hydralazine has been researched along with Hypotension in 78 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both intravenous hydralazine and oral nifedipine are equally effective in lowering of blood pressure in acute hypertensive emergency of pregnancy." | 9.24 | Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. ( Gupta, A; Sharma, C; Soni, A; Verma, A; Verma, S, 2017) |
| "We previously reported that the fixed-dose combination of isosorbide dinitrate and hydralazine hydrochloride (FDC I/H) significantly decreased the risk of all-cause death and first hospitalization for heart failure (HF) and improved quality of life in patients with New York Heart Association class III or IV heart failure in the African-American Heart Failure Trial (A-HeFT)." | 9.12 | Early and sustained benefit on event-free survival and heart failure hospitalization from fixed-dose combination of isosorbide dinitrate/hydralazine: consistency across subgroups in the African-American Heart Failure Trial. ( Adams, K; Carson, P; Cohn, JN; Ferdinand, K; Ofili, E; Olukotun, AY; Sabolinski, ML; Tam, SW; Taylor, AL; Taylor, M; Worcel, M; Yancy, CW; Ziesche, S, 2007) |
| "To compare the efficacy of intravenous Labetalol and intravenous Hydralazine in reduction of blood pressure in patients with severe pre-eclampsia." | 8.31 | Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women. ( Husain, S; Hussain, R; Kausar, M, 2023) |
| "Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally (hydralazine) evoked hypotension in female rats." | 7.77 | Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats. ( Abdel-Rahman, AA; El-Mas, MM, 2011) |
| " Hydralazine (HDZ)-induced hypotension activates NK3R expressed by magnocellular neurons, increases plasma VP and OT levels, and induces c-Fos expression in VP and OT neurons." | 7.74 | Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension. ( Flynn, FW; Haley, GE, 2008) |
| "This study sought to assess the effect of baseline systolic blood pressure (SBP) and changes in SBP on the effectiveness of treatment with fixed-dose combination of isosorbide dinitrate and hydralazine (FDC I/H) in patients with heart failure (HF)." | 7.74 | Influence of blood pressure on the effectiveness of a fixed-dose combination of isosorbide dinitrate and hydralazine in the African-American Heart Failure Trial. ( Adams, KF; Anand, IS; Archambault, WT; Cohn, JN; Olukotun, AY; Rector, TS; Sabolinski, ML; Tam, SW; Taylor, AL; Worcel, M, 2007) |
| "Clonidine (a mixed alpha2-adrenoceptor and imidazoline I1 receptor agonist)-evoked hypotension was associated with dissimilar reductions in c-jun gene expression in the rostral ventrolateral medulla (RVLM) and the nucleus tractus solitarius (NTS) in normotensive rats." | 7.73 | Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. ( Abdel-Rahman, AA; Li, G; Wang, X, 2005) |
| "Previous experiments have indicated that arterial hypotension increases plasma oxytocin (OT) levels in rats and that OT infused intravenously causes an increase in plasma renin activity (PRA)." | 7.71 | Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. ( Huang, W; Sjöquist, M; Skott, O; Stricker, EM; Sved, AF, 2001) |
| "The oral angiotensin-converting enzyme inhibitor captopril (CPT) produces beneficial hemodynamic and clinical responses in patients with chronic congestive heart failure (CHF)." | 7.66 | Captopril in congestive heart failure: improved left ventricular function with decreased metabolic cost. ( Chatterjee, K; Parmley, WW; Rouleau, JL, 1982) |
| "The hemodynamic benefits and safety of combined therapy with captopril and hydralazine were studied during invasive hemodynamic monitoring in 14 patients with severe heart failure." | 7.66 | Hemodynamic responses to combined therapy with captopril and hydralazine in patients with severe heart failure. ( Combs, DT; Hanlon, JT; Massie, BM; Packer, M, 1983) |
| "Propranolol was demonstrated to block hydralazine-induced increases in serum renin activity in genetically hypertensive rats." | 5.25 | Altered renin release and propranolol potentiation of vasodilatory drug hypotension. ( Keeton, K; Pettinger, WA, 1975) |
