Page last updated: 2024-10-28

hydralazine and Cerebrovascular Disorders

hydralazine has been researched along with Cerebrovascular Disorders in 39 studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.

Research Excerpts

ExcerptRelevanceReference
"The incidence of thromboembolism and stroke in class II or III congestive heart failure is not high and may not be significantly reduced with warfarin treatment."5.07Incidence of thromboembolic events in congestive heart failure. The V-HeFT VA Cooperative Studies Group. ( Bhat, G; Carson, PE; Cohn, JN; Dunkman, WB; Farrell, L; Johnson, GR, 1993)
"Effects of benidipine hydrochloride or triple therapy (hydralazine, reserpine, and hydrochlorothiazide) on renal cortical and medullary intrinsic antioxidant enzyme (AOE) activity were evaluated in stroke-prone spontaneously hypertensive rats (SHR-SP) as an animal model for human essential hypertension with cerebral stroke."3.69Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP). ( Fukui, M; Shou, I; Takahashi, Y; Tomino, Y; Wang, LN, 1997)
" Treatment of hypertension was begun at 3 months of age with cilazapril (45 mg/kg/day), an angiotensin converting enzyme (ACE) inhibitor, or with hydralazine (18 mg/kg/day)."3.68Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats. ( Baumbach, GL; Hajdu, MA; Heistad, DD, 1991)
" Cerebral infarctions occurred whether or not SHRSP rats were treated with an antihypertensive agent when they were fed a high dosage of L-NNA."1.29Detailed examination of vascular lesions triggered by an inhibitor of endothelium-derived relaxing factor. ( Fujino, H; Ikeda, K; Kubota, A; Nara, Y; Numano, F; Tagami, M; Yamori, Y, 1995)
"It is hypothesized that enlargement of berry aneurysms, the progression of cerebral atherosclerosis, and embolism from carotid lesions might all be decreased by the selection of antihypertensive agents which decrease blood velocity."1.26Effects of antihypertensive drugs on blood velocity: implications for prevention of cerebral vascular disease. ( Spence, JD, 1977)
"So far as hypertension was controlled under about 210 mmHg, no stroke was observed, while nontreated group developed cerebrovascular lesions spontaneously in about 80 per cent."1.25Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR). (2) Prophylactic effect of moderate control of blood pressure on stroke. ( Horie, R; Yamori, Y, 1975)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199028 (71.79)18.7374
1990's11 (28.21)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
SANCHETTI, P1
FAVERO, S1
ATARASHI, J1
YOSHIMURA, M1
NOZAWA, G1
HOSHINO, T1
Howe, PR1
West, MJ1
Provis, JC1
Chalmers, JP1
Ram, CV1
Eninia, GI1
Smeltere, ES1
Godlevska, MA1
Uzulinia, IP1
Freis, E1
Vakaliuk, PM1
Shvedenko, LA1
Iurkevich, ST1
Nikulin, KE1
Ilika, VG1
Murakami, T1
Takemori, K1
Yoshizumi, H1
Tagami, M2
Ikeda, K2
Nara, Y2
Fujino, H1
Kubota, A1
Numano, F1
Yamori, Y3
Dunkman, WB1
Johnson, GR1
Carson, PE1
Bhat, G1
Farrell, L1
Cohn, JN1
Shou, I1
Wang, LN1
Takahashi, Y1
Fukui, M1
Tomino, Y1
Shinyama, H1
Nagai, H1
Kawamura, T1
Narita, Y1
Nakamura, N1
Kagitani, Y1
Wilhelmsen, L1
Berglund, G1
Sannerstedt, R1
Hansson, L1
Andersson, O1
Sievertsson, R1
Wikstrand, J1
Spence, JD1
Becker, CE1
Benowitz, NL1
Fleischmann, LE1
Pascual, AV1
Horie, R1
Okamoto, K2
Ohta, Y2
Chikugo, T2
Shiokawa, H2
Morita, N2
Hamada, Y1
Hajdu, MA1
Heistad, DD1
Baumbach, GL1
Slivka, A1
Coutard, M1
Osborne-Pellegrin, M1
Tanaka, S1
Ishihara, M1
Shibamura, S1
Sekiguchi, F1
Hirohashi, M1
Shirasaki, Y1
Akashi, A1
Harper, SL1
Soltis, EE1
Bohr, DF1
Kilcoyne, MM1
Thomson, GE1
Branche, G1
Williams, M1
Garnier, C1
Chiles, B1
Soland, T1
Freis, ED2
Amery, A1
Fagard, R1
Misotten, A1
Shank, LF1
Ludewig, J1
Finnerty, FA1
Koch-Weser, J1
Laidlaw, JC1
Breslin, DJ1
Vidt, DG1

Reviews

6 reviews available for hydralazine and Cerebrovascular Disorders

ArticleYear
[GENERAL PRINCIPLES IN THE DRUG THERAPY OF CEREBROVASCULAR DISORDERS].
    [Sogo rinsho] Clinic all-round, 1964, Volume: 13

    Topics: Adenosine Triphosphate; Adrenal Cortex Hormones; Antihypertensive Agents; Blood Circulation; Cerebro

1964
Hypertensive crisis.
    Cardiology clinics, 1984, Volume: 2, Issue:2

    Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia

1984
How to manage hypertensive emergencies and urgencies.
    Geriatrics, 1976, Volume: 31, Issue:1

    Topics: Adult; Antihypertensive Agents; Aortic Aneurysm; Brain Diseases; Cerebrovascular Disorders; Diazoxid

