hydralazine has been researched along with Muscle Contraction in 59 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Excerpt | Relevance | Reference |
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"We studied the effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam (a dopamine D1-agonist) on isolated human umbilical arteries (HUA) from patients classified as normotensive and with pregnancy-induced hypertension (PIH)." | 3.72 | The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. ( Arias, ME; Levy, JH; Sato, N; Szlam, F; Tanaka, KA; Tsuda, A, 2003) |
" Budralazine was orally effective against various types of hypertension in rats and it, like reserpine but unlike hydralazine, produced a much greater pressure reduction in hypertensive than in normotensive rats." | 3.66 | Pharmacology of budralazine, a new antihypertensive drug. ( Akashi, A; Chiba, T; Hashimoto, H; Suzuki, I, 1978) |
"Hydralazine is a hydrazine derivative used clinically as a vasodilator and antihypertensive agent." | 1.32 | Effects of hydrazine derivatives on vascular smooth muscle contractility, blood pressure and cGMP production in rats: comparison with hydralazine. ( Alvarez, E; Fernández, G; Medina, M; Orallo, F; Vidrio, H, 2003) |
"Treatment with ramipril reduced blood pressure and force development in response to Bay K8644 in adult SHRSP, although not to levels of WKY rats, whereas WKY rats were unaffected by treatment." | 1.29 | Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats. ( Traub, O; Webb, RC, 1993) |
"The combination of hydralazine and nitrates has been shown to provide long-term benefit in congestive heart failure, despite a nitrate dosage that should induce tolerance." | 1.29 | Interaction between hydralazine and nitrovasodilators in vascular smooth muscle. ( Berkenboom, G; Fontaine, J; Unger, P, 1993) |
"Amlodipine is a dihydropyridine that blocks L-type channels, thereby preventing entry of Ca2+ into the muscle." | 1.29 | Effect of chronic blood pressure reduction on soleus muscle contractile properties in spontaneously hypertensive rats. ( Atherley, R; Carlsen, RC; Gray, SD, 1994) |
"Hydralazine (0." | 1.28 | Comparison of the effects of hydralazine and nifedipine on contractions and 45Ca influx of rat aorta. ( Bardán, B; Calleja, JM; Gil-Longo, J; Orallo, F, 1991) |
"Phentolamine (10(-6) M) pretreatment had no effect on the ouabain-induced contraction but partially suppressed it in both SHR and WKY aortas when diltiazem (10(-5) M) was also added." | 1.27 | Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine. ( Iwasaki, T; Kawai, Y; Miyata, S; Morita, S; Nagai, K, 1988) |
" Substantially, cadralazine does not exert any effect on cumulative dose-response curves of these agonists in both vessel preparations even with the highest concentration of 10(-4) mol/l." | 1.27 | Effects of cadralazine on contractions induced by norepinephrine, serotonin, angiotensin II and K+ in rabbit aortic and renal arterial strips. ( Higashio, T; Kuroda, K, 1988) |
" CaCl2 dose-response (in the presence of 10(-5) mol." | 1.27 | Mechanism of hydralazine-induced relaxation of arterial smooth muscle. ( Aloamaka, CP; Ebeigbe, AB, 1985) |
"Hydralazine prevented the increase of arterial pressure and the decrease of stress developed to NA by the aortic strips from both SHR and DOCA/salt rats." | 1.26 | Hydralazine prevents changes in the contractile response of aortic but not portal vein strips in hypertensive rats. ( Pang, CC; Sutter, MC, 1980) |
