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hydrochloric acid and Disease Models, Animal

hydrochloric acid has been researched along with Disease Models, Animal in 198 studies

Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
hydrogen chloride : A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
" Hydrochloric acid (HCl) has been used to induce inflammation in the lungs and stomach but not tested for reproductive organs."7.83Establishment of hydrochloric acid/lipopolysaccharide-induced pelvic inflammatory disease model. ( Hahn, TW; Han, JH; Jung, BD; Kim, HC; Koo, DB; Kwon, YS; Lee, J; Oh, Y; Park, JJ; Rhee, KJ; Yoon, BI, 2016)
"We investigated the effect of the multi-herbal medicine, WSY-1075 in an animal model of hydrochloric acid (HCl)-induced cystitis."7.81Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis. ( Bae, WJ; Ha, US; Hong, SH; Hwang, SY; Hwang, TK; Kim, HJ; Kim, S; Kim, SJ; Kim, SW; Lee, JY, 2015)
"To clarify the basic mechanism involved in the pathophysiology of cystitis by characterizing the urodynamic parameters, pharmacologically relevant (muscarinic and purinergic) receptors, and the in vivo release of adenosine triphosphate (ATP) in the bladder of hydrochloric acid (HCl)-treated rats."7.76Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. ( Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A, 2010)
"We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism."7.71Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001)
"Effect of superimposed high frequency oscillatory ventilation on pulmonary gas exchange was investigated in seven anesthetized and paralyzed dogs with pulmonary edema induced by intrapulmonary injection of hydrochloric acid."7.68[Effect of superimposed high frequency oscillation on pulmonary edema induced by intrapulmonary injection of hydrochloric acid in dogs]. ( Sakai, T; Takaori, M; Yoshida, H, 1991)
"Previous abdominal aortic aneurysm (AAA) animal modeling methodologies were either expensive or complicated."5.91A novel abdominal aortic aneurysm model produced by periarterial application of hydrochloric acid. ( Chang, X; Duan, C; Guo, W; Wei, R; Wu, Z; Xiong, J, 2023)
"Selective intra-bronchial instillation of hydrochloric acid (HCl) to the murine left mainstem bronchus causes acute tissue injury with histopathologic findings similar to human acute respiratory distress syndrome (ARDS)."3.91A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation. ( Abdulnour, RE; Colby, JK; Levy, BD; Tavares, AH, 2019)
" Hydrochloric acid (HCl) has been used to induce inflammation in the lungs and stomach but not tested for reproductive organs."3.83Establishment of hydrochloric acid/lipopolysaccharide-induced pelvic inflammatory disease model. ( Hahn, TW; Han, JH; Jung, BD; Kim, HC; Koo, DB; Kwon, YS; Lee, J; Oh, Y; Park, JJ; Rhee, KJ; Yoon, BI, 2016)
"We investigated the effect of the multi-herbal medicine, WSY-1075 in an animal model of hydrochloric acid (HCl)-induced cystitis."3.81Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis. ( Bae, WJ; Ha, US; Hong, SH; Hwang, SY; Hwang, TK; Kim, HJ; Kim, S; Kim, SJ; Kim, SW; Lee, JY, 2015)
"5% hypertonic saline in an experimental model of acute lung injury induced by hydrochloric acid."3.81Effect of hypertonic saline treatment on the inflammatory response after hydrochloric acid-induced lung injury in pigs. ( Auler Junior, JO; Fantoni, DT; Gutierrez, PS; Holms, CA; Kahvegian, M; Massoco, CO; Otsuki, DA, 2015)
"Aspiration of hydrochloric acid (HCl)-containing gastric juice leads to acute lung injury (ALI) and hypoxemic respiratory failure due to an exuberant inflammatory response associated with pulmonary edema from increased vascular and epithelial permeability."3.78Acid-induced acute lung injury in mice is associated with P44/42 and c-Jun N-terminal kinase activation and requires the function of tumor necrosis factor α receptor I. ( Armaganidis, A; Kollias, G; Kotanidou, A; Magkou, C; Maniatis, NA; Nikitopoulou, I; Orfanos, SE; Roussos, C; Sfika, A; Vassiliou, AG, 2012)
"Zerumbone (1) showed potent cytoprotective effect against necrotizing agent (HCl) and non-steroidal anti-inflammatory drug (indomethacin) induced gastric ulceration."3.78Antiulcer principle from Zingiber montanum. ( Al-Amin, M; Hossain, CF; Sultana, GN, 2012)
"To develop experimental models to evaluate the effects of hydrochloric acid associated with the pepsin instilled in the mucosa of the upper esophagus and the esophagogastric junction of young male rats Wistar, simulating injury caused by gastroesophageal reflux on the mucosa of aero-digestive tract in humans as well as the action of the risk exposure of mucosa to cigarette smoke."3.78Experimental model of smoking and simulation of reflux with acid and pepsin in rats. ( Altemani, AM; Andreollo, NA; Araujo, MR; Colli Neto, JA; Del Negro, A; Zen Junior, JH, 2012)
" The aim of this work was to assess the gastroprotective effect of amino acid amides from imbricatolic acid and its 8(9)-en isomer in the ethanol/HCl-induced gastric lesions model in mice as well as to determine the cytotoxicity of the obtained compounds on the following human cell lines: normal lung fibroblasts (MRC-5), gastric adenocarcinoma (AGS), and liver hepatocellular carcinoma (Hep G2)."3.77Gastroprotective effect and cytotoxicity of labdeneamides with amino acids. ( Rodríguez, JA; Schmeda-Hirschmann, G; Theoduloz, C; Valderrama, JA, 2011)
" Acute gastric ulcer was induced using absolute ethanol, HCl/ethanol and indomethacin."3.77Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae). ( Caldas, GF; da Costa, JG; da Nóbrega, RF; da Silva, JB; do Amaral Costa, IM; Rodrigues, FF; Wanderley, AG, 2011)
" Finally, whether Pa-EE was orally available, ethanol (EtOH)/hydrochloric acid (HCl)-induced gastritis model in mice was used."3.77Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. ( Ahn, HM; Cha, SH; Cho, JY; Han, MH; Jang, HJ; Kim, C; Kim, JH; Kim, SY; Kim, TW; Lee, J; Lee, YJ; Shen, T; Yang, HM; Yoon, K; Yu, T, 2011)
"To clarify the basic mechanism involved in the pathophysiology of cystitis by characterizing the urodynamic parameters, pharmacologically relevant (muscarinic and purinergic) receptors, and the in vivo release of adenosine triphosphate (ATP) in the bladder of hydrochloric acid (HCl)-treated rats."3.76Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. ( Fujino, T; Kageyama, A; Nozawa, Y; Yamada, S; Yoshida, A, 2010)
"Stomach ulcers were induced by oral ingestion of hydrochloride (HCl)/ethanol or indomethacin."3.76Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. ( Hara, H; Kakino, M; Ogawa, K; Oyagi, A, 2010)
"The gastroprotective effect of the sesquiterpene cyperenoic acid and seven semi-synthetic derivatives was assessed in the HCl/ethanol-induced gastric ulcer model in mice."3.73Gastroprotective activity and cytotoxic effect of cyperenoic acid derivatives. ( Pertino, M; Razmilic, I; Rodríguez, JA; Schmeda-Hirschmann, G; Theoduloz, C, 2006)
" In a chronic model, by acetic acid-induced gastric ulcers, COX-2 was expressed at 7 days and was also associated with PGE(2) increase."3.73COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. ( Alarcón de la Lastra, C; Bruseghini, L; Manuel Herrerias, J; Motilva, V; Sánchez-Fidalgo, S, 2005)
"The effects of beta-cyclodextrin (betaCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied."3.72Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin. ( Almeida, AB; Brito, AR; De Azevedo, MB; Durán, N; Haun, M; Justo, GZ; Melo, PS, 2003)
"The double indicator method is useful for evaluation of pulmonary edema in indirect lung injury, as induced by oleic acid, but produces misleading values in direct lung injury, as produced by hydrochloric instillation."3.72Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury. ( Auffray, JP; Bregeon, F; Carpentier, JP; Delliaux, S; Ghez, O; Lambert, D; Michelet, P; Papazian, L; Perrin, G; Roch, A; Saby, C; Thomas, P, 2004)
" Laryngospasm was associated with prolonged apnea and total cessation of diaphragmatic EMG activity in 1 animal, and in another, initial tachypnea was followed by erratic diaphragmatic activity and brief apnea."3.71Laryngospasm and diaphragmatic arrest in immature dogs after laryngeal acid exposure: a possible model for sudden infant death syndrome. ( Averill, DB; Duke, SG; Koufman, JA; McGuirt, WF; Postma, GN; Ririe, D, 2001)
"We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism."3.71Effects of diacerein on indomethacin-induced gastric ulceration. ( Ohmori, K; Tamura, T; Yokoyama, T, 2001)
"We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats."3.70Anti-ulcer effects of antioxidants: effect of probucol. ( Ishihara, M; Ito, M; Suzuki, Y, 1998)
"To evaluate the effects of teprenone on acute gastritis, its inhibitory effects on gastric mucosal damage were compared to that of gefarnate in taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats."3.70[Protective effects of teprenone and gefarnate against taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats]. ( Katoh, Y; Kawashima, H; Tanaka, M, 1998)
"Effect of superimposed high frequency oscillatory ventilation on pulmonary gas exchange was investigated in seven anesthetized and paralyzed dogs with pulmonary edema induced by intrapulmonary injection of hydrochloric acid."3.68[Effect of superimposed high frequency oscillation on pulmonary edema induced by intrapulmonary injection of hydrochloric acid in dogs]. ( Sakai, T; Takaori, M; Yoshida, H, 1991)