1976
Effectiveness of drug therapy in hypertension: present status. A review.
    Circulation research, 1971, Volume: 28, Issue:5

    Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block

1971
Hypertensive emergencies.
    The New England journal of medicine, 1974, Jan-24, Volume: 290, Issue:4

    Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Brain Edema; Cerebrovascular Disorders; Coronary D

1974
Hypertensive crisis.
    The Medical clinics of North America, 1969, Volume: 53, Issue:2

    Topics: Antihypertensive Agents; Brain Edema; Cerebrovascular Disorders; Diazoxide; Emergencies; Humans; Hyd

1969

Trials

4 trials available for hydralazine and Cerebrovascular Disorders

ArticleYear
[Current state of the treatment of arterial hypertension].
    Cardiology, 1980, Volume: 66 Suppl 2

    Topics: Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Heart Failure; Humans; Hydralazine

1980
Incidence of thromboembolic events in congestive heart failure. The V-HeFT VA Cooperative Studies Group.
    Circulation, 1993, Volume: 87, Issue:6 Suppl

    Topics: Cerebrovascular Disorders; Drug Therapy, Combination; Enalapril; Heart Failure; Humans; Hydralazine;

1993
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.
    Circulation, 1972, Volume: 45, Issue:5

    Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu

1972
Hypertension: a challenge in preventive medicine.
    Journal of the Royal College of Physicians of London, 1974, Volume: 9, Issue:1

    Topics: Age Factors; Attitude to Health; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disea

1974

Other Studies

29 other studies available for hydralazine and Cerebrovascular Disorders

ArticleYear
[CLINICAL STUDY OF A NEW COMPLEX HYPOTENSIVE DRUG COMBINATION].
    Gazzetta medica italiana, 1963, Volume: 122

    Topics: Antihypertensive Agents; Arteriosclerosis; Carbamates; Cerebrovascular Disorders; Coronary Disease;

1963
[ON APOPLEXY IN A CERTAIN REGION AND THE PROPHYLACTIC USE OF ANTIHYPERTENSIVE AGENTS].
    [Chiryo] [Therapy], 1964, Volume: 46

    Topics: Adolescent; Antihypertensive Agents; Benzothiadiazines; Cerebrovascular Disorders; Child; Epidemiolo

1964
Content and turnover of noradrenaline in spinal cord and cerebellum of spontaneously hypertensive and stroke-prone rats.
    European journal of pharmacology, 1981, Jul-17, Volume: 73, Issue:2-3

    Topics: Animals; Blood Pressure; Cerebellum; Cerebrovascular Disorders; Female; Hydralazine; Hypertension; M

1981
[Characteristics of the action of gemiton, adelfan and dopegit on cerebral circulation in arterial hypertension].
    Klinicheskaia meditsina, 1984, Volume: 62, Issue:3

    Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disea

1984
[Changes In myocardial contractile function and microcirculation in hypertension].
    Vrachebnoe delo, 1982, Issue:4

    Topics: Adult; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Conjunctiva; Drug Combinations; Dru

1982
Prediction of stroke lesions in stroke-prone spontaneously hypertensive rats by glutathione peroxidase in erythrocytes.
    Bioscience, biotechnology, and biochemistry, 1995, Volume: 59, Issue:8

    Topics: Animals; Antihypertensive Agents; Brain; Cerebrovascular Disorders; Diet; Disease Models, Animal; Er

1995
Detailed examination of vascular lesions triggered by an inhibitor of endothelium-derived relaxing factor.
    Laboratory investigation; a journal of technical methods and pathology, 1995, Volume: 72, Issue:2

    Topics: Animals; Arginine; Arterial Occlusive Diseases; Blood Pressure; Blood Vessels; Cerebrovascular Disor

1995
Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP).
    Journal of clinical laboratory analysis, 1997, Volume: 11, Issue:3

    Topics: Animals; Antioxidants; Blood Pressure; Calcium Channel Blockers; Catalase; Cerebrovascular Disorders

1997
Nitric oxide deficiency induces myocardial infarction in hypercholesterolaemic stroke-prone spontaneously hypertensive rats.
    Clinical and experimental pharmacology & physiology, 1997, Volume: 24, Issue:5

    Topics: Animals; Blood Pressure; Cerebrovascular Disorders; Coronary Vessels; Enzyme Inhibitors; Fibrosis; H

1997
Therapeutic effects of AE0047, a novel calcium antagonist, on progression of brain damage after stroke in stroke-prone spontaneously hypertensive rats.
    General pharmacology, 1998, Volume: 30, Issue:3

    Topics: Animals; Brain; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hydralazine;

1998
Effect of treatment of hypertension in the primary preventive trial, Göteborg, Sweden.
    British journal of clinical pharmacology, 1979, Volume: 7 Suppl 2

    Topics: Adrenergic beta-Antagonists; Bethanidine; Cardiovascular Diseases; Cerebrovascular Disorders; Corona

1979
Effects of antihypertensive drugs on blood velocity: implications for prevention of cerebral vascular disease.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1977, Volume: 4, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Circulation; Blood Flow Velocity; Cerebrovascular Disorders;

1977
Hypertensive emergencies.
    The Medical clinics of North America, 1979, Volume: 63, Issue:1

    Topics: Adrