hydrochlorothiazide has been researched along with Acidosis in 21 studies
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to investigate whether or not there is a causal relationship between the metabolic acidosis and the ocular hypotension induced by acetazolamide, we undertook to correlate over a period of time the blood-acidifying and ocular-hypotonizing effects of administering the lowest intravenous effective dose of acetazolamide; to treat the metabolic acidosis induced by acetazolamide by means of the intravenous introduction of bases, and pulmonary hyperventilation (respiratory alkalosis); to evaluate the effects on the intraocular pressure (IOP) by neutralizing the acetazolamide-induced metabolic acidosis by means of a continuous infusion of sodium bicarbonate; to determine the relationship between the metabolic acidosis induced by blood-acidifying agents, which do not inhibit carbonic anhydrase, and the IOP; and to determine the changes in the acid-base status of the aqueous humor induced by acetazolamide and other blood-acidifying drugs." | 7.65 | Acetazolamide, metabolic acidosis, and intraocular pressure. ( Bietti, G; Pecori-Giraldi, J; Virno, M, 1975) |
| "A patient who developed significant metabolic acidosis and severe hyperkalaemia while taking Moduretic (amiloride and hydrochlorothiazide) is reported." | 3.66 | Moduretic-induced metabolic acidosis and hyperkalaemia. ( Lye, MD; Wan, HH, 1980) |
| "In order to investigate whether or not there is a causal relationship between the metabolic acidosis and the ocular hypotension induced by acetazolamide, we undertook to correlate over a period of time the blood-acidifying and ocular-hypotonizing effects of administering the lowest intravenous effective dose of acetazolamide; to treat the metabolic acidosis induced by acetazolamide by means of the intravenous introduction of bases, and pulmonary hyperventilation (respiratory alkalosis); to evaluate the effects on the intraocular pressure (IOP) by neutralizing the acetazolamide-induced metabolic acidosis by means of a continuous infusion of sodium bicarbonate; to determine the relationship between the metabolic acidosis induced by blood-acidifying agents, which do not inhibit carbonic anhydrase, and the IOP; and to determine the changes in the acid-base status of the aqueous humor induced by acetazolamide and other blood-acidifying drugs." | 3.65 | Acetazolamide, metabolic acidosis, and intraocular pressure. ( Bietti, G; Pecori-Giraldi, J; Virno, M, 1975) |
| "Chlorothiazide has been shown to be almost ineffective as a diuretic agent per se." | 1.24 | SULFONAMYL DIURETICS--MECHANISM OF ACTION AND THERAPEUTIC USE. ( ROBERTS, KE, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, YW | 1 |
| Yang, SS | 1 |
| Cheng, CJ | 1 |
| Tseng, MH | 1 |
| Hsu, HM | 1 |
| Lin, SH | 1 |
| Paulais, M | 1 |
| Bloch-Faure, M | 1 |
| Picard, N | 1 |
| Jacques, T | 1 |
| Ramakrishnan, SK | 1 |
| Keck, M | 1 |
| Sohet, F | 1 |
| Eladari, D | 1 |
| Houillier, P | 1 |
| Lourdel, S | 1 |
| Teulon, J | 1 |
| Tucker, SJ | 1 |
| LABADIE, P | 1 |
| IWAKI, J | 1 |
| CALI, G | 1 |
| PIETROPAOLO, C | 1 |
| BAGROS, P | 1 |
| ROBERTS, KE | 1 |
| MODI, KN | 1 |
| DELIWALA, CV | 1 |
| SHETH, UK | 1 |
| BEYER, KH | 1 |
| BAER, JE | 1 |
| MICHAELSON, JK | 1 |
| RUSSO, HF | 1 |
| Gremske, D | 1 |
| Brien, G | 1 |
| Bick, C | 1 |
| Nimmergut, S | 1 |
| Wan, HH | 1 |
| Lye, MD | 1 |
| Frassetto, LA | 1 |
| Nash, E | 1 |
| Morris, RC | 1 |
| Sebastian, A | 1 |
| Suzuki, Y | 1 |
| Hamaguchi, Y | 1 |
| Yamagami, I | 1 |
| Bietti, G | 1 |
| Virno, M | 1 |
| Pecori-Giraldi, J | 1 |
| Tannen, RL | 1 |
| Gerrits, L | 1 |
| Weinstein, SF | 1 |
| Allan, DM | 1 |
| Mendoza, SA | 1 |
| Dretler, SP | 1 |
| Holzgreve, H | 1 |
| Loeschke, K | 1 |
| Rampini, S | 1 |
| Fanconi, A | 1 |
| Illig, R | 1 |
| Prader, A | 1 |
| Wiecko, W | 1 |
| Gussin, RZ | 1 |
| Cummings, JR | 1 |
| Stokey, EH | 1 |
| Ronsberg, MA | 1 |
1 trial available for hydrochlorothiazide and Acidosis
| Article | Year |
|---|---|
Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion.
Topics: Acid-Base Equilibrium; Acidosis; Aged; Bicarbonates; Calcium; Creatinine; Diuretics; Double-Blind Me | 2000 |
20 other studies available for hydrochlorothiazide and Acidosis
| Article | Year |
|---|---|
Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.
Topics: Acidosis; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Chemical Analysis; | 2016 |
Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.
Topics: Acidosis; Amiloride; Animals; Diuretics; Furosemide; Humans; Hydrochlorothiazide; Hypokalemia; Kidne | 2011 |
[RENAL CARBONIC ANHYDRASE: ITS PHYSIOLOGICAL ACTION; ITS INHIBITORS].
Topics: Acetazolamide; Acidosis; Ammonia; Carbonic Anhydrases; Chlorothiazide; Chlorthalidone; Dichlorphenam | 1963 |
[A COMPARATIVE STUDY ON SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Alkalosis; Blood Pressure; Cats; Chlorothiazide; Chlorthalidone; Diuretics; | 1963 |
[GRAVE DISORDER OF CARBOHYDRATE METABOLISM IN A PATIENT WITH HEPATIC CIRRHOSIS FOLLOWING TREATMENT WITH HYDROCHLOROTHIAZIDE].
Topics: Acidosis; Blood Chemical Analysis; Carbohydrate Metabolism; Diabetes Mellitus; Hydrochlorothiazide; | 1963 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
SULFONAMYL DIURETICS--MECHANISM OF ACTION AND THERAPEUTIC USE.
Topics: Acetazolamide; Acidosis; Alkalosis; Ammonia; Benzothiadiazines; Blood Chemical Analysis; Chlorothiaz | 1964 |
DIURETIC AND PHARMACOLOGICAL STUDY OF R-37 (2-AMINO-4-META-CHLOROANILINO-S-TRIAZINE)--A TRIAZINE DERIVATIVE.
Topics: Acidosis; Alkalosis; Anemia; Blood Urea Nitrogen; Diuretics; Dogs; Heart Failure; Hydrochlorothiazid | 1964 |
RENOTROPIC CHARACTERISTICS OF ETHACRYNIC ACID: A PHENOXYACETIC SALURETIC-DIURETIC AGENT.
Topics: Acidosis; Alkalosis; Chlorothiazide; Creatine; Creatinine; Diuretics; Dogs; Ethacrynic Acid; Hydroch | 1965 |
[Distal form of renal tubular acidosis and nephrolithiasis].
Topics: Acidosis; Ethacrynic Acid; Humans; Hydrochlorothiazide; Kidney Calculi; Kidney Tubules; Kidney Tubul | 1980 |
Moduretic-induced metabolic acidosis and hyperkalaemia.
Topics: Acidosis; Aged; Amiloride; Drug Combinations; Humans; Hydrochlorothiazide; Hyperkalemia; Male; Pyraz | 1980 |
[Pharmacological studies on diuretics (8). Diuretic activity and mechanism of action of a new hypotensive diuretic, SE-1520 (author's transl)].
Topics: Acidosis; Alkalosis; Animals; Antihypertensive Agents; Chlorine; Diuretics; Dogs; Glomerular Filtrat | 1977 |
Acetazolamide, metabolic acidosis, and intraocular pressure.
Topics: Acetazolamide; Acid-Base Equilibrium; Acidosis; Alkalosis, Respiratory; Animals; Ascorbic Acid; Buff | 1975 |
Response of the renal K+-conserving mechanism to kaliuretic stimuli: evidence for a direct kaliuretic effect by furosemide.
Topics: Absorption; Acidosis; Alkalosis; Alkalosis, Respiratory; Animals; Bicarbonates; Furosemide; Glomerul | 1986 |
Hyperkalemia, acidosis, and short stature associated with a defect in renal potassium excretion.
Topics: Acidosis; Administration, Oral; Ammonium Chloride; Bicarbonates; Blood; Body Height; Body Weight; Ca | 1974 |
The pathogenesis of urinary tract calculi occurring after ileal conduit diversion. I. Clinical study. II. Conduit study. 3. Prevention.
Topics: Acidosis; Adult; Bacteriuria; Bicarbonates; Calcium; Child; Dilatation; Female; Humans; Hydrochlorot | 1973 |
Renal effects and side effects of diuretics.
Topics: Absorption; Acetazolamide; Acidosis; Animals; Antihypertensive Agents; Bicarbonates; Chlorides; Chlo | 1970 |
Effect of hydrochlorothiazide on proximal renal tubular acidosis in a patient with idiopathic "de toni-debré-fanconi syndrome".
Topics: Acidosis; Adolescent; Bicarbonates; Calcium; Fanconi Syndrome; Female; Humans; Hydrochlorothiazide; | 1968 |
[Diabetic acidosis during hydrochlorothiazide treatment].
Topics: Acidosis; Aged; Diabetes Mellitus; Female; Humans; Hydrochlorothiazide | 1968 |
CL 65,562 (4-(a,a,a-trifluoro-m-toluidino)-nicotinic acid), a novel "high ceiling" diuretic.
Topics: Acidosis; Aminohippuric Acids; Animals; Chemical Phenomena; Chemistry; Chlorides; Diuresis; Diuretic | 1969 |