hydralazine and Eclampsia studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Eclampsia: Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).

Research Excerpts

Excerpt	Relevance	Reference
"The objective was to compare the fetal and maternal effects between parenteral hydralazine and sublingual nifedipine used like antihypertensive drugs in the management of severe preeclampsia."	9.07	[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. ( Flores Padilla, LM; Walss Rodriguez, RJ, 1993)
"The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy."	9.05	Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy. ( Davey, DA; Dommisse, J; Garden, A, 1982)
"The objective was to compare the fetal and maternal effects between parenteral hydralazine and sublingual nifedipine used like antihypertensive drugs in the management of severe preeclampsia."	5.07	[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. ( Flores Padilla, LM; Walss Rodriguez, RJ, 1993)
"The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy."	5.05	Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy. ( Davey, DA; Dommisse, J; Garden, A, 1982)
" Given her undifferentiated headache and the possibility of preeclampsia, the patient was treated with magnesium sulfate, which was subsequently stopped due to worsening bradycardia."	3.81	Late Postpartum Eclampsia with Postpartum Angiopathy: An Uncommon Diagnosis in the Emergency Department. ( Dickman, E; Garg, D; Rahaman, B; Stein, EG, 2015)
"Since 1955 standardized treatment applied uniformly to all cases of eclampsia at Parkland Memorial Hospital has consisted of (1) magnesium sulfate intravenously and intramuscularly to control convulsions, (2) intravenous hydralazine intermittently to lower diastolic blood pressure when it exceeded 110 mm."	3.65	Standardized treatment of 154 consecutive cases of eclampsia. ( Pritchard, JA; Pritchard, SA, 1975)
"Postpartum preeclampsia/eclampsia is the presence of hypertension and proteinuria, with or without seizures, occurring up to 4 weeks after delivery."	1.37	Postpartum preeclampsia: emergency department presentation and management. ( Abbott, J; Bakes, K; Withers, E; Yancey, LM, 2011)
"3 U/MPL), mild preeclampsia (6."	1.30	Anticardiolipin antibodies and the severity of preeclampsia-eclampsia. ( Cortés-Llamas, V; González-Ortiz, M; Martínez-Abundis, E; Salazar-Páramo, M, 1999)
"Hydralazine to lower the diastolic blood pressure somewhat, when it was 110 mm Hg or higher, prevented intracranial hemorrhage."	1.27	The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. ( Cunningham, FG; Pritchard, JA; Pritchard, SA, 1984)
"Although the recognition and treatment of preeclampsia theoretically should eliminate eclampsia, it has not disappeared and remains a substantial threat to maternal and fetal well-being."	1.26	Eclampsia: treatment and referral. ( Anderson, GD; Dilts, PV; McCubbin, JH; Sibai, BM, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (80.00)	18.7374
1990's	3 (6.67)	18.2507
2000's	2 (4.44)	29.6817
2010's	4 (8.89)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Arulkumaran, N	1
