hydralazine has been researched along with Spinal Cord Injuries in 15 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury (SCI) in the central nervous system (CNS) and its mechanism in promoting the structural and functional recovery of the injured CNS." | 8.31 | Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation. ( Guo, K; Ma, T; Qi, CC; Quan, X; Song, BQ; Wang, H; Yu, CY, 2023) |
| "This study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury (SCI) in the central nervous system (CNS) and its mechanism in promoting the structural and functional recovery of the injured CNS." | 4.31 | Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation. ( Guo, K; Ma, T; Qi, CC; Quan, X; Song, BQ; Wang, H; Yu, CY, 2023) |
| "This inpatient nursing driven-protocol for treating autonomic dysreflexia utilizing conservative measures, nitroglycerin paste and oral hydralazine achieved target blood pressure with a high success rate and a low incidence of adverse events." | 3.83 | A retrospective review of safety using a nursing driven protocol for autonomic dysreflexia in patients with spinal cord injuries. ( Bunnell, AE; Burns, SP; James, JJ; Solinsky, R; Svircev, JN, 2016) |
| "Acrolein has a significantly longer half-life than the transient free radicals, and thus may represent a potentially better target of therapeutic intervention to attenuate oxidative stress." | 2.45 | Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury. ( Hamann, K; Shi, R, 2009) |
| " The results show that phenelzine is indeed capable of attenuating neuropathic pain behaviors in acute, delayed, and chronic administration schedules after injury in a rat model of SCI." | 1.43 | Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury. ( Acosta, G; Butler, B; Cao, P; Chen, Z; McCain, R; Ouyang, Z; Park, J; Shi, R; Tang, J; Vega-Alvarez, S; Zhang, W; Zheng, L, 2016) |
| "Acrolein can directly activate a pro-algesic transient receptor protein ankyrin 1 (TRPA1) channel that exists in sensory neurons." | 1.42 | Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury. ( Acosta, G; Cao, P; Chen, Z; Muratori, B; Park, J; Shi, R; Vega-Alvarez, S; Zheng, L, 2015) |
| "Autonomic hyperreflexia is a serious peripartum complication associated with spinal cord lesions." | 1.27 | Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion. ( Gimovsky, ML; Ojeda, A; Ozaki, R; Zerne, S, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herr, SA | 1 |
| Gardeen, SS | 1 |
| Low, PS | 1 |
| Shi, R | 7 |
| Quan, X | 2 |
| Yu, C | 1 |
| Fan, Z | 1 |
| Wu, T | 1 |
| Qi, C | 1 |
| Zhang, H | 1 |
| Wu, S | 1 |
| Wang, X | 1 |
| Ma, T | 1 |
| Guo, K | 1 |
| Wang, H | 2 |
| Yu, CY | 1 |
| Qi, CC | 1 |
| Song, BQ | 1 |
| Due, MR | 1 |
| Park, J | 4 |
| Zheng, L | 4 |
| Walls, M | 2 |
| Allette, YM | 1 |
| White, FA | 1 |
| Marquis, A | 1 |
| Duerstock, B | 2 |
| Pond, A | 1 |
| Vega-Alvarez, S | 3 |
| Ouyang, Z | 2 |
| Acosta, G | 2 |
| Chen, Z | 2 |
| Muratori, B | 1 |
| Cao, P | 2 |
| Solinsky, R | 1 |
| Svircev, JN | 1 |
| James, JJ | 1 |
| Burns, SP | 1 |
| Bunnell, AE | 1 |
| Butler, B | 1 |
| Tang, J | 1 |
| McCain, R | 1 |
| Zhang, W | 1 |
| Squair, JW | 1 |
| Phillips, AA | 1 |
| Harmon, M | 1 |
| Krassioukov, AV | 1 |
| Hamann, K | 2 |
| Nehrt, G | 1 |
| Ouyang, H | 1 |
| Burcham, PC | 1 |
| Kaminskas, LM | 1 |
| Tan, D | 1 |
| Pyke, SM | 1 |
| Erickson, RP | 1 |
| Comarr, AE | 1 |
| Gimovsky, ML | 1 |
| Ojeda, A | 1 |
| Ozaki, R | 1 |
| Zerne, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886] | 8 participants (Anticipated) | Interventional | 2021-06-08 | Recruiting | |||
| The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388] | 46 participants (Anticipated) | Interventional | 2020-02-01 | Not yet recruiting | |||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923] | 8 participants (Anticipated) | Interventional | 2021-12-31 | Recruiting | |||
| Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093] | 20 participants (Anticipated) | Interventional | 2021-11-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydralazine and Spinal Cord Injuries
| Article | Year |
|---|---|
Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury.
Topics: Acrolein; Animals; Free Radical Scavengers; Humans; Hydralazine; Lipid Peroxidation; Models, Biologi | 2009 |
Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury.
Topics: Acrolein; Alzheimer Disease; Animals; Atherosclerosis; Cell Death; Free Radical Scavengers; Humans; | 2008 |
Autonomic hyperreflexia: pathophysiology and medical management.
Topics: Anesthesia, Spinal; Catecholamines; Diazoxide; Humans; Hydralazine; Neurotransmitter Agents; Nitropr | 1980 |
12 other studies available for hydralazine and Spinal Cord Injuries
| Article | Year |
|---|---|
Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation.
Topics: Acrolein; Animals; Folic Acid; Humans; Hydralazine; Lipid Peroxidation; Rats; Spinal Cord Injuries | 2022 |
Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury.
Topics: Acrolein; Animals; Hydralazine; Macrophages; Male; Mice; Pain; Rats; Spinal Cord; Spinal Cord Injuri | 2023 |
Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation.
Topics: Acrolein; Animals; Hydralazine; Inflammation; Macrophages; Mice; Neuralgia; Oxidative Stress; Phosph | 2023 |
Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat.
Topics: Acrolein; Animals; Behavior, Animal; Blotting, Western; Cold Temperature; DNA, Complementary; Electr | 2014 |
Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage.
Topics: Acrolein; Animals; Behavior, Animal; Blotting, Western; Contusions; Hydralazine; Locomotion; Male; N | 2014 |
Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.
Topics: Acetylcysteine; Acrolein; Animals; Disease Models, Animal; Ganglia, Spinal; Hydralazine; Hyperalgesi | 2015 |
A retrospective review of safety using a nursing driven protocol for autonomic dysreflexia in patients with spinal cord injuries.
Topics: Adult; Aged; Aged, 80 and over; Autonomic Dysreflexia; Guideline Adherence; Humans; Hydralazine; Mal | 2016 |
Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.
Topics: Animals; Behavior, Animal; Contusions; Disease Models, Animal; Hydralazine; Hyperalgesia; Male; Neur | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Emergency management of autonomic dysreflexia with neurologic complications.
Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc | 2016 |
Hydralazine inhibits compression and acrolein-mediated injuries in ex vivo spinal cord.
Topics: Acrolein; Analysis of Variance; Animals; Antihypertensive Agents; Dextrans; Drug Interactions; Gluta | 2008 |
Autonomic dysreflexia (hyperreflexia).
Topics: Antihypertensive Agents; Autonomic Nervous System; Autonomic Nervous System Diseases; Ganglionic Blo | 1984 |
Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion.
Topics: Adult; Autonomic Nervous System Diseases; Cesarean Section; Female; Humans; Hydralazine; Obstetric L | 1985 |