"Dihydralazine was found to have a very low potency in all types of vessels, and no difference between the effects on arterial and venous preparations was found." | 1.26 | Comparison of the in vitro effects of prazosin, nifedipine, and dihydralazine in isolated human mesenteric and crural vessels. ( Andersson, KE; Mikkelsen, E; Pedersen, OL, 1979) |
" Dose-response relationships to K+ were determined in isolated strips of rabbit aorta." | 1.26 | Comparative evaluation of the in vitro effects of hydralazine and hydralazine acetonide on arterial smooth muscle. ( Barron, K; Carrier, O; Du Souich, P; Haegele, KD; McLean, AJ; McNay, JL, 1977) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 43 (72.88) | 18.7374 |
1990's | 13 (22.03) | 18.2507 |
2000's | 2 (3.39) | 29.6817 |
2010's | 1 (1.69) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Chapleo, CB | 1 |
Doxey, JC | 1 |
Myers, PL | 1 |
Evans, JM | 1 |
Fake, CS | 1 |
Hamilton, TC | 1 |
Poyser, RH | 1 |
Watts, EA | 1 |
Lemkens, P | 1 |
Spijkers, LJ | 1 |
Meens, MJ | 1 |
Nelissen, J | 1 |
Janssen, B | 1 |
Peters, SL | 1 |
Schiffers, PM | 1 |
De Mey, JG | 1 |
Sato, N | 1 |
Tanaka, KA | 1 |
Szlam, F | 1 |
Tsuda, A | 1 |
Arias, ME | 1 |
Levy, JH | 1 |
Vidrio, H | 1 |
Fernández, G | 1 |
Medina, M | 1 |
Alvarez, E | 1 |
Orallo, F | 5 |
Kreye, VA | 2 |
Mellow, MH | 1 |
Jacobs, M | 1 |
Diamond, J | 4 |
Janis, RA | 3 |
Albrecht, T | 1 |
Speelman, DJ | 1 |
Steinsland, OS | 1 |
Lipe, S | 2 |
Moulds, RF | 3 |
Wilson, JR | 1 |
Hoyt, RW | 1 |
Ferraro, N | 1 |
Janicki, JS | 1 |
Weber, KT | 1 |
Hermsmeyer, K | 2 |
Trapani, A | 1 |
Abel, PW | 1 |
Worcel, M | 3 |
Hay, DW | 1 |
Wadsworth, RM | 1 |
Elkayam, U | 1 |
McKay, CR | 1 |
Weber, L | 1 |
Eisenberg, D | 1 |
Rahimtoola, SH | 1 |
Khayyal, M | 1 |
Gross, F | 1 |
Krishnamurty, VS | 1 |
Shaikh, MI | 1 |
Pang, CC | 2 |
Sutter, MC | 2 |
Traub, O | 2 |
Webb, RC | 2 |
Unger, P | 1 |
Berkenboom, G | 1 |
Fontaine, J | 1 |
Moina, MJ | 1 |
Bardan, B | 2 |
Campos Toimil, M | 1 |
Alzueta, AF | 1 |
Gil-Longo, J | 3 |
Gray, SD | 1 |
Carlsen, RC | 1 |
Atherley, R | 1 |
Campos-Toimil, M | 2 |
Verde, I | 1 |
Loza, I | 1 |
Fernández-Alzueta, A | 1 |
Lloyd, MC | 1 |
Nasu, T | 2 |
Yanagimoto, S | 2 |
Shimamura, K | 1 |
Matsuda, K | 1 |
Sekiguchi, F | 1 |
Sunano, S | 1 |
Shibata, H | 1 |
Estévez, I | 1 |
Raviña, E | 1 |
Ezimokhai, M | 1 |
Ishii, A | 1 |
Kubo, K | 1 |
Deguchi, T | 1 |
Tanaka, M | 1 |
Pedersen, OL | 1 |
Mikkelsen, E | 1 |
Andersson, KE | 1 |
Barron, K | 4 |
Carrier, O | 4 |
Haegele, KD | 4 |
McLean, AJ | 4 |
McNay, JL | 4 |
Du Souich, P | 4 |
Briggs, A | 1 |
Laquer, J | 1 |
Akashi, A | 1 |
Chiba, T | 1 |
Suzuki, I | 1 |
Hashimoto, H | 1 |
Baker, JR | 1 |
Hedwall, PR | 1 |
Calleja, JM | 1 |
Nakajima, S | 1 |
Kurokawa, K | 1 |
Imamura, N | 1 |
Ueda, M | 1 |
Sada, T | 1 |
Koike, H | 1 |
Miyamoto, M | 1 |
DeFeo, TT | 1 |
Morgan, KG | 1 |
Morita, S | 1 |
Iwasaki, T | 1 |
Nagai, K | 1 |
Miyata, S | 1 |
Kawai, Y | 1 |
Nelson, SH | 1 |
Suresh, MS | 1 |
Higashio, T | 2 |
Kuroda, K | 2 |
Ebeigbe, AB | 1 |
Aloamaka, CP | 1 |
Perry, HM | 1 |
Schoepfle, E | 1 |
Bourgoignie, J | 1 |
Ward, CO | 1 |
Gautieri, RF | 1 |
Lamid, S | 1 |
Wolff, FW | 1 |
Loev, B | 1 |
Goodman, MM | 1 |
Snader, MK | 1 |
Tedeschi, R | 1 |
Macko, E | 1 |
Uchida, E | 1 |
Bohr, DF | 1 |
2 reviews available for hydralazine and Muscle Contraction
Article | Year |
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Direct vasodilators with unknown modes of action: the nitro-compounds and hydralazine.
Topics: Animals; Calcium; Cell Membrane; Cyclic GMP; Humans; Hydralazine; Muscle Contraction; Muscle Protein | 1984 |
Calcium, drug action and hypertension.
Topics: Animals; Arteries; Calcium; Chelating Agents; Humans; Hydralazine; Hypertension; Lanthanum; Muscle C | 1983 |
1 trial available for hydralazine and Muscle Contraction
Article | Year |
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Long-term inhibition of angiotensin converting enzyme suppresses calcium channel agonist-induced contraction of aorta in hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Calcium Channel Agonists; Calcium Chloride; Dose-Response Relationsh | 1989 |
56 other studies available for hydralazine and Muscle Contraction
Article | Year |
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Synthesis of some potential antihypertensive phthalazinyl- and quinoxalinylguanidines.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Chemical Phenomena; | 1982 |
Synthesis and antihypertensive activity of substituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Biological Assay; Hypertension; Indicators and Reagen | 1983 |
Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzazepines; Bosentan; Endothelin-Converting Enzy | 2017 |
The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Dopamine; Dose-Response Relation | 2003 |
Effects of hydrazine derivatives on vascular smooth muscle contractility, blood pressure and cGMP production in rats: comparison with hydralazine.
Topics: Animals; Blood Pressure; Cyclic GMP; Dose-Response Relationship, Drug; Hydralazine; Hydrazines; Male | 2003 |
Effect of isosorbide and hydralazine in painful primary esophageal motility disorders.
Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Deglutition Disorders; Esophageal Diseases; Esophag | 1982 |
Mechanism of action of hydralazine on vascular smooth muscle.
Topics: Actomyosin; Adenosine Triphosphatases; Animals; Calcium; Cattle; Enzyme Activation; Hydralazine; Mus | 1984 |
Effects of hydralazine and verapamil on phosphorylase activity and guanosine cyclic 3',5'-monophosphate levels in guinea-pig taenia coli.
Topics: Animals; Calcium; Colon; Cyclic GMP; Female; Guinea Pigs; Hydralazine; In Vitro Techniques; Muscle C | 1980 |
Similarities between cytomegalovirus-induced cell rounding and contraction of smooth muscle cells.
Topics: Cytomegalovirus; Cytomegalovirus Infections; Cytopathogenic Effect, Viral; Diazoxide; Fibroblasts; H | 1983 |
Effect of hydralazine on nutritive flow to working canine gracilis skeletal muscle.
Topics: Animals; Dogs; Hydralazine; In Vitro Techniques; Lactates; Muscle Contraction; Muscles; Oxygen; Oxyg | 1984 |
Effect of hydralazine on tension and membrane potential in the rat caudal artery.
Topics: Animals; Arteries; Hydralazine; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle | 1983 |
The effects of calcium channel inhibitors and other procedures affecting calcium translocation on drug-induced rhythmic contractions in the rat vas deferens.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Hydralazine; In Vitro Techniques; Magnesium; Mal | 1983 |
Favorable effects of hydralazine on the hemodynamic response to isometric exercise in chronic severe aortic regurgitation.
Topics: Adult; Aged; Aortic Valve Insufficiency; Blood Pressure; Female; Heart Rate; Hemodynamics; Humans; H | 1984 |
Differential effects of hydralazine on the biphasic responses of helical strips from rat tail arteries.
Topics: Animals; Arteries; Calcium; Cell Membrane; Hydralazine; In Vitro Techniques; Muscle Contraction; Mus | 1983 |
In vitro differences between human arteries and veins in their responses to hydralazine.
Topics: Arteries; Calcium; Humans; Hydralazine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vas | 1981 |
Dual influence of hydralazine on constrictor response to noradrenaline in isolated arterial smooth muscle.
Topics: Animals; Arteries; Electric Stimulation; Female; Guanethidine; Hydralazine; Magnesium; Male; Muscle | 1981 |
Effects of hydralazine and D-600 on KCl induced contraction and phosphorylase activation in rabbit aorta.
Topics: Animals; Aorta; Drug Interactions; Enzyme Activation; Gallopamil; Hydralazine; In Vitro Techniques; | 1980 |
Hydralazine prevents changes in the contractile response of aortic but not portal vein strips in hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Desoxycorticosterone; Hydralazine; Hypertension; In Vitro Techniques | 1980 |
Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Interaction between hydralazine and nitrovasodilators in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Drug Interactions; Drug Tolerance; Hydralazine; In Vitro Techniques; Isoni | 1993 |
Effects of hydralazine on contractile responses to alpha 1 and alpha 2-adrenoceptor agonists in isolated rubbed rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Drug Interactions; Endothelium, Vascular; Femal | 1994 |
Effect of chronic blood pressure reduction on soleus muscle contractile properties in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Blood Pressure; Hindlimb; Hydralazine; Male; Muscle Contraction; Rats; Rats, In | 1994 |
Pharmacological study of several effects of hydralazine in the bisected rat vas deferens.
Topics: Animals; Calcium; Calcium Chloride; Calcium Radioisotopes; Cocaine; Hydralazine; In Vitro Techniques | 1994 |
Long-term effects of brief antihypertensive treatment on systolic blood pressure and vascular reactivity in young genetically hypertensive rats.
Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; B | 1995 |
Inhibition of calcium influx and tonic response to K+ of intestinal smooth muscle by hydralazine.
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels; Dose-Response | 1996 |
Blood pressure and age-dependent changes of endothelium-dependent tension oscillations in different strains of spontaneously hypertensive rats.
Topics: Acetylcholine; Aging; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Captopril; Endotheliu | 1996 |
Effects of hydralazine on responses to histamine and caffeine in ileal longitudinal muscle and taenia coli of the guinea pig.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Colon; Guinea Pigs; Histamine; Hydralazine; Ileum; In | 1997 |
Pyridazine derivatives XIV. Study of the vasorelaxant action of 6-aryl-5-piperidino-3-hydrazinopyridazines in isolated rat thoracic aorta: comparison with hydralazine.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; Hydralazine; In Vitro Techniques; Male; Muscle Contract | 1998 |
The alterations of vascular smooth muscle reactivity in vitro by human chorionic gonadotrophin.
Topics: Acetylcholine; Animals; Blood Pressure; Chorionic Gonadotropin; Estradiol; Female; Hydralazine; In V | 1998 |
Increases in cyclic GMP levels may not mediate relaxant effects of sodium nitroprusside, verapamil and hydralazine in rat vas deferens.
Topics: Animals; Cyclic GMP; Hydralazine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nit | 1978 |
Relationship between cyclic nucleotide levels and drug-induced relaxation of smooth muscle.
Topics: Animals; Cyclic AMP; Cyclic GMP; Diazoxide; Drug Interactions; Female; Guinea Pigs; Hydralazine; In | 1979 |
[Inhibition of cyclic AMP phosphodiesterase activity by ecarazine hydrochloride, hydralazine and their metabolites (author's transl)].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Guinea Pigs; Hydralazine; Hydrazines; In Vitro Techniq | 1979 |
Comparison of the in vitro effects of prazosin, nifedipine, and dihydralazine in isolated human mesenteric and crural vessels.
Topics: Adolescent; Adult; Aged; Calcium; Dihydralazine; Humans; Hydralazine; In Vitro Techniques; Leg; Mese | 1979 |
Comparative evaluation of the in vitro effects of hydralazine and hydralazine acetonide on arterial smooth muscle.
Topics: Animals; Aorta; Blood Vessels; Drug Interactions; Hydralazine; In Vitro Techniques; Muscle Contracti | 1977 |
Mechanism of action of hydralazine and ISF 2123 on arterial smooth muscle [proceedings].
Topics: Animals; Arteries; Hydralazine; Hydrazines; In Vitro Techniques; Male; Muscle Contraction; Muscle, S | 1978 |
Interaction of hydralazine and hydrazone derivatives with contractile mechanisms in rabbit aortic smooth muscle.
Topics: Animals; Aorta, Thoracic; Blood Vessels; Calcium; Depression, Chemical; Drug Interactions; Hydralazi | 1978 |
Identification of hydrallazine and hydrallazine hydrazone metabolites in human body fluids and quantitative in vitro comparisons of their smooth muscle relaxant activity.
