hydralazine and Emergencies studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.

Research Excerpts

Excerpt	Relevance	Reference
"We sought to compare the efficacy of intravenously administered hydralazine and oral nifedipine for acute blood pressure control in acute hypertensive emergency of pregnancy."	9.24	Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. ( Gupta, A; Sharma, C; Soni, A; Verma, A; Verma, S, 2017)
"We sought to compare the efficacy of intravenously administered hydralazine and oral nifedipine for acute blood pressure control in acute hypertensive emergency of pregnancy."	5.24	Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. ( Gupta, A; Sharma, C; Soni, A; Verma, A; Verma, S, 2017)
" Oral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenting with pre-eclampsia."	4.98	Focused Update on Pharmacologic Management of Hypertensive Emergencies. ( Broscious, R; Devabhakthuni, S; Noel, ZR; Watson, K, 2018)
" Hydralazine has been widely used in treatment of hypertension in eclampsia and preeclampsia, and its safety has been demonstrated in these patients."	4.79	Management of hypertensive urgencies and emergencies. ( Abdelwahab, W; Frishman, W; Landau, A, 1995)
" The American College of Obstetricians and Gynecologists recommends that acute-onset, severe hypertension be treated with first line-therapy (intravenous labetalol, intravenous hydralazine or oral nifedipine) within 60 minutes to reduce risk of maternal morbidity and death."	3.96	Identification of factors associated with delayed treatment of obstetric hypertensive emergencies. ( Akerman, MB; Elsayad, A; Halpern, TA; Heiselman, CJ; Heo, HJ; Kantorowska, A; Muscat, JC; Sicuranza, GB; Vintzileos, AM, 2020)
"To evaluate the efficacy and safety of intravenous hydralazine in arterial hypertension."	3.68	[Use of intravenous hydralazine in treatment of hypertensive crisis]. ( Amato, R; Bellotti, G; Cesar, LA; Pfeferman, E; Pileggi, F; Ramires, JA; Serrano, CV, 1991)
"Although hypertension is the most common and significant risk factor in pregnancy, the risks can be minimized with careful supervision and therapy."	2.37	Hypertension in pregnant women. ( Gallery, ED, 1985)
"Amlodipine was the most common first-line agent (n=10), followed by hydralazine (n=4) and hypertonic saline (n=1)."	1.72	Evaluation of presentation, treatment and outcome in hypertensive emergency in dogs and cats: 15 cases (2003-2019). ( Beeston, D; Cortellini, S; Jepson, R, 2022)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (64.86)	18.7374
1990's	4 (10.81)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (18.92)	24.3611
2020's	2 (5.41)	2.80

Authors	Studies
Beeston, D	1
Jepson, R	1
Cortellini, S	1
Kantorowska, A	1
Heiselman, CJ	1
Halpern, TA	1
Akerman, MB	1
Elsayad, A	1
Muscat, JC	1
Sicuranza, GB	1
Vintzileos, AM	1
Heo, HJ	1
Sharma, C	1
Soni, A	1
Gupta, A	1
Verma, A	1
Verma, S	1
Watson, K	1
Broscious, R	1
Devabhakthuni, S	1
Noel, ZR	1
Vadhera, RB	1
Simon, M	1
Olson-Chen, C	1
Seligman, NS	1
Squair, JW	1
Phillips, AA	1
Harmon, M	1
Krassioukov, AV	1
Legler, A	1
Kim, RK	1
Chawla, N	1
Odunukan, OW	1
Abudiab, MM	1
Sinak, LJ	1
WOLF, RL	1
MENDLOWITZ, M	1
NAFTCHI, NE	1
GITLOW, SE	1
Ram, CV	2
Segal, JL	1
Abdelwahab, W	1
Frishman, W	1
Landau, A	1
Nies, AS	1
Romankiewicz, JA	2
Becker, CE	1
Benowitz, NL	1
Pascual, AV	1
Zimmerman, SW	1
McLain, LG	1
Deal, JE	1
Barratt, TM	1
Dillon, MJ	1
Cesar, LA	1
Amato, R	1
Pfeferman, E	1
Serrano, CV	1
Ramires, JA	1
Bellotti, G	1
Pileggi, F	1
Gallery, ED	1
Ferguson, RK	1
Vlasses, PH	1
Vidt, DG	2
Burris, JF	1
Philipp, T	1
Nast, HP	1
Seedat, YK	1
Koch-Weser, J	1
Fernandes, M	1
Kim, KE	1
Moyer, JH	1
Herting, RL	1
Hunter, HL	1
Breslin, DJ	1
Himathongkam, T	1

