hydralazine and Pre-Eclampsia studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.

Research Excerpts

Excerpt	Relevance	Reference
"The objectives were to compare the efficacy and safety of intravenous hydralazine and labetalol for acutely lowering severe hypertension in pregnancy."	9.51	Comparison of intravenous labetalol and hydralazine for severe hypertension in pregnancy in Northeastern Nigeria: A randomized controlled trial. ( Bako, B; Dawha, YM; Muhammad, S; Usman, H; Yahya, A; Yekeen, A, 2022)
"Nifedipine is safe and more effective than hydralazine in controlling blood pressure in severe pre-eclampsia."	9.10	Nifedipine or hydralazine as a first-line agent to control hypertension in severe preeclampsia. ( Aali, BS; Nejad, SS, 2002)
"Although hydralazine has been the drug of choice for treating pregnancy-induced hypertension for some time owing to its effect on peripheral vascular tonus, its effects on utero- and feto-placental circulation are less well understood."	9.08	Effects of hydralazine on placental and renal circulation in pre-eclampsia. ( Gennser, G; Gudmundsson, S; Marsal, K, 1995)
"To compare ketanserin with hydralazine in the treatment of hypertension in late pregnancy."	9.08	Ketanserin and hydralazine in hypertension in pregnancy--a randomised double-blind trial. ( Howarth, G; Odendaal, HJ; Rossouw, HJ, 1995)
"The objective was to compare the fetal and maternal effects between parenteral hydralazine and sublingual nifedipine used like antihypertensive drugs in the management of severe preeclampsia."	9.07	[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. ( Flores Padilla, LM; Walss Rodriguez, RJ, 1993)
"The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy."	9.05	Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy. ( Davey, DA; Dommisse, J; Garden, A, 1982)
"Tradiational drug therapy choices for hypertension in pregnancy continue to be hydralazine for acute reduction of blood pressure and methyldopa for the management of chronic hypertension."	8.79	Use of nifedipine in the hypertensive diseases of pregnancy. ( Doering, PL; Hatton, RC; Levin, AC, 1994)
"To compare the efficacy of intravenous Labetalol and intravenous Hydralazine in reduction of blood pressure in patients with severe pre-eclampsia."	8.31	Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women. ( Husain, S; Hussain, R; Kausar, M, 2023)
" Cyclic GMP concentrations were also determined in 12 women with severe pre-eclampsia before and after treatment with hydralazine."	7.69	Cyclic guanosine 3',5' monophosphate concentrations in pre-eclampsia: effects of hydralazine. ( Calle, A; Jácome, P; López-Jaramillo, P; Narváez, M; Nava, E; Rivera, J; Ruano, C, 1996)
"Seventy consecutive women who received hydralazine for the treatment of sustained severe hypertension."	7.69	Hydralazine boluses for the treatment of severe hypertension in pre-eclampsia. ( de Swiet, M; Paterson-Brown, S; Redfern, N; Robson, SC; Walkinshaw, SA, 1994)
"The apex cardiogram and its 1st differential quotient were simultaneously registered with the phonocardiogram, the electrocardiogram and the curve of the carotid pulse in 10 female patients with pregnancy-induced hypertension before and after the therapy with dihydralazine sulphate."	7.67	[Studies of heart function using apex cardiography in pregnancy-induced hypertension before and following therapy with dihydralazine sulfate]. ( Benndorf, S; Kehrbein, C; Nahrendorf, W; Rading, A; Steinig, G; Weidler, B, 1986)
"The hemodynamic changes after intravenous administration of hydralazine were assessed using M-mode echocardiography in 13 pregnant patients with severe hypertension."	7.67	Hemodynamic effects of intravenous hydralazine in pregnant women with severe hypertension. ( Kuzniar, J; Piela, A; Skret, A; Szmigiel, Z; Zaczek, T, 1985)
"The uteroplacental blood flow was measured in 12 women with hypertension during pregnancy before and after intravenous injection of dihydralazine."	7.66	Acute effect of dihydralazine on uteroplacental blood flow in hypertension during pregnancy. ( Lewander, R; Lunell, NO; Nylund, L; Sarby, B; Thornström, S, 1983)
" The duration of action also varied in the labetalol group, with the shortest duration occurring in those patients who required the highest dosage for BP control."	6.66	A comparative trial of labetalol and hydralazine in the acute management of severe hypertension complicating pregnancy. ( Amon, E; Gonzalez, AR; Mabie, WC; Sibai, BM, 1987)
"The objectives were to compare the efficacy and safety of intravenous hydralazine and labetalol for acutely lowering severe hypertension in pregnancy."	5.51	Comparison of intravenous labetalol and hydralazine for severe hypertension in pregnancy in Northeastern Nigeria: A randomized controlled trial. ( Bako, B; Dawha, YM; Muhammad, S; Usman, H; Yahya, A; Yekeen, A, 2022)
"Twenty mothers with moderate to severe preeclampsia were allocated to labetalol (Trandate) or hydralazine (Apresolin) antihypertensive treatment."	5.29	Neonatal adaptation in hypertensive pregnancy--a study of labetalol vs hydralazine treatment. ( Faxelius, G; Hjertberg, R; Lagercrantz, H, 1993)
"Nifedipine is safe and more effective than hydralazine in controlling blood pressure in severe pre-eclampsia."	5.10	Nifedipine or hydralazine as a first-line agent to control hypertension in severe preeclampsia. ( Aali, BS; Nejad, SS, 2002)
"Although hydralazine has been the drug of choice for treating pregnancy-induced hypertension for some time owing to its effect on peripheral vascular tonus, its effects on utero- and feto-placental circulation are less well understood."	5.08	Effects of hydralazine on placental and renal circulation in pre-eclampsia. ( Gennser, G; Gudmundsson, S; Marsal, K, 1995)
"To compare ketanserin with hydralazine in the treatment of hypertension in late pregnancy."	5.08	Ketanserin and hydralazine in hypertension in pregnancy--a randomised double-blind trial. ( Howarth, G; Odendaal, HJ; Rossouw, HJ, 1995)
"The objective was to compare the fetal and maternal effects between parenteral hydralazine and sublingual nifedipine used like antihypertensive drugs in the management of severe preeclampsia."	5.07	[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. ( Flores Padilla, LM; Walss Rodriguez, RJ, 1993)
"The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy."	5.05	Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy. ( Davey, DA; Dommisse, J; Garden, A, 1982)
" Oral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenting with pre-eclampsia."	4.98	Focused Update on Pharmacologic Management of Hypertensive Emergencies. ( Broscious, R; Devabhakthuni, S; Noel, ZR; Watson, K, 2018)
"Tradiational drug therapy choices for hypertension in pregnancy continue to be hydralazine for acute reduction of blood pressure and methyldopa for the management of chronic hypertension."	4.79	Use of nifedipine in the hypertensive diseases of pregnancy. ( Doering, PL; Hatton, RC; Levin, AC, 1994)
"To compare the efficacy of intravenous Labetalol and intravenous Hydralazine in reduction of blood pressure in patients with severe pre-eclampsia."	4.31	Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women. ( Husain, S; Hussain, R; Kausar, M, 2023)