"Previous abdominal aortic aneurysm (AAA) animal modeling methodologies were either expensive or complicated."1.91A novel abdominal aortic aneurysm model produced by periarterial application of hydrochloric acid. ( Chang, X; Duan, C; Guo, W; Wei, R; Wu, Z; Xiong, J, 2023)
"Based on our experiments, HCl-RFA in the liver appears to be as safe as NS-RFA while also resulting in larger ablation zones."1.48Safety and effect on ablation size of hydrochloric acid-perfused radiofrequency ablation in animal livers. ( Gao, F; Gu, YK; Huang, JH; Huang, SM; Huang, ZM; Jiang, XY; Liu, DX; Zhang, TQ, 2018)
"Severe acute respiratory distress syndrome (ARDS) presents typically with an initializing event, followed by the need for mechanical ventilation."1.48Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury. ( Angulo, M; Blackburn, MR; Burns, N; Eltzschig, HK; Francis, D; Hoegl, S; Mills, TW; Osborne, CM; Vohwinkel, CU, 2018)
"Objective As pulmonary inflammation stimulates TF expression and TF modulates immune responses, we aimed to elucidate its impact on ALI."1.46Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury. ( Assinger, A; Ay, C; Datler, H; Hell, L; Horvath, V; Jilma, B; Knapp, S; Kral-Pointner, JB; Mackman, N; Niederreiter, B; Schabbauer, G; Schmid, JA; Schrottmaier, WC, 2017)
"A hallmark of acute respiratory distress syndrome (ARDS) is accumulation of protein-rich edema in the distal airspaces and its removal is critical for patient survival."1.46Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. ( Burns, N; Edwards, MG; Eltzschig, HK; Hoffman, O; Vadász, I; Vohwinkel, CU, 2017)
"Evans Blue (EB) dye was applied by injection of tail vein after mucosal damage to observe the neurogenic plasma extravasation dots in the skin of the rats."1.46Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric mucosal injury in rats. ( Bai, WZ; Cheng, B; He, W; Jing, XH; Shi, H; Su, YS; Wang, XY; Yu, XC; Zhu, B, 2017)
"Aspiration-induced lung injury can decrease gas exchange and increase mortality."1.42Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats. ( Bergmann, R; Koch, T; Musch, G; Pietzsch, J; Richter, T, 2015)
"Gastroesophageal reflux is a common disorder closely related to chronic airway diseases, such as chronic cough, asthma, chronic bronchitis, and chronic obstructive disease."1.40Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs. ( Cao, AL; Cheng, YM; Liu, CF; Sun, YS; Wang, HW; Wang, Y; Wu, DZ; Zhang, BB; Zheng, JP; Zhu, SL, 2014)
"In a murine model of acute respiratory distress syndrome, lipid mediator metabololipidomics uncovered MaR1 generation in vivo in a temporally regulated manner."1.40Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. ( Abdulnour, RE; Colas, RA; Colby, JK; Dalli, J; Krishnamoorthy, N; Levy, BD; Petasis, NA; Serhan, CN; Tan, SH; Timmons, JY, 2014)
"Oral ulcers are relatively common and these lesions cause strong pain and discomfort."1.38Characterization of oral ulcer and pathological scar in nude mice model. ( Amiranashvili, I; Gogilashvili, Q; Imnadze, I; Sukhitashvili, N; Tabaghua, G, 2012)
"Gastroesophageal reflux disease (GERD) has been linked to a number of extra-esophageal symptoms and disorders, primarily in the respiratory tract."1.36A novel external esophageal perfusion model for reflux-associated respiratory symptoms. ( Kang, J; Kong, L; Li, Q; Liu, X; Wang, J; Zhang, S; Zhong, Z, 2010)
"Gastro-oesophageal reflux is frequent in chronic airway diseases and is considered a trigger for symptoms."1.36Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux. ( Advenier, C; Chen, H; Cui, Y; Devillier, P; Kuang, X; Wang, H; Xia, Z; Xu, Z; Zemoura, L; Zhu, L, 2010)
" immediately after each dosing of 5-FU significantly reversed the delay in healing by 5-FU, and this effect was attenuated by the chemical ablation of capsaicin-sensitive afferent neurons."1.35Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons. ( Amagase, K; Hayashi, S; Komatsu, Y; Kotani, T; Murashima, Y; Nakagiri, A; Takeuchi, K, 2009)
"Pretreatment with beraprost attenuated AGML and downregulated the expression of HNE and HO-1, while sensory denervation aggravated AGML and upregulated the expression of HNE and HO-1."1.35Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions. ( Ichinose, M; Ito, T; Kimura, H; Oka, M; Shimizu, Y; Tsuruo, Y; Ueda, K; Ueyama, T; Yoshida, K, 2008)
" EDE had gastroprotective effect related to increase of glutathione bioavailability and stimulated higher levels of NO, H2O2 and TNF-alpha production."1.35Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action. ( Bauab, TM; Brito, AR; Carlos, IZ; Hiruma-Lima, CA; Kushima, H; Nishijima, CM; Rinaldo, D; Rodrigues, CM; Sassá, MF; Stasi, LC; Vilegas, W, 2009)
"Lung inflammation was analyzed by quantifying cell influx, cytokine levels, and oxidized lipids."1.35Bbeta(15-42) protects against acid-induced acute lung injury and secondary pseudomonas pneumonia in vivo. ( Bauer, M; Binder, CJ; Dietl, W; Doninger, B; Haslinger, I; Knapp, S; Matt, U; Mesteri, I; Perkmann, T; Petzelbauer, P; Reingruber, S; Schabbauer, G; Warszawska, JM, 2009)
"Acute lung injury (ALI) is a severe illness with excess mortality and no specific therapy."1.33Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. ( Bonnans, C; Fredenburgh, LE; Fukunaga, K; Kohli, P; Levy, BD, 2005)
"Gastroesophageal reflux is related to various laryngeal manifestations."1.33Effect of acid and pepsin on glottic wound healing: a simulated reflux model. ( Roh, JL; Yoon, YH, 2006)
"Naloxone pretreatment abolished the effect of morphine, but was enable to block the inhibitory effect of nociceptin."1.32Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation. ( Advenier, C; Bardou, M; Cui, YY; D'Agostino, B; Faisy, C; Naline, E; Rouget, C, 2004)
"To quantify hyperalgesia, paw withdrawal latency to radiant heat (heat hyperalgesia) and withdrawal threshold to mechanical stimuli (mechanical hyperalgesia) were measured."1.31Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia. ( Kalra, A; Moore, SA; Sluka, KA, 2001)
"Cartilage necrosis is prominent during the early stages after laryngotracheoplasty."1.31Simulated reflux and laryngotracheal reconstruction: a rabbit model. ( Carron, JD; Derkay, CS; Greinwald, JH; Oberman, JP; Werner, AL, 2001)
"To induce acute lung injury, hydrochloric acid was instilled into the tracheas of paralyzed sheep receiving controlled mechanical ventilation."1.31Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume. ( Banner, MJ; Burchfield, DJ; Davenport, PW; Jaeger, MJ; Skimming, JW; Spalding, HK, 2001)
"The additional decrease in pulmonary edema with a tidal volume of 3 ml/kg is partly accounted for by greater protection of the alveolar epithelium."1.31Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. ( Allen, L; Dobbs, L; Frank, JA; Gutierrez, JA; Jones, KD; Matthay, MA, 2002)
"Gastro-oesophageal reflux is a common clinical disorder associated with a variety of respiratory symptoms, including chronic cough and exacerbation of asthma."1.31Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation. ( Advenier, C; Alt, XE; D'Agostino, B; Daoui, S; Gallelli, L; Rossi, F, 2002)
"Furthermore, acidosis caused lung inflammation, as suggested by the increase in lung myeloperoxidase activity (282."1.30Acidosis stimulates nitric oxide production and lung damage in rats. ( Camporesi, EM; Caruso, JE; Hakim, TS; Hoffmann, SP; McGraw, DJ; Nandi, J; Oler, A; Pedoto, A; Tassiopoulos, AK, 1999)
"Pretreatment with glycine significantly protected animals against stress-, indomethacin- and necrotizing agents induced gastric lesions."1.30Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine. ( Al Moutaery, AR; Tariq, M, 1997)
"The results show that at the site of aspiration pneumonia, anti-CD11b F(ab')2 did not inhibit neutrophil sequestration or edema formation, either with or without endotoxin pretreatment."1.30Role of CD11b in focal acid-induced pneumonia and contralateral lung injury in rats. ( Bree, M; Doerschuk, CM; Motosugi, H; Quinlan, WM, 1998)
"Reflux esophagitis and hiatal hernia commonly coexist, yet a cause and effect relationship remains unclear."1.29Esophageal shortening induced by short-term intraluminal acid perfusion in opossum: a cause for hiatus hernia? ( Kolyn, DM; Paterson, WG, 1994)
"Acute tracheal injury model (Mendelson Syndrome) were made."1.29[An aspiration pneumonia in acute airway damage model induced by HCl and/or LPS]. ( Fukuchi, Y; Higashimoto, Y; Ishida, K; Jo, C; Matsui, H; Matsuse, T; Nagase, T; Oka, T; Sudo, E; Teramoto, S, 1993)
"The adult respiratory distress syndrome is a form of acute lung injury (ALI) that is frequently associated with systemic organ injury and often occurs in the setting of wide-spread inflammatory cell activation."1.29Acid aspiration-induced acute lung injury causes leukocyte-dependent systemic organ injury. ( Dorinsky, PM; Kindt, GC; Mizer, LA; Moore, SA; St John, RC; Weisbrode, SE, 1993)
" In animals pretreated by anti-inflammatory drugs in toxic doses an earlier development of ulceration was observed by distention with acid."1.26Distention ulcer as a model for testing of drugs for ulcerogenic side effects. ( Szelenyi, I; Thiemer, K, 1978)
"A severe respiratory acidosis resulted."1.25Ventilation and blood-gas studies during experimentally produced Mendelson's syndrome in the dog. ( Fabre, J; Francois, G; Gouin, F; Ohresser, P; Tournigand, T, 1975)

