hydralazine and Heart Septal Defects, Ventricular studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Heart Septal Defects, Ventricular: Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.

Research Excerpts

Excerpt	Relevance	Reference
"Hydralazine is a smooth muscle relaxant and a potent arteriolar dilator."	6.36	Hydralazine in heart failure. ( Chatterjee, K, 1983)
"Hydralazine is a smooth muscle relaxant and a potent arteriolar dilator."	2.36	Hydralazine in heart failure. ( Chatterjee, K, 1983)
"Hydralazine was administered at cardiac catheterization to eight children with a ventricular septal defect (age: 2."	1.29	Afterload reduction by hydralazine in children with a ventricular septal defect as determined by aortic input impedance. ( Endo, H; Shiraishi, H; Yanagisawa, M, 1994)
"Hydralazine, 0."	1.27	Afterload reduction treatment for large ventricular septal defects. Dependence of haemodynamic effects of hydralazine on pretreatment systemic blood flow. ( Chon, Y; Nakazawa, M; Shimizu, T; Takao, A, 1983)
"Prehydralazine baseline data were therefore compared with values 35 minutes after hydralazine."	1.26	Hemodynamic effects of hydralazine in infants with a large ventricular septal defect. ( Beekman, RH; Rocchini, AP; Rosenthal, A, 1982)
" 4) In the management of essential moderate or severe hypertension is preferable to employ a mild dosage of betablockers and diuretics, rather than use higher doses of a single agent."	1.26	[The role of renin after betablocking diuretic and vasodilator treatment in essential hypertension (author's transl)]. ( Fusco, M; Lombardo, M; Valente, D, 1979)

Research

Studies (9)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Early Diastolic Mitral Annular Velocity

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (88.89)	18.7374
1990's	1 (11.11)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Chatterjee, K	1
Beekman, RH	1
Rocchini, AP	1
Rosenthal, A	1
Schmidt, H	1
Köhler, W	1
von Jan, V	1
Boucek, MM	1
Chang, R	1
Synhorst, DP	1
Nakazawa, M	2
Takao, A	2
Shimizu, T	2
Chon, Y	2
Kanaya, M	1
Momma, K	1
Friedlander, RP	1
Schwartz, MJ	1
Endo, H	1
Shiraishi, H	1
Yanagisawa, M	1
Lombardo, M	1
Fusco, M	1
Valente, D	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Organic Nitrates and Hydralazine on Wave Reflections and Left Ventricular Structure and Function in Heart Failure With Preserved Ejection Fraction[NCT01516346]	Phase 2	44 participants (Actual)	Interventional	2012-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Diastolic mitral annular velocity measured at the basal septal mitral annulus (NCT01516346)
Timeframe: 24 weeks

LV Mass

Intervention	cm/s (Mean)
Isosorbide Dinitrate	6.8
Isosorbide Dinitrate + Hydralazine	7.3
Placebo	6.5

LV mass measured by MRI, in grams normalized to height in meters raised to the 1.7 power (m^1.7) (NCT01516346)
Timeframe: 24 weeks

Myocardial Extracellular Volume Fraction

Intervention	grams / meters ^1.7 (Mean)
Isosorbide Dinitrate	68.2
Isosorbide Dinitrate + Hydralazine	66.2
Placebo	67.2

Myocardial extracellular volume, expressed as percent of total tissue volume, measured by MRI (T1 mapping pre and post-gadolinium administration) (NCT01516346)
Timeframe: 24 weeks

Quality of Life (Kansas City Cardiomyopathy Questionnaire Score)

Intervention	Percentage (Mean)
Isosorbide Dinitrate	29.0
Isosorbide Dinitrate + Hydralazine	31.3
Placebo	29.5

Quality of life, assessed with the Kansas City cardiomyopathy questionnaire (overall summary score, which ranges from 0 to 100). Higher values imply better quality of life. (NCT01516346)
Timeframe: 24 weeks

Wave Reflection Magnitude

Intervention	Points on a scale (Mean)
Isosorbide Dinitrate	62.1
Isosorbide Dinitrate + Hydralazine	44.9
Placebo	62.1

The dimensionless ratio of backward (reflected) to forward wave amplitude. Higher values imply more wave reflection. (NCT01516346)
Timeframe: 24 weeks

Article	Year
Hemodynamic effects of hydralazine in infants with a large ventricular septal defect. Circulation, 1982, Volume: 65, Issue:3 Topics: Blood Pressure; Cardiomegaly; Female; Heart Failure; Heart Septal Defects, Ventricular; Hemodynamics	1982
[Use of vasodilators in pediatric cardiology: left-right shunt modification by dihydralazine (Depressan)]. Kinderarztliche Praxis, 1984, Volume: 52, Issue:6 Topics: Child; Child, Preschool; Dihydralazine; Heart Septal Defects, Ventricular; Hemodynamics; Humans; Hyd	1984
Vasodilators and ventricular septal defect: comparison of prazosin, minoxidil, and hydralazine in a chronic lamb model. Pediatric research, 1984, Volume: 18, Issue:9 Topics: Animals; Blood Pressure; Heart Rate; Heart Septal Defects, Ventricular; Hydralazine; Minoxidil; Praz	1984
Afterload reduction treatment for large ventricular septal defects. Dependence of haemodynamic effects of hydralazine on pretreatment systemic blood flow. British heart journal, 1983, Volume: 49, Issue:5 Topics: Female; Heart Septal Defects, Ventricular; Hemodynamics; Humans; Hydralazine; Infant; Male; Pulmonar	1983
Significance of systemic vascular resistance in determining the hemodynamic effects of hydralazine on large ventricular septal defects. Circulation, 1983, Volume: 68, Issue:2 Topics: Blood Circulation; Blood Pressure; Child, Preschool; Heart Septal Defects, Ventricular; Hemodynamics	1983
Selective afterload reduction in the treatment of septal rupture complicating myocardial infarction. A case report. Cardiology, 1980, Volume: 65, Issue:1 Topics: Female; Heart Septal Defects, Ventricular; Humans; Hydralazine; Middle Aged; Myocardial Infarction;	1980
Afterload reduction by hydralazine in children with a ventricular septal defect as determined by aortic input impedance. Cardiovascular drugs and therapy, 1994, Volume: 8, Issue:1 Topics: Aorta; Cardiac Catheterization; Child; Child, Preschool; Electric Impedance; Female; Heart Septal De	1994
[The role of renin after betablocking diuretic and vasodilator treatment in essential hypertension (author's transl)]. Giornale italiano di cardiologia, 1979, Volume: 9, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Chlorthalidone; Diuretics; Drug Therapy	1979

hydralazine and Heart Septal Defects, Ventricular