| "Both intravenous hydralazine and oral nifedipine are equally effective in lowering of blood pressure in acute hypertensive emergency of pregnancy." | 5.24 | Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. ( Gupta, A; Sharma, C; Soni, A; Verma, A; Verma, S, 2017) |
| "We previously reported that the fixed-dose combination of isosorbide dinitrate and hydralazine hydrochloride (FDC I/H) significantly decreased the risk of all-cause death and first hospitalization for heart failure (HF) and improved quality of life in patients with New York Heart Association class III or IV heart failure in the African-American Heart Failure Trial (A-HeFT)." | 5.12 | Early and sustained benefit on event-free survival and heart failure hospitalization from fixed-dose combination of isosorbide dinitrate/hydralazine: consistency across subgroups in the African-American Heart Failure Trial. ( Adams, K; Carson, P; Cohn, JN; Ferdinand, K; Ofili, E; Olukotun, AY; Sabolinski, ML; Tam, SW; Taylor, AL; Taylor, M; Worcel, M; Yancy, CW; Ziesche, S, 2007) |
| " Glyceryl trinitrate and labetalol were associated with fewer incidences of tachycardia and palpitation respectively than hydralazine." | 4.98 | Drugs for treating severe hypertension in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials. ( Sequeira, RP; Sridharan, K, 2018) |
| "To compare the efficacy of intravenous Labetalol and intravenous Hydralazine in reduction of blood pressure in patients with severe pre-eclampsia." | 4.31 | Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women. ( Husain, S; Hussain, R; Kausar, M, 2023) |
| "To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine." | 3.83 | Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low. ( Aghajanian, P; Greene, N; Kilpatrick, SJ; Rodriguez, M; Sharma, KJ, 2016) |
| "Our previous studies showed that chronic ethanol feeding attenuates centrally (clonidine) evoked and potentiates peripherally (hydralazine) evoked hypotension in female rats." | 3.77 | Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats. ( Abdel-Rahman, AA; El-Mas, MM, 2011) |
| " Hydralazine (HDZ)-induced hypotension activates NK3R expressed by magnocellular neurons, increases plasma VP and OT levels, and induces c-Fos expression in VP and OT neurons." | 3.74 | Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension. ( Flynn, FW; Haley, GE, 2008) |
| "Activation of the neurokinin 3 receptor (NK3R) by a receptor agonist, hypotension, and hyperosmolarity results in the internalization of NK3R expressed by magnocellular neurons and the release of vasopressin (VP) and oxytocin (OT) into the circulation." | 3.74 | Tachykinin NK3 receptor contribution to systemic release of vasopressin and oxytocin in response to osmotic and hypotensive challenge. ( Flynn, FW; Haley, GE, 2007) |
| "This study sought to assess the effect of baseline systolic blood pressure (SBP) and changes in SBP on the effectiveness of treatment with fixed-dose combination of isosorbide dinitrate and hydralazine (FDC I/H) in patients with heart failure (HF)." | 3.74 | Influence of blood pressure on the effectiveness of a fixed-dose combination of isosorbide dinitrate and hydralazine in the African-American Heart Failure Trial. ( Adams, KF; Anand, IS; Archambault, WT; Cohn, JN; Olukotun, AY; Rector, TS; Sabolinski, ML; Tam, SW; Taylor, AL; Worcel, M, 2007) |
| "Clonidine (a mixed alpha2-adrenoceptor and imidazoline I1 receptor agonist)-evoked hypotension was associated with dissimilar reductions in c-jun gene expression in the rostral ventrolateral medulla (RVLM) and the nucleus tractus solitarius (NTS) in normotensive rats." | 3.73 | Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. ( Abdel-Rahman, AA; Li, G; Wang, X, 2005) |
| " Because SP stimulates vasopressin (VP) and oxytocin release from explants of the hypothalamo-neurohypophyseal system (HNS), two hypotheses were tested: (1) SP-stimulated VP release is mediated by NK3-Rs, and (2) stimulation of the A1 pathway by hypotension activates SON NK3-Rs." | 3.72 | Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. ( Howe, HE; Sladek, CD; Somponpun, SJ, 2004) |
| " The functional implications of this pathway in cardiovascular functions were verified using Fos protein induction in response to hypotension induced by continuous intravenous administration of hydralazine-hydrochloride." | 3.72 | Parabrachial inputs to Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension: a light and electron microscopic study in the rat. ( Gu, H; Li, HP; Matsumoto, Y; Miki, T; Satriotomo, I; Takeuchi, Y; Xie, Q, 2004) |
| "Previous experiments have indicated that arterial hypotension increases plasma oxytocin (OT) levels in rats and that OT infused intravenously causes an increase in plasma renin activity (PRA)." | 3.71 | Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. ( Huang, W; Sjöquist, M; Skott, O; Stricker, EM; Sved, AF, 2001) |
| " The RVLM of six unanesthetized rats subjected to 2 hours of hydralazine-induced hypotension contained tenfold more c-Fos-ir DNPI/VGLUT2 neurons than that of six saline-treated controls." | 3.71 | Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla. ( Guyenet, PG; Rosin, DL; Schreihofer, AM; Sevigny, CP; Stornetta, RL, 2002) |
| " Plasma epinephrine and norepinephrine levels in response to hydralazine-induced hypotension were measured in these animals." | 3.69 | Modulatory effects of endogenous adenosine on epinephrine secretion from the adrenal medulla of the rat. ( Ho, WY; Kuan, CJ; Lin, HC; Tseng, CJ; Tung, CS, 1994) |
| "Hydralazine (H) induces hypotension accompanied by cardiac stimulation due to activation of the arterial baroreflex." | 3.69 | Patterns of heart rate responses to hydralazine in normotensive and hypertensive rats. ( Vidrio, H, 1996) |
| "We evaluated the effect of different vasodilators on ventricular end-systolic stress by investigating the impact of sodium nitroprusside, nifedipine, and hydralazine on blood pressure, aortic stiffness, and wave reflection during drug-induced hypotension (to 80 mm Hg mean blood pressure) in normotensive (central aortic mean blood pressure, 116 to 119 mm Hg; systolic pressure, 133 to 137 mm Hg), nonanesthetized, unrestrained rats." | 3.69 | Vasodilators, aortic elasticity, and ventricular end-systolic stress in nonanesthetized unrestrained rats. ( Atkinson, J; Duvivier, C; Lartaud-Idjouadiene, I; Marque, V; Niederhoffer, N; Peslin, R, 1997) |
| "Sixteen patients (13-38 yr) undergoing spinal fusion for scoliosis under controlled hypotension were studied to determine the haemodynamic and neuroendocrine responses to IV dihydralazine (1." | 3.67 | Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. ( Bourreli, B; Drouet, JC; Gunst, JP; Passuti, N; Pinaud, M; Remi, JP, 1988) |
| "The oral angiotensin-converting enzyme inhibitor captopril (CPT) produces beneficial hemodynamic and clinical responses in patients with chronic congestive heart failure (CHF)." | 3.66 | Captopril in congestive heart failure: improved left ventricular function with decreased metabolic cost. ( Chatterjee, K; Parmley, WW; Rouleau, JL, 1982) |
| "The hemodynamic benefits and safety of combined therapy with captopril and hydralazine were studied during invasive hemodynamic monitoring in 14 patients with severe heart failure." | 3.66 | Hemodynamic responses to combined therapy with captopril and hydralazine in patients with severe heart failure. ( Combs, DT; Hanlon, JT; Massie, BM; Packer, M, 1983) |
| " Other reported effects are toxic confusional states and psychotic reactions." | 2.36 | Psychiatric side effects of antihypertensive drugs other than reserpine. ( Fleminger, R; Paykel, ES; Watson, JP, 1982) |
| "A 31-year-old woman developed bilateral posterior ischemic optic neuropathy and infarctions of the cerebral arterial border zones and spinal cord after correction of malignant hypertension." | 1.35 | Simultaneous posterior ischemic optic neuropathy, cerebral border zone infarction, and spinal cord infarction after correction of malignant hypertension. ( An, SJ; Choi, JH; Choi, KD; Kim, HJ; Kim, JS; Lee, JE, 2008) |
| "Hydroxylamine hypotension was enhanced by the SSAO inhibitor isoniazid and the SSAO substrate methylamine, a pattern shared by hydralazine." | 1.34 | Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor. ( Medina, M; Vidrio, H, 2007) |
| "The hypotension was caused by decreases in cardiac index and stroke volume because peripheral resistance did not change." | 1.30 | Role of cardiac output in ethanol-evoked attenuation of centrally mediated hypotension in conscious rats. ( Abdel-Rahman, AA; El-Mas, MM, 1997) |
| "Propranolol was demonstrated to block hydralazine-induced increases in serum renin activity in genetically hypertensive rats." | 1.25 | Altered renin release and propranolol potentiation of vasodilatory drug hypotension. ( Keeton, K; Pettinger, WA, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (55.13) | 18.7374 |
| 1990's | 9 (11.54) | 18.2507 |
| 2000's | 17 (21.79) | 29.6817 |
| 2010's | 8 (10.26) | 24.3611 |
| 2020's | 1 (1.28) | 2.80 |
| Authors | Studies |
|---|---|
| Kausar, M | 1 |
| Husain, S | 1 |
| Hussain, R | 1 |
| Sharma, C | 1 |
| Soni, A | 1 |
| Gupta, A | 1 |
| Verma, A | 1 |
| Verma, S | 1 |
| Sridharan, K | 1 |
| Sequeira, RP | 1 |
| Nedoboy, PE | 1 |
| Mohammed, S | 1 |
| Kapoor, K | 1 |
| Bhandare, AM | 1 |
| Farnham, MM | 1 |
| Pilowsky, PM | 1 |
| Sharma, KJ | 1 |
| Rodriguez, M | 1 |
| Kilpatrick, SJ | 1 |
| Greene, N | 1 |
| Aghajanian, P | 1 |
| Parker, LM | 1 |
| Le, S | 1 |
| Wearne, TA | 1 |
| Hardwick, K | 1 |
| Kumar, NN | 1 |
| Robinson, KJ | 1 |
| McMullan, S | 1 |
| Goodchild, AK | 2 |
| Haley, GE | 2 |
| Flynn, FW | 3 |
| Choi, JH | 1 |
| Choi, KD | 1 |
| Kim, JS | 1 |
| Kim, HJ | 1 |
| Lee, JE | 1 |
| An, SJ | 1 |
| El-Mas, MM | 2 |
| Abdel-Rahman, AA | 3 |
| Sladek, CD | 2 |
| Stevens, W | 1 |
| Levinson, SR | 1 |
| Song, Z | 1 |
| Jensen, DD | 1 |
| Damanhuri, HA | 1 |
| Burke, PG | 1 |
| Ong, LK | 1 |
| Bobrovskaya, L | 1 |
| Dickson, PW | 1 |
| Dunkley, PR | 1 |
| Pelaez, NM | 1 |
| Schreihofer, AM | 2 |
| Guyenet, PG | 2 |
| Vidrio, H | 3 |
| Medina, M | 2 |
| González-Romo, P | 1 |
| Lorenzana-Jiménez, M | 1 |
| Díaz-Arista, P | 1 |
| Baeza, A | 1 |
| SHAPIRO, AP | 1 |
| GROLLMAN, A | 1 |
| BEIN, HJ | 2 |
| GROSS, F | 2 |
| TRIPOD, J | 3 |
| MEIER, R | 3 |
| SCHUMANN, H | 1 |
| GIAROLA, A | 1 |
| TUCHMANN-DUPLESSIS, H | 1 |
| VANDERKOLK, K | 1 |
| DONTAS, AS | 1 |
| HOOBLER, SW | 1 |
| SILVA MALTEZ, J | 1 |
| BRUNI, C | 1 |
| DRUEY, J | 1 |
| MARXER, A | 1 |
| ABE, T | 1 |
| SUGITA, M | 1 |
| OBATA, K | 1 |
| OGASAWARA, S | 1 |
| YOKOI, T | 1 |
| GARDNER, DL | 1 |
| TANGRI, KK | 1 |
| BHARGAVA, KP | 1 |
| BRICAUD, H | 1 |
| DALLOCCHIO, M | 1 |
| SAUTRON, J | 1 |
| BROUSTET, P | 1 |
| FRIGERIO, G | 1 |
| HUEGIN, W | 1 |
| BOETTIGER, LE | 1 |
| MALMBORG, RO | 1 |
| MICHAELI, EW | 1 |
| BELLUSCHI, A | 1 |
| VACCHINI, V | 1 |
| MORRIS, JA | 1 |
| SMITH, RW | 1 |
| ASSALI, NS | 1 |
| SKINNER, DG | 1 |
| HAYES, MA | 1 |
| SCHMITT, H | 1 |
| GICQUEL, J | 1 |
| CRAVER, BN | 1 |
| BARRETT, W | 1 |
| CAMERON, A | 1 |
| YONKMAN, FF | 1 |
| Takeuchi, Y | 1 |
| Xie, Q | 1 |
| Miki, T | 1 |
| Matsumoto, Y | 1 |
| Satriotomo, I | 1 |
| Li, HP | 1 |
| Gu, H | 1 |
| Howe, HE | 1 |
| Somponpun, SJ | 1 |
| Wang, X | 1 |
| Li, G | 1 |
| Kihara, M | 1 |
| Sato, K | 1 |
| Hashimoto, T | 1 |
| Imai, N | 1 |
| Toya, Y | 1 |
| Umemura, S | 1 |
| Anand, IS | 1 |
| Tam, SW | 2 |
| Rector, TS | 1 |
| Taylor, AL | 2 |
| Sabolinski, ML | 2 |
| Archambault, WT | 1 |
| Adams, KF | 1 |
| Olukotun, AY | 2 |
| Worcel, M | 2 |
| Cohn, JN | 3 |
| Ahlgren, J | 1 |
| Porter, K | 1 |
| Hayward, LF | 1 |
| Ziesche, S | 1 |
| Yancy, CW | 1 |
| Carson, P | 1 |
| Ferdinand, K | 1 |
| Taylor, M | 1 |
| Adams, K | 1 |
| Ofili, E | 1 |
| Lin, HC | 2 |
| Wan, FJ | 1 |
| Paykel, ES | 1 |
| Fleminger, R | 1 |
| Watson, JP | 1 |
| Chatterjee, K | 1 |
| Rouleau, JL | 1 |
| Parmley, WW | 1 |
| Rubin, LJ | 1 |
| Massie, BM | 1 |
| Packer, M | 1 |
| Hanlon, JT | 1 |
| Combs, DT | 1 |
| Baum, T | 1 |
| Sabin, C | 1 |
| Moran, RM | 1 |
| Kaplan, RP | 1 |
| Tseng, CJ | 1 |
| Ho, WY | 1 |
| Tung, CS | 1 |
| Kuan, CJ | 1 |
| Radulovacki, M | 1 |
| Trbovic, S | 1 |
