Compounds > hydralazine
Page last updated: 2024-10-28

hydralazine and Scleroderma, Systemic

hydralazine has been researched along with Scleroderma, Systemic in 22 studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

Research Excerpts

ExcerptRelevanceReference
"Until recently acute renal failure in scleroderma has been uniformly fatal."1.26Medical treatment of hypertension and renal failure in scleroderma. ( Barnett, AJ, 1981)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199019 (86.36)18.7374
1990's3 (13.64)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
OSHIMA, Y1
HAZAMA, T1
Blumenkrantz, N2
Asboe-Hansen, G6
Jacobs, RP1
Burns, TW1
Barnett, AJ1
McWeeney, J1
Finnegan, P1
Moorthy, AV1
Wu, MJ1
Beirne, GJ1
Sundstrom, WS1
Markenson, JA1
Sherman, RL1
Mitnick, PD1
Feig, PU1
Lam, M1
Ricanati, ES1
Khan, MA1
Kushner, I1
Langevitz, P1
Buskila, D1
Lee, P1
Hercz, G1
Phlippoteau, C1
Brenot, F1
Blétry, O1
Simmonneau, G1
Duroux, P1
Nässberger, L1
Sjöholm, AG1
Jonsson, H1
Sturfelt, G1
Akesson, A1
Stevens, MB1
Ohar, J1
Polatty, C1
Robichaud, A1
Fowler, A1
Vetrovec, G1
Glauser, F1
Christiansen, AH1
Ullman, S1
Maas, D1
Mattern, WD1
Sommers, SC1
Kassirer, JP1

Reviews

2 reviews available for hydralazine and Scleroderma, Systemic

ArticleYear
Connective tissue disease in the elderly.
    Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1

    Topics: Aged; Connective Tissue Diseases; Dermatomyositis; Female; Giant Cell Arteritis; Humans; Hydralazine

1986
[Antinuclear factors. Demonstration and clinico-diagnostic significance].
    Medizinische Klinik, 1969, Jul-18, Volume: 64, Issue:29

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Chronic Disease

1969

Trials

1 trial available for hydralazine and Scleroderma, Systemic

ArticleYear
Treatment of generalized scleroderma with inhibitors of connective tissue formation.
    Acta dermato-venereologica, 1975, Volume: 55, Issue:6

    Topics: Adult; Age Factors; Clinical Trials as Topic; Connective Tissue; Depression, Chemical; Dextrothyroxi

1975

Other Studies

19 other studies available for hydralazine and Scleroderma, Systemic

ArticleYear
[COLLAGEN DISEASES].
    Naika. Internal medicine, 1964, Volume: 13

    Topics: Adolescent; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Behcet Syndrome; Child; Collagen Disease

1964
Variation of urinary acid glycosaminoglycan and collagen metabolite excretion with disease activity in generalized scleroderma.
    Acta dermato-venereologica, 1980, Volume: 60, Issue:1

    Topics: Adult; Aged; Collagen; Female; Follow-Up Studies; Glutamine; Glycosaminoglycans; Humans; Hydralazine

1980
Drug-induced rheumatic diseases.
    Comprehensive therapy, 1984, Volume: 10, Issue:8

    Topics: Adrenal Cortex Hormones; Anticonvulsants; Antineoplastic Agents; Diuretics; Gout; Heparin; Humans; H

1984
Motor disorders of the esophagus: diagnosis and treatment.
    Southern medical journal, 1984, Volume: 77, Issue:8

    Topics: Bethanechol Compounds; Calcium Channel Blockers; Esophageal Achalasia; Esophageal Diseases; Esophagi

1984
Medical treatment of hypertension and renal failure in scleroderma.
    Australian and New Zealand journal of medicine, 1981, Volume: 11, Issue:4

    Topics: Acute Kidney Injury; Adult; Female; Humans; Hydralazine; Hypertension; Minoxidil; Propranolol; Scler

1981
Treatment of generalized scleroderma with inhibitors of collagen synthesis.
    International journal of dermatology, 1982, Volume: 21, Issue:3