" The American College of Obstetricians and Gynecologists recommends that acute-onset, severe hypertension be treated with first line-therapy (intravenous labetalol, intravenous hydralazine or oral nifedipine) within 60 minutes to reduce risk of maternal morbidity and death."	3.96	Identification of factors associated with delayed treatment of obstetric hypertensive emergencies. ( Akerman, MB; Elsayad, A; Halpern, TA; Heiselman, CJ; Heo, HJ; Kantorowska, A; Muscat, JC; Sicuranza, GB; Vintzileos, AM, 2020)
"The incidence of maternal hypotension was low and did not differ following antepartum IV labetalol versus hydralazine use."	3.83	Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low. ( Aghajanian, P; Greene, N; Kilpatrick, SJ; Rodriguez, M; Sharma, KJ, 2016)
"We studied the effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam (a dopamine D1-agonist) on isolated human umbilical arteries (HUA) from patients classified as normotensive and with pregnancy-induced hypertension (PIH)."	3.72	The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. ( Arias, ME; Levy, JH; Sato, N; Szlam, F; Tanaka, KA; Tsuda, A, 2003)
"These findings demonstrate that agents commonly used for the treatment of hypertensive disease in pregnancy, excluding alpha-methyldopa, have significant direct effects on the feto-placental circulation."	3.72	Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance. ( Dennedy, MC; Houlihan, DD; Morrison, JJ; Ravikumar, N, 2004)
" With the exception of one subject, all pre-eclamptics were taking clonidine (a known suppressant of rapid eye movement-REM-sleep) for control of their hypertension."	3.70	Pre-eclampsia is associated with marked alterations in sleep architecture. ( Blyton, CM; Edwards, N; Kesby, GJ; Sullivan, CE; Wilcox, I, 2000)
" Cyclic GMP concentrations were also determined in 12 women with severe pre-eclampsia before and after treatment with hydralazine."	3.69	Cyclic guanosine 3',5' monophosphate concentrations in pre-eclampsia: effects of hydralazine. ( Calle, A; Jácome, P; López-Jaramillo, P; Narváez, M; Nava, E; Rivera, J; Ruano, C, 1996)
"Seventy consecutive women who received hydralazine for the treatment of sustained severe hypertension."	3.69	Hydralazine boluses for the treatment of severe hypertension in pre-eclampsia. ( de Swiet, M; Paterson-Brown, S; Redfern, N; Robson, SC; Walkinshaw, SA, 1994)
"The apex cardiogram and its 1st differential quotient were simultaneously registered with the phonocardiogram, the electrocardiogram and the curve of the carotid pulse in 10 female patients with pregnancy-induced hypertension before and after the therapy with dihydralazine sulphate."	3.67	[Studies of heart function using apex cardiography in pregnancy-induced hypertension before and following therapy with dihydralazine sulfate]. ( Benndorf, S; Kehrbein, C; Nahrendorf, W; Rading, A; Steinig, G; Weidler, B, 1986)
"The hemodynamic changes after intravenous administration of hydralazine were assessed using M-mode echocardiography in 13 pregnant patients with severe hypertension."	3.67	Hemodynamic effects of intravenous hydralazine in pregnant women with severe hypertension. ( Kuzniar, J; Piela, A; Skret, A; Szmigiel, Z; Zaczek, T, 1985)
"The uteroplacental blood flow was measured in 12 women with hypertension during pregnancy before and after intravenous injection of dihydralazine."	3.66	Acute effect of dihydralazine on uteroplacental blood flow in hypertension during pregnancy. ( Lewander, R; Lunell, NO; Nylund, L; Sarby, B; Thornström, S, 1983)
"An active approach to the management of severe pre-eclampsia is outlined using sedation with diazepam, hypotensive therapy with hydralazine and immediate steps to terminate the pregnancy."	3.65	Active management of severe pre-eclampsia. ( Baskett, TF; Bradford, CR, 1973)
" The duration of action also varied in the labetalol group, with the shortest duration occurring in those patients who required the highest dosage for BP control."	2.66	A comparative trial of labetalol and hydralazine in the acute management of severe hypertension complicating pregnancy. ( Amon, E; Gonzalez, AR; Mabie, WC; Sibai, BM, 1987)
"The incidence of neonatal jaundice was higher in the control group (P less than 0."	2.66	Lumbar epidural analgesia in hypertensive patients during labour. ( Lachman, E; Neri, A; Nitke, S; Ovadia, J, 1986)
"The incidence of preeclampsia in the randomized prophylactic antihypertensive group was statistically lower than that in the nonrandomized group (8."	2.65	The effects of prophylactic management and therapeutics on hypertensive disease in pregnancy: preliminary studies. ( Crenshaw, MC; Dorminy, JH; Gall, SA; Jelovsek, FR; Welt, SI, 1981)
"Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second half of pregnancy."	2.55	Pathophysiology and Current Clinical Management of Preeclampsia. ( Amaral, LM; LaMarca, B; Owens, M; Wallace, K, 2017)
"Risk factors for the development of preeclampsia include microvascular diseases, such as diabetes mellitus; vascular and connective tissue disorders; hypertension; antiphospholipid antibody syndrome; and nephropathy."	2.45	Pharmacotherapeutic options for the treatment of preeclampsia. ( Baldwin, K; McCoy, S, 2009)
"Management of preeclampsia is bed rest, aspirin administration, antihypertensive agents (beta-blockers, hydralazine, alpha-methyldopa) would be used for reduction of blood pressure."	2.40	[Pregnancy induced hypertension]. ( Suzuki, H, 1997)
"Although hypertension is the most common and significant risk factor in pregnancy, the risks can be minimized with careful supervision and therapy."	2.37	Hypertension in pregnant women. ( Gallery, ED, 1985)
"Postpartum preeclampsia/eclampsia often presents to the ED without a history of preeclampsia during the pregnancy."	1.37	Postpartum preeclampsia: emergency department presentation and management. ( Abbott, J; Bakes, K; Withers, E; Yancey, LM, 2011)
"Coincident with the preeclampsia was a postdural puncture headache complicating the diagnosis of late postpartum preeclampsia."	1.32	Late postpartum eclampsia coincident with postdural puncture headache: a case report. ( Norman, D; Winston, AW, 2003)
"Mean IL-18 levels were lower in preeclampsia than in controls (185 +/- 74 pg/mL vs 224 +/- 75 pg/mL, P =."	1.32	Interleukin-18 in the plasma of women with preeclampsia. ( Adams, KM; Atkinson, MW; Guthrie, KA; Mandel, LS, 2003)
"3 U/MPL), mild preeclampsia (6."	1.30	Anticardiolipin antibodies and the severity of preeclampsia-eclampsia. ( Cortés-Llamas, V; González-Ortiz, M; Martínez-Abundis, E; Salazar-Páramo, M, 1999)
"We present a case of acute renal failure due to severe preeclampsia successfully treated with the infusion of a low dose of dopamine."	1.29	Low-dose dopamine in treating acute renal failure caused by preeclampsia. ( Anai, T; Miyakawa, I; Nasu, K; Yoshimatsu, J, 1996)
"Twenty mothers with moderate to severe preeclampsia were allocated to labetalol (Trandate) or hydralazine (Apresolin) antihypertensive treatment."	1.29	Neonatal adaptation in hypertensive pregnancy--a study of labetalol vs hydralazine treatment. ( Faxelius, G; Hjertberg, R; Lagercrantz, H, 1993)
"A case of severe preeclampsia in which hemolysis and rapid platelet consumption persisted after delivery, but in which the blood urea nitrogen and serum glutamic oxaloacetic acid transaminase levels returned to normal is presented."	1.27	Severe preeclampsia with persistent postpartum hemolysis and thrombocytopenia treated by plasmapheresis. ( Brenner, W; Schwartz, ML, 1985)
