a drug is the culprit.
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Clofibrate; Depression; Drug-Related Side Effect | 1973 |
A cure for iatrogenic disease: look before you leap.
Topics: Chlordiazepoxide; Digitoxin; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and | 1973 |
Pulmonary complications of drug therapy.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Busulfan; Child; Drug-Related Side Effects and Advers | 1970 |
["Nil nocere" in drug pretreatment of surgical patients].
Topics: Acetazolamide; Adrenal Cortex Hormones; Anesthesia; Anti-Bacterial Agents; Anticoagulants; Antihyper | 1967 |