hydralazine has been researched along with Experimental Neoplasms in 35 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of hydralazine on the blood flow in various normal tissues and R3230 Ac adenocarcinomas grown in different sites in rats were studied." | 3.68 | Effect of hydralazine on the blood flow in tumors and normal tissues in rats. ( Hasegawa, T; Song, CW, 1991) |
| " Administration of 5 mg/kg of hydralazine following dosing with the PFOB emulsion reduced the 19F signal intensity from the murine tumors RIF-1 and KHT and from the human tumour HT29 with no or little reduction in the SCCVII/Ha murine and HX118 human tumours." | 1.29 | [Use of fluorine-19 nuclear resonance spectroscopy for the measurement of changes induced in blood perfusion volume in experimental tumors in vivo]. ( Adams, G; Counsell, C; Thomas, C; Wood, P, 1993) |
| "Hydralazine has been widely used to reduce tumor blood flow in mice." | 1.28 | Comparative effects of hydralazine on perfusion of KHT tumor, kidney and liver and on renal function in mice. ( Bleehen, NM; Honess, DJ, 1992) |
| "Hydralazine is a peripheral vasodilator used as an antihypertensive agent." | 1.28 | Effects of hydralazine on the blood flow in RIF-1 tumors and normal tissues of mice. ( Lin, JC; Song, CW, 1990) |
| " Our studies with one such agent, the vasodilator hydralazine, have clearly demonstrated that it can increase the tumor cytotoxicity of drugs which are known to be more toxic under hypoxic conditions." | 1.28 | Potentiation of the tumor cytotoxicity of melphalan by vasodilating drugs. ( Acker, B; Chaplin, DJ; Olive, PL, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (40.00) | 18.7374 |
| 1990's | 20 (57.14) | 18.2507 |
| 2000's | 1 (2.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jarm, T | 1 |
| Sersa, G | 1 |
| Miklavcic, D | 1 |
| Chan, RC | 2 |
| Babbs, CF | 2 |
| Vetter, RJ | 1 |
| Lamar, CH | 1 |
| Jones, GR | 1 |
| DeWitt, DP | 1 |
| Voorhees, WD | 1 |
| McCaw, JS | 1 |
| Thomas, C | 2 |
| Counsell, C | 1 |
| Wood, P | 1 |
| Adams, G | 1 |
| Bradley, JK | 1 |
| Counsell, CJ | 2 |
| Bremner, JC | 2 |
| Sansom, JM | 1 |
| Adams, GE | 6 |
| Aoki, Y | 1 |
| Akagi, K | 1 |
| Kitada, N | 1 |
| Tanaka, Y | 1 |
| Fritz-Zieroth, B | 1 |
| Bhujwalla, ZM | 3 |
| Shungu, DC | 1 |
| Glickson, JD | 2 |
| Aboagye, EO | 1 |
| Maxwell, RJ | 3 |
| Kelson, AB | 1 |
| Tracy, M | 1 |
| Lewis, AD | 1 |
| Graham, MA | 1 |
| Horsman, MR | 3 |
| Griffiths, JR | 3 |
| Workman, P | 1 |
| Robinson, SP | 1 |
| van den Boogaart, A | 1 |
| Hamilton, E | 1 |
| Waterton, JC | 1 |
| Toth, B | 1 |
| Blackband, SJ | 1 |
| Wehrle, JP | 1 |
| Skarsgard, LD | 1 |
| Chaplin, DJ | 7 |
| Wilson, DJ | 1 |
| Skwarchuk, MW | 1 |
| Vinczan, A | 1 |
| Kristl, J | 1 |
| Honess, DJ | 1 |
| Bleehen, NM | 1 |
| Hurd, RE | 1 |
| Freeman, D | 1 |
| Peters, CE | 2 |
| Stratford, IJ | 5 |
| Wood, PJ | 1 |
| Overgaard, J | 1 |
| Trotter, MJ | 2 |
| Hasegawa, T | 1 |
| Song, CW | 2 |
| Guichard, M | 1 |
| Lespinasse, F | 1 |
| Trotter, M | 1 |
| Durand, R | 1 |
| Chaplin, D | 1 |
| Tozer, GM | 2 |
| Field, SB | 1 |
| Proctor, E | 1 |
| Busza, A | 1 |
| Williams, SR | 1 |
| Pham, P | 1 |
| Lin, JC | 1 |
| Zeman, EM | 1 |
| Lemmon, MJ | 1 |
| Brown, JM | 1 |
| Godden, J | 2 |
| Howells, N | 3 |
| Acker, B | 1 |
| Olive, PL | 1 |
| Okunieff, P | 1 |
| Walsh, CS | 1 |
| Vaupel, P | 1 |
| Kallinowski, F | 1 |
| Hitzig, BM | 1 |
| Neuringer, LJ | 1 |
| Suit, HD | 1 |
| Nethersell, AB | 1 |
| White, RD | 1 |
| Dunn, JF | 1 |
| Frostick, S | 1 |
| Hogan, G | 1 |
| Radda, GK | 1 |
| Acker, BD | 1 |
| Tobari, C | 1 |
| Van Kersen, I | 1 |
| Hahn, GM | 1 |
2 reviews available for hydralazine and Experimental Neoplasms
| Article | Year |
|---|---|
Hydralazine and hydralazine hydrochloride.
