hydralazine has been researched along with Myocardial Ischemia in 10 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of the calcium channel blockers, verapamil and nifedipine on myocardial ischaemia and oedema evoked by endothelin-1 (ET-1) or IRL 1620, an ETB receptor-selective agonist were studied in anaesthetized and conscious rats." | 7.69 | Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat. ( Filep, JG; Földes-Filep, E; Fournier, A; Skrobik, Y, 1996) |
| " The effects of the calcium channel blockers, verapamil and nifedipine on myocardial ischaemia and oedema evoked by endothelin-1 (ET-1) or IRL 1620, an ETB receptor-selective agonist were studied in anaesthetized and conscious rats." | 3.69 | Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat. ( Filep, JG; Földes-Filep, E; Fournier, A; Skrobik, Y, 1996) |
| "Effects of reduction of blood pressure and regression of left ventricular hypertrophy following hydralazine and captopril therapy on ischemic cardiac function and myocardial metabolism were studied in spontaneously hypertensive rats (SHR)." | 3.68 | Effect of regression of cardiac hypertrophy on ischemic myocardial damage in spontaneously hypertensive rats. ( Abe, M; Haneda, T; Okamoto, K, 1993) |
| "Hydralazine is an efficient reactive oxygen species (ROS) scavenger and an inhibitor of O2- generation." | 2.43 | The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine. ( Daiber, A; Hink, U; Mollnau, H; Mülsch, A; Münzel, T; Oelze, M; Warnholtz, A, 2005) |
| "Heart failure is an established predictor of primary cardiac events during pregnancy." | 1.40 | Treatment of pre-existing cardiomyopathy during pregnancy. ( Ascoop, AK; De Backer, J; De Pauw, M; Gevaert, S; Roelens, K; Tromp, F, 2014) |
| "Treatment with captopril significantly reduced the incidence of VT/Vf although hydralazine failed to reduce the incidence." | 1.29 | [Effect of chronic antihypertensive treatment on ischemia-induced lethal ventricular tachyarrhythmias and electrophysiological property in hypertrophied rat hearts]. ( Yokoshiki, H, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gevaert, S | 1 |
| De Pauw, M | 1 |
| Tromp, F | 1 |
| Ascoop, AK | 1 |
| Roelens, K | 1 |
| De Backer, J | 1 |
| Nako, H | 1 |
| Kataoka, K | 1 |
| Koibuchi, N | 1 |
| Dong, YF | 1 |
| Toyama, K | 1 |
| Yamamoto, E | 1 |
| Yasuda, O | 1 |
| Ichijo, H | 1 |
| Ogawa, H | 1 |
| Kim-Mitsuyama, S | 1 |
| Dikow, R | 1 |
| Kihm, LP | 1 |
| Zeier, M | 1 |
| Kapitza, J | 1 |
| Törnig, J | 1 |
| Amann, K | 1 |
| Tiefenbacher, C | 1 |
| Ritz, E | 1 |
| Daiber, A | 1 |
| Mülsch, A | 1 |
| Hink, U | 1 |
| Mollnau, H | 1 |
| Warnholtz, A | 1 |
| Oelze, M | 1 |
| Münzel, T | 1 |
| Yokoshiki, H | 1 |
| Okamoto, K | 1 |
| Abe, M | 1 |
| Haneda, T | 1 |
| Filep, JG | 1 |
| Skrobik, Y | 1 |
| Fournier, A | 1 |
| Földes-Filep, E | 1 |
| Martins, S | 1 |
| do Rosário, L | 1 |
| Soares, RM | 1 |
| Sequeira, A | 1 |
| Sousa, MJ | 1 |
| Sousa, L | 1 |
| Oliveira, M | 1 |
| Ferreira, R | 1 |
| Branco, L | 1 |
| Ferreira, L | 1 |
| Ramos, S | 1 |
| Antunes, AM | 1 |
| Bassenge, E | 1 |
| Sommer, O | 1 |
| Schwemmer, M | 1 |
| Bünger, R | 1 |
| Cohen, JD | 1 |
1 review available for hydralazine and Myocardial Ischemia
| Article | Year |
|---|---|
The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine.
Topics: Animals; Clinical Trials as Topic; Coronary Angiography; Disease Models, Animal; Dose-Response Relat | 2005 |
9 other studies available for hydralazine and Myocardial Ischemia
| Article | Year |
|---|---|
Treatment of pre-existing cardiomyopathy during pregnancy.
Topics: Adult; Antihypertensive Agents; Cardiomyopathy, Dilated; Female; Follow-Up Studies; Heart Failure; H | 2014 |
Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Biphenyl Compounds; Blood Pressure; Blo | 2012 |
Increased infarct size in uremic rats: reduced ischemia tolerance?
Topics: Animals; Body Weight; Coronary Vessels; Heart Ventricles; Hydralazine; Imidazoles; Ischemia; Male; M | 2004 |
[Effect of chronic antihypertensive treatment on ischemia-induced lethal ventricular tachyarrhythmias and electrophysiological property in hypertrophied rat hearts].
Topics: Action Potentials; Animals; Captopril; Drug Administration Schedule; Electrophysiology; Hemodynamics | 1993 |
Effect of regression of cardiac hypertrophy on ischemic myocardial damage in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Captopril; Hydralazine; Hypertrophy, Left Ventricular; In Vitro Techniques; | 1993 |
Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat.
Topics: Albumins; Animals; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Edema | 1996 |
[The influence of therapy (sympathomimetic amines versus vasodilators) in the indexes of ejection fraction derived from an analysis of Doppler aortic flow].
Topics: Captopril; Cardiomyopathy, Dilated; Dobutamine; Dopamine; Echocardiography, Doppler; Female; Humans; | 1998 |
Antioxidant pyruvate inhibits cardiac formation of reactive oxygen species through changes in redox state.
Topics: Animals; Antioxidants; Coumaric Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea P | 2000 |
Abnormal electrocardiograms and cardiovascular risk: role of silent myocardial ischemia. Evidence from MRFIT.
Topics: Adult; Antihypertensive Agents; Chlorthalidone; Cholesterol, Dietary; Coronary Disease; Electrocardi | 1992 |