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hydralazine and EHS Tumor

hydralazine has been researched along with EHS Tumor in 19 studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Research Excerpts

ExcerptRelevanceReference
"To test this hypothesis, we reduced blood flow in subcutaneously grown Radiation Induced Fibrosarcoma-1 (RIF-1) tumors, either by creating partial ischemia with a bolus injection of hydralazine or by occlusion with surgical sutures."3.69Reduced blood flow increases the in vivo ammonium ion concentration in the RIF-1 tumor. ( Constantinidis, I; Gamcsik, MP, 1995)
"The effects of the vasodilator hydralazine (HYD) on microcirculatory function and hyperthermic response were studied in early generation isotransplants of a spontaneous C3Hf/Sed mouse fibrosarcoma (FSall)."3.68Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors. ( Kalmus, J; Okunieff, P; Vaupel, P, 1990)
"The effects of the two vasodilating substances, dihydralazine and the adrenergic alpha-receptor blocker phenoxybenzamine, were studied on the distribution and growth of MCG-L-SS metastases from intravenously injected tumour cells."3.65Alteration of metastases distribution by vaso-dilating drugs. ( Boeryd, B; Hagmar, B; Johnsson, G; Ryd, W, 1975)
"When nigericin and EIPA were combined with administration of hydralazine, the surviving fraction of cells in both tumors was reduced by a factor of 0."1.29Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. ( Hasuda, K; Lee, C; Tannock, IF, 1994)
"Hydralazine, which may cause tumour hypoxia and lower pHi as well as pHe, caused cytotoxity when given alone by chronic infusion, and enhanced the cytotoxicity due to nigericin."1.29The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects. ( Tannock, IF; Yamagata, M, 1996)
"Both nigericin and CCCP were observed to penetrate tissue based on their ability to kill tumour cells in spheroids."1.28Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours. ( Newell, K; Stratford, I; Tannock, I; Wood, P, 1992)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.79)18.7374
1990's15 (78.95)18.2507
2000's1 (5.26)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jones, GR1
Frohn, MJ1
Beckett, AH1
Constantinidis, I1
Gamcsik, MP1
Hasuda, K1
Lee, C1
Tannock, IF3
Luo, J1
Bhujwalla, ZM1
Shungu, DC1
Chatham, JC1
Wehrle, JP1
Glickson, JD1
Belfi, CA2
Paul, CR1
Shan, S1
Ngo, FQ2
Yamagata, M1
Lee, J1
Siemann, DW2
Koch, CJ1
Lord, EM1
Rao, BS1
Devi, PU1
Begg, AC1
Hofland, I1
Van Der Pavert, I1
Van Der Schueren, B1
Haustermans, K1
Boeryd, B1
Hagmar, B1
Johnsson, G1
Ryd, W1
Thomas, C1
Counsell, C1
Sansom, J1
Wood, P2
Stratford, I2
Adams, G1
Newell, K1
Tannock, I1
Ting, LL1
Hassenbusch, SJ1
Tefft, M1
Bremner, JC2
Counsell, CJ1
Adams, GE3
Stratford, IJ3
Wood, PJ1
Dunn, JF1
Radda, GK1
Bowler, J1
Kalmus, J1
Okunieff, P1
Vaupel, P1
Godden, J1
Nolan, J1
Howells, N1
Timpson, N1

Other Studies

19 other studies available for hydralazine and EHS Tumor

ArticleYear
Liminal therapy: a strategy for the complete and selective destruction of malignant tissue in situ.
    Medical hypotheses, 1984, Volume: 15, Issue:4

    Topics: Animals; Antineoplastic Agents; Cell Survival; Dihydralazine; Drug Resistance; Energy Metabolism; Hu

1984
Reduced blood flow increases the in vivo ammonium ion concentration in the RIF-1 tumor.
    International journal of radiation oncology, biology, physics, 1995, Aug-30, Volume: 33, Issue:1

