hydralazine has been researched along with EHS Tumor in 19 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test this hypothesis, we reduced blood flow in subcutaneously grown Radiation Induced Fibrosarcoma-1 (RIF-1) tumors, either by creating partial ischemia with a bolus injection of hydralazine or by occlusion with surgical sutures." | 3.69 | Reduced blood flow increases the in vivo ammonium ion concentration in the RIF-1 tumor. ( Constantinidis, I; Gamcsik, MP, 1995) |
| "The effects of the vasodilator hydralazine (HYD) on microcirculatory function and hyperthermic response were studied in early generation isotransplants of a spontaneous C3Hf/Sed mouse fibrosarcoma (FSall)." | 3.68 | Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors. ( Kalmus, J; Okunieff, P; Vaupel, P, 1990) |
| "The effects of the two vasodilating substances, dihydralazine and the adrenergic alpha-receptor blocker phenoxybenzamine, were studied on the distribution and growth of MCG-L-SS metastases from intravenously injected tumour cells." | 3.65 | Alteration of metastases distribution by vaso-dilating drugs. ( Boeryd, B; Hagmar, B; Johnsson, G; Ryd, W, 1975) |
| "When nigericin and EIPA were combined with administration of hydralazine, the surviving fraction of cells in both tumors was reduced by a factor of 0." | 1.29 | Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. ( Hasuda, K; Lee, C; Tannock, IF, 1994) |
| "Hydralazine, which may cause tumour hypoxia and lower pHi as well as pHe, caused cytotoxity when given alone by chronic infusion, and enhanced the cytotoxicity due to nigericin." | 1.29 | The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects. ( Tannock, IF; Yamagata, M, 1996) |
| "Both nigericin and CCCP were observed to penetrate tissue based on their ability to kill tumour cells in spheroids." | 1.28 | Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours. ( Newell, K; Stratford, I; Tannock, I; Wood, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 15 (78.95) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, GR | 1 |
| Frohn, MJ | 1 |
| Beckett, AH | 1 |
| Constantinidis, I | 1 |
| Gamcsik, MP | 1 |
| Hasuda, K | 1 |
| Lee, C | 1 |
| Tannock, IF | 3 |
| Luo, J | 1 |
| Bhujwalla, ZM | 1 |
| Shungu, DC | 1 |
| Chatham, JC | 1 |
| Wehrle, JP | 1 |
| Glickson, JD | 1 |
| Belfi, CA | 2 |
| Paul, CR | 1 |
| Shan, S | 1 |
| Ngo, FQ | 2 |
| Yamagata, M | 1 |
| Lee, J | 1 |
| Siemann, DW | 2 |
| Koch, CJ | 1 |
| Lord, EM | 1 |
| Rao, BS | 1 |
| Devi, PU | 1 |
| Begg, AC | 1 |
| Hofland, I | 1 |
| Van Der Pavert, I | 1 |
| Van Der Schueren, B | 1 |
| Haustermans, K | 1 |
| Boeryd, B | 1 |
| Hagmar, B | 1 |
| Johnsson, G | 1 |
| Ryd, W | 1 |
| Thomas, C | 1 |
| Counsell, C | 1 |
| Sansom, J | 1 |
| Wood, P | 2 |
| Stratford, I | 2 |
| Adams, G | 1 |
| Newell, K | 1 |
| Tannock, I | 1 |
| Ting, LL | 1 |
| Hassenbusch, SJ | 1 |
| Tefft, M | 1 |
| Bremner, JC | 2 |
| Counsell, CJ | 1 |
| Adams, GE | 3 |
| Stratford, IJ | 3 |
| Wood, PJ | 1 |
| Dunn, JF | 1 |
| Radda, GK | 1 |
| Bowler, J | 1 |
| Kalmus, J | 1 |
| Okunieff, P | 1 |
| Vaupel, P | 1 |
| Godden, J | 1 |
| Nolan, J | 1 |
| Howells, N | 1 |
| Timpson, N | 1 |
19 other studies available for hydralazine and EHS Tumor
| Article | Year |
|---|---|
Liminal therapy: a strategy for the complete and selective destruction of malignant tissue in situ.
Topics: Animals; Antineoplastic Agents; Cell Survival; Dihydralazine; Drug Resistance; Energy Metabolism; Hu | 1984 |
Reduced blood flow increases the in vivo ammonium ion concentration in the RIF-1 tumor.
Topics: Animals; Fibrosarcoma; Hydralazine; Ligation; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3 | 1995 |
Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH.
Topics: Amiloride; Animals; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Drug Screening Assays, A | 1994 |
Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy.
Topics: Amiloride; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimida | 1994 |
Glucose metabolism in RIF-1 tumors after reduction in blood flow: an in vivo 13C and 31P NMR study.
Topics: Acidosis; Alanine; Animals; Autoradiography; Blood Glucose; Carbon Isotopes; Energy Metabolism; Fema | 1994 |
Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI.
Topics: Animals; Dose-Response Relationship, Drug; Gadolinium DTPA; Hydralazine; Magnetic Resonance Imaging; | 1994 |
The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Antipor | 1996 |
Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts.
Topics: Anemia; Animals; Antibodies, Monoclonal; Carbon Dioxide; Cell Hypoxia; Cell Survival; Etanidazole; F | 1996 |
Multimodality treatment using AK-2123, hydralazine, radiation & hyperthermia on a transplantable mouse tumour.
Topics: Animals; Combined Modality Therapy; Female; Hydralazine; Hyperthermia, Induced; Mice; Mice, Inbred B | 1996 |
Use of thymidine analogues to indicate vascular perfusion in tumours.
Topics: Animals; Blood Flow Velocity; Female; Flow Cytometry; Hydralazine; Idoxuridine; Image Processing, Co | 2000 |
Alteration of metastases distribution by vaso-dilating drugs.
Topics: Animals; Dihydralazine; Hydralazine; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred CBA; Neopla | 1975 |
The perfluorocarbon emulsion PFOB: potential indicator of change in blood volume using fluorine-19 NMR spectroscopy.
Topics: Animals; Blood Volume; Carcinoma, Squamous Cell; Contrast Media; Fluorocarbons; Hydralazine; Hydroca | 1992 |
Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours.
Topics: Amiloride; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Division; Cell Survival; Fibrosa | 1992 |
Determination of changes in tumor blood perfusion after hydralazine treatment by dynamic paramagnetic-enhanced magnetic resonance imaging.
Topics: Animals; Blood Circulation; Hydralazine; Magnetic Resonance Imaging; Mice; Mice, Inbred C3H; Neoplas | 1992 |
In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts: effects of blood flow modification.
Topics: Animals; Colonic Neoplasms; Humans; Hydralazine; Magnetic Resonance Spectroscopy; Melanoma, Experime | 1991 |
Bioreductive drugs and the selective induction of tumour hypoxia.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Constriction; Hydralazine; Mice; Mice, Inbred C3H; Mis | 1990 |
Enhancement of chemotherapy and nitroimidazole-induced chemopotentiation by the vasoactive agent hydralazine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cyclophosphamide; Drug Synerg | 1990 |
Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors.
Topics: Animals; Blood Pressure; Female; Fibrosarcoma; Heart Rate; Hydralazine; Hyperthermia, Induced; Laser | 1990 |
Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Hydralazine; Male; Melphal | 1988 |