"Pregnancies complicated by severe preeclampsia in the second trimester are associated with a high incidence of perinatal morbidity and mortality."	1.27	Maternal and perinatal outcome of conservative management of severe preeclampsia in midtrimester. ( Abdella, TN; Anderson, GD; Brooks, TF; Sibai, BM; Spinnato, JA; Taslimi, M, 1985)
"Autonomic hyperreflexia is a serious peripartum complication associated with spinal cord lesions."	1.27	Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion. ( Gimovsky, ML; Ojeda, A; Ozaki, R; Zerne, S, 1985)
"Although the recognition and treatment of preeclampsia theoretically should eliminate eclampsia, it has not disappeared and remains a substantial threat to maternal and fetal well-being."	1.26	Eclampsia: treatment and referral. ( Anderson, GD; Dilts, PV; McCubbin, JH; Sibai, BM, 1982)
"Pregnancy-related hypertension is not thought to be an absolute contraindication to glucocorticoid therapy for the induction of pulmonary maturity."	1.26	Glucocorticoid therapy for the induction of pulmonary maturity in severely hypertensive gravid women. ( Nochimson, DJ; Petrie, RH, 1979)

Timeframe	Studies, this research(%)	All Research%
pre-1990	95 (62.91)	18.7374
1990's	26 (17.22)	18.2507
2000's	11 (7.28)	29.6817
2010's	14 (9.27)	24.3611
2020's	5 (3.31)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial[NCT03262961]	Phase 2/Phase 3	80 participants (Anticipated)	Interventional	2016-09-15	Recruiting
A Comparison of Fetal Hemodynamic Measurements Between Pregnant Women Taking Anti-hypertensive Medication and Controls[NCT00759278]		0 participants (Actual)	Observational	2008-08-31	Withdrawn (stopped due to No participants)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Treatment of acute-onset hypertension in pregnancy: A network meta-analysis of randomized controlled trials comparing anti-hypertensives and route of administration. Pregnancy hypertension, 2023, Volume: 34 Topics: Antihypertensive Agents; Calcium Channel Blockers; Female; Humans; Hydralazine; Hypertension; Infant	2023
Pathophysiology and Current Clinical Management of Preeclampsia. Current hypertension reports, 2017, Volume: 19, Issue:8 Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Delivery, Obstetric; Endothelium,	2017
Focused Update on Pharmacologic Management of Hypertensive Emergencies. Current hypertension reports, 2018, 06-08, Volume: 20, Issue:7 Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Emergencies; Enalapri	2018
Treatment and Prevention of Hypertensive Disorders During Pregnancy. Clinics in perinatology, 2019, Volume: 46, Issue:2 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Aspirin; Calcium Channel Blockers; Chronic Dis	2019
Hypertensive emergencies of pregnancy. Obstetrics and gynecology clinics of North America, 2013, Volume: 40, Issue:1 Topics: Antihypertensive Agents; Calcium Channel Blockers; Creatine; Diuretics; Emergency Medicine; Female;	2013
Severe pre-eclampsia and hypertensive crises. Best practice & research. Clinical obstetrics & gynaecology, 2013, Volume: 27, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Antihypertensive Agents; Critical Care; Early Dia	2013
Hypertensive emergencies in pregnancy. Clinical obstetrics and gynecology, 2014, Volume: 57, Issue:4 Topics: Antihypertensive Agents; Eclampsia; Emergencies; Female; Humans; Hydralazine; Hypertension; Hyperten	2014
Hypertensive Emergencies in Pregnancy. Critical care clinics, 2016, Volume: 32, Issue:1 Topics: Antihypertensive Agents; Cesarean Section; Chronic Disease; Congenital Abnormalities; Emergencies; E	2016
Pharmacotherapeutic options for the treatment of preeclampsia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, Feb-15, Volume: 66, Issue:4 Topics: Female; Humans; Hydralazine; Magnesium Sulfate; Nicardipine; Nifedipine; Nitroprusside; Pre-Eclampsi	2009
[Clinical efficacy and perinatal outcome of nifedipine for severe preeclampsia: meta-analysis]. Zhonghua fu chan ke za zhi, 2012, Volume: 47, Issue:8 Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Infant, Newborn;	2012
The control of hypertension in pregnancy. Obstetrics and gynecology annual, 1981, Volume: 10 Topics: Adrenergic beta-Antagonists; Angiotensin II; Antihypertensive Agents; Diazoxide; Diuretics; Eclampsi	1981
Preeclampsia--eclampsia: an overview. The Journal of the Florida Medical Association, 1983, Volume: 70, Issue:9 Topics: Blood Pressure; Eclampsia; Electroencephalography; Female; Hospitalization; Humans; Hydralazine; Inf	1983
[Arterial hypertension in pregnancy. Concise review]. Minerva medica, 1983, Apr-28, Volume: 74, Issue:18 Topics: Cesarean Section; Diet, Sodium-Restricted; Female; Humans; Hydralazine; Hypertension; Labor, Induced	1983
The management of hypertension in pregnancy. Scandinavian journal of clinical and laboratory investigation. Supplementum, 1984, Volume: 169 Topics: Cerebrovascular Circulation; Clinical Trials as Topic; Diazoxide; Diuretics; Female; Humans; Hydrala	1984
Anti-hypertensive drugs in the pregnant patient. Obstetrical & gynecological survey, 1980, Volume: 35, Issue:4 Topics: Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Diuretics; Female; Fetus; Furosemide	1980
Management of preeclampsia and eclampsia. Kidney international, 1980, Volume: 18, Issue:2 Topics: Anticonvulsants; Antihypertensive Agents; Delivery, Obstetric; Diuretics; Eclampsia; Female; Humans;	1980
Treatment of hypertension in pregnancy. Kidney international, 1980, Volume: 18, Issue:2 Topics: Diazoxide; Diuretics; Female; Humans; Hydralazine; Hypertension; Methyldopa; Placenta; Pre-Eclampsia	1980
Use of nifedipine in the hypertensive diseases of pregnancy. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:12 Topics: Female; Humans; Hydralazine; Hypertension; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Complicat	1994
[Pregnancy induced hypertension]. Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:8 Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bed Rest; Contraindications; Fema	1997
The use of antihypertensive drugs in hypertension in pregnancy. Clinics in obstetrics and gynaecology, 1977, Volume: 4, Issue:3 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Diuretic	1977
Pharmacology and clinical use of drugs in hypertensive emergencies. American journal of hospital pharmacy, 1977, Volume: 34, Issue:2 Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Aorta; Brain Diseases; Cerebral Hemorrhage; Diazox	1977
Severe preeclampsia: is vasodilation therapy with hydralazine dangerous for the preterm fetus? American journal of perinatology, 1990, Volume: 7, Issue:3 Topics: Female; Fetus; Humans; Hydralazine; Hypotension; Pre-Eclampsia; Pregnancy	1990
Hypertension in pregnancy. The Mount Sinai journal of medicine, New York, 1985, Volume: 52, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Chronic Disease; Clonidine; Diuretics; Female; Humans; Hydrala	1985
Hypertension in pregnant women. The Medical journal of Australia, 1985, Jul-08, Volume: 143, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Delivery, Obstetric; Diazoxide; Emergencies; F	1985
Antihypertensive drugs in pregnancy. Clinics in perinatology, 1985, Volume: 12, Issue:3 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Female; Fetus; Humans; H	1985