Topics: Animals; Aorta; Humans; Hydralazine; Hydrazones; In Vitro Techniques; Mass Spectrometry; Muscle Cont | 1978 |
Relationship between the direct inhibitory effect of hydralazine and propildazine on arterial smooth muscle contractility and sympathetic innervation.
Topics: Animals; Arteries; Dose-Response Relationship, Drug; Hydralazine; Hydrazines; In Vitro Techniques; M | 1978 |
Pharmacology of budralazine, a new antihypertensive drug.
Topics: Animals; Antihypertensive Agents; Dogs; Female; Heart Rate; Hydralazine; Hypertension; Male; Methyld | 1978 |
Study of in vitro effects of hydralazine metabolites--comparative evaluation of products of hydroxylation, hydrolysis and conjugation.
Topics: Animals; Hydralazine; Hydrolysis; Hydroxylation; In Vitro Techniques; Muscle Contraction; Muscle, Sm | 1978 |
Subcellular distribution of hydralazine in rat single vascular muscle cells.
Topics: Animals; Aorta; Cells, Cultured; Hydralazine; Microscopy, Electron; Muscle Contraction; Muscle, Smoo | 1992 |
Comparison of the effects of hydralazine and nifedipine on contractions and 45Ca influx of rat aorta.
Topics: Animals; Calcium Radioisotopes; Hydralazine; In Vitro Techniques; Male; Muscle Contraction; Muscle, | 1991 |
A study on the hypotensive mechanism of pinacidil: relationship between its vasodilating effect and intracellular Ca2+ levels.
Topics: Animals; Antihypertensive Agents; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; | 1989 |
Calcium-force coupling mechanisms during vasodilator-induced relaxation of ferret aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Carnivora; Colforsin; Ferrets; Hydralazine; In Vitro Techniques; | 1989 |
Clinical pharmacology of vasodilator drugs.
Topics: Adrenergic alpha-Antagonists; Calcium Channel Blockers; Coronary Disease; Humans; Hydralazine; Hyper | 1985 |
Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium; Calcium Radioisotopes; Hydralazine; Hypertensi | 1988 |
Comparison of nitroprusside and hydralazine in isolated uterine arteries from pregnant and nonpregnant patients.
Topics: Arteries; Female; Ferricyanides; Humans; Hydralazine; In Vitro Techniques; Muscle Contraction; Muscl | 1988 |
Effects of cadralazine on contractions induced by norepinephrine, serotonin, angiotensin II and K+ in rabbit aortic and renal arterial strips.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Hydralazine; In Vitro Techniques; Male; Muscle Contractio | 1988 |
Effects of cadralazine on contractions induced by Ca2+ and norepinephrine in isolated rabbit aortic strips.
Topics: Animals; Aorta, Abdominal; Calcium; Hydralazine; In Vitro Techniques; Male; Muscle Contraction; Musc | 1988 |
Mechanism of hydralazine-induced relaxation of arterial smooth muscle.
Topics: Animals; Barium; Barium Compounds; Calcium; Calcium Chloride; Chlorides; Dose-Response Relationship, | 1985 |
Chronic treatment of rats with D-600 causes a compensatory decrease in the calcium requirement for contractility of vascular smooth and cardiac muscles.
Topics: Animals; Blood Pressure; Calcium; Gallopamil; Heart Rate; Hydralazine; In Vitro Techniques; Isoprote | 1985 |
In vitro production and inhibition of aortic vasoconstriction by mercuric, cadmium, and other metal ions.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Cadmium; Cyanides; Edetic Acid; Epinephrine; Ethylmaleimid | 1967 |
Effect of certain drugs on perfused human placenta. IX. Mode of action of angiotensin.
Topics: Angiotensin II; Blood Vessels; Constriction; Dipyridamole; Ethanolamines; Female; Humans; Hydralazin | 1969 |
Drug failure in reducing pressor effect of isometric handgrip stress test in hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Electrocardiogra | 1973 |
"Hantzsch-type" dihydropyridine hypotensive agents. 3.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carotid Arteries; Cats; Central Nervous System; De | 1974 |
Myogenic tone in isolated perfused resistance vessels from rats.
Topics: Animals; Blood Vessels; Calcium; Hydralazine; Jejunum; Male; Methods; Muscle Contraction; Muscle, Sm | 1969 |