Topics: Animals; Chemical Phenomena; Chemistry; Humans; Hydralazine; Mice; Mutagenicity Tests; Neoplasms, Ex | 1980 |
The use of blood flow modifiers to improve the treatment response of solid tumors.
Topics: Animals; Combined Modality Therapy; Hydralazine; Mice; Neoplasms, Experimental; Niacinamide; Pyrazin | 1991 |
33 other studies available for hydralazine and Experimental Neoplasms
| Article | Year |
|---|---|
Oxygenation and blood flow in tumors treated with hydralazine: evaluation with a novel luminescence-based fiber-optic sensor.
Topics: Animals; Female; Fibrosarcoma; Hydralazine; Injections, Intravenous; Laser-Doppler Flowmetry; Mice; | 2002 |
Abnormal response of tumor vasculature to vasoactive drugs.
Topics: Animals; Cardiac Output; Cerebrovascular Circulation; Hydralazine; Male; Neoplasms, Experimental; Ph | 1984 |
Interference with energy production as a means of causing injury to a human pancreatic carcinoma.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism; | 1983 |
Theoretical feasibility of vasodilator-enhanced local tumor heating.
Topics: Animals; Blood Flow Velocity; Computers; Cricetinae; Dogs; Female; Hot Temperature; Hydralazine; Mal | 1982 |
[Use of fluorine-19 nuclear resonance spectroscopy for the measurement of changes induced in blood perfusion volume in experimental tumors in vivo].
Topics: Animals; Blood Volume; Fluorine Radioisotopes; Hydralazine; Magnetic Resonance Spectroscopy; Mice; N | 1993 |
The accuracy and reproducibility of measuring blood flow in murine tumours by the D2O uptake and clearance techniques.
Topics: Animals; Deuterium Oxide; Hydralazine; Magnetic Resonance Spectroscopy; Metabolic Clearance Rate; Mi | 1994 |
[Study of anti-tumor effects of hyperthermia combined with hydralazine on experimental tumor].
Topics: Adenosine Triphosphate; Animals; Combined Modality Therapy; Energy Metabolism; Hydralazine; Hyperthe | 1995 |
Effects of blood flow modifiers on tumor metabolism observed in vivo by proton magnetic resonance spectroscopic imaging.
Topics: Animals; Antihypertensive Agents; Glycerylphosphorylcholine; Hydralazine; Magnetic Resonance Spectro | 1996 |
Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Chromatography, High Pressure Liquid; Drug Evaluation, Precli | 1997 |
31P-magnetic resonance spectroscopy and 2H-magnetic resonance imaging studies of a panel of early-generation transplanted murine tumour models.
Topics: Animals; Cell Division; Female; Hydralazine; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; | 1998 |
Tumorigenic effect of 1-hydrazinophthalazine hydrochloride in mice.
Topics: Adenocarcinoma; Adenoma; Animals; Female; Humans; Hydralazine; Lung Neoplasms; Male; Mice; Neoplasms | 1978 |
Spatial heterogeneity of the metabolic response of RIF-1 tumors to a vasoactive agent evaluated in vivo by one-dimensional 31P chemical-shift imaging.
Topics: Animals; Energy Metabolism; Hydralazine; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; Mi | 1992 |
The effect of hypoxia and low pH on the cytotoxicity of chlorambucil.