Lightstone, L	1
Vadhera, RB	1
Simon, M	1
Garg, D	1
Rahaman, B	1
Stein, EG	1
Dickman, E	1
Yancey, LM	1
Withers, E	1
Bakes, K	1
Abbott, J	1
RENZI, AA	1
GAUNT, R	1
JORDAN, WK	1
DRAPS, H	1
DRAPS, MH	1
SUNDFOR, H	1
SATTENSPIEL, E	1
SMITH, GC	1
SPIELMANN, W	1
KAHN, K	1
DAVIS, CD	1
NEWTON, M	1
ALEXANDER, JA	2
ROGERS, SF	2
JACOBS, WM	2
WILLS, SH	2
MACLAVERTY, MP	1
PAVLIC, RS	1
SMITH, CJ	1
Olatunji, AO	1
Sule-Odu, AO	1
Omu, AE	1
Al-Harmi, J	1
Vedi, HL	1
Mlechkova, L	1
Sayed, AF	1
Al-Ragum, NS	1
Chesley, LC	1
Knuppel, RA	1
Montenegro, R	1
Ram, CV	1
Hankins, GD	1
Wendel, GD	1
Cunningham, FG	3
Leveno, KJ	1
Rocchi, G	1
Pritchard, JA	5
Pritchard, SA	2
Liebowitz, HA	1
Hall, PE	1
Sibai, BM	2
McCubbin, JH	1
Anderson, GD	2
Dilts, PV	1
Garden, A	1
Davey, DA	1
Dommisse, J	1
Gant, NF	1
Walss Rodriguez, RJ	1
Flores Padilla, LM	1
Martínez-Abundis, E	1
González-Ortiz, M	1
Cortés-Llamas, V	1
Salazar-Páramo, M	1
Redman, CW	1
Armon, PJ	1
Hibbard, BM	1
Rosen, M	1
Rubin, PC	1
Spinnato, JA	1
Martin, JD	1
Leroux-Robert, C	1
Beaufils, M	1
Richet, G	1
Haller, J	1
Harbert, GM	1
Cornell, GW	1
Thornton, WN	1
Stone, SR	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial[NCT03262961]			Phase 2/Phase 3	80 participants (Anticipated)	Interventional	2016-09-15	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Severe pre-eclampsia and hypertensive crises. Best practice & research. Clinical obstetrics & gynaecology, 2013, Volume: 27, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Antihypertensive Agents; Critical Care; Early Dia	2013
Hypertensive emergencies in pregnancy. Clinical obstetrics and gynecology, 2014, Volume: 57, Issue:4 Topics: Antihypertensive Agents; Eclampsia; Emergencies; Female; Humans; Hydralazine; Hypertension; Hyperten	2014
The control of hypertension in pregnancy. Obstetrics and gynecology annual, 1981, Volume: 10 Topics: Adrenergic beta-Antagonists; Angiotensin II; Antihypertensive Agents; Diazoxide; Diuretics; Eclampsi	1981
Preeclampsia--eclampsia: an overview. The Journal of the Florida Medical Association, 1983, Volume: 70, Issue:9 Topics: Blood Pressure; Eclampsia; Electroencephalography; Female; Hospitalization; Humans; Hydralazine; Inf	1983
Hypertensive crisis. Cardiology clinics, 1984, Volume: 2, Issue:2 Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia	1984
Management of preeclampsia and eclampsia. Kidney international, 1980, Volume: 18, Issue:2 Topics: Anticonvulsants; Antihypertensive Agents; Delivery, Obstetric; Diuretics; Eclampsia; Female; Humans;	1980
Management of eclampsia. Seminars in perinatology, 1994, Volume: 18, Issue:2 Topics: Adult; Anticonvulsants; Antihypertensive Agents; Eclampsia; Female; Fetal Diseases; Fetus; Humans; H	1994
The use of antihypertensive drugs in hypertension in pregnancy. Clinics in obstetrics and gynaecology, 1977, Volume: 4, Issue:3 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Diuretic	1977
Treatment of hypertension in pregnancy. Clinics in obstetrics and gynaecology, 1986, Volume: 13, Issue:2 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Eclampsia; Female; Human	1986