| Carley, DW | 1 |
| Schiltz, JC | 1 |
| Hoffman, GE | 1 |
| Stricker, EM | 3 |
| Sved, AF | 3 |
| Niederhoffer, N | 1 |
| Marque, V | 1 |
| Lartaud-Idjouadiene, I | 1 |
| Duvivier, C | 1 |
| Peslin, R | 1 |
| Atkinson, J | 1 |
| Curtis, KS | 1 |
| Cunningham, JT | 1 |
| Heesch, CM | 1 |
| Stocker, SD | 1 |
| Huang, W | 1 |
| Sjöquist, M | 1 |
| Skott, O | 1 |
| Stornetta, RL | 1 |
| Sevigny, CP | 1 |
| Rosin, DL | 1 |
| Gant, NF | 1 |
| Madden, JD | 1 |
| Siiteri, PK | 1 |
| MacDonald, PC | 1 |
| Pettinger, WA | 1 |
| Keeton, K | 1 |
| Imhof, P | 1 |
| Haeusler, G | 1 |
| Gerold, M | 1 |
| Henrich, WL | 1 |
| Cronin, R | 1 |
| Miller, PD | 1 |
| Anderson, RJ | 1 |
| Mizroch, S | 1 |
| Yurasek, M | 1 |
| Zhang, C | 1 |
| Hsueh, W | 1 |
| Derham, RJ | 1 |
| Robinson, J | 1 |
| Hammond, TG | 1 |
| Mosesson, MW | 1 |
| Hubbard, JW | 1 |
| Buchholz, RA | 1 |
| Reed, K | 1 |
| Nathan, MA | 1 |
| Keeton, TK | 1 |
| Bourreli, B | 1 |
| Pinaud, M | 1 |
| Passuti, N | 1 |
| Gunst, JP | 1 |
| Drouet, JC | 1 |
| Remi, JP | 1 |
| Cummings, JR | 1 |
| Welter, AN | 1 |
| Grace, JL | 1 |
| Gray, WD | 1 |
| Tristani, FE | 1 |
| Dahr, AS | 1 |
| George, CF | 1 |
| Dollery, CT | 1 |
| Carstens, E | 1 |
| Balazs, T | 1 |
| Payne, BJ | 1 |
| Higgins, JT | 1 |
6 reviews available for hydralazine and Hypotension
| Article | Year |
|---|---|
Drugs for treating severe hypertension in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials.
Topics: Antihypertensive Agents; Dose-Response Relationship, Drug; Female; Headache; Humans; Hydralazine; Hy | 2018 |
[PROBLEMS OF ANESTHESIA IN PATIENTS UNDER TREATMENT OF HYPERTENSION].
Topics: Anesthesia; Antihypertensive Agents; Bretylium Compounds; Cardiovascular Diseases; Chlorothiazide; C | 1963 |
Psychiatric side effects of antihypertensive drugs other than reserpine.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Anxiety; Bethanidine; Clonidine; Debrisoquin; | 1982 |
Cardiovascular effects of vasodilator therapy for pulmonary arterial hypertension.
Topics: Cardiac Output; Echocardiography; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Hypote | 1983 |
[Treatment of cardiac failure with vasodilators (author's transl)].
Topics: Cardiac Glycosides; Diuretics; Drug Therapy, Combination; Heart Failure; Hydralazine; Hypotension; I | 1978 |
Severe preeclampsia: is vasodilation therapy with hydralazine dangerous for the preterm fetus?
Topics: Female; Fetus; Humans; Hydralazine; Hypotension; Pre-Eclampsia; Pregnancy | 1990 |
3 trials available for hydralazine and Hypotension
| Article | Year |
|---|---|
Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial.
Topics: Acute Disease; Adolescent; Adult; Apgar Score; Double-Blind Method; Emergencies; Female; Humans; Hyd | 2017 |
Early and sustained benefit on event-free survival and heart failure hospitalization from fixed-dose combination of isosorbide dinitrate/hydralazine: consistency across subgroups in the African-American Heart Failure Trial.
Topics: Adult; Aged; Arthralgia; Biomarkers; Black or African American; Cardiovascular Agents; Cause of Deat | 2007 |
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension.
Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide; | 1983 |
69 other studies available for hydralazine and Hypotension
| Article | Year |
|---|---|
Comparison of efficacy of intravenous labetalol and intravenous hydralazine for management of pre-eclampsia in pregnant women.
Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Hypotension; Lab | 2023 |
pSer40 tyrosine hydroxylase immunohistochemistry identifies the anatomical location of C1 neurons in rat RVLM that are activated by hypotension.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hybrido | 2016 |
Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension, Pregnancy | 2016 |
Neurochemistry of neurons in the ventrolateral medulla activated by hypotension: Are the same neurons activated by glucoprivation?
Topics: Animals; Antihypertensive Agents; Catecholamines; Deoxyglucose; Enkephalins; Gene Expression Regulat | 2017 |
Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension.
Topics: Animals; Blood Pressure; Cell Nucleus; Hydralazine; Hypotension; Hypothalamus, Anterior; Immunohisto | 2008 |
Simultaneous posterior ischemic optic neuropathy, cerebral border zone infarction, and spinal cord infarction after correction of malignant hypertension.
Topics: Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Brain; Brain Stem Infarctions; C | 2008 |
Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats.
Topics: Animals; Baroreflex; Bradykinin; Clonidine; Enalapril; Ethanol; Female; Hemodynamics; Hydralazine; H | 2011 |
Characterization of nuclear neurokinin 3 receptor expression in rat brain.
Topics: Animals; Brain; Cell Line, Transformed; Cell Nucleus; CHO Cells; Cricetinae; Cricetulus; Epitopes; G | 2011 |
Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: a marker of activation following acute hypotension and glucoprivation.
Topics: Animals; Brain; Catecholamines; Hydralazine; Hypotension; Male; Phosphorylation; Rats; Rats, Sprague | 2012 |
Decompensated hemorrhage activates serotonergic neurons in the subependymal parapyramidal region of the rat medulla.
Topics: Animals; Blood Pressure; Enkephalins; gamma-Aminobutyric Acid; Heart Rate; Hydralazine; Hypotension; | 2002 |
Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide.
Topics: Amine Oxidase (Copper-Containing); Anesthesia; Animals; Aorta; Hydralazine; Hydrogen Peroxide; Hypot | 2003 |
A critical evaluation of the hypotensive asction of hydrallazine, hexamethonium, tetraethylammonium and dibenzyline salts in human and experimental hypertension.
Topics: Cardiovascular Agents; Hexamethonium; Hydralazine; Hypertension; Hypotension; Muscle Relaxants, Cent | 1953 |
[Experimental studies on the effects of the hypotension provoking hydrazinophthalazine derivatives apresoline and nepresol on blood circulation].
Topics: Antihypertensive Agents; Blood Circulation; Humans; Hydralazine; Hypotension; Mental Disorders; Symp | 1953 |
[Effect of hypotensive nepresol on heart volume and vascular resistance in hypertensive patients].
Topics: Blood Circulation; Cardiac Volume; Heart; Hydralazine; Hypertension; Hypotension; Sympatholytics; Va | 1953 |
[Clinico-experimental research on circulatory action of some hydrazinophthalazine derivatives with hypotensive action].
Topics: Antihypertensive Agents; Female; Hydralazine; Hypertension; Hypotension; Pregnancy; Pregnancy Compli | 1953 |
[Hypotensive and cardiovascular effect of two hydrazinophthalazines in animals].
Topics: Animals; Blood Pressure; Blood Pressure Determination; Cardiovascular System; Humans; Hydralazine; H | 1954 |
Renal and hypotensive effects of acute and chronic oral treatment with 1-hydrazinophthalazine (apresoline) in hypertension.
Topics: Administration, Oral; Humans; Hydralazine; Hypertension; Hypotension; Kidney; Sympatholytics | 1954 |
[Clinical trial of a new hypotensive drug, 1-hydrazinophthalazine (apresoline)].
Topics: Antihypertensive Agents; Hydralazine; Hypertension; Hypotension; Sympatholytics | 1954 |
[The change of hypotensive effect of apresoline and nepresol by the reaction with serum components].
Topics: Blood Pressure; Blood Pressure Determination; Blood Proteins; Hydralazine; Hypotension; Serum; Sympa | 1954 |
Hypotensive hydrazinophthalazines and related compounds.
Topics: Hydralazine; Hypotension; Sympatholytics | 1959 |
[Hypotensive effect of combined treatment with esidres and serpasil-apresoline].
Topics: Chlorothiazide; Combined Modality Therapy; Hydralazine; Hydrazines; Hypotension; Manipulation, Osteo | 1961 |
The relationship between intermittent hypotension and the prevention by hydralazine of acute vascular disease in rats with steroid hypertension.
Topics: Animals; Hydralazine; Hypertension; Hypotension; Peripheral Vascular Diseases; Rats; Vascular Diseas | 1960 |
The central hypotensive action of 1-hydrazinophthalazine (C-5968).
Topics: Humans; Hydralazine; Hypotension | 1960 |
[A new hypotensive drug: guanethidine. Its association with the hydralazines].
Topics: Amidines; Antihypertensive Agents; Guanethidine; Hydralazine; Hypertension; Hypotension | 1961 |
[Controlled clinical research on a new hypotensive combination (mebutamate-hydralazine-reserpine)].
Topics: Antihypertensive Agents; Antipsychotic Agents; Carbamates; Hydralazine; Hypotension; Reserpine | 1963 |
[SEVERE NEUROLOGICAL SIDE-EFFECTS IN HYPOTENSION THERAPY].
Topics: Amobarbital; Antihypertensive Agents; Arteriosclerosis; Chlorothiazide; Chlorthalidone; Guanethidine | 1964 |
[CLINICAL EVALUATION OF A PHARMACOLOGIC ASSOCIATION WITH HYPOTENSIVE ACTION].
Topics: Antihypertensive Agents; Biomedical Research; Carbamates; Drug Therapy; Electric Impedance; Humans; | 1964 |
HEMODYNAMIC ACTION OF VASOPRESSOR AND VASODEPRESSOR AGENTS IN ENDOTOXIN SHOCK.
Topics: Angiotensins; Blood Circulation; Blood Pressure; Blood Pressure Determination; Cardiac Output; Dogs; | 1965 |
EFFECT OF STAPHYLOCOCCAL TOXIN ON RENAL FUNCTION: IRREVERSIBLE SHOCK.
Topics: Angiotensins; Antitoxins; Dogs; Hydralazine; Hypotension; Kidney Diseases; Kidney Function Tests; Pa | 1965 |
[Central origin of the hypotensive action of hydralazine].
Topics: Humans; Hydralazine; Hypotension; Sympatholytics | 1955 |
The activities of 1-hydrazinophthalazine (Ba-5968); a hypotensive agent.
Topics: Antihypertensive Agents; Hydralazine; Hypotension; Sympatholytics | 1951 |
Parabrachial inputs to Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension: a light and electron microscopic study in the rat.
Topics: Amygdala; Animals; Biotin; Dextrans; Horseradish Peroxidase; Hydralazine; Hypotension; Immunohistoch | 2004 |
Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons.
Topics: Acetates; Animals; Catecholamines; Cell Compartmentation; Cell Nucleus; Cytoplasm; Endosomes; Hydral | 2004 |
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2005 |
Expression of endothelial nitric oxide synthase is suppressed in the renal vasculature of angiotensinogen-gene knockout mice.
Topics: Angiotensin II; Animals; Blood Pressure; Blood Vessels; Blotting, Western; Hydralazine; Hypotension; | 2006 |
Influence of blood pressure on the effectiveness of a fixed-dose combination of isosorbide dinitrate and hydralazine in the African-American Heart Failure Trial.
Topics: Adult; Aged; Antihypertensive Agents; Black or African American; Blood Pressure; Comorbidity; Drug C | 2007 |
Hemodynamic responses and c-Fos changes associated with hypotensive hemorrhage: standardizing a protocol for severe hemorrhage in conscious rats.
Topics: Animals; Blood Pressure; Blood Volume; Brain; Consciousness; Heart Rate; Hemorrhage; Hydralazine; Hy | 2007 |
Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor.
Topics: Amine Oxidase (Copper-Containing); Animals; Blood Pressure; Dose-Response Relationship, Drug; Enzyme | 2007 |
Tachykinin NK3 receptor contribution to systemic release of vasopressin and oxytocin in response to osmotic and hypotensive challenge.
Topics: Animals; Hydralazine; Hypotension; Hypothalamus; Infusions, Intravenous; Injections, Intraventricula | 2007 |
Hyperbaric oxygenation reduces overexpression of c-Fos and oxidative stress in the brain stem of experimental endotoxemic rats.
Topics: Analysis of Variance; Animals; Brain Stem; Guanidines; Hydralazine; Hyperbaric Oxygenation; Hypotens | 2008 |
Captopril in congestive heart failure: improved left ventricular function with decreased metabolic cost.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Heart Failure; Heart Ventricles; Hemodynamics; | 1982 |
Hemodynamic responses to combined therapy with captopril and hydralazine in patients with severe heart failure.
Topics: Aged; Blood Pressure; Captopril; Cardiac Output; Drug Therapy, Combination; Female; Heart Failure; H | 1983 |
Comparison of hypotensive, orthostatic and sympathetic inhibitory actions of antihypertensive drugs in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diazepam; Guanethidine; Heart Rate; Hyd | 1981 |
When pruritus leads to hypotension.
Topics: Humans; Hydralazine; Hypotension; Medication Errors; Pruritus | 1980 |
Modulatory effects of endogenous adenosine on epinephrine secretion from the adrenal medulla of the rat.
Topics: Adenosine; Adrenal Medulla; Animals; Captopril; Epinephrine; Hydralazine; Hypotension; Male; Norepin | 1994 |
Patterns of heart rate responses to hydralazine in normotensive and hypertensive rats.
Topics: Animals; Antihypertensive Agents; Baroreflex; Bradycardia; Female; Heart Rate; Hydralazine; Hyperten | 1996 |
Hypotension reduces sleep apneas in Zucker lean and Zucker obese rats.
Topics: Animals; Electromyography; Hydralazine; Hypotension; Injections, Intraperitoneal; Male; Rats; Sleep | 1996 |
Role of cardiac output in ethanol-evoked attenuation of centrally mediated hypotension in conscious rats.
Topics: Animals; Antihypertensive Agents; Brain; Cardiac Output; Clonidine; Ethanol; Hemodynamics; Hydralazi | 1997 |
Decreases in arterial pressure activate oxytocin neurons in conscious rats.
Topics: Animals; Antihypertensive Agents; Avoidance Learning; Blood Pressure; Chlorisondamine; Conditioning, | 1997 |
Vasodilators, aortic elasticity, and ventricular end-systolic stress in nonanesthetized unrestrained rats.
Topics: Animals; Aorta; Blood Pressure; Elasticity; Hydralazine; Hypotension; Male; Nifedipine; Nitroprussid | 1997 |
Fos expression in brain stem nuclei of pregnant rats after hydralazine-induced hypotension.
Topics: Animals; Antihypertensive Agents; Brain Stem; Cerebral Ventricles; Female; Hydralazine; Hypotension; | 1999 |
Role of renin-angiotensin system in hypotension-evoked thirst: studies with hydralazine.
Topics: Animals; Diazoxide; Drinking; Drug Combinations; Hydralazine; Hypotension; Isoproterenol; Male; Poly | 2000 |
Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats.
Topics: Animals; Diazoxide; Heart Rate; Hormone Antagonists; Hydralazine; Hypotension; Kinetics; Male; Oxyto | 2001 |
Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla.
Topics: Amines; Animals; Carrier Proteins; Electrophysiology; Growth Inhibitors; Hydralazine; Hypotension; M | 2002 |
The metabolic clearance rate of dehydroisoandrosterone sulfate. IV. Acute effects of induced hypertension, hypotension, and naturesis in normal and hypertensive pregnancies.
Topics: Adult; Angiotensin II; Blood Pressure; Dehydroepiandrosterone; Female; Furosemide; Humans; Hydralazi | 1976 |
Altered renin release and propranolol potentiation of vasodilatory drug hypotension.
Topics: Angiotensin II; Animals; Blood Pressure; Central Nervous System; Depression, Chemical; Dose-Response | 1975 |
Increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine, dihydralazine and minoxidil.
Topics: Angiotensin II; Animals; Blood Pressure; Dihydralazine; Dogs; Female; Guinea Pigs; Hydralazine; Hypo | 1979 |
Hypotensive sequelae of diazoxide and hydralazine therapy.
Topics: Adult; Diazoxide; Drug Synergism; Female; Humans; Hydralazine; Hypotension; Male; Middle Aged; Pregn | 1977 |
Hypotension and bradycardia following diazoxide and hydralazine therapy.
Topics: Bradycardia; Diazoxide; Humans; Hydralazine; Hypertension; Hypotension; Male; Middle Aged | 1977 |
PAF-induced bowel necrosis. Effects of vasodilators.
Topics: Alprostadil; Animals; Hydralazine; Hypotension; Indazoles; Intestinal Diseases; Leukopenia; Male; Me | 1991 |
Fatal small-bowel necrosis and pulmonary hypertension in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Humans; Hydralazine; Hypertension, Pulmonary; Hypotension; Infarction; I | 1989 |
Changes in plasma catecholamines and plasma renin activity during hypotension in conscious rats with lesions of the nucleus tractus solitarii.
Topics: Animals; Atenolol; Blood Pressure; Cardiovascular System; Consciousness; Denervation; Electric Stimu | 1988 |
Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion.
Topics: Adolescent; Adult; Anesthesia; Anesthetics; Dihydralazine; Drug Synergism; Enflurane; Female; Humans | 1988 |
Angiotensin blocking actions of guancydine.
Topics: Angiotensin II; Animals; Atropine; Blood Flow Velocity; Blood Pressure; Carotid Arteries; Epinephrin | 1969 |
Studies in clinical shock and hypotension. VII. Renal hemodynamics before and during treatment.
Topics: Acetylcholine; Adult; Aged; Angiotensin II; Blood Flow Velocity; Blood Urea Nitrogen; Cardiac Output | 1970 |
The effect of selective cardiac adrenergic beta-blockade on the hypotensive effect of hydrallazine.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Dogs; Drug Antagonism; Electrocardiography; He | 1971 |
[Antihypertensive agents].
Topics: Acetazolamide; Antihypertensive Agents; Bis-Trimethylammonium Compounds; Bretylium Compounds; Chlori | 1972 |
Myocardial papillary muscle necrosis induced by hypotensive agents in dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carboxylic Acids; Dogs; Electrocardiography; Femal | 1971 |
Escape from sodium-retaining effects of deoxycorticosterone in hypotensive and hypertensive dogs.
Topics: Aminohippuric Acids; Animals; Blood Pressure; Creatinine; Desoxycorticosterone; Dogs; Ephedrine; Fem | 1970 |