    Topics: Animals; Fibrosarcoma; Hydralazine; Ligation; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3

1995
Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH.
    Oncology research, 1994, Volume: 6, Issue:6

    Topics: Amiloride; Animals; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Drug Screening Assays, A

1994
Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy.
    British journal of cancer, 1994, Volume: 70, Issue:4

    Topics: Amiloride; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimida

1994
Glucose metabolism in RIF-1 tumors after reduction in blood flow: an in vivo 13C and 31P NMR study.
    Magnetic resonance in medicine, 1994, Volume: 32, Issue:3

    Topics: Acidosis; Alanine; Animals; Autoradiography; Blood Glucose; Carbon Isotopes; Energy Metabolism; Fema

1994
Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI.
    International journal of radiation oncology, biology, physics, 1994, Jun-15, Volume: 29, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Gadolinium DTPA; Hydralazine; Magnetic Resonance Imaging;

1994
The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.
    British journal of cancer, 1996, Volume: 73, Issue:11

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Antipor

1996
Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts.
    International journal of cancer, 1996, Jul-29, Volume: 67, Issue:3

    Topics: Anemia; Animals; Antibodies, Monoclonal; Carbon Dioxide; Cell Hypoxia; Cell Survival; Etanidazole; F

1996
Multimodality treatment using AK-2123, hydralazine, radiation & hyperthermia on a transplantable mouse tumour.
    The Indian journal of medical research, 1996, Volume: 104

    Topics: Animals; Combined Modality Therapy; Female; Hydralazine; Hyperthermia, Induced; Mice; Mice, Inbred B

1996
Use of thymidine analogues to indicate vascular perfusion in tumours.
    British journal of cancer, 2000, Volume: 83, Issue:7

    Topics: Animals; Blood Flow Velocity; Female; Flow Cytometry; Hydralazine; Idoxuridine; Image Processing, Co

2000
Alteration of metastases distribution by vaso-dilating drugs.
    Pathologia Europaea, 1975, Volume: 10, Issue:3

    Topics: Animals; Dihydralazine; Hydralazine; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred CBA; Neopla

1975
The perfluorocarbon emulsion PFOB: potential indicator of change in blood volume using fluorine-19 NMR spectroscopy.
    EXS, 1992, Volume: 61

    Topics: Animals; Blood Volume; Carcinoma, Squamous Cell; Contrast Media; Fluorocarbons; Hydralazine; Hydroca

1992
Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours.
    British journal of cancer, 1992, Volume: 66, Issue:2

    Topics: Amiloride; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Division; Cell Survival; Fibrosa

1992
Determination of changes in tumor blood perfusion after hydralazine treatment by dynamic paramagnetic-enhanced magnetic resonance imaging.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3

    Topics: Animals; Blood Circulation; Hydralazine; Magnetic Resonance Imaging; Mice; Mice, Inbred C3H; Neoplas

1992
In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts: effects of blood flow modification.
    British journal of cancer, 1991, Volume: 64, Issue:5

    Topics: Animals; Colonic Neoplasms; Humans; Hydralazine; Magnetic Resonance Spectroscopy; Melanoma, Experime

1991
Bioreductive drugs and the selective induction of tumour hypoxia.
    British journal of cancer, 1990, Volume: 61, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Constriction; Hydralazine; Mice; Mice, Inbred C3H; Mis

1990
Enhancement of chemotherapy and nitroimidazole-induced chemopotentiation by the vasoactive agent hydralazine.
    British journal of cancer, 1990, Volume: 62, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cyclophosphamide; Drug Synerg

1990
Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors.
    Cancer research, 1990, Jan-01, Volume: 50, Issue:1

    Topics: Animals; Blood Pressure; Female; Fibrosarcoma; Heart Rate; Hydralazine; Hyperthermia, Induced; Laser

1990
Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine.
    British journal of cancer, 1988, Volume: 58, Issue:2

    Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Hydralazine; Male; Melphal

1988