Research

Studies (198)

TimeframeStudies, this research(%)All Research%
pre-199031 (15.66)18.7374
1990's24 (12.12)18.2507
2000's63 (31.82)29.6817
2010's70 (35.35)24.3611
2020's10 (5.05)2.80

Authors

AuthorsStudies
Zhang, Y3
Sun, L2
Lai, X1
Peng, X1
Wen, S1
Zhang, Z1
Xie, Y1
Li, Q2
Chen, R1
Zheng, X1
Zhang, K1
Sun, S1
Li, D1
Wei, R1
Chang, X1
Wu, Z1
Duan, C1
Xiong, J1
Guo, W1
Hendawy, H1
Metwally, E1
Elfadadny, A1
Yoshida, T1
Ma, D1
Shimada, K1
Hamabe, L1
Sasaki, K1
Tanaka, R1
Tavares, AH1
Colby, JK2
Levy, BD3
Abdulnour, RE2
Puri, G1
Naura, AS2
Cakir, E1
Cakir, U1
Tayman, C1
Turkmenoglu, TT1
Gonel, A1
Turan, IO1
Guillamat-Prats, R2
Camprubí-Rimblas, M1
Puig, F2
Herrero, R2
Tantinyà, N1
Serrano-Mollar, A2
Artigas, A2
Engel, M1
Nowacki, RME1
Jonker, EM1
Ophelders, D1
Nikiforou, M1
Kloosterboer, N1
Zimmermann, LJI1
van Waardenburg, DA1
Kramer, BW1
Boeing, T1
Mejía, JAA1
Ccana-Ccapatinta, GV1
Mariott, M1
Melo Vilhena de Andrade Fonseca Da Silva, RC1
de Souza, P1
Mariano, LNB1
Oliveira, GR1
da Rocha, IM1
da Costa, GA1
de Andrade, SF1
da Silva, LM1
Bastos, JK1
Jodłowski, PJ1
Kurowski, G1
Kuterasiński, Ł1
Sitarz, M1
Jeleń, P1
Jaśkowska, J1
Kołodziej, A1
Pajdak, A1
Majka, Z1
Boguszewska-Czubara, A1
Kim, JK1
Choi, E1
Hong, YH1
Kim, H1
Jang, YJ1
Lee, JS1
Choung, ES1
Woo, BY1
Hong, YD1
Lee, S1
Lee, BH1
Bach, TT1
Kim, JH3
Cho, JY3
Kral-Pointner, JB1
Schrottmaier, WC1
Horvath, V1
Datler, H1
Hell, L1
Ay, C1
Niederreiter, B1
Jilma, B1
Schmid, JA1
Assinger, A1
Mackman, N1
Knapp, S2
Schabbauer, G2
Yang, HJ1
Kim, MJ1
Kwon, DY1
Kang, ES1
Kang, S1
Park, S1
Tayeby, F1
Salman, AAA1
Kamran, S1
Khaing, SL1
Salehen, NB1
Mohan, GMAD1
Hamdi, A2
Majouli, K2
Abdelhamid, A2
Marzouk, B1
Belghith, H1
Chraief, I1
Bouraoui, A4
Marzouk, Z1
Heyden, YV1
Güzel, A1
Doğan, E1
Türkçü, G1
Kuyumcu, M1
Kaplan, İ1
Çelik, F1
Yıldırım, ZB1
Wang, X1
Chen, Q1
Tian, W1
Wang, J2
Cheng, L2
Lu, J1
Chen, M1
Pei, Y1
Li, C1
Chen, G1
Gu, N1
Kenani, A1
Zhang, TQ1
Huang, SM1
Gu, YK1
Gao, F1
Huang, ZM1
Jiang, XY1
Liu, DX1
Huang, JH1
Pourfathi, M1
Cereda, M1
Chatterjee, S1
Xin, Y1
Kadlecek, S1
Duncan, I1
Hamedani, H1
Siddiqui, S1
Profka, H1
Ehrich, J1
Ruppert, K1
Rizi, RR1
Hoegl, S1
Burns, N2
Angulo, M1
Francis, D1
Osborne, CM1
Mills, TW1
Blackburn, MR1
Eltzschig, HK2
Vohwinkel, CU2
Setzer, F1
Schmidt, B1
Hueter, L1
Schwarzkopf, K1
Sänger, J1
Schreiber, T1
Fletcher, JWA1
Williams, S1
Whitehouse, MR1
Gill, HS1
Preatoni, E1
Sahu, B1
Sandhir, R1
Qian, Y2
Zhang, J1
Fu, X1
Yi, R1
Sun, P3
Zou, M1
Long, X1
Zhao, X3
Jia, BY1
Xie, CE1
Wang, ZB1
Pei, WJ1
Li, XH1
Shi, L1
Liu, JL1
Han, YF1
Tan, X1
Ding, PH1
Sun, ZM1
Yuan, WJ1
Li, JX1
Richter, T3
Bergmann, R3
Knels, L1
Hofheinz, F1
Kasper, M1
Deile, M1
Pietzsch, J3
Ragaller, M1
Koch, T3
Lampland, AL1
Wolfson, MR1
Mazela, J1
Henderson, C1
Gregory, TJ1
Meyers, P1
Plumm, B1
Worwa, C1
Mammel, MC1
Bae, WJ1
Ha, US1
Kim, S1
Kim, SJ1
Hong, SH1
Lee, JY1
Hwang, TK1
Hwang, SY1
Kim, HJ1
Kim, SW1
Puntorieri, V2
Hiansen, JQ1
McCaig, LA1
Yao, LJ1
Veldhuizen, RA2
Lewis, JF2
Yamashita, CM1
Fessler, MB1
Vasanthamohan, L1
Lac, J1
Madenspacher, J1
McCaig, L1
Yao, L1
Wang, L2
Mehta, S1
Cheng, YM1
Cao, AL1
Zheng, JP1
Wang, HW1
Sun, YS1
Liu, CF1
Zhang, BB1
Wang, Y1
Zhu, SL1
Wu, DZ1
Mueller, MP1
Deghrigue, M1
Festa, C1
Ghribi, L1
D'auria, MV1
de Marino, S1
Ben Jannet, H1
Ben Said, R2
Felder, M1
Stucki, AO1
Stucki, JD1
Geiser, T1
Guenat, OT1
Dalli, J1
Krishnamoorthy, N1
Timmons, JY1
Tan, SH1
Colas, RA1
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Geisinger, KR2
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Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intravesical Botulinum Toxin A Injection in Treatment of Interstitial Cystitis Refractory to Conventional Treatment - A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial[NCT01969773]Phase 260 participants (Actual)Interventional2012-12-31Completed
Hemodynamics and Extravascular Lung Water in Acute Lung Injury: A Prospective Randomized Controlled Multicentered Trial of Goal Directed Treatment of EVLW Versus Standard Management for the Treatment of Acute Lung Injury[NCT00624650]Phase 233 participants (Actual)Interventional2008-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

198 other studies available for hydrochloric acid and Disease Models, Animal

ArticleYear
Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 144

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis Regulatory Proteins; D

2021
A novel abdominal aortic aneurysm model produced by periarterial application of hydrochloric acid.
    Experimental animals, 2023, Feb-21, Volume: 72, Issue:1

    Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Hydrochloric Acid; Ma

2023
Cultured versus freshly isolated adipose-derived stem cells in improvement of the histopathological outcomes in HCL-induced cystitis in a rat model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 153

    Topics: Adipose Tissue; Animals; Cells, Cultured; Cystitis, Interstitial; Disease Models, Animal; Female; Fi

2022
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation.
    Journal of visualized experiments : JoVE, 2019, 08-30, Issue:150

    Topics: Acute Lung Injury; Animals; Bronchi; Disease Models, Animal; Hydrochloric Acid; Leukocytes; Lung; Ma

2019
Critical role of mitochondrial oxidative stress in acid aspiration induced ALI in mice.
    Toxicology mechanisms and methods, 2020, Volume: 30, Issue:4

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Gene Ex

2020
Favorable Effects of Astaxanthin on Brain Damage due to Ischemia- Reperfusion Injury.
    Combinatorial chemistry & high throughput screening, 2020, Volume: 23, Issue:3

    Topics: Animals; Brain; Disease Models, Animal; Hydrochloric Acid; Injections, Intraperitoneal; Male; Neurop

2020
Alveolar Type II Cells or Mesenchymal Stem Cells: Comparison of Two Different Cell Therapies for the Treatment of Acute Lung Injury in Rats.
    Cells, 2020, 07-31, Volume: 9, Issue:8

    Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Bone Marrow Cells; Cells, Cultured; Cytokines

2020
A comparison of four different models of acute respiratory distress syndrome in sheep.
    Respiratory research, 2020, Aug-08, Volume: 21, Issue:1

    Topics: Albumins; Animals; Biomarkers; Bronchoalveolar Lavage; Disease Models, Animal; Female; Hydrochloric

2020
The gastroprotective effect of red propolis extract from Northeastern Brazil and the role of its isolated compounds.
    Journal of ethnopharmacology, 2021, Mar-01, Volume: 267

    Topics: Animals; Anti-Ulcer Agents; Brazil; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucins; G

2021
Cracking the Chloroquine Conundrum: The Application of Defective UiO-66 Metal-Organic Framework Materials to Prevent the Onset of Heart Defects-In Vivo and In Vitro.
    ACS applied materials & interfaces, 2021, Jan-13, Volume: 13, Issue:1

    Topics: Animals; Chloroquine; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Heart Diseases

2021
Syk/NF-κB-targeted anti-inflammatory activity of Melicope accedens (Blume) T.G. Hartley methanol extract.
    Journal of ethnopharmacology, 2021, May-10, Volume: 271

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Ethanol;

2021
Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury.
    Journal of thrombosis and haemostasis : JTH, 2017, Volume: 15, Issue:8

    Topics: Acute Lung Injury; Animals; Antithrombin III; Blood Coagulation; Cells, Cultured; Chemotaxis, Leukoc

2017
Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis.
    Journal of ethnopharmacology, 2017, Aug-17, Volume: 208

    Topics: Animals; Diet, High-Fat; Disease Models, Animal; Energy Metabolism; Ethanol; Flavonoids; Gastric Muc

2017
Ulcer Prevention Effect Of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol-3yl)Methylidene]Benzohydrazide In HCl/Ethanol-Induced Gastric Mucosal Damage In Rats.
    International journal of medical sciences, 2017, Volume: 14, Issue:13

    Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Disease Models, Animal; Ethanol; Gallic Acid; Gas

2017
Pharmacological activities of the organic extracts and fatty acid composition of the petroleum ether extract from Haplophyllum tuberculatum leaves.
    Journal of ethnopharmacology, 2018, Apr-24, Volume: 216

    Topics: Acetic Acid; Alkanes; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan;

2018
Dexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2019, Volume: 32, Issue:4

    Topics: Acute Lung Injury; Administration, Intravenous; Animals; Anti-Inflammatory Agents; Antioxidants; Dex

2019
Measurement of In Vitro Single Cell Temperature by Novel Thermocouple Nanoprobe in Acute Lung Injury Models.
    Journal of biomedical nanotechnology, 2017, Volume: 13, Issue:1

    Topics: Acute Lung Injury; Adenosine Triphosphate; Animals; Cell Line; Cobalt; Disease Models, Animal; Energ

2017
Anti-inflammatory activity and gastroprotective effect of Hertia cheirifolia L. roots extract.
    Journal of ethnopharmacology, 2018, May-10, Volume: 217

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Asteraceae; Carrageenan; Disease Models, Anima

2018
Safety and effect on ablation size of hydrochloric acid-perfused radiofrequency ablation in animal livers.
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2018, Volume: 34, Issue:7

    Topics: Animals; Disease Models, Animal; Hydrochloric Acid; Liver; Perfusion; Rabbits; Radiofrequency Ablati

2018
Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach.
    Scientific reports, 2018, 02-23, Volume: 8, Issue:1

    Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Isotopes; Disease Models, Animal; Gene Expression; Hu

2018
Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury.
    Physiological reports, 2018, Volume: 6, Issue:6

    Topics: Animals; Disease Models, Animal; Female; Hydrochloric Acid; Lipopolysaccharides; Male; Mice; Mice, I

2018
Characterization of the seven-day course of pulmonary response following unilateral lung acid injury in rats.
    PloS one, 2018, Volume: 13, Issue:6

    Topics: Acute Lung Injury; Animals; Arterial Pressure; Bronchoalveolar Lavage Fluid; Case-Control Studies; C

2018
Juvenile bovine bone is an appropriate surrogate for normal and reduced density human bone in biomechanical testing: a validation study.
    Scientific reports, 2018, 07-05, Volume: 8, Issue:1

    Topics: Age Factors; Animals; Biomechanical Phenomena; Bone Demineralization Technique; Bone Density; Cattle

2018
Two hit induced acute lung injury impairs cognitive function in mice: A potential model to study cross talk between lung and brain.
    Brain, behavior, and immunity, 2018, Volume: 73

    Topics: Acute Lung Injury; Animals; Blood-Brain Barrier; Brain; Cognition; Cognitive Dysfunction; Disease Mo

2018
Preventive Effect of Raw Liubao Tea Polyphenols on Mouse Gastric Injuries Induced by HCl/Ethanol via Anti-Oxidative Stress.
    Molecules (Basel, Switzerland), 2018, Nov-01, Volume: 23, Issue:11

    Topics: Animals; Antioxidants; Biomarkers; Biopsy; Cytokines; Disease Models, Animal; Ethanol; Gastric Juice

2018
The effect of Heweijiangni-decoction on esophageal morphology in a rat model of OVA-induced visceral hypersensitivity followed by acid exposure.
    Cellular and molecular biology (Noisy-le-Grand, France), 2019, Jun-30, Volume: 65, Issue:5

    Topics: Animals; Desmosomes; Disease Models, Animal; Drugs, Chinese Herbal; Esophagus; Extracellular Space;

2019
Pulmonary blood flow increases in damaged regions directly after acid aspiration in rats.
    Anesthesiology, 2013, Volume: 119, Issue:4

    Topics: Animals; Disease Models, Animal; Gallium Radioisotopes; Hydrochloric Acid; Lung; Positron-Emission T

2013
Aerosolized KL4 surfactant improves short-term survival and gas exchange in spontaneously breathing newborn pigs with hydrochloric acid-induced acute lung injury.
    Pediatric pulmonology, 2014, Volume: 49, Issue:5

    Topics: Acute Lung Injury; Administration, Inhalation; Aerosols; Animals; Animals, Newborn; Continuous Posit

2014
Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis.
    Neurourology and urodynamics, 2015, Volume: 34, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cystitis; Disease Models, Animal; Female; Hydrochlo

2015
The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury.
    BMC pulmonary medicine, 2013, Nov-20, Volume: 13

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eicosan

2013
Apolipoprotein E-deficient mice are susceptible to the development of acute lung injury.
    Respiration; international review of thoracic diseases, 2014, Volume: 87, Issue:5

    Topics: Acute Lung Injury; Animals; Apolipoproteins E; Disease Models, Animal; Genetic Predisposition to Dis

2014
Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs.
    American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:5

    Topics: Airway Remodeling; Animals; Bronchial Hyperreactivity; Calcium Channels, L-Type; Disease Models, Ani

2014
Effects of pulmonary acid aspiration on the regional pulmonary blood flow within the first hour after injury: An observational study in rats.
    Clinical hemorheology and microcirculation, 2015, Jul-16, Volume: 60, Issue:2

    Topics: Animals; Disease Models, Animal; Hydrochloric Acid; Lung; Lung Injury; Male; Positron-Emission Tomog

2015
Pharmacological evaluation of the semi-purified fractions from the soft coral Eunicella singularis and isolation of pure compounds.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2014, Sep-10, Volume: 22

    Topics: Animals; Anthozoa; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; Disease Models, Animal;

2014
The potential of microfluidic lung epithelial wounding: towards in vivo-like alveolar microinjuries.
    Integrative biology : quantitative biosciences from nano to macro, 2014, Volume: 6, Issue:12

    Topics: Animals; Disease Models, Animal; Equipment Design; Equipment Failure Analysis; Feasibility Studies;

2014
Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Nov-18, Volume: 111, Issue:46

    Topics: Animals; Arachidonate 12-Lipoxygenase; Blood Platelets; Bronchoalveolar Lavage Fluid; Cell Hypoxia;

2014
Physico-chemical characterization and pharmacological evaluation of sulfated polysaccharides from three species of Mediterranean brown algae of the genus Cystoseira.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2015, Jan-13, Volume: 23

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response

2015
Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats.
    BMC anesthesiology, 2015, Volume: 15

    Topics: Animals; Disease Models, Animal; Gallium Radioisotopes; Hydrochloric Acid; Lung Injury; Male; Micros

2015
Intravesical treatment with cis-urocanic acid improves bladder function in rat model of acute bladder inflammation.
    Neurourology and urodynamics, 2016, Volume: 35, Issue:7

    Topics: Administration, Intravesical; Animals; Cystitis; Disease Models, Animal; Female; Hyaluronic Acid; Hy

2016
Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.
    American journal of respiratory cell and molecular biology, 2016, Volume: 54, Issue:3

    Topics: Acute Lung Injury; Animals; Bone Marrow Transplantation; Calcium Signaling; Capillary Permeability;

2016
Effect of hypertonic saline treatment on the inflammatory response after hydrochloric acid-induced lung injury in pigs.
    Clinics (Sao Paulo, Brazil), 2015, Volume: 70, Issue:8

    Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Blood Cell Count; Cytokines; Disease Models, A

2015
Investigation of Antiulcer and Antioxidant Activity of Juniperus phoenicea L. (1753) Essential Oil in an Experimental Rat Model.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:11

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Bicyclic Monoterpenes; Catalase; Disease Models, Animal; E

2015
Establishment of hydrochloric acid/lipopolysaccharide-induced pelvic inflammatory disease model.
    Journal of veterinary science, 2016, Sep-30, Volume: 17, Issue:3

    Topics: Animals; Blotting, Western; Cytokines; Disease Models, Animal; Female; Humans; Hydrochloric Acid; In

2016
Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects.
    Nutrients, 2016, Mar-10, Volume: 8, Issue:3

    Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Ethanol; Gastric Juice; Gastric Mucosa; Ga

2016
Gastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a β-cyclodextrin complex with microbial and chemical transformations.
    Bioorganic & medicinal chemistry letters, 2016, 07-15, Volume: 26, Issue:14

    Topics: Alcohols; Animals; Anti-Ulcer Agents; Apiaceae; beta-Cyclodextrins; Disease Models, Animal; Diterpen

2016
PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities.
    Journal of ethnopharmacology, 2016, Aug-22, Volume: 190

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; D

2016
A new experimental model of acid- and endotoxin-induced acute lung injury in rats.
    American journal of physiology. Lung cellular and molecular physiology, 2016, 08-01, Volume: 311, Issue:2

    Topics: Acute Lung Injury; Animals; Apoptosis; Disease Models, Animal; Hydrochloric Acid; Lipopolysaccharide

2016
Preventive effect of Gardenia jasminoides on HCl/ethanol induced gastric injury in mice.
    Journal of pharmacological sciences, 2017, Volume: 133, Issue:1

    Topics: Animals; Antioxidants; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Gardenia; Hydrochlori

2017
A Zinc Morpholine Complex Prevents HCl/Ethanol-Induced Gastric Ulcers in a Rat Model.
    Scientific reports, 2016, 07-27, Volume: 6

    Topics: Animals; Cell Line; Disease Models, Animal; DNA Damage; Ethanol; Humans; Hydrochloric Acid; Hydrogen

2016
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.
    Disease models & mechanisms, 2016, 09-01, Volume: 9, Issue:9

    Topics: Anemia; Animals; Disease Models, Animal; Gastric Acid; Gastrins; Gene Knock-In Techniques; H(+)-K(+)

2016
Gastroprotective activity of the resin from Virola oleifera.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, Thin Layer; Disease Models

2017
Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: A549 Cells; Animals; Disease Models, Animal; ELAV-Like Protein 1; Glycogen Synthase Kinase 3 beta; H

2017
Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric mucosal injury in rats.
    BMC complementary and alternative medicine, 2017, Mar-07, Volume: 17, Issue:1

    Topics: Acupuncture Points; Animals; Antibodies; Biomarkers; Coloring Agents; Disease Models, Animal; Evans

2017
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.
    Digestive diseases and sciences, 2009, Volume: 54, Issue:1

    Topics: Acetamides; Animals; Antimetabolites, Antineoplastic; Capsaicin; Cell Line; Cell Movement; Cell Prol

2009
Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 295, Issue:3

    Topics: Adaptation, Physiological; Aldehydes; Animals; Capsaicin; Cytoprotection; Denervation; Disease Model

2008
Alterations in N-methyl-D-aspartate receptor subunits in primary sensory neurons following acid-induced esophagitis in cats.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:1

    Topics: Animals; Blotting, Western; Cats; Disease Models, Animal; Eosinophil Peroxidase; Esophagitis; Esopha

2009
Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:2

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Echocardiography, Transesophageal; Hemodynamics;

2009
Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.
    European journal of anaesthesiology, 2009, Volume: 26, Issue:4

    Topics: Anesthesia, Inhalation; Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Endothe

2009
Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:5

    Topics: Animals; Capsaicin; Cystitis; Disease Models, Animal; Female; Hydrochloric Acid; Kv1.4 Potassium Cha

2009
Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action.
    Journal of ethnopharmacology, 2009, Jun-25, Volume: 123, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A

2009
Bbeta(15-42) protects against acid-induced acute lung injury and secondary pseudomonas pneumonia in vivo.
    American journal of respiratory and critical care medicine, 2009, Dec-15, Volume: 180, Issue:12

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Fibrin Fibrinogen Degradation Products; Hydrochl

2009
Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux.
    The European respiratory journal, 2010, Volume: 35, Issue:6

    Topics: Acetylcholine; Animals; Anti-Inflammatory Agents; Atropine; Biopsy; Bronchoalveolar Lavage Fluid; Br

2010
Anti-ulcer role of herbomineral Siddha drug - Thamira parpam on experimentally induced gastric mucosal damage in rats.
    Human & experimental toxicology, 2010, Volume: 29, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Body Weight; Cytoprotection; Disease Models, Anim

2010
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 2010, Volume: 77, Issue:3

    Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Esophagitis, Peptic; Esophagus; Feasi

2010
Simulated reflux decreases vocal fold epithelial barrier resistance.
    The Laryngoscope, 2010, Volume: 120, Issue:8

    Topics: Animals; Disease Models, Animal; Electric Impedance; Gastroesophageal Reflux; Gastrointestinal Agent

2010
Divergent effects of irritants on the gastric mucosa in rats during various stages after bile duct ligation.
    Journal of gastroenterology and hepatology, 2010, Volume: 25, Issue:6

    Topics: Animals; Cholestasis, Extrahepatic; Common Bile Duct; Dinoprostone; Disease Models, Animal; Disease

2010
Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice.
    BMC complementary and alternative medicine, 2010, Aug-18, Volume: 10

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Ga

2010
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
    Urology, 2010, Volume: 76, Issue:4

    Topics: Adenosine Triphosphate; Animals; Benzhydryl Compounds; Benzofurans; Cresols; Cystitis; Disease Model

2010
Gastroprotective effect and cytotoxicity of labdeneamides with amino acids.
    Planta medica, 2011, Volume: 77, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenocarcinoma; Amides; Amino Acids; Animals; Anti-Ulcer Ag

2011
Stable mixed acidemia in anesthetized pigs--a model for research on biocompatibility of hemofilters under a deteriorated acid-base balance.
    Artificial organs, 2011, Volume: 35, Issue:2

    Topics: Acidosis; Animals; Disease Models, Animal; Hemofiltration; Hydrochloric Acid; Lactic Acid; Male; Mat

2011
Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models.
    Journal of ethnopharmacology, 2011, Sep-01, Volume: 137, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Catalase; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Eth

2011
Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae).
    Journal of ethnopharmacology, 2011, Sep-01, Volume: 137, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gas C

2011
Time-dependent changes in bladder function and plantar sensitivity in a rat model of fibromyalgia syndrome induced by hydrochloric acid injection into the gluteus.
    BJU international, 2012, Volume: 109, Issue:2

    Topics: Anesthetics, Local; Animals; Case-Control Studies; Chronic Pain; Disease Models, Animal; Female; Fib

2012
Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans.
    Journal of ethnopharmacology, 2011, Oct-11, Volume: 137, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cyclic AMP Response Element-Binding Protein

2011
Protective effect of Polyalthia longifolia var. pendula leaves on ethanol and ethanol/HCl induced ulcer in rats and its antimicrobial potency.
    Asian Pacific journal of tropical medicine, 2011, Volume: 4, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Disease Models, Animal; Ethanol; Fe

2011
Resolution of acute lung injury and inflammation: a translational mouse model.
    The European respiratory journal, 2012, Volume: 39, Issue:5

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Hydroch

2012
Intravesical chondroitin sulfate inhibits recruitment of inflammatory cells in an acute acid damage "leaky bladder" model of cystitis.
    Urology, 2012, Volume: 79, Issue:2

    Topics: Animals; Burns, Chemical; Chemotaxis, Leukocyte; Chondroitin Sulfates; Cystitis; Disease Models, Ani

2012
Experimental model of smoking and simulation of reflux with acid and pepsin in rats.
    Acta cirurgica brasileira, 2012, Volume: 27, Issue:1

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Gastric Mucosa; Gastroesophagea

2012
Time course of metabolic activity and cellular infiltration in a murine model of acid-induced lung injury.
    Intensive care medicine, 2012, Volume: 38, Issue:4

    Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Cell Proliferation; Disease Models, Animal; Female;

2012
Gastric cytoprotection and honey intake in albino rats.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2011, Nov-23, Volume: 26, Issue:1

    Topics: Albinism; Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Honey;

2011
Gastro-protective effect of crude hexane leaf extract of Sesamum indicum in rabbits.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2011, Nov-23, Volume: 26, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Cimetidine; Cytoprotection; Disease Models, Animal; Dose-Response Relati

2011
Antiulcer principle from Zingiber montanum.
    Journal of ethnopharmacology, 2012, May-07, Volume: 141, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Chromatography; Cytoprotection; Disease Models, Animal; Dose-Response Re

2012
Modified yukmijihwangtang suppresses the production of proinflammatory cytokines in the intravesical hydrochloric acid-induced cystitis rat model via the NF-κB pathway.
    The American journal of Chinese medicine, 2012, Volume: 40, Issue:2

    Topics: Administration, Intravesical; Animals; Cystitis; Cytokines; Disease Models, Animal; Drugs, Chinese H

2012
Platelets induce endothelial tissue factor expression in a mouse model of acid-induced lung injury.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Jun-01, Volume: 302, Issue:11

    Topics: Acute Lung Injury; Animals; Antigens, CD; Blood Coagulation; Blood Platelets; Cadherins; Disease Mod

2012
Effects of intravesical dexpanthenol use on lipid peroxidation and bladder histology in a chemical cystitis animal model.
    Urology, 2012, Volume: 79, Issue:5

    Topics: Administration, Intravesical; Animals; Cystitis, Interstitial; Disease Models, Animal; Female; Hydro

2012
Progress in modelling acute lung injury in a pre-clinical mouse model.
    The European respiratory journal, 2012, Volume: 39, Issue:5

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Hydrochloric Acid; Male; Pneumonia; Translationa

2012
Characterization of oral ulcer and pathological scar in nude mice model.
    Georgian medical news, 2012, Issue:205

    Topics: Animals; Cicatrix; Disease Models, Animal; Fibrosis; Humans; Hydrochloric Acid; Immunohistochemistry

2012
Acid-induced acute lung injury in mice is associated with P44/42 and c-Jun N-terminal kinase activation and requires the function of tumor necrosis factor α receptor I.
    Shock (Augusta, Ga.), 2012, Volume: 38, Issue:4

    Topics: Acute Lung Injury; Animals; Apoptosis; Bronchoalveolar Lavage; Caspase 3; Disease Models, Animal; En

2012
Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation.
    The European respiratory journal, 2002, Volume: 20, Issue:2

    Topics: Animals; Asthma; Capillary Permeability; Disease Models, Animal; Esophagus; Female; Gastroesophageal

2002
Role of acid back-diffusion, glutathione, oxyradical, and histamine in antral hemorrhagic ulcer in rats: the protective effect of lysozyme chloride and antioxidants.
    The Journal of laboratory and clinical medicine, 2002, Volume: 140, Issue:3

    Topics: Animals; Antioxidants; Diffusion; Disease Models, Animal; Dose-Response Relationship, Drug; Gastric

2002
Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice.
    BMC pharmacology, 2002, Dec-19, Volume: 2

    Topics: Anethum graveolens; Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Acid; Hydrochloric A

2002
Botulinum toxin type A may improve bladder function in a rat chemical cystitis model.
    Urological research, 2003, Volume: 30, Issue:6

    Topics: Animals; Botulinum Toxins, Type A; Chronic Disease; Cystitis; Disease Models, Animal; Female; Hydroc

2003
Real-time visualization of partial liquid ventilation in a model of acute lung injury.
    Surgery, 2003, Volume: 133, Issue:2

    Topics: Acute Disease; Albumins; Animals; Blood Pressure; Computer Systems; Disease Models, Animal; Heart Ra

2003
Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin.
    Canadian journal of physiology and pharmacology, 2003, Volume: 81, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Chemistry, Pharmaceutical; Cimetidine; Cyclodextrins; D

2003
Intravascular infusion of acid promotes intrapulmonary inducible nitric oxide synthase activity and impairs blood oxygenation in rats.
    Critical care medicine, 2003, Volume: 31, Issue:5

    Topics: Acidosis; Animals; Blotting, Western; Breath Tests; Disease Models, Animal; Enzyme-Linked Immunosorb

2003
c-Fos immunoreactivity in the brain after esophageal acid stimulation.
    The American journal of medicine, 2003, Aug-18, Volume: 115 Suppl 3A

    Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Gastroesophageal Reflux; Hydrochloric Acid; Immu

2003
Gastroprotective and anti-inflammatory effects of resin from Protium heptaphyllum in mice and rats.
    Pharmacological research, 2004, Volume: 49, Issue:2

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Brazil; Burseraceae; Capillary Pe

2004
Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
    The American journal of Chinese medicine, 2003, Volume: 31, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Hydrochloric Acid; Hypo

2003
Activation of the STAT pathway in acute lung injury.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:6

    Topics: Acute Disease; Animals; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins; Hydrochloric

2004
Surfactant lavage with lidocaine improves pulmonary function in piglets after HCl-induced acute lung injury.
    Lung, 2004, Volume: 182, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Bronchoalveolar Lavage; Disease Models, Animal; Drug Therapy, Combi

2004
Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.
    British journal of pharmacology, 2004, Volume: 141, Issue:6

    Topics: Animals; Benzimidazoles; Bronchi; Capillary Permeability; Disease Models, Animal; Gastroesophageal R

2004
Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury.
    Critical care medicine, 2004, Volume: 32, Issue:3

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Extravascular Lung Water; Female; Hemodynamic

2004
Effects of nitric oxide synthase inhibitor on acid aspiration-induced lung injury in rats.
    Pulmonary pharmacology & therapeutics, 2005, Volume: 18, Issue:1

    Topics: Amidines; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Enzyme Inhibito

2005
COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions.
    International immunopharmacology, 2005, Volume: 5, Issue:2

    Topics: Acetic Acid; Acute Disease; Animals; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge

2005
Lipid compositions of human gastric fluid and epithelium: the role of sulfated lipids in gastric cytoprotection.
    Journal of clinical gastroenterology, 2005, Volume: 39, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Animals; Anticarcinogenic Agents; Cholesterol Esters; Chromatography

2005
Gastroprotective activity of a new semi-synthetic solidagenone derivative in mice.
    The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Animals; Anti-Ulcer Agents; Cell Line

2005
Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Apr-15, Volume: 174, Issue:8

    Topics: Animals; Base Sequence; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena

2005
[Prophylactic effect of ambroxol on acute hydrochloric acid aspiration - induced lung injury].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2005, Volume: 17, Issue:6

    Topics: Acute Lung Injury; Ambroxol; Animals; Disease Models, Animal; Expectorants; Female; Hydrochloric Aci

2005
Low positive end-expiratory pressure does not exacerbate nebulized-acid lung injury in dogs.
    Journal of critical care, 2005, Volume: 20, Issue:1

    Topics: Animals; Disease Models, Animal; Dogs; Female; Hydrochloric Acid; Male; Nebulizers and Vaporizers; P

2005
In vitro model of acute esophagitis in the cat.
    American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 289, Issue:5

    Topics: Acute Disease; Animals; Cats; Cell Survival; Disease Models, Animal; Esophagitis; Hydrochloric Acid;

2005
Inhibition of acid-induced lung injury by hyperosmolar sucrose in rats.
    American journal of respiratory and critical care medicine, 2005, Oct-15, Volume: 172, Issue:8

    Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Count; Disease Models, Animal; D

2005
Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model.
    World journal of gastroenterology, 2006, Mar-21, Volume: 12, Issue:11

    Topics: Animals; Bile Acids and Salts; Chronic Disease; Cyclooxygenase Inhibitors; Dinoprostone; Disease Mod

2006
[Comparison of single-indicator thermodilution versus gravimetric measurement in determination of extra-vascular lung water in dogs with acute respiratory distress syndrome].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2006, Volume: 18, Issue:6

    Topics: Animals; Disease Models, Animal; Dogs; Extravascular Lung Water; Female; Hydrochloric Acid; Male; Ol

2006
[Effects of different modes of artificial ventilation on lung injury in dog model of acute respiratory distress syndrome].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2006, Volume: 18, Issue:6

    Topics: Administration, Inhalation; Animals; Disease Models, Animal; Dogs; Hydrochloric Acid; Lung Diseases;

2006
Comparison of systemic and local effects of nitric acid and hydrochloric acid: an experimental study in a rat model.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2006, Volume: 12, Issue:3

    Topics: Administration, Oral; Animals; Burns, Chemical; Calcium; Disease Models, Animal; Esophagus; Hydrochl

2006
Effect of acid and pepsin on glottic wound healing: a simulated reflux model.
    Archives of otolaryngology--head & neck surgery, 2006, Volume: 132, Issue:9

    Topics: Animals; Disease Models, Animal; Gastroesophageal Reflux; Glottis; Hydrochloric Acid; Male; Pepsin A

2006
Gastroprotective activity and cytotoxic effect of cyperenoic acid derivatives.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:11

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cell Line; Cell Survival; Disease Models, Animal;

2006
[Effect of lung stress index on titration of positive end-expiratory pressure at post-recruitment in three canine acute respiratory distress syndrome models].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 2006, Sep-01, Volume: 44, Issue:17

    Topics: Animals; Disease Models, Animal; Dogs; Female; Hydrochloric Acid; Lung; Lung Compliance; Male; Oleic

2006
The response to recruitment worsens with progression of lung injury and fibrin accumulation in a mouse model of acid aspiration.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:6

    Topics: Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Disease Progression; Fema

2007
Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice.
    Gastroenterology, 2007, Volume: 132, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Brain; Cholera Toxin; Disease Models, Animal; Female; Ganglia, Spin

2007
Gastroprotective effect and cytotoxicity of labdenamides.
    Planta medica, 2007, Volume: 73, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Cells, Cultured; Disease Models, Animal; Diterpenes; Dose-Response Relat

2007
Evaluation of Tectona grandis leaves for wound healing activity.
    Pakistan journal of pharmaceutical sciences, 2007, Volume: 20, Issue:2

    Topics: Administration, Oral; Administration, Topical; Aloe; Animals; Burns; Chemistry, Pharmaceutical; Derm

2007
Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Airway Obstruction; Animals; Benzoxazines; Bronchi; Bronchoconstriction; Camphanes; Cannabinoids; Ca

2007
Airway responses to esophageal acidification.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:1

    Topics: Airway Resistance; Animals; Bronchi; Cats; Disease Models, Animal; Esophagus; Female; Gastroesophage

2008
Laryngeal stimulation by an acid solution in the pre-term lamb.
    Advances in experimental medicine and biology, 2008, Volume: 605

    Topics: Aging; Animals; Animals, Newborn; Citric Acid; Disease Models, Animal; Gastroesophageal Reflux; Hydr

2008
Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:4

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Cytokines; Disease Models, Animal; Hydrochloric Acid; L

2008
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.
    Respirology (Carlton, Vic.), 2008, Volume: 13, Issue:2

    Topics: Animals; Bronchoalveolar Lavage; Disease Models, Animal; Dogs; Hydrochloric Acid; Interleukin-10; In

2008
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.
    Anesthesiology, 2008, Volume: 108, Issue:6

    Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Female; Fibrosis; Hydrochloric Acid; Instillati

2008
Secondary hypocapnia fails to protect "whole body" intracellular pH during chronic HCl-acidosis in the dog.
    Kidney international, 1983, Volume: 23, Issue:2

    Topics: Acidosis; Animals; Bicarbonates; Body Fluids; Body Water; Body Weight; Carbon Dioxide; Chlorides; Di

1983
Hypophosphaturia impairs the renal defense against metabolic acidosis.
    Kidney international, 1984, Volume: 26, Issue:3

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Chlorides; Creatinine; Disease Models, Anima

1984
[Development of lung edema following endotracheal instillation of hydrochloric acid (aspiration pneumonitis model)].
    Masui. The Japanese journal of anesthesiology, 1984, Volume: 33, Issue:11

    Topics: Animals; Capillary Permeability; Disease Models, Animal; Dogs; Hydrochloric Acid; Pneumonia, Aspirat

1984
Ethanol-induced mucosal injury in rabbit oesophagus.
    Scandinavian journal of gastroenterology, 1983, Volume: 18, Issue:6

    Topics: Animals; Bile Acids and Salts; Carbon Radioisotopes; Disease Models, Animal; Erythritol; Esophagitis

1983
Aspiration pneumonitis. Correlation of experimental models with clinical disease.
    Clinics in chest medicine, 1982, Volume: 3, Issue:1

    Topics: Animals; Disease Models, Animal; Dogs; Gastric Acid; Humans; Hydrochloric Acid; Hydrogen-Ion Concent

1982
Reduction of gastric stress ulcers by intraduodenal infusion of liquids--observations in a rat model.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1980, Volume: 177, Issue:2

    Topics: Animals; Disease Models, Animal; Duodenum; Hydrochloric Acid; Infusions, Parenteral; Male; Rats; Res

1980
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci

1995
Aspiration-induced lung injury: role of complement.
    Critical care medicine, 1995, Volume: 23, Issue:8

    Topics: Animals; Capillary Permeability; Complement Activation; Complement System Proteins; Disease Models,

1995
[Effect of acid aspiration on right lymph duct lymph flow and prostaglandin metabolites in dogs].
    Masui. The Japanese journal of anesthesiology, 1995, Mar-03, Volume: 44, Issue:3

    Topics: Anesthesia, Intravenous; Animals; Capillary Permeability; Disease Models, Animal; Dogs; Hydrochloric

1995
Esophageal shortening induced by short-term intraluminal acid perfusion in opossum: a cause for hiatus hernia?
    Gastroenterology, 1994, Volume: 107, Issue:6

    Topics: Animals; Atropine; Constriction, Pathologic; Disease Models, Animal; Epithelium; Esophagus; Female;

1994
[Diffuse aspiration bronchiolitis (DAB) produced in animals by repeated HCl microaspiration].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1994, Volume: 31, Issue:6

    Topics: Animals; Bronchiolitis; Disease Models, Animal; Hydrochloric Acid; Pneumonia, Aspiration; Rats; Rats

1994
[An aspiration pneumonia in acute airway damage model induced by HCl and/or LPS].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1993, Volume: 30, Issue:12

    Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydrochloric Acid; Lip

1993
Sucralfate does not reduce the risk of acid aspiration pneumonitis.
    Critical care medicine, 1993, Volume: 21, Issue:9

    Topics: Airway Resistance; Animals; Digestive System; Disease Models, Animal; Drug Evaluation, Preclinical;

1993
Acid aspiration-induced acute lung injury causes leukocyte-dependent systemic organ injury.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 74, Issue:4

    Topics: Animals; Capillary Permeability; Cats; Cell Adhesion; Disease Models, Animal; Hydrochloric Acid; Ile

1993
Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice.
    Gastroenterology, 1997, Volume: 113, Issue:2

    Topics: Animals; Bicarbonates; Biological Transport, Active; Cystic Fibrosis; Cystic Fibrosis Transmembrane

1997
Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine.
    Research communications in molecular pathology and pharmacology, 1997, Volume: 97, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Caustics; Disease Models, Anima

1997
Role of CD11b in focal acid-induced pneumonia and contralateral lung injury in rats.
    American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:1

    Topics: Animals; CD18 Antigens; Cell Adhesion; Cell Movement; Disease Models, Animal; Endotoxins; Hydrochlor

1998
Role of mast cell-derived mediators in acid-induced shortening of the esophagus.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Animals; Bronchodilator Agents; Constriction, Pathologic; Cromolyn Sodium; Disease Models, Animal; E

1998
A comparison among animal models of acute lung injury.
    Critical care medicine, 1998, Volume: 26, Issue:5

    Topics: Animals; Disease Models, Animal; Endotoxins; Escherichia coli; Hemodynamics; Hydrochloric Acid; Olei

1998
Anti-ulcer effects of antioxidants: effect of probucol.
    European journal of pharmacology, 1998, Aug-07, Volume: 354, Issue:2-3

    Topics: Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Antioxidants; Chronic Disease; Cimetidine; D

1998
Experimental esophagitis induced by acid and pepsin in rabbits mimicking human reflux esophagitis.
    Gastroenterology, 1999, Volume: 116, Issue:1

    Topics: Acute Disease; Animals; Cell Division; Chronic Disease; Disease Models, Animal; Esophagitis, Peptic;

1999
Nitric oxide production after acute, unilateral hydrochloric acid-induced lung injury in a canine model.
    Critical care medicine, 1998, Volume: 26, Issue:12

    Topics: Animals; Breath Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dogs; Hemodynamics; Hum

1998
Acidosis stimulates nitric oxide production and lung damage in rats.
    American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:2

    Topics: Acidosis; Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Dose-Response Relatio

1999
N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.
    Bioorganic & medicinal chemistry letters, 1999, Jan-18, Volume: 9, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Disease Models, Anim

1999
[Protective effects of teprenone and gefarnate against taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112, Issue:5

    Topics: Acute Disease; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpenes; Dose-Response Relatio

1998
Partial liquid ventilation decreases serum tumor necrosis factor-alpha concentrations in a rat acid aspiration lung injury model.
    Critical care medicine, 2000, Volume: 28, Issue:2

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Causality; Disease Models, Animal; Drug Evaluation, Pre

2000
The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs.
    Brain research, 2000, Apr-17, Volume: 862, Issue:1-2

    Topics: Acetic Acid; Animals; Behavior, Animal; Buffers; Disease Models, Animal; Epidermis; Formates; Hydroc

2000
Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:5

    Topics: Acetaldehyde; Animals; Anti-Ulcer Agents; Aspirin; Cycadopsida; Disease Models, Animal; Gastric Juic

2000
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:7

    Topics: Animals; Disease Models, Animal; Glycine; Hydrochloric Acid; Leukocyte Elastase; Male; Pneumonia, As

2000
Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia.
    Muscle & nerve, 2001, Volume: 24, Issue:1

    Topics: Animals; Behavior, Animal; Body Weight; Coloring Agents; Disease Models, Animal; Drug Combinations;

2001
Esophagitis-related esophageal shortening in opossum is associated with longitudinal muscle hyperresponsiveness.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:3

    Topics: Animals; Deglutition; Disease Models, Animal; Epithelial Cells; Esophageal Motility Disorders; Esoph

2001
Simulated reflux and laryngotracheal reconstruction: a rabbit model.
    Archives of otolaryngology--head & neck surgery, 2001, Volume: 127, Issue:5

    Topics: Animals; Cartilage; Disease Models, Animal; Feasibility Studies; Gastroesophageal Reflux; Hydrochlor

2001
Supraspinal delta- and mu-opioid receptors mediate gastric mucosal protection in the rat.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3

    Topics: Animals; beta-Endorphin; Brain; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug;

2001
Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume.
    Critical care medicine, 2001, Volume: 29, Issue:6

    Topics: Administration, Inhalation; Analysis of Variance; Animals; Carbon Dioxide; Cross-Over Studies; Disea

2001
Laryngospasm and diaphragmatic arrest in immature dogs after laryngeal acid exposure: a possible model for sudden infant death syndrome.
    The Annals of otology, rhinology, and laryngology, 2001, Volume: 110, Issue:8

    Topics: Animals; Animals, Newborn; Apnea; Diaphragm; Disease Models, Animal; Dogs; Electromyography; Humans;

2001
Effects of diacerein on indomethacin-induced gastric ulceration.
    Pharmacology, 2001, Volume: 63, Issue:4

    Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dinoprostone; D

2001
The role of substance P release in the lung with esophageal acid.
    The American journal of medicine, 2001, Dec-03, Volume: 111 Suppl 8A

    Topics: Animals; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Esophagus; Extravasat

2001
Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs.
    American journal of respiratory and critical care medicine, 2002, Jan-15, Volume: 165, Issue:2

    Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Endothelium; Hemodynamics; Hydrochloric Acid; P

2002
Serum SP-D is a marker of lung injury in rats.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers; Bleomycin; Bronchoalveolar Lavage Fluid; Disea

2002
Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice.
    Journal of ethnopharmacology, 2002, Volume: 81, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Biotransformation; Disease Models, Animal; Diterpenes; Ethanol; Furans;

2002
Failure of cholestyramine to prevent bile salt injury to mouse gastric mucosa.
    Gastroenterology, 1975, Volume: 68, Issue:6

    Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholestyramine Resin; Disease Models, Animal;

1975
Ventilation and blood-gas studies during experimentally produced Mendelson's syndrome in the dog.
    British journal of anaesthesia, 1975, Volume: 47, Issue:1

    Topics: Acidosis, Respiratory; Anesthesia, General; Animals; Carbon Dioxide; Disease Models, Animal; Dogs; F

1975
Immediate histopathology of hydrochloric acid aspiration.
    Scanning electron microscopy, 1979, Issue:3

    Topics: Animals; Disease Models, Animal; Dogs; Hemorrhage; Hydrochloric Acid; Lung Diseases; Male; Microcirc

1979
[Animal model of acute respiratory insufficiency by HCl aspiration in Lewe mini-pigs].
    Acta biologica et medica Germanica, 1979, Volume: 38, Issue:7

    Topics: Acute Disease; Animals; Blood Gas Analysis; Disease Models, Animal; Hydrochloric Acid; Lung Complian

1979
Distention ulcer as a model for testing of drugs for ulcerogenic side effects.
    Archives of toxicology, 1978, Oct-13, Volume: 41, Issue:1

    Topics: Animals; Aspirin; Disease Models, Animal; Hydrochloric Acid; Indomethacin; Male; Rats; Stomach; Stom

1978
The primary antibacterial defense mechanism of the bladder.
    Investigative urology, 1975, Volume: 13, Issue:1

    Topics: Animals; Antibiosis; Bacterial Infections; Disease Models, Animal; Escherichia coli; Female; Humans;

1975
Haemodynamic effects of selective positive end-expiratory pressure after unilateral pulmonary hydrochloric acid-aspiration in dogs.
    Intensive care medicine, 1992, Volume: 18, Issue:6

    Topics: Animals; Cardiac Output; Disease Models, Animal; Dogs; Evaluation Studies as Topic; Functional Resid

1992
Continuous versus intermittent acid exposure in production of esophagitis in feline model.
    Digestive diseases and sciences, 1992, Volume: 37, Issue:8

    Topics: Analysis of Variance; Animals; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Esoph

1992
A reliable method for the production of antral gastric ulcer by a combination of 2-deoxy-D-glucose, aspirin and ammonia in rats.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:4

    Topics: Administration, Oral; Ammonia; Animals; Aspirin; Deoxyglucose; Disease Models, Animal; Drug Interact

1991
[Effect of superimposed high frequency oscillation on pulmonary edema induced by intrapulmonary injection of hydrochloric acid in dogs].
    Masui. The Japanese journal of anesthesiology, 1991, Volume: 40, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; High-Frequency Ventilation; Hydrochloric Acid; Pulmonary Edem

1991
The histologic development of acid-induced esophagitis in the cat.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1990, Volume: 3, Issue:5

    Topics: Animals; Cats; Disease Models, Animal; Esophagitis, Peptic; Hydrochloric Acid; Hyperplasia; Infusion

1990
Chemotactic factor generation and cell accumulation in acute lung injury induced by endotracheal acid instillation.
    Prostaglandins, leukotrienes, and essential fatty acids, 1989, Volume: 37, Issue:1

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemotactic Factors; Complement C5; Complement C5

1989
Effect of cytoprotective and antiulcer drugs on the healing process of subacute gastric ulcer in rat (a new model).
    Acta physiologica Hungarica, 1989, Volume: 73, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Ethylma

1989
The free radical mechanisms in beta-carotene induced gastric cytoprotection in HCl model.
    Acta physiologica Hungarica, 1989, Volume: 73, Issue:2-3

    Topics: Animals; beta Carotene; Carotenoids; Catalase; Disease Models, Animal; Female; Free Radicals; Gastri

1989
Conjugated diene production after airway acid aspiration.
    Progress in clinical and biological research, 1989, Volume: 299

    Topics: Administration, Inhalation; Animals; Disease Models, Animal; Female; Free Radicals; Hydrochloric Aci

1989
Hemodynamic effects of nifedipine in a canine model of acid aspiration.
    Anesthesia and analgesia, 1988, Volume: 67, Issue:12

    Topics: Animals; Disease Models, Animal; Dogs; Hemodynamics; Hydrochloric Acid; Nifedipine; Pneumonia, Aspir

1988
Sites of leakage in three models of acute lung injury.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 64, Issue:3

    Topics: Animals; Arteries; Arterioles; Blood Pressure; Capillary Permeability; Disease Models, Animal; Embol

1988
Endogenous opioids do not mediate HCl-induced myocardial dysfunction.
    Pediatric research, 1988, Volume: 23, Issue:6

    Topics: Acidosis; Animals; Animals, Newborn; Asphyxia Neonatorum; Bradycardia; Cardiac Output, Low; Disease

1988
Acid ingestion in an experimental model.
    Surgery, gynecology & obstetrics, 1985, Volume: 161, Issue:1

    Topics: Acids; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Caustics; Child, Preschool; Disease

1985
Intrajejunal administration of an elemental diet at neutral pH avoids pancreatic stimulation. Studies in dog and man.
    American journal of surgery, 1973, Volume: 126, Issue:5

    Topics: Acetates; Amino Acids; Animals; Disease Models, Animal; Duodenum; Female; Glucose; Humans; Hydrochlo

1973
[Fluoresceinangiography in experimental quinine poisoning (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1974, Volume: 164, Issue:6

    Topics: Action Potentials; Acute Disease; Animals; Disease Models, Animal; Electroretinography; Fluorescein

1974
[Experimental peptic ulcer in rats].
    Casopis lekaru ceskych, 1972, Dec-01, Volume: 111, Issue:49

    Topics: Animals; Disease Models, Animal; Female; Gastric Mucosa; Hydrochloric Acid; Male; Methods; Peptic Ul

1972
Steroid treatment for acid-aspiration pneumonitis.
    Anesthesiology, 1974, Volume: 40, Issue:2

    Topics: Animals; Blood; Body Weight; Carbon Dioxide; Dexamethasone; Disease Models, Animal; Hydrochloric Aci

1974
The role of vagotomy in preventing bile salt-induced stress ulcers during hemorrhagic shock.
    The Journal of trauma, 1972, Volume: 12, Issue:8

    Topics: Animals; Bile Acids and Salts; Disease Models, Animal; Dogs; Gastric Mucosa; Hydrochloric Acid; Hydr

1972
Acute response to acid-base stress in the dog.
    The American journal of physiology, 1972, Volume: 223, Issue:3

    Topics: Acidosis; Alkalosis; Ammonium Chloride; Animals; Bicarbonates; Blood; Carbon Dioxide; Computers; Dis

1972
Experimental gastroduodenal ulcer.
    American journal of surgery, 1971, Volume: 121, Issue:6

    Topics: Animals; Disease Models, Animal; Dogs; Duodenum; Gastric Juice; Gastric Mucosa; Hydrochloric Acid; M

1971
The acute effect of acid aspiration on lung mechanics and gas exchange in the rabbit.
    Israel journal of medical sciences, 1971, Volume: 7, Issue:11

    Topics: Acidosis, Respiratory; Animals; Blood Pressure Determination; Carbon Dioxide; Disease Models, Animal

1971
Ultrastructural elements in experimental intimal thickening. I. Electron microscopic study of the development and cellular elements of intimal proliferation.
    Experimental and molecular pathology, 1969, Volume: 11, Issue:2

    Topics: Animals; Aorta, Abdominal; Arteries; Arteriosclerosis; Cell Membrane; Disease Models, Animal; Elasti

1969
Ultrastructural elements in experimental intimal thickening. II. Study of the development of elastic elements in intimal proliferation.
    Experimental and molecular pathology, 1969, Volume: 11, Issue:2

    Topics: Animals; Aorta, Abdominal; Arteries; Arteriosclerosis; Basement Membrane; Disease Models, Animal; El

1969
[The pathogenesis of acute pancreatitis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1970, Volume: 69, Issue:5

    Topics: Acute Disease; Animals; Disease Models, Animal; Hydrochloric Acid; Pancreatitis; Peptide Hydrolases;

1970