hydrochlorothiazide has been researched along with Acute Liver Injury, Drug-Induced in 17 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrochlorothiazide and other thiazide-like diuretics are considered as a first-line drug for initial therapy in uncomplicated arterial hypertension [1]." | 3.72 | Hydrochlorothiazide induced hepato-cholestatic liver injury. ( Alexander, P; Arinzon, Z; Berner, Y, 2004) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Malézieux, E | 1 |
| Meunier, L | 1 |
| Rivière, B | 1 |
| Larrey, D | 1 |
| Valhovd, M | 1 |
| Kildahl-Andersen, O | 1 |
| CASCIO, G | 1 |
| PALAZZOADRIANO, M | 1 |
| DINES, DE | 1 |
| MORIN, Y | 1 |
| TURMEL, L | 1 |
| FORTIER, J | 1 |
| Arinzon, Z | 1 |
| Alexander, P | 1 |
| Berner, Y | 1 |
| Long, RC | 1 |
| Wofford, MR | 1 |
| Harkins, KG | 1 |
| Minor, DS | 1 |
| Hansen, JL | 1 |
| Swanson, LN | 1 |
| Hourmand-Ollivier, I | 1 |
| Dargere, S | 1 |
| Cohen, D | 1 |
| Galais, MP | 1 |
| Mosquet, B | 1 |
| Rousselot, P | 1 |
| Dao, T | 1 |
| Weisburst, M | 1 |
| Self, T | 1 |
| Peace, R | 1 |
| Cooper, J | 1 |
| Schweitzer, IL | 1 |
| Peters, RL | 1 |
1 review available for hydrochlorothiazide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
16 other studies available for hydrochlorothiazide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI.
Topics: Aged, 80 and over; Biopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; | 2021 |
[Drug-induced severe jaundice].
Topics: Adult; Amiloride; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Diuretics; Humans | 2003 |
[PHARMACOLOGICAL ACTIONS OF 2 HETEROCYCLIC GLYOXYLIC ALDEHYDES WITH NOTABLE DIURETIC ACTIVITY].
Topics: Aldehydes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorothiazide; C | 1964 |
POLYARTERITIS NODOSA. REPORT OF A PATIENT RECEIVING LONG-TERM ANTICOAGULANT THERAPY.
Topics: Anticoagulants; Biopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Guanethidin | 1964 |
METHYLDOPA: CLINICAL STUDIES IN ARTERIAL HYPERTENSION.
Topics: Cardiac Output; Chemical and Drug Induced Liver Injury; Drug Therapy; Hemodynamics; Hepatitis; Human | 1964 |
Hydrochlorothiazide induced hepato-cholestatic liver injury.
Topics: Aged; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Di | 2004 |
Hepatocellular necrosis associated with labetalol.
Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inj | 2007 |
Case study: Drug interference in clinical chemistry.
Topics: Aspartate Aminotransferases; Blood Glucose; Chemical and Drug Induced Liver Injury; Clinical Enzyme | 1981 |
[Fatal subfulminant hepatitis probably due to the combination benazepril-hydrochlorothiazide (Briazide)].
Topics: Aged; Antihypertensive Agents; Benzazepines; Chemical and Drug Induced Liver Injury; Drug Combinatio | 2000 |
Jaundice and rash associated with the use of phenobarbital and hydrochlorothiazide.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Drug Eruptions; Female; Humans; Hydrochlorothiaz | 1976 |
Acute submassive hepatic necrosis due to methyldopa. A case demonstrating possible initiation of chronic liver disease.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biopsy, Needle; Chemical and Drug Induced Liver I | 1974 |