hydralazine has been researched along with Fibrosarcoma in 11 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test this hypothesis, we reduced blood flow in subcutaneously grown Radiation Induced Fibrosarcoma-1 (RIF-1) tumors, either by creating partial ischemia with a bolus injection of hydralazine or by occlusion with surgical sutures." | 3.69 | Reduced blood flow increases the in vivo ammonium ion concentration in the RIF-1 tumor. ( Constantinidis, I; Gamcsik, MP, 1995) |
| "The effects of the vasodilator hydralazine (HYD) on microcirculatory function and hyperthermic response were studied in early generation isotransplants of a spontaneous C3Hf/Sed mouse fibrosarcoma (FSall)." | 3.68 | Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors. ( Kalmus, J; Okunieff, P; Vaupel, P, 1990) |
| "In KHT tumors, perfused vessel numbers decreased significantly at 30 min post-hydralazine, then recovered somewhat by 60 min." | 1.31 | Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models. ( Fenton, BM, 2001) |
| "When nigericin and EIPA were combined with administration of hydralazine, the surviving fraction of cells in both tumors was reduced by a factor of 0." | 1.29 | Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. ( Hasuda, K; Lee, C; Tannock, IF, 1994) |
| "Hydralazine, which may cause tumour hypoxia and lower pHi as well as pHe, caused cytotoxity when given alone by chronic infusion, and enhanced the cytotoxicity due to nigericin." | 1.29 | The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects. ( Tannock, IF; Yamagata, M, 1996) |
| "Both nigericin and CCCP were observed to penetrate tissue based on their ability to kill tumour cells in spheroids." | 1.28 | Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours. ( Newell, K; Stratford, I; Tannock, I; Wood, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jarm, T | 2 |
| Sersa, G | 2 |
| Miklavcic, D | 2 |
| Podobnik, B | 1 |
| Constantinidis, I | 1 |
| Gamcsik, MP | 1 |
| Burney, IA | 2 |
| Maxwell, RJ | 3 |
| Field, SB | 3 |
| McCoy, CL | 1 |
| Griffiths, JR | 3 |
| Hasuda, K | 1 |
| Lee, C | 1 |
| Tannock, IF | 2 |
| Yamagata, M | 1 |
| Fenton, BM | 1 |
| Newell, K | 1 |
| Wood, P | 1 |
| Stratford, I | 1 |
| Tannock, I | 1 |
| Needham, S | 1 |
| Coggle, JE | 1 |
| Bhujwalla, ZM | 1 |
| Tozer, GM | 1 |
| Kalmus, J | 1 |
| Okunieff, P | 1 |
| Vaupel, P | 1 |
11 other studies available for hydralazine and Fibrosarcoma
| Article | Year |
|---|---|
Oxygenation and blood flow in tumors treated with hydralazine: evaluation with a novel luminescence-based fiber-optic sensor.
Topics: Animals; Female; Fibrosarcoma; Hydralazine; Injections, Intravenous; Laser-Doppler Flowmetry; Mice; | 2002 |
Effect of hydralazine on blood flow, oxygenation, and interstitial fluid pressure in subcutaneous tumors.
Topics: Animals; Blood Flow Velocity; Extracellular Space; Fibrosarcoma; Hydralazine; Luminescent Measuremen | 2003 |
Reduced blood flow increases the in vivo ammonium ion concentration in the RIF-1 tumor.
Topics: Animals; Fibrosarcoma; Hydralazine; Ligation; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3 | 1995 |
Effect of vasoactive drugs on tumour blood flow as determined by 2H nuclear magnetic resonance spectroscopy.
Topics: Animals; Blood Pressure; Body Water; Calcitonin Gene-Related Peptide; Cell Hypoxia; Deuterium; Deute | 1995 |
Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH.
Topics: Amiloride; Animals; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Drug Screening Assays, A | 1994 |
The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Antipor | 1996 |
Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models.
Topics: Animals; Carbocyanines; Cell Hypoxia; Etanidazole; Female; Fibrosarcoma; Fluorescent Dyes; Hydralazi | 2001 |
Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours.
Topics: Amiloride; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Division; Cell Survival; Fibrosa | 1992 |
Differences in vascular response between primary and transplanted tumours.
Topics: Animals; Fibroma; Fibrosarcoma; Histiocytoma, Benign Fibrous; Hydralazine; Magnetic Resonance Spectr | 1991 |
The energy metabolism of RIF-1 tumours following hydralazine.
Topics: Animals; Energy Metabolism; Fibrosarcoma; Hydralazine; Magnetic Resonance Spectroscopy; Male; Mice; | 1990 |
Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors.
Topics: Animals; Blood Pressure; Female; Fibrosarcoma; Heart Rate; Hydralazine; Hyperthermia, Induced; Laser | 1990 |