Topics: Animals; Cell Hypoxia; Cell Survival; Chlorambucil; Cricetinae; Drug Synergism; Hydralazine; Hydroge | 1992 |
Comparative effects of hydralazine on perfusion of KHT tumor, kidney and liver and on renal function in mice.
Topics: Animals; Blood Flow Velocity; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; | 1992 |
Proton editing and imaging of lactate.
Topics: Animals; Hydralazine; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectros | 1991 |
Blood flow modification in the SCCVII tumor: effects of 5-hydroxytryptamine, hydralazine, and propranolol.
Topics: Animals; Blood Flow Velocity; Cell Survival; Erythrocytes; Hydralazine; Injections, Intraperitoneal; | 1992 |
Magnetic resonance spectroscopy studies on experimental murine and human tumors: comparison of changes in phosphorus metabolism with induced changes in vascular volume.
Topics: Animals; Blood Volume; Humans; Hydralazine; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; | 1992 |
Drug induced perturbations in tumor blood flow: therapeutic potential and possible limitations.
Topics: Animals; Cell Hypoxia; Hydralazine; Mice; Neoplasms, Experimental; Niacinamide; Propranolol; Regiona | 1991 |
Effect of hydralazine on the blood flow in tumors and normal tissues in rats.
Topics: Adenocarcinoma; Animals; Blood Circulation; Cardiac Output; Depression, Chemical; Hydralazine; Male; | 1991 |
The effect of hydralazine on blood flow and misonidazole toxicity in human tumour xenografts.
Topics: Animals; Cell Hypoxia; Cell Line; Humans; Hydralazine; Misonidazole; Neoplasm Transplantation; Neopl | 1991 |
The combined measurement of blood flow and metabolism in RIF-1 tumours in vivo. A study using H2 flow and 31P NMR spectroscopy.
Topics: Animals; Cell Line; Energy Metabolism; Hydralazine; Magnetic Resonance Spectroscopy; Male; Mice; Mic | 1990 |
Modification of the 31P magnetic resonance spectra of a rat tumour using vasodilators and its relationship to hypotension.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Energy Metabolism; Epoprostenol; Heart Ra | 1990 |
Effects of hydralazine on the blood flow in RIF-1 tumors and normal tissues of mice.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Female; Hydralazine; Kidney; Liver; | 1990 |
Aerobic radiosensitization by SR 4233 in vitro and in vivo.
Topics: Animals; Cell Hypoxia; Drug Interactions; Hydralazine; Mice; Neoplasms, Experimental; Radiation-Sens | 1990 |
Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo.
Topics: Animals; Combined Modality Therapy; Female; Hydralazine; Mice; Mice, Inbred C3H; Misonidazole; Neopl | 1989 |
Hydralazine-induced tumor hypoxia: a potential target for cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Aziridines; Drug Synergism; Female; Hydralazine; Mice; Mice, Inbred | 1989 |
Potentiation of the tumor cytotoxicity of melphalan by vasodilating drugs.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Female; Hydralazine; Melphalan; Mice; Mice, Inbr | 1989 |
Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Hydralazine; Melphalan; Mice; Neoplasms, Experim | 1989 |
Effects of hydralazine on in vivo tumor energy metabolism, hematopoietic radiation sensitivity, and cardiovascular parameters.
Topics: Animals; Energy Metabolism; Female; Hematopoietic Stem Cells; Hemodynamics; Hydralazine; Male; Mice; | 1989 |
Induction of severe tumor hypoxia by modifiers of the oxygen affinity of hemoglobin.
Topics: Aldehydes; Animals; Benzaldehydes; Hydralazine; Mice; Neoplasms, Experimental; Oxygen; Oxyhemoglobin | 1989 |
Induction of tumour hypoxia by a vasoactive agent. A combined NMR and radiobiological study.
Topics: Animals; Hydralazine; Magnetic Resonance Spectroscopy; Mice; Neoplasm Transplantation; Neoplasms, Ex | 1989 |
Histological evidence for nonperfused vasculature in a murine tumor following hydralazine administration.
Topics: Animals; Carcinoma, Squamous Cell; Erythrocyte Indices; Female; Hydralazine; Male; Mice; Mice, Inbre | 1989 |
Modification of pH of normal and malignant mouse tissue by hydralazine and glucose, with and without breathing of 5% CO2 and 95% air.
Topics: Adipose Tissue; Animals; Carbon Dioxide; Glucose; Hydralazine; Hydrogen-Ion Concentration; Kidney; L | 1988 |