hydralazine has been researched along with Ehlers-Danlos Syndrome in 3 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Ehlers-Danlos Syndrome: A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydralazine treatment, with or without ascorbate, severely decreased the alpha 1(I) collagen mRNAs in fibroblasts from both AT750 and the normal donor; total collagen synthesis was similarly reduced." | 5.29 | The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI. ( Marshall, MK; Murad, S; Pinnell, SR; Walker, LC; Yeowell, HN, 1995) |
| "Hydralazine treatment, with or without ascorbate, severely decreased the alpha 1(I) collagen mRNAs in fibroblasts from both AT750 and the normal donor; total collagen synthesis was similarly reduced." | 1.29 | The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI. ( Marshall, MK; Murad, S; Pinnell, SR; Walker, LC; Yeowell, HN, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yeowell, HN | 2 |
| Walker, LC | 2 |
| Marshall, MK | 1 |
| Murad, S | 2 |
| Pinnell, SR | 2 |
| Gallop, PM | 1 |
| Paz, MA | 1 |
1 review available for hydralazine and Ehlers-Danlos Syndrome
| Article | Year |
|---|---|
Posttranslational protein modifications, with special attention to collagen and elastin.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Ascorbic Acid; Collagen; Connective Tissue; Copp | 1975 |
2 other studies available for hydralazine and Ehlers-Danlos Syndrome
| Article | Year |
|---|---|
The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI.
Topics: Ascorbic Acid; Blotting, Northern; Cell Line; Cells, Cultured; Collagen; Ehlers-Danlos Syndrome; Fib | 1995 |
A common duplication in the lysyl hydroxylase gene of patients with Ehlers Danlos syndrome type VI results in preferential stimulation of lysyl hydroxylase activity and mRNA by hydralazine.
Topics: 2,2'-Dipyridyl; Ascorbic Acid; Blotting, Northern; Ehlers-Danlos Syndrome; Enzyme Activation; Fibrob | 1997 |