Treatment of hypertension in pregnancy. Clinics in obstetrics and gynaecology, 1986, Volume: 13, Issue:2 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Eclampsia; Female; Human	1986
Recent advances in the medical and surgical treatment of hypertension. The Medical clinics of North America, 1968, Volume: 52, Issue:5 Topics: Adrenocortical Hyperfunction; Antihypertensive Agents; Diet, Sodium-Restricted; Diuretics; Ethacryni	1968

Article	Year
Comparison of intravenous labetalol and hydralazine for severe hypertension in pregnancy in Northeastern Nigeria: A randomized controlled trial. Pregnancy hypertension, 2022, Volume: 29 Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Infant; Infant,	2022
Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia: a randomized control trial. F1000Research, 2022, Volume: 11 Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Labetalol; Nifedipine; Pre-Eclampsia; Pregnanc	2022
The management of hypertension in pregnancy. Scandinavian journal of clinical and laboratory investigation. Supplementum, 1984, Volume: 169 Topics: Cerebrovascular Circulation; Clinical Trials as Topic; Diazoxide; Diuretics; Female; Humans; Hydrala	1984
Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy. Clinical and experimental hypertension. Part B, Hypertension in pregnancy, 1982, Volume: 1, Issue:2-3 Topics: Adult; Blood Pressure; Dihydralazine; Eclampsia; Ethanolamines; Female; Fetus; Humans; Hydralazine;	1982
The effects of prophylactic management and therapeutics on hypertensive disease in pregnancy: preliminary studies. Obstetrics and gynecology, 1981, Volume: 57, Issue:5 Topics: Adult; Antihypertensive Agents; Birth Weight; Blood Pressure; Body Weight; Female; Humans; Hydralazi	1981
Effects of hydralazine on placental and renal circulation in pre-eclampsia. Acta obstetricia et gynecologica Scandinavica, 1995, Volume: 74, Issue:6 Topics: Adult; Birth Weight; Blood Circulation; Blood Flow Velocity; Blood Pressure; Drug Evaluation; Female	1995
Ketanserin and hydralazine in hypertension in pregnancy--a randomised double-blind trial. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1995, Volume: 85, Issue:6 Topics: Adolescent; Adult; Blood Pressure; Double-Blind Method; Female; Humans; Hydralazine; Ketanserin; Pre	1995
Comparison of outcome of labetalol or hydralazine therapy during hypertension in pregnancy in very low birth weight infants. Acta obstetricia et gynecologica Scandinavica, 1993, Volume: 72, Issue:8 Topics: Adult; Female; Humans; Hydralazine; Infant, Low Birth Weight; Infant, Newborn; Labetalol; Pre-Eclamp	1993
[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. Ginecologia y obstetricia de Mexico, 1993, Volume: 61 Topics: Administration, Sublingual; Antihypertensive Agents; Apgar Score; Drug Evaluation; Eclampsia; Female	1993
Effect of antihypertensive therapy in preeclampsia on levels of serum interleukin-4. Gynecologic and obstetric investigation, 1996, Volume: 42, Issue:4 Topics: Adult; Antihypertensive Agents; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydralazine; Infu	1996
Oral nifedipine therapy in the management of severe preeclampsia. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1995, Volume: 49, Issue:3 Topics: Administration, Oral; Adult; Antihypertensive Agents; Female; Humans; Hydralazine; Infusions, Intrav	1995
Nifedipine or hydralazine as a first-line agent to control hypertension in severe preeclampsia. Acta obstetricia et gynecologica Scandinavica, 2002, Volume: 81, Issue:1 Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Nifedipine;	2002
[Management of severe pre-eclampsia in the puerperium. Comparative study of sublingual nifedipine and hydralazine]. Ginecologia y obstetricia de Mexico, 1991, Volume: 59 Topics: Administration, Sublingual; Adolescent; Adult; Antihypertensive Agents; Female; Humans; Hydralazine;	1991
Nifedipine in the treatment of severe preeclampsia. Obstetrics and gynecology, 1991, Volume: 77, Issue:3 Topics: Adult; Blood Pressure; Female; Humans; Hydralazine; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy	1991
Haemodynamic changes in gestational proteinuric hypertension: the effects of rapid volume expansion and vasodilator therapy. British journal of obstetrics and gynaecology, 1989, Volume: 96, Issue:6 Topics: Adult; Cardiac Output; Catheterization, Swan-Ganz; Dihydralazine; Female; Fluid Therapy; Hemodynamic	1989
A comparative trial of labetalol and hydralazine in the acute management of severe hypertension complicating pregnancy. Obstetrics and gynecology, 1987, Volume: 70, Issue:3 Pt 1 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; H	1987
Lumbar epidural analgesia in hypertensive patients during labour. European journal of obstetrics, gynecology, and reproductive biology, 1986, Volume: 22, Issue:1-2 Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Blood Pressure; Delivery, Obstetric; Female; Humans;	1986

Article	Year
Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women. African health sciences, 2023, Volume: 23, Issue:1 Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Hypotension; Lab	2023
Identification of factors associated with delayed treatment of obstetric hypertensive emergencies. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:2 Topics: Administration, Intravenous; Administration, Oral; Adult; After-Hours Care; Antihypertensive Agents;	2020
In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia. PloS one, 2014, Volume: 9, Issue:9 Topics: Activins; Angiogenic Proteins; Antigens, CD; Antihypertensive Agents; Chorionic Gonadotropin; Chorio	2014
Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low. Hypertension in pregnancy, 2016, Volume: 35, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension, Pregnancy	2016
Controversies Regarding Diagnosis and Treatment of Severe Hypertension in Pregnancy. Clinical obstetrics and gynecology, 2017, Volume: 60, Issue:1 Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Labetalol; Pre-E	2017
Postpartum preeclampsia: emergency department presentation and management. The Journal of emergency medicine, 2011, Volume: 40, Issue:4 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Antihypertensive Agents; Benzodiazepines; E	2011
Vascular endothelial growth factor receptor 1 (Flt1) and apoptosis in the preeclamptic placenta and effects of in vivo anti-hypertensive exposure. Hypertension in pregnancy, 2008, Volume: 27, Issue:4 Topics: Adult; Antihypertensive Agents; Apoptosis; Case-Control Studies; Clonidine; Female; Fetal Growth Ret	2008
Electrical velocimetry follows the hemodynamics of drug therapy and aortocaval compression in preeclampsia. International journal of obstetric anesthesia, 2011, Volume: 20, Issue:1 Topics: Adult; Antihypertensive Agents; Aorta; Blood Pressure; Cardiac Output; Cardiography, Impedance; Fema	2011
Effect of intravenous hydralazine infusion on maternal plasma nitric oxide levels in gestations complicated with severe preeclampsia: a pilot study. Archives of gynecology and obstetrics, 2012, Volume: 285, Issue:4 Topics: Adolescent; Adult; Antihypertensive Agents; Birth Weight; Blood Pressure; Female; Humans; Hydralazin	2012
The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. Anesthesia and analgesia, 2003, Volume: 96, Issue:2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Dopamine; Dose-Response Relation	2003