Trial	Enrollment	Study Type	Start Date	Status
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886]	8 participants (Anticipated)	Interventional	2021-06-08	Recruiting
The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388]	46 participants (Anticipated)	Interventional	2020-02-01	Not yet recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923]	8 participants (Anticipated)	Interventional	2021-12-31	Recruiting
Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093]	20 participants (Anticipated)	Interventional	2021-11-29	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Focused Update on Pharmacologic Management of Hypertensive Emergencies. Current hypertension reports, 2018, 06-08, Volume: 20, Issue:7 Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Emergencies; Enalapri	2018
Hypertensive emergencies in pregnancy. Clinical obstetrics and gynecology, 2014, Volume: 57, Issue:4 Topics: Antihypertensive Agents; Eclampsia; Emergencies; Female; Humans; Hydralazine; Hypertension; Hyperten	2014
Hypertensive Emergencies in Pregnancy. Critical care clinics, 2016, Volume: 32, Issue:1 Topics: Antihypertensive Agents; Cesarean Section; Chronic Disease; Congenital Abnormalities; Emergencies; E	2016
CURRENT TREATMENT OF HYPERTENSION WITH DRUGS. American heart journal, 1963, Volume: 66 Topics: Antihypertensive Agents; Benzothiadiazines; Bretylium Compounds; Diuretics; Emergencies; Ganglionic	1963
Hypertensive crisis. Cardiology clinics, 1984, Volume: 2, Issue:2 Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia	1984
Hypertensive emergencies: practical approach to treatment. Postgraduate medicine, 1980, Volume: 68, Issue:2 Topics: Administration, Oral; Antihypertensive Agents; Child; Clonidine; Diazoxide; Emergencies; Female; Hum	1980
Management of hypertensive urgencies and emergencies. Journal of clinical pharmacology, 1995, Volume: 35, Issue:8 Topics: Administration, Oral; Antihypertensive Agents; Emergencies; Enalaprilat; Female; Humans; Hydralazine	1995
Clinical pharmacology of antihypertensive drugs. The Medical clinics of North America, 1977, Volume: 61, Issue:3 Topics: Adrenergic alpha-Antagonists; Aldosterone; Angiotensin II; Antihypertensive Agents; Bethanidine; Blo	1977
Drug therapy reviews. Pharmacology and clinical use of drugs in hypertensive emergencies. The Journal of the Maine Medical Association, 1977, Volume: 68, Issue:2 Topics: Adult; Diazoxide; Emergencies; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Nitroprus	1977
Pharmacology and clinical use of drugs in hypertensive emergencies. American journal of hospital pharmacy, 1977, Volume: 34, Issue:2 Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Aorta; Brain Diseases; Cerebral Hemorrhage; Diazox	1977
How to manage hypertensive emergencies and urgencies. Geriatrics, 1976, Volume: 31, Issue:1 Topics: Adult; Antihypertensive Agents; Aortic Aneurysm; Brain Diseases; Cerebrovascular Disorders; Diazoxid	1976
Management of hypertensive emergencies: changing therapeutic options. American heart journal, 1991, Volume: 122, Issue:1 Pt 2 Topics: Emergencies; Humans; Hydralazine; Hypertension; Labetalol; Nicardipine; Nitroprusside	1991
Hypertension in pregnant women. The Medical journal of Australia, 1985, Jul-08, Volume: 143, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Delivery, Obstetric; Diazoxide; Emergencies; F	1985
Hypertensive emergencies and urgencies. JAMA, 1986, Mar-28, Volume: 255, Issue:12 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers;	1986
Choice of antihypertensive drugs for the treatment of hypertension, including hypertensive emergencies. Cardiovascular clinics, 1974, Volume: 6, Issue:2 Topics: Antihypertensive Agents; Bethanechol Compounds; Clonidine; Diazoxide; Diuretics; Emergencies; Ferric	1974
Hypertensive emergencies. The New England journal of medicine, 1974, Jan-24, Volume: 290, Issue:4 Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Brain Edema; Cerebrovascular Disorders; Coronary D	1974
Hypertensive emergencies. Pennsylvania medicine, 1974, Volume: 77, Issue:7 Topics: Acute Kidney Injury; Adrenal Gland Neoplasms; Antihypertensive Agents; Aortic Aneurysm; Blood Volume	1974
The physiologic and pharmacologic basis for the clinical treatment of hypertension. The Medical clinics of North America, 1967, Volume: 51, Issue:1 Topics: Antihypertensive Agents; Benzothiadiazines; Emergencies; Guanethidine; Humans; Hydralazine; Hyperten	1967
Hypertensive crisis. The Medical clinics of North America, 1969, Volume: 53, Issue:2 Topics: Antihypertensive Agents; Brain Edema; Cerebrovascular Disorders; Diazoxide; Emergencies; Humans; Hyd	1969