Article	Year
Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy. Clinical and experimental hypertension. Part B, Hypertension in pregnancy, 1982, Volume: 1, Issue:2-3 Topics: Adult; Blood Pressure; Dihydralazine; Eclampsia; Ethanolamines; Female; Fetus; Humans; Hydralazine;	1982
[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents]. Ginecologia y obstetricia de Mexico, 1993, Volume: 61 Topics: Administration, Sublingual; Antihypertensive Agents; Apgar Score; Drug Evaluation; Eclampsia; Female	1993

hydralazine and Eclampsia

Research Excerpts

Research

Studies (45)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Late Postpartum Eclampsia with Postpartum Angiopathy: An Uncommon Diagnosis in the Emergency Department. The Journal of emergency medicine, 2015, Volume: 49, Issue:6 Topics: Adult; Anticonvulsants; Antihypertensive Agents; Drug Therapy, Combination; Eclampsia; Emergency Ser	2015
Postpartum preeclampsia: emergency department presentation and management. The Journal of emergency medicine, 2011, Volume: 40, Issue:4 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Antihypertensive Agents; Benzodiazepines; E	2011
Apresoline (l-hydrazinophthalazine) in the experimental eclampsia-like syndrome and related aspects of water metabolism. The American journal of physiology, 1953, Volume: 175, Issue:2 Topics: Eclampsia; Edema; Female; Hydralazine; Kidney; Pregnancy; Sympatholytics; Syndrome; Water	1953
Apresoline (hydralazine hydrochloride) and its use in cases of hypertensive pregnancy. American journal of obstetrics and gynecology, 1954, Volume: 68, Issue:2 Topics: Eclampsia; Female; Hydralazine; Hypertension; Pre-Eclampsia; Pregnancy; Sympatholytics	1954
[Trial of hydrazinophthalazine therapy of hypertension in two cases of grave eclampsia]. Bulletin de la Federation des societes de gynecologie et dobstetrique de langue francaise, 1953, Volume: 5, Issue:5 Topics: Eclampsia; Female; Hydralazine; Hypertension; Pregnancy; Sympatholytics	1953
[Experimental hydralazine therapy of hypertension in two cases of severe eclampsia]. Bruxelles medical, 1954, Sep-05, Volume: 34, Issue:36 Topics: Eclampsia; Female; Hydralazine; Hypertension; Pregnancy; Sympatholytics; Therapies, Investigational	1954
[Nepresol therapy of eclampsia & pre-eclampsia]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1957, Nov-01, Volume: 77, Issue:21 Topics: Eclampsia; Female; Humans; Hydralazine; Pre-Eclampsia; Pregnancy; Sympatholytics	1957
Routine use of intramuscular apresoline for the prevention of eclampsia. Obstetrics and gynecology, 1959, Volume: 13, Issue:4 Topics: Biomedical Research; Eclampsia; Female; Humans; Hydralazine; Injections, Intramuscular; Pregnancy	1959
[On the treatment of eclampsia]. Zeitschrift fur Geburtshilfe und Gynakologie, 1962, Volume: 159 Topics: Eclampsia; Female; Hibernation; Humans; Hydralazine; Hypothermia, Induced; Pregnancy; Rauwolfia	1962
A SYSTEMATIC APPROACH TO THE THERAPY OF SEVERE PRE-ECLAMPSIA AND ECLAMPSIA. Connecticut medicine, 1963, Volume: 27 Topics: Abortion, Therapeutic; Anesthesia; Anesthesia, Obstetrical; Anticonvulsants; Antihypertensive Agents	1963
THE CONTINUING PROBLEM OF ECLAMPSIA. Surgery, gynecology & obstetrics, 1964, Volume: 118 Topics: Amobarbital; Antihypertensive Agents; Cesarean Section; Eclampsia; Female; Humans; Hydralazine; Hype	1964
RAPID STABILIZATION BY HYPOTENSIVE DRUGS FOLLOWED BY EARLY DELIVERY IN ANTEPARTUM ECLAMPSIA TREATMENT. American journal of obstetrics and gynecology, 1964, May-01, Volume: 89 Topics: Adolescent; Antihypertensive Agents; Cesarean Section; Delivery, Obstetric; Eclampsia; Female; Human	1964
CESAREAN SECTION IN THE ECLAMPTIC PATIENT ON ANTIHYPERTENSIVE THERAPY: A REVIEW OF FOURTEEN CASES. Southern medical journal, 1964, Volume: 57 Topics: Adolescent; Anesthesia; Antihypertensive Agents; Cesarean Section; Child; Drug Therapy; Eclampsia; F	1964
PROGRAM FOR TOXEMIA CONTROL: STUDY OF 551 CASES. American journal of obstetrics and gynecology, 1965, May-01, Volume: 92 Topics: Anticonvulsants; Delivery, Obstetric; Drug Therapy; Eclampsia; Female; Humans; Hydralazine; Pre-Ecla	1965
Presentation and outcome of eclampsia at a Nigerian university hospital. Nigerian journal of clinical practice, 2007, Volume: 10, Issue:1 Topics: Adolescent; Adult; Diazepam; Eclampsia; Female; Hospitals, University; Humans; Hydralazine; Incidenc	2007