Interleukin-18 in the plasma of women with preeclampsia. American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:5 Topics: Adult; Antihypertensive Agents; Betamethasone; Case-Control Studies; Drug Therapy, Combination; Fema	2003
Fatal reaction to 1-hydrazinophthalazine (apresoline). American heart journal, 1953, Volume: 45, Issue:6 Topics: Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Sympatholytics	1953
Hemodynamic effects of 1-hydrazinophthalazine (apresoline) in human pregnancy: results of intravenous administration. The Journal of clinical investigation, 1953, Volume: 32, Issue:10 Topics: Administration, Intravenous; Female; Hemodynamics; Hydralazine; Pre-Eclampsia; Pregnancy; Sympatholy	1953
Effects of apresoline, veratrum alkaloids, high spinal anesthesia, and arfonad on renal hemodynamics of pregnant patients with toxemia and essential hypertension. Surgery, gynecology & obstetrics, 1953, Volume: 97, Issue:4 Topics: Anesthesia, Spinal; Essential Hypertension; Female; Hemodynamics; Hydralazine; Hypertension; Pre-Ecl	1953
Cerebral circulation and metabolism in toxemia of pregnancy; observations on the effects of veratrum viride and apresoline (1-hydrazinophthalazine). American journal of obstetrics and gynecology, 1953, Volume: 66, Issue:5 Topics: Brain; Cerebrovascular Circulation; Female; Hydralazine; Pre-Eclampsia; Pregnancy; Sympatholytics; V	1953
Apresoline (hydralazine hydrochloride) and its use in cases of hypertensive pregnancy. American journal of obstetrics and gynecology, 1954, Volume: 68, Issue:2 Topics: Eclampsia; Female; Hydralazine; Hypertension; Pre-Eclampsia; Pregnancy; Sympatholytics	1954
The clinical use of apresoline in the toxemias of pregnancy: a preliminary report. American journal of obstetrics and gynecology, 1954, Volume: 68, Issue:4 Topics: Female; Hydralazine; Pre-Eclampsia; Pregnancy; Sympatholytics; Toxemia	1954
Continuing vasodilator infusion therapy; utilization of a blend of 1-hydrazinophthalazine (apresoline) and cryptenamine (unitensen) in toxemia of pregnancy. Obstetrics and gynecology, 1954, Volume: 4, Issue:4 Topics: Female; Hydralazine; Pre-Eclampsia; Pregnancy; Protoveratrines; Sympatholytics; Vasodilator Agents;	1954
Further experience with apresoline in toxemia and hypertension of pregnancy. American journal of obstetrics and gynecology, 1956, Volume: 72, Issue:1 Topics: Female; Hydralazine; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Sepsis; Sympat	1956
[Treatment of gestosis by new hypotensive drugs]. Casopis lekaru ceskych, 1957, Jan-18, Volume: 96, Issue:3 Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Reserpine; Sympathol	1957
Antihypertension therapy in toxemia of pregnancy; a 30 month progress report. American journal of obstetrics and gynecology, 1957, Volume: 74, Issue:5 Topics: Female; Humans; Hydralazine; Hypertension; Pre-Eclampsia; Pregnancy; Research Report; Veratrum Alkal	1957
Hypotensive drugs in the management of toxemia of pregnancy. Postgraduate medicine, 1957, Volume: 22, Issue:4 Topics: Antihypertensive Agents; Disease Management; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy;	1957
[Nepresol therapy of eclampsia & pre-eclampsia]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1957, Nov-01, Volume: 77, Issue:21 Topics: Eclampsia; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Sympatholytics	1957
A clinical trial of intravenous apresoline in the management of toxaemia of late pregnancy. The Journal of obstetrics and gynaecology of the British Empire, 1958, Volume: 65, Issue:3 Topics: Bacterial Infections; Disease Management; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Sep	1958
Antihypertensive drugs in toxemia: a practical integrated plan of management. Obstetrics and gynecology, 1959, Volume: 13, Issue:2 Topics: Antihypertensive Agents; Bacterial Infections; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy	1959
[Can infant mortality in late pregnancy toxemia be reduced by treatment with hypotensive drugs]. Geburtshilfe und Frauenheilkunde, 1959, Volume: 19, Issue:5 Topics: Antihypertensive Agents; Bacterial Infections; Female; Hydralazine; Infant Mortality; Pre-Eclampsia;	1959
Treatment of severe toxemia of pregnancy with intravenous magnesium sulfate and apresoline. Obstetrics and gynecology, 1959, Volume: 14, Issue:2 Topics: Administration, Intravenous; Female; Humans; Hydralazine; Magnesium Sulfate; Pre-Eclampsia; Pregnanc	1959
[On the treatment of pre-eclampsia with Esidrex and Adelphan-Esidrex]. Wiener medizinische Wochenschrift (1946), 1961, Jun-10, Volume: 111 Topics: Chlorothiazide; Drug Combinations; Female; Hydralazine; Hydrazines; Hydrochlorothiazide; Pre-Eclamps	1961
Peripheral vascular response to hydralazine in toxemia of pregnancy. Obstetrics and gynecology, 1961, Volume: 18 Topics: Blood Vessels; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy	1961
PRE-ECLAMPTIC TOXAEMIA OF PREGNANCY AND THE USE OF ANTI-HYPERTENSIVE DRUGS. The Journal of the Egyptian Medical Association, 1963, Volume: 46 Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Hydrochlorothiazide; Pre-Eclampsia; Pregnancy;	1963
A SYSTEMATIC APPROACH TO THE THERAPY OF SEVERE PRE-ECLAMPSIA AND ECLAMPSIA. Connecticut medicine, 1963, Volume: 27 Topics: Abortion, Therapeutic; Anesthesia; Anesthesia, Obstetrical; Anticonvulsants; Antihypertensive Agents	1963
THE CONTINUING PROBLEM OF ECLAMPSIA. Surgery, gynecology & obstetrics, 1964, Volume: 118 Topics: Amobarbital; Antihypertensive Agents; Cesarean Section; Eclampsia; Female; Humans; Hydralazine; Hype	1964
[MEDICAL TREATMENT OF HYPERTENSIVE CRISES]. Ugeskrift for laeger, 1964, Apr-23, Volume: 126 Topics: Diuretics; Female; Ganglionic Blockers; Glomerulonephritis; Hexamethonium Compounds; Humans; Hydrala	1964
[THERAPEUTICS OF ARTERIAL HYPERTENSION IN PREGNANCY]. Revista de la Asociacion Medica Argentina, 1964, Volume: 78 Topics: Female; Guanethidine; Hibernation; Humans; Hydralazine; Hypertension; Hypothermia, Induced; Maternal	1964
CESAREAN SECTION IN THE ECLAMPTIC PATIENT ON ANTIHYPERTENSIVE THERAPY: A REVIEW OF FOURTEEN CASES. Southern medical journal, 1964, Volume: 57 Topics: Adolescent; Anesthesia; Antihypertensive Agents; Cesarean Section; Child; Drug Therapy; Eclampsia; F	1964
THE NEPHROTIC SYNDROME DUE TO PRE-ECLAMPTIC NEPHROPATHY; REPORT OF A CASE. Annals of internal medicine, 1964, Volume: 61 Topics: Blood Pressure; Blood Pressure Determination; Drug Therapy; Female; Humans; Hydralazine; Kidney Dise	1964
[TREATMENT OF PREGNANCY TOXICOSIS WITH ADELPHIN-ESIDREX-K]. Svenska lakartidningen, 1964, Oct-21, Volume: 61 Topics: Drug Therapy; Female; Hydralazine; Hydrochlorothiazide; Pre-Eclampsia; Pregnancy; Reserpine	1964
PROGRAM FOR TOXEMIA CONTROL: STUDY OF 551 CASES. American journal of obstetrics and gynecology, 1965, May-01, Volume: 92 Topics: Anticonvulsants; Delivery, Obstetric; Drug Therapy; Eclampsia; Female; Humans; Hydralazine; Pre-Ecla	1965
Hexamethonium chloride and apresoline in toxemia of pregnancy; a preliminary report. Obstetrics and gynecology, 1955, Volume: 5, Issue:3 Topics: Female; Hexamethonium; Hydralazine; Muscle Relaxants, Central; Pre-Eclampsia; Pregnancy; Sympatholyt	1955
Late postpartum eclampsia coincident with postdural puncture headache: a case report. AANA journal, 2003, Volume: 71, Issue:5 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anticonvulsants; Antihypertensive Agents; Bloo	2003
Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance. Journal of perinatal medicine, 2004, Volume: 32, Issue:4 Topics: Adult; Antihypertensive Agents; Dose-Response Relationship, Drug; Female; Fetus; Humans; Hydralazine	2004
Magnesium sulphate therapy in women with pre-eclampsia and eclampsia in Kuwait. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2008, Volume: 17, Issue:3 Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Drug Therapy, Combination; Eclampsia; Fema	2008
Medical grand rounds from the University of Alabama Medical Center. Southern medical journal, 1967, Volume: 60, Issue:6 Topics: Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Pregnancy in Diabetics	1967
Therapeutic regime on pregnancy induced hypertension. Clinical and experimental hypertension. Part B, Hypertension in pregnancy, 1982, Volume: 1, Issue:4 Topics: Dextrans; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydralazine; Hypertension; I	1982
[Hemodynamic response to hydralazine in pregnant women with hypertension]. Ginekologia polska, 1984, Volume: 55, Issue:3 Topics: Female; Hemodynamics; Humans; Hydralazine; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complic	1984
Acute effect of dihydralazine on uteroplacental blood flow in hypertension during pregnancy. Gynecologic and obstetric investigation, 1983, Volume: 16, Issue:5 Topics: Blood Pressure; Dihydralazine; Female; Heart Rate; Humans; Hydralazine; Hypertension; Placenta; Pre-	1983
[Acute liver disease during treatment of severe preeclampsia]. Harefuah, 1983, May-01, Volume: 104, Issue:9 Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Liver Dis	1983
Intrapartum treatment of preeclamptic hypertension by ketanserin--a serotonin receptor antagonist. American journal of obstetrics and gynecology, 1984, Jul-01, Volume: 149, Issue:5 Topics: Adult; Antihypertensive Agents; Delivery, Obstetric; Female; Humans; Hydralazine; Hypertension; Infa	1984
Severe consequence of hypertension in pregnancy. American journal of obstetrics and gynecology, 1983, Jan-01, Volume: 145, Issue:1 Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Hypertension; Pre-Eclampsia; Pr	1983
Eclampsia: treatment and referral. Southern medical journal, 1982, Volume: 75, Issue:3 Topics: Adolescent; Adult; Delivery, Obstetric; Eclampsia; Female; Humans; Hydralazine; Infant Mortality; In	1982
[Significance & treatment of abnormal blood viscosities in pre-eclamptic patients (author's transl)]. Nihon Sanka Fujinka Gakkai zasshi, 1982, Volume: 34, Issue:5 Topics: Adenosine Triphosphate; Adult; Blood Viscosity; Blood Volume Determination; Erythrocyte Count; Femal	1982
Preeclampsia and eclampsia. The Western journal of medicine, 1981, Volume: 135, Issue:1 Topics: Adult; Diazoxide; Eclampsia; Female; Humans; Hydralazine; Magnesium Sulfate; Pre-Eclampsia; Pregnanc	1981
Hydralazine-induced neonatal thrombocytopenia. The New England journal of medicine, 1980, Nov-20, Volume: 303, Issue:21 Topics: Adult; Female; Humans; Hydralazine; Hypertension; Infant, Newborn; Infant, Newborn, Diseases; Pre-Ec	1980
Depressed sodium-calcium exchange in human umbilical arteries from women with preeclampsia. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:2 Topics: Adult; Blood Pressure; Calcium; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Sodium; Umbil	1995
Hydralazine boluses for the treatment of severe hypertension in pre-eclampsia. British journal of obstetrics and gynaecology, 1995, Volume: 102, Issue:7 Topics: Female; Humans; Hydralazine; Hypertension; Pre-Eclampsia; Pregnancy; Randomized Controlled Trials as	1995
Pre-eclampsia and gestational age differently alter binding of endothelin-1 to placental and trophoblast membrane preparations. Molecular and cellular endocrinology, 1995, Apr-28, Volume: 110, Issue:1-2 Topics: Adult; Cell Membrane; Endothelins; Female; Humans; Hydralazine; Placenta; Pre-Eclampsia; Pregnancy;	1995
Pre-eclampsia and hypertension in pregnancy. Current therapy in endocrinology and metabolism, 1994, Volume: 5 Topics: Antihypertensive Agents; Contraindications; Female; Guidelines as Topic; Hospitalization; Humans; Hy	1994
Hydralazine boluses for the treatment of severe hypertension in pre-eclampsia. British journal of obstetrics and gynaecology, 1995, Volume: 102, Issue:1 Topics: Female; Humans; Hydralazine; Hypertension; Pre-Eclampsia; Pregnancy	1995
Hydralazine injection still available. American journal of hospital pharmacy, 1994, Dec-15, Volume: 51, Issue:24 Topics: Female; Humans; Hydralazine; Injections, Intravenous; Pre-Eclampsia; Pregnancy; United States	1994
Hydralazine boluses for the treatment of severe hypertension in pre-eclampsia. British journal of obstetrics and gynaecology, 1994, Volume: 101, Issue:5 Topics: Adult; Blood Pressure; Clinical Protocols; Female; Gestational Age; Humans; Hydralazine; Hydrogen-Io	1994
Periarterial lidocaine/hydralazine aids arterial catheter insertion in patients with preeclampsia. Anesthesiology, 1993, Volume: 79, Issue:2 Topics: Arteries; Catheterization, Peripheral; Female; Humans; Hydralazine; Lidocaine; Pre-Eclampsia; Pregna	1993
Neonatal adaptation in hypertensive pregnancy--a study of labetalol vs hydralazine treatment. Journal of perinatal medicine, 1993, Volume: 21, Issue:1 Topics: Adolescent; Adult; Female; Fetal Hypoxia; Hemodynamics; Humans; Hydralazine; Infant, Newborn; Labeta	1993
Cyclic guanosine 3',5' monophosphate concentrations in pre-eclampsia: effects of hydralazine. British journal of obstetrics and gynaecology, 1996, Volume: 103, Issue:1 Topics: Adult; Arginine; Birth Weight; Blood Pressure; Cyclic GMP; Female; Humans; Hydralazine; Nitric Oxide	1996
Low-dose dopamine in treating acute renal failure caused by preeclampsia. Gynecologic and obstetric investigation, 1996, Volume: 42, Issue:2 Topics: Acute Kidney Injury; Adult; Antihypertensive Agents; Blood Urea Nitrogen; Cesarean Section; Creatini	1996
Anticardiolipin antibodies and the severity of preeclampsia-eclampsia. Gynecologic and obstetric investigation, 1999, Volume: 48, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Antibodies, Anticardiolipin; Antihypertensive Agents; Cross-Sectiona	1999
Pre-eclampsia is associated with marked alterations in sleep architecture. Sleep, 2000, Aug-01, Volume: 23, Issue:5 Topics: Adult; Antihypertensive Agents; Clonidine; Electroencephalography; Electrooculography; Female; Human	2000
Factor analysis, including antihypertensive medication, of the outcome of pregnancy in pregnancy-associated hypertension. Kidney & blood pressure research, 2001, Volume: 24, Issue:2 Topics: Antihypertensive Agents; Apgar Score; Cesarean Section; Comorbidity; Disease Susceptibility; Female;	2001
Antihypertensive treatment decreased serum leptin levels in severe preeclampsia during pregnancy. Annals of nutrition & metabolism, 2001, Volume: 45, Issue:5 Topics: Adult; Antihypertensive Agents; Body Mass Index; Enzyme-Linked Immunosorbent Assay; Female; Gestatio	2001
[Value of hydralazine-beta blockader association in hypertension of pregnancy]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1978, Volume: 23, Issue:9 Topics: Adrenergic beta-Antagonists; Adult; Drug Therapy, Combination; Female; Fetus; Humans; Hydralazine; H	1978