Article	Year
Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial. American journal of obstetrics and gynecology, 2017, Volume: 217, Issue:6 Topics: Acute Disease; Adolescent; Adult; Apgar Score; Double-Blind Method; Emergencies; Female; Humans; Hyd	2017
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension. Acta medica Scandinavica. Supplementum, 1983, Volume: 678 Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide;	1983

hydralazine and Emergencies

Research Excerpts

Research

Studies (37)

Authors

Clinical Trials (4)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Evaluation of presentation, treatment and outcome in hypertensive emergency in dogs and cats: 15 cases (2003-2019). The Journal of small animal practice, 2022, Volume: 63, Issue:10 Topics: Amlodipine; Animals; Antihypertensive Agents; Blindness; Cat Diseases; Cats; Dog Diseases; Dogs; Eme	2022
Identification of factors associated with delayed treatment of obstetric hypertensive emergencies. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:2 Topics: Administration, Intravenous; Administration, Oral; Adult; After-Hours Care; Antihypertensive Agents;	2020
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Emergency management of autonomic dysreflexia with neurologic complications. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Oct-18, Volume: 188, Issue:15 Topics: Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Autonomic Dysreflexia; Brain; Consc	2016
Glucagon-induced hypertensive emergency: a case report. Journal of clinical anesthesia, 2016, Volume: 35 Topics: Antihypertensive Agents; Emergencies; Female; Gastrointestinal Agents; Glucagon; Humans; Hydralazine	2016
48-year-old man with cough and leg swelling. Mayo Clinic proceedings, 2012, Volume: 87, Issue:12 Topics: Acute Disease; Antihypertensive Agents; Cerebrovascular Circulation; Cough; Dyspnea; Echocardiograph	2012
Hypertensive emergencies. The Medical clinics of North America, 1979, Volume: 63, Issue:1 Topics: Adrenal Gland Neoplasms; Angiotensin II; Animals; Aortic Aneurysm; Aortic Dissection; Brain Diseases	1979
Treatment of hypertensive emergencies. Wisconsin medical journal, 1975, Volume: 74, Issue:7 Topics: Diazoxide; Emergencies; Humans; Hydralazine; Hypertension; Methyldopa; Nitroprusside; Reserpine; Tri	1975
Drugs in the management of hypertensive emergencies in children. Notes and comments on currently popular agents. Clinical pediatrics, 1976, Volume: 15, Issue:1 Topics: Antihypertensive Agents; Child; Diazoxide; Diuretics; Drug Combinations; Drug Therapy, Combination;	1976
Management of hypertensive emergencies. Archives of disease in childhood, 1992, Volume: 67, Issue:9 Topics: Adolescent; Child; Child, Preschool; Diazoxide; Emergencies; Female; Humans; Hydralazine; Hypertensi	1992
[Use of intravenous hydralazine in treatment of hypertensive crisis]. Arquivos brasileiros de cardiologia, 1991, Volume: 56, Issue:5 Topics: Adult; Aged; Blood Pressure; Drug Evaluation; Emergencies; Female; Heart Rate; Humans; Hydralazine;	1991
Current concepts in treatment of hypertensive emergencies. American heart journal, 1986, Volume: 111, Issue:1 Topics: Diazoxide; Drug Therapy, Combination; Emergencies; Humans; Hydralazine; Hypertension; Labetalol; Met	1986
Drugs for hypertensive emergencies. The Medical letter on drugs and therapeutics, 1985, Mar-01, Volume: 27, Issue:682 Topics: Administration, Oral; Captopril; Clonidine; Diazoxide; Emergencies; Humans; Hydralazine; Hypertensio	1985
Hypertensive emergencies. American family physician, 1985, Volume: 32, Issue:1 Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Emergencies; Humans; Hydralazine; Hyp	1985
[Hypertensive emergencies]. Der Internist, 1974, Volume: 15, Issue:3 Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies;	1974
The medical treatment of hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1970, Jun-13, Volume: 44, Issue:24 Topics: Antihypertensive Agents; Chlorothiazide; Diet Therapy; Emergencies; Furosemide; Ganglionic Blockers;	1970
Hypertensive emergencies. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1972, Volume: 55, Issue:8 Topics: Diazoxide; Emergencies; Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension	1972