Magnesium sulphate therapy in women with pre-eclampsia and eclampsia in Kuwait. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2008, Volume: 17, Issue:3 Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Drug Therapy, Combination; Eclampsia; Fema	2008
Longitudinal evaluation of hemodynamic changes in eclampsia. American journal of obstetrics and gynecology, 1984, Nov-01, Volume: 150, Issue:5 Pt 1 Topics: Adolescent; Adult; Cardiac Output; Delivery, Obstetric; Diuresis; Eclampsia; Female; Fluid Therapy;	1984
[Eclampsia: critical considerations on its therapy]. La Clinica terapeutica, 1983, May-15, Volume: 105, Issue:3 Topics: Anesthesia, Epidural; Benzothiadiazines; Diuresis; Eclampsia; Female; Humans; Hydralazine; Magnesium	1983
The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. American journal of obstetrics and gynecology, 1984, Apr-01, Volume: 148, Issue:7 Topics: Analgesics; Anesthetics; Delivery, Obstetric; Eclampsia; Female; Fetal Death; Fluid Therapy; Humans;	1984
Cortical blindness as a complication of eclampsia. Annals of emergency medicine, 1984, Volume: 13, Issue:5 Topics: Adult; Blindness; Eclampsia; Female; Humans; Hydralazine; Hypertension; Labor, Induced; Oxytocin; Pr	1984
Eclampsia: treatment and referral. Southern medical journal, 1982, Volume: 75, Issue:3 Topics: Adolescent; Adult; Delivery, Obstetric; Eclampsia; Female; Humans; Hydralazine; Infant Mortality; In	1982
Preeclampsia and eclampsia. The Western journal of medicine, 1981, Volume: 135, Issue:1 Topics: Adult; Diazoxide; Eclampsia; Female; Humans; Hydralazine; Magnesium Sulfate; Pre-Eclampsia; Pregnanc	1981
Anticardiolipin antibodies and the severity of preeclampsia-eclampsia. Gynecologic and obstetric investigation, 1999, Volume: 48, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Antibodies, Anticardiolipin; Antihypertensive Agents; Cross-Sectiona	1999
Pre-eclampsia and eclampsia. Tropical doctor, 1978, Volume: 8, Issue:4 Topics: Anesthesia, Obstetrical; Bed Rest; Cesarean Section; Delivery, Obstetric; Eclampsia; Female; Humans;	1978
Management of severe preeclampsia and eclampsia. Seminars in perinatology, 1978, Volume: 2, Issue:1 Topics: Adolescent; Adult; Delivery, Obstetric; Eclampsia; Female; Humans; Hydralazine; Magnesium Sulfate; P	1978
The management of severe pre-eclampsia and eclampsia. British journal of anaesthesia, 1977, Volume: 49, Issue:1 Topics: Chlormethiazole; Delivery, Obstetric; Diazepam; Diuretics; Eclampsia; Female; Humans; Hydralazine; H	1977
Management of eclampsia. British medical journal, 1976, Jul-24, Volume: 2, Issue:6029 Topics: Adult; Chlormethiazole; Clonidine; Eclampsia; Female; Humans; Hydralazine; Pregnancy	1976
Standardized treatment of 154 consecutive cases of eclampsia. American journal of obstetrics and gynecology, 1975, Nov-01, Volume: 123, Issue:5 Topics: Abruptio Placentae; Anesthesia; Bradycardia; Delivery, Obstetric; Diuretics; Eclampsia; Female; Feta	1975
Fetal distress after hydralazine therapy for severe pregnancy-induced hypertension. Southern medical journal, 1986, Volume: 79, Issue:5 Topics: Acute Disease; Cesarean Section; Eclampsia; Female; Fetal Distress; Gestational Age; Humans; Hydrala	1986
A critical survey of drugs used in the treatment of hypertensive crises of pregnancy. The Medical journal of Australia, 1974, Aug-17, Volume: 2, Issue:7 Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Barbiturates; Chlormethiazole; Clonidine; Diazepam;	1974
[Pregnancy toxemia. Mechanism, prevention and treatment]. La Revue du praticien, 1974, Nov-11, Volume: 24, Issue:51 Topics: Blood Coagulation Disorders; Diet, Sodium-Restricted; Diuretics; Eclampsia; Edema; Female; Hospitali	1974
[Therapy of EPH gestosis]. Deutsche medizinische Wochenschrift (1946), 1973, Jul-06, Volume: 98, Issue:27 Topics: Chlorthalidone; Diazepam; Diet Therapy; Eclampsia; Edema; Female; Furosemide; Guanethidine; Humans;	1973
Effect of toxemia therapy on uterine dynamics. American journal of obstetrics and gynecology, 1969, Sep-01, Volume: 105, Issue:1 Topics: Amniotic Fluid; Animals; Arteries; Blood Pressure; Eclampsia; Female; Haplorhini; Humans; Hydralazin	1969
Clinical and laboratory observations on eclampsia. American journal of obstetrics and gynecology, 1967, Nov-15, Volume: 99, Issue:6 Topics: Blood Chemical Analysis; Blood Volume Determination; Cesarean Section; Delivery, Obstetric; Eclampsi	1967