    Topics: Catechin; Chlorpromazine; Collagen; Dextrothyroxine; Glutamine; Humans; Hydralazine; Levodopa; Penic

1982
Vasodilator therapy of pulmonary hypertension in the CRST syndrome.
    Irish journal of medical science, 1982, Volume: 151, Issue:5

    Topics: Calcinosis; Female; Humans; Hydralazine; Hypertension, Pulmonary; Male; Middle Aged; Raynaud Disease

1982
Control of hypertension with acute renal failure in scleroderma without nephrectomy.
    Lancet (London, England), 1978, Mar-11, Volume: 1, Issue:8063

    Topics: Acute Kidney Injury; Humans; Hydralazine; Hypertension, Malignant; Male; Middle Aged; Propranolol; R

1978
Treatment of generalized scleroderma: updated results.
    Acta dermato-venereologica, 1979, Volume: 59, Issue:5

    Topics: Chlorpromazine; Collagen; Drug Evaluation; Glutamine; Glycosaminoglycans; Humans; Hydralazine; Levod

1979
Renal involvement in progressive systemic sclerosis: prolonged survival with aggressive antihypertensive management.
    Arthritis and rheumatism, 1979, Volume: 22, Issue:10

    Topics: Adult; Antihypertensive Agents; Cardiomegaly; Digoxin; Drug Therapy, Combination; Female; Furosemide

1979
Control of hypertension and reversal of renal failure in scleroderma.
    The New England journal of medicine, 1978, Oct-19, Volume: 299, Issue:16

    Topics: Acute Kidney Injury; Adult; Antihypertensive Agents; Humans; Hydralazine; Hypertension, Malignant; M

1978
Reversal of severe renal failure in systemic sclerosis.
    Annals of internal medicine, 1978, Volume: 89, Issue:5 Pt 1

    Topics: Acute Kidney Injury; Biopsy; Female; Humans; Hydralazine; Hypertension, Renal; Kidney; Methyldopa; M

1978
[Treatment of generalized scleroderma with connective tissue inhibitors].
    Ugeskrift for laeger, 1976, May-24, Volume: 138, Issue:22

    Topics: Adrenal Cortex Hormones; Adult; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydral

1976
Scleroderma hypertensive renal crisis and the changing pattern of mortality in systemic sclerosis (scleroderma)
    Nephron, 1991, Volume: 57, Issue:1

    Topics: Adult; Captopril; Female; Humans; Hydralazine; Hypertension, Renal; Kidney; Male; Middle Aged; Minox

1991
[Vasodilator agents in pulmonary artery hypertension of systemic scleroderma].
    Revue des maladies respiratoires, 1990, Volume: 7, Issue:3

    Topics: Adult; Aged; Blood Pressure; Cardiac Output; Epoprostenol; Female; Humans; Hydralazine; Hypertension

1990
Autoantibodies against neutrophil cytoplasm components in systemic lupus erythematosus and in hydralazine-induced lupus.
    Clinical and experimental immunology, 1990, Volume: 81, Issue:3

    Topics: Autoantibodies; Autoantigens; Cytoplasm; Female; Follow-Up Studies; Humans; Hydralazine; Lupus Eryth

1990
The role of vasodilators in patients with progressive systemic sclerosis. Interstitial lung disease and pulmonary hypertension.
    Chest, 1985, Volume: 88, Issue:4 Suppl

    Topics: Humans; Hydralazine; Hypertension, Pulmonary; Lung Diseases; Nifedipine; Pulmonary Fibrosis; Sarcoid

1985
Hydralazine-induced Lupoid syndrome. Biochemical and immunological studies.
    Acta medica Scandinavica, 1974, Volume: 195, Issue:6

    Topics: Adult; Biopsy; Blood Sedimentation; Chemical Precipitation; Complement System Proteins; DNA; Fluores

1974
Oliguric acute renal failure in malignant hypertension.
    The American journal of medicine, 1972, Volume: 52, Issue:2

    Topics: Acute Kidney Injury; Adult; Anuria; Blood Urea Nitrogen; Diagnosis, Differential; Female; Glomerulon

1972