hydralazine and Intraventricular Septal Defects studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Research Excerpts

Excerpt	Relevance	Reference
"Hydralazine is a smooth muscle relaxant and a potent arteriolar dilator."	6.36	Hydralazine in heart failure. ( Chatterjee, K, 1983)
"Hydralazine is a smooth muscle relaxant and a potent arteriolar dilator."	2.36	Hydralazine in heart failure. ( Chatterjee, K, 1983)
"Hydralazine was administered at cardiac catheterization to eight children with a ventricular septal defect (age: 2."	1.29	Afterload reduction by hydralazine in children with a ventricular septal defect as determined by aortic input impedance. ( Endo, H; Shiraishi, H; Yanagisawa, M, 1994)
"Hydralazine, 0."	1.27	Afterload reduction treatment for large ventricular septal defects. Dependence of haemodynamic effects of hydralazine on pretreatment systemic blood flow. ( Chon, Y; Nakazawa, M; Shimizu, T; Takao, A, 1983)
"Prehydralazine baseline data were therefore compared with values 35 minutes after hydralazine."	1.26	Hemodynamic effects of hydralazine in infants with a large ventricular septal defect. ( Beekman, RH; Rocchini, AP; Rosenthal, A, 1982)
" 4) In the management of essential moderate or severe hypertension is preferable to employ a mild dosage of betablockers and diuretics, rather than use higher doses of a single agent."	1.26	[The role of renin after betablocking diuretic and vasodilator treatment in essential hypertension (author's transl)]. ( Fusco, M; Lombardo, M; Valente, D, 1979)

Research

Studies (9)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Early Diastolic Mitral Annular Velocity

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (88.89)	18.7374
1990's	1 (11.11)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Chatterjee, K	1
Beekman, RH	1
Rocchini, AP	1
Rosenthal, A	1
Schmidt, H	1
Köhler, W	1
von Jan, V	1
Boucek, MM	1
Chang, R	1
Synhorst, DP	1
Nakazawa, M	2
Takao, A	2
Shimizu, T	2
Chon, Y	2
Kanaya, M	1
Momma, K	1
Friedlander, RP	1
Schwartz, MJ	1
Endo, H	1
Shiraishi, H	1
Yanagisawa, M	1
Lombardo, M	1
Fusco, M	1
Valente, D	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Organic Nitrates and Hydralazine on Wave Reflections and Left Ventricular Structure and Function in Heart Failure With Preserved Ejection Fraction[NCT01516346]	Phase 2	44 participants (Actual)	Interventional	2012-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Diastolic mitral annular velocity measured at the basal septal mitral annulus (NCT01516346)
Timeframe: 24 weeks

LV Mass

Intervention	cm/s (Mean)
Isosorbide Dinitrate	6.8
Isosorbide Dinitrate + Hydralazine	7.3
Placebo	6.5

LV mass measured by MRI, in grams normalized to height in meters raised to the 1.7 power (m^1.7) (NCT01516346)
Timeframe: 24 weeks

Myocardial Extracellular Volume Fraction

Intervention	grams / meters ^1.7 (Mean)
Isosorbide Dinitrate	68.2
Isosorbide Dinitrate + Hydralazine	66.2
Placebo	67.2

Myocardial extracellular volume, expressed as percent of total tissue volume, measured by MRI (T1 mapping pre and post-gadolinium administration) (NCT01516346)
Timeframe: 24 weeks

Quality of Life (Kansas City Cardiomyopathy Questionnaire Score)

Intervention	Percentage (Mean)
Isosorbide Dinitrate	29.0
Isosorbide Dinitrate + Hydralazine	31.3
Placebo	29.5

Quality of life, assessed with the Kansas City cardiomyopathy questionnaire (overall summary score, which ranges from 0 to 100). Higher values imply better quality of life. (NCT01516346)
Timeframe: 24 weeks

Wave Reflection Magnitude

Intervention	Points on a scale (Mean)
Isosorbide Dinitrate	62.1
Isosorbide Dinitrate + Hydralazine	44.9
Placebo	62.1

The dimensionless ratio of backward (reflected) to forward wave amplitude. Higher values imply more wave reflection. (NCT01516346)
Timeframe: 24 weeks

Article	Year
Hemodynamic effects of hydralazine in infants with a large ventricular septal defect. Circulation, 1982, Volume: 65, Issue:3 Topics: Blood Pressure; Cardiomegaly; Female; Heart Failure; Heart Septal Defects, Ventricular; Hemodynamics	1982
[Use of vasodilators in pediatric cardiology: left-right shunt modification by dihydralazine (Depressan)]. Kinderarztliche Praxis, 1984, Volume: 52, Issue:6 Topics: Child; Child, Preschool; Dihydralazine; Heart Septal Defects, Ventricular; Hemodynamics; Humans; Hyd	1984
Vasodilators and ventricular septal defect: comparison of prazosin, minoxidil, and hydralazine in a chronic lamb model. Pediatric research, 1984, Volume: 18, Issue:9 Topics: Animals; Blood Pressure; Heart Rate; Heart Septal Defects, Ventricular; Hydralazine; Minoxidil; Praz	1984
Afterload reduction treatment for large ventricular septal defects. Dependence of haemodynamic effects of hydralazine on pretreatment systemic blood flow. British heart journal, 1983, Volume: 49, Issue:5 Topics: Female; Heart Septal Defects, Ventricular; Hemodynamics; Humans; Hydralazine; Infant; Male; Pulmonar	1983
Significance of systemic vascular resistance in determining the hemodynamic effects of hydralazine on large ventricular septal defects. Circulation, 1983, Volume: 68, Issue:2 Topics: Blood Circulation; Blood Pressure; Child, Preschool; Heart Septal Defects, Ventricular; Hemodynamics	1983
Selective afterload reduction in the treatment of septal rupture complicating myocardial infarction. A case report. Cardiology, 1980, Volume: 65, Issue:1 Topics: Female; Heart Septal Defects, Ventricular; Humans; Hydralazine; Middle Aged; Myocardial Infarction;	1980
Afterload reduction by hydralazine in children with a ventricular septal defect as determined by aortic input impedance. Cardiovascular drugs and therapy, 1994, Volume: 8, Issue:1 Topics: Aorta; Cardiac Catheterization; Child; Child, Preschool; Electric Impedance; Female; Heart Septal De	1994
[The role of renin after betablocking diuretic and vasodilator treatment in essential hypertension (author's transl)]. Giornale italiano di cardiologia, 1979, Volume: 9, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Chlorthalidone; Diuretics; Drug Therapy	1979

hydralazine and Intraventricular Septal Defects