Evaluation of a program of bed rest in the treatment of chronic hypertension in pregnancy. Obstetrics and gynecology, 1979, Volume: 53, Issue:3 Topics: Bed Rest; Birth Weight; Chronic Disease; Female; Fetal Death; Humans; Hydralazine; Hypertension; Inf	1979
Hypertensive emergencies. The Medical clinics of North America, 1979, Volume: 63, Issue:1 Topics: Adrenal Gland Neoplasms; Angiotensin II; Animals; Aortic Aneurysm; Aortic Dissection; Brain Diseases	1979
Glucocorticoid therapy for the induction of pulmonary maturity in severely hypertensive gravid women. American journal of obstetrics and gynecology, 1979, Feb-15, Volume: 133, Issue:4 Topics: Betamethasone; Female; Humans; Hydralazine; Hypertension; Infant, Newborn; Labor, Induced; Pre-Eclam	1979
Pre-eclampsia and eclampsia. Tropical doctor, 1978, Volume: 8, Issue:4 Topics: Anesthesia, Obstetrical; Bed Rest; Cesarean Section; Delivery, Obstetric; Eclampsia; Female; Humans;	1978
Management of severe preeclampsia and eclampsia. Seminars in perinatology, 1978, Volume: 2, Issue:1 Topics: Adolescent; Adult; Delivery, Obstetric; Eclampsia; Female; Humans; Hydralazine; Magnesium Sulfate; P	1978
Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy. Gynecologic investigation, 1978, Volume: 9, Issue:4 Topics: Apgar Score; Drug Evaluation; Drug Therapy, Combination; Female; Fetal Growth Retardation; Fetus; Hu	1978
The management of severe pre-eclampsia and eclampsia. British journal of anaesthesia, 1977, Volume: 49, Issue:1 Topics: Chlormethiazole; Delivery, Obstetric; Diazepam; Diuretics; Eclampsia; Female; Humans; Hydralazine; H	1977
Drugs used in the management of toxemia of pregnancy. Clinical obstetrics and gynecology, 1977, Volume: 20, Issue:2 Topics: Anticonvulsants; Antihypertensive Agents; Barbiturates; Benzothiadiazines; Blood Volume; Diazepam; D	1977
The treatment of gestational hypertension. The Journal of reproductive medicine, 1975, Volume: 15, Issue:5 Topics: Antihypertensive Agents; Chronic Disease; Diazoxide; Female; Humans; Hydralazine; Hypertension; Hype	1975
[Reduction of the arterial pressure with the help of dihydralazin in late toxemia of pregnancy]. Akusherstvo i ginekologiia, 1975, Issue:11 Topics: Blood Pressure; Dihydralazine; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy	1975
[Antepartum CTG: extreme growth retardation and choice of delivery time]. Der Gynakologe, 1992, Volume: 25, Issue:1 Topics: Adult; Cardiotocography; Delivery, Obstetric; Female; Fetal Growth Retardation; Gestational Age; Hum	1992
How do perinatologists manage preeclampsia? American journal of perinatology, 1991, Volume: 8, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure Determination; Data Collection; Delivery, Obstetr	1991
Should continuous hydralazine infusions be utilized in severe pregnancy-induced hypertension? American journal of perinatology, 1991, Volume: 8, Issue:3 Topics: Apgar Score; Blood Pressure; Female; Fetal Distress; Hemodynamics; Humans; Hydralazine; Infant, Newb	1991
Implications of sino-aortic baroreceptor reflex dysfunction in severe preeclampsia. Obstetrics and gynecology, 1989, Volume: 74, Issue:1 Topics: Adult; Blood Pressure; Cardiac Output; Female; Heart Rate; Hemodynamics; Humans; Hydralazine; Pre-Ec	1989
Elevated blood pressure during pregnancy. Hospital practice (Office ed.), 1986, Feb-15, Volume: 21, Issue:2 Topics: Adult; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Me	1986
The management of severe preeclampsia with intravenous magnesium sulphate, hydralazine and central venous catheterization. The Australian & New Zealand journal of obstetrics & gynaecology, 1987, Volume: 27, Issue:2 Topics: Acute Disease; Catheterization, Central Venous; Drug Therapy, Combination; Female; Humans; Hydralazi	1987
Fetal distress after hydralazine therapy for severe pregnancy-induced hypertension. Southern medical journal, 1986, Volume: 79, Issue:5 Topics: Acute Disease; Cesarean Section; Eclampsia; Female; Fetal Distress; Gestational Age; Humans; Hydrala	1986
[Studies of heart function using apex cardiography in pregnancy-induced hypertension before and following therapy with dihydralazine sulfate]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1986, Apr-15, Volume: 41, Issue:8 Topics: Blood Pressure; Dihydralazine; Female; Hemodynamics; Humans; Hydralazine; Kinetocardiography; Myocar	1986
Effects of dihydralazine infusion on the fetoplacental blood flow and maternal prostanoids. Obstetrics and gynecology, 1985, Volume: 65, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Blood Pressure; Dihydralazine; Female; Fetal Heart; Humans; Hydralazin	1985
Severe preeclampsia with persistent postpartum hemolysis and thrombocytopenia treated by plasmapheresis. Obstetrics and gynecology, 1985, Volume: 65, Issue:3 Suppl Topics: Adult; Anemia, Hemolytic; Aspartate Aminotransferases; Blood Transfusion; Blood Urea Nitrogen; Femal	1985
Maternal and perinatal outcome of conservative management of severe preeclampsia in midtrimester. American journal of obstetrics and gynecology, 1985, May-01, Volume: 152, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bed Rest; Birth Weight; Delivery, Obstetric; Diuretic	1985
Hypertension in pregnancy. A study of 142 women presenting before 32 weeks' gestation. The Medical journal of Australia, 1985, Jul-08, Volume: 143, Issue:1 Topics: Antihypertensive Agents; Clonidine; Diazoxide; Female; Humans; Hydralazine; Hypertension; Infant Mor	1985
Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion. American journal of obstetrics and gynecology, 1985, Sep-15, Volume: 153, Issue:2 Topics: Adult; Autonomic Nervous System Diseases; Cesarean Section; Female; Humans; Hydralazine; Obstetric L	1985
Hemodynamic effects of intravenous hydralazine in pregnant women with severe hypertension. Obstetrics and gynecology, 1985, Volume: 66, Issue:4 Topics: Blood Pressure; Body Surface Area; Cardiac Output; Echocardiography; Female; Hemodynamics; Humans; H	1985
Management of severe hypertension. The American journal of cardiology, 1973, Sep-20, Volume: 32, Issue:4 Topics: Benzothiadiazines; Blood Pressure; Clonidine; Diazoxide; Diet, Sodium-Restricted; Disseminated Intra	1973
A critical survey of drugs used in the treatment of hypertensive crises of pregnancy. The Medical journal of Australia, 1974, Aug-17, Volume: 2, Issue:7 Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Barbiturates; Chlormethiazole; Clonidine; Diazepam;	1974
[Pregnancy toxemia. Mechanism, prevention and treatment]. La Revue du praticien, 1974, Nov-11, Volume: 24, Issue:51 Topics: Blood Coagulation Disorders; Diet, Sodium-Restricted; Diuretics; Eclampsia; Edema; Female; Hospitali	1974
Intravenous chlormethiazole in the management of severe pre-eclampsia. The Australian & New Zealand journal of obstetrics & gynaecology, 1973, Volume: 13, Issue:3 Topics: Adolescent; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Apgar Score; Chlormethiazole; Chlo	1973
The use of diazepam and hydrallazine in the treatment of severe pre-eclampsia. The Journal of obstetrics and gynaecology of the British Commonwealth, 1972, Volume: 79, Issue:3 Topics: Adult; Blood Pressure; Diazepam; Ethanol; Female; Gestational Age; Humans; Hydralazine; Hypothermia;	1972
The management of hypertension during pregnancy. The Journal of reproductive medicine, 1972, Volume: 8, Issue:2 Topics: Adolescent; Adult; Blood Pressure; Clinical Laboratory Techniques; Diagnosis, Differential; Dihydrox	1972
[Therapy of EPH gestosis]. Deutsche medizinische Wochenschrift (1946), 1973, Jul-06, Volume: 98, Issue:27 Topics: Chlorthalidone; Diazepam; Diet Therapy; Eclampsia; Edema; Female; Furosemide; Guanethidine; Humans;	1973
Diuretic-hypotensive therapy and fetal prognosis in toxaemia of pregnancy. 1. Fetal prognosis in 705 selected cases. Annales chirurgiae et gynaecologiae Fenniae, 1973, Volume: 62, Issue:3 Topics: Acetazolamide; Ammonium Chloride; Antihypertensive Agents; Barbiturates; Birth Weight; Chlorothiazid	1973
Active management of severe pre-eclampsia. Canadian Medical Association journal, 1973, Dec-15, Volume: 109, Issue:12 Topics: Adult; Animals; Apgar Score; Birth Weight; Delivery, Obstetric; Diazepam; Female; Fetal Death; Human	1973
Effect of toxemia therapy on uterine dynamics. American journal of obstetrics and gynecology, 1969, Sep-01, Volume: 105, Issue:1 Topics: Amniotic Fluid; Animals; Arteries; Blood Pressure; Eclampsia; Female; Haplorhini; Humans; Hydralazin	1969
[Therapy of pregnancy toxemias (EPH-gestosis, preeclampsia)]. Deutsche medizinische Wochenschrift (1946), 1972, Apr-28, Volume: 97, Issue:17 Topics: Blood Pressure Determination; Chlorpromazine; Dextrans; Diazepam; Diet Therapy; Edema; Female; Human	1972
[Indication for cesarean section: pregnancy toxemia]. Sanfujinka no jissai. Practice of gynecology and obstetrics, 1972, Volume: 21, Issue:1 Topics: Adult; Cesarean Section; Chlorpromazine; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Rese	1972
Coexistent trophoblastic tumor and viable pregnancy. Obstetrics and gynecology, 1971, Volume: 38, Issue:6 Topics: Adult; Choriocarcinoma; Chorionic Gonadotropin; Female; Humans; Hydatidiform Mole; Hydralazine; Hype	1971
[Cerebral anoxia during treatment of severe toxemias with hypotensive infusion]. Ugeskrift for laeger, 1969, Nov-06, Volume: 131, Issue:45 Topics: Adult; Chlorpromazine; Female; Humans; Hydralazine; Hypoxia, Brain; Pre-Eclampsia; Pregnancy	1969
Aggressive toxemia management (preeclampsia and eclampsia). Obstetrics and gynecology, 1969, Volume: 33, Issue:5 Topics: Antihypertensive Agents; Cesarean Section; Female; Humans; Hydralazine; Magnesium Sulfate; Pre-Eclam	1969

hydralazine and Pre-Eclampsia

Research Excerpts

Research

Studies (151)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Muhammad, S	1
Usman, H	1
Dawha, YM	1
Yahya, A	1
Yekeen, A	1
Bako, B	1
S, D	1
Novri, DA	1
Hamidy, Y	1
Savira, M	1
Kausar, M	1
Husain, S	1
Hussain, R	1
Bhat, AD	1
Keasler, PM	1
Kolluru, L	1
Dombrowski, MM	1
Palanisamy, A	1
Singh, PM	1
Kantorowska, A	1
Heiselman, CJ	1
Halpern, TA	1
Akerman, MB	1
Elsayad, A	1
Muscat, JC	1
Sicuranza, GB	1
Vintzileos, AM	1
Heo, HJ	1
Amaral, LM	1
Wallace, K	1
Owens, M	1
LaMarca, B	1
Watson, K	1
Broscious, R	1
Devabhakthuni, S	1
Noel, ZR	1
Leavitt, K	1
Običan, S	1
Yankowitz, J	1
Alexander, JM	1
Wilson, KL	1
Arulkumaran, N	1
Lightstone, L	1
Gangooly, S	1
Muttukrishna, S	1
Jauniaux, E	1
Vadhera, RB	1
Simon, M	1
Olson-Chen, C	1
Seligman, NS	1
Sharma, KJ	1
Rodriguez, M	1
Kilpatrick, SJ	1
Greene, N	1
Aghajanian, P	1
Barton, JR	1
Sibai, BM	5
Yancey, LM	1
Withers, E	1
Bakes, K	1
Abbott, J	1
Machaalani, R	1
Makris, A	1
Thornton, C	1
Hennessy, A	1
McCoy, S	1
Baldwin, K	1
Archer, TL	1
Conrad, BE	1
Teran, E	1
Briones, F	1
Nicolalde, V	1
Vivero, S	1
Chedraui, P	1
Pérez-López, FR	1
Liu, QQ	1
Yu, YH	1
Gong, SP	1
Huang, LP	1
Sato, N	1
Tanaka, KA	1
Szlam, F	1
Tsuda, A	1
Arias, ME	1
Levy, JH	1
Adams, KM	1
Mandel, LS	1
Guthrie, KA	1
Atkinson, MW	1
COHEN, BM	1
ASSALI, NS	2
KAPLAN, S	1
OIGHENSTEIN, S	1
SUYEMOTO, R	1
KAPLAN, SA	1
McCALL, ML	2
JORDAN, WK	1
CHAPMAN, ER	1
STROZIER, WE	1
MAGEE, RA	1
RIVA, HL	1
PICKHARDT, WL	1
HOLZWORTH, RH	1
SHERMAN, RL	1
TALAS, M	1
HECZKO, P	1
VASKOVA, M	1
FARRIS, C	1
KRUPP, PJ	1
BRYANT, RD	1
SUNDFOR, H	1
JOHNSON, GT	1
THOMPSON, RB	1
GRODY, MH	1
BECK, L	1
MOLUMPHY, PE	1
GARCIA, R	1
HOPFGARTNER, A	1
TACCHI, D	1
KAMAL, I	1
DAVIS, CD	1
NEWTON, M	1
KROGSGAARD, AR	1
URANGAIMAZ, FA	2
TONNELIER, E	1
KLAUER, D	1
CHEKERDEMIAN, M	1
ALEXANDER, JA	2
ROGERS, SF	2
JACOBS, WM	1
WILLS, SH	1
SARLES, HE	1
HERRING, ME	1
WATSON, TF	1
GREGORY, RL	1
REMMERS, AR	1
BELONOSCHKIN, B	1
MACLAVERTY, MP	1
PAVLIC, RS	1
SMITH, CJ	1
ASHE, JR	1
THOMAS, WL	1
Winston, AW	1
Norman, D	1
Houlihan, DD	1
Dennedy, MC	1
Ravikumar, N	1
Morrison, JJ	1
Omu, AE	2
Al-Harmi, J	1
Vedi, HL	1
Mlechkova, L	1
Sayed, AF	1
Al-Ragum, NS	1
Kreisberg, RA	1
Morgan, J	1
Carmichael, E	1
Pittman, J	1
Chesley, LC	1
Liu, TL	1
Knuppel, RA	1
Montenegro, R	1
Tullio, D	1
Redman, CW	4
Skret, A	2
Kuźniar, J	2
Piela, A	2
Zaczek, T	2
Szmigiel, Z	2
Lunell, NO	1
Lewander, R	1
Nylund, L	1
Sarby, B	1
Thornström, S	1
Hod, M	2
Friedman, S	2
Theodor, E	1
Ovadia, J	3
Weiner, CP	1
Gelfan, R	1
Socol, ML	1
Berkowitz, RL	2
Pritchard, JA	2
McCubbin, JH	1
Anderson, GD	3
Dilts, PV	1
Karasawa, T	1
Hayano, Y	1
Imai, N	1
Garden, A	1
Davey, DA	2
Dommisse, J	2
Welt, SI	1
Dorminy, JH	1
Jelovsek, FR	1
Crenshaw, MC	1
Gall, SA	1
Widerlöv, E	1
Karlman, I	1
Storsäter, J	1
Sato, K	1
Kojima, M	1
Dohi, Y	1
Gudmundsson, S	1
Gennser, G	1
Marsal, K	1
Duley, L	2
Rossouw, HJ	1
Howarth, G	1
Odendaal, HJ	1
Cervar, M	1
Kainer, F	1
Desoye, G	1
Levin, AC	1
Doering, PL	1
Hatton, RC	1
Hsueh, WA	1
Bowlby, H	1
Paterson-Brown, S	1
Robson, SC	1
Redfern, N	1
Walkinshaw, SA	1
de Swiet, M	1
Hjertberg, R	2
Faxelius, G	2
Belfrage, P	1
Pue, AF	1
Walss Rodriguez, RJ	2
Flores Padilla, LM	1
Lagercrantz, H	1
López-Jaramillo, P	1
Narváez, M	1
Calle, A	1
Rivera, J	1
Jácome, P	1
Ruano, C	1
Nava, E	1
Nasu, K	1
Yoshimatsu, J	1
Anai, T	1
Miyakawa, I	1
Makhseed, M	1
al-Qattan, F	1
Suzuki, H	1
Kwawukume, EY	1
Ghosh, TS	1
Martínez-Abundis, E	1
González-Ortiz, M	1
Cortés-Llamas, V	1
Salazar-Páramo, M	1
Edwards, N	1
Blyton, CM	1
Kesby, GJ	1
Wilcox, I	1
Sullivan, CE	1
Hussein, M	1
Mooij, JM	1
Roujouleh, H	1
Anato, V	1
Garmendia, JV	1
Bianco, NE	1
De Sanctis, JB	1
Aali, BS	1
Nejad, SS	1
Monnier, JC	1
Honore, P	1
Lanciaux, B	1
Boulogne, M	1
Romankiewicz, JA	1
Curet, LB	1
Olson, RW	1
Becker, CE	1
Benowitz, NL	1
Nochimson, DJ	1
Petrie, RH	1
Armon, PJ	1
Sandström, B	1
Hibbard, BM	1
Rosen, M	1
Kelly, JV	1
Woods, JR	1
Brinkman, CR	1
Shvarts, R	1
Rettske, U	1
Baumann, P	1
Künzel, W	1
Catanzarite, V	1
Quirk, JG	1
Aisenbrey, G	1
Villarreal Ordaz, F	1
Fenakel, K	1
Fenakel, G	1
Appelman, Z	1
Lurie, S	1
Katz, Z	1
Shoham, Z	1
Kirshon, B	2
Wasserstrum, N	2
Cotton, DB	2
Derham, RJ	1
Robinson, J	1
Rossavik, IK	1
Willis, RS	1
Moise, KJ	1
Belfort, M	1
Uys, P	1
Chervenak, FA	1
Gallery, ED	1
Naden, RP	1
Rubin, PC	1
Sullivan, JM	1
Mabie, WC	1
Gonzalez, AR	1
Amon, E	1
Reti, LL	1
Ross, A	1
Kloss, M	1
Paull, J	1
Markman, L	1
Spinnato, JA	2
Neri, A	1
Nitke, S	1
Lachman, E	1
Rading, A	1
Kehrbein, C	1
Benndorf, S	1
Steinig, G	1
Nahrendorf, W	1
Weidler, B	1
Jouppila, P	1
Kirkinen, P	1
Koivula, A	1
Ylikorkala, O	1
Schwartz, ML	1
Brenner, W	1
Taslimi, M	1
Abdella, TN	1
Brooks, TF	1
Horvath, JS	1
Korda, A	1
Child, A	1
Henderson-Smart, D	1
Phippard, A	1
Duggin, GG	1
Hall, BM	1
Tiller, DJ	1
Gimovsky, ML	1
Ojeda, A	1
Ozaki, R	1
Zerne, S	1
Kincaid-Smith, P	1
Martin, JD	1
Leroux-Robert, C	1
Beaufils, M	1
Richet, G	1
Tischler, E	1
Joyce, DN	1
Kenyon, VG	1
Wilber, JA	1
Haller, J	1
Eklöf-Slangus, S	1
Baskett, TF	1
Bradford, CR	1
Tucker, RM	1
Hunt, JC	1
Harbert, GM	1
Cornell, GW	1
Thornton, WN	1
Graf, H	1
Nohira, T	1
Hohe, PT	1
Cochrane, CR	1
Gmelich, JT	1
Austin, JA	1
Jorring, K	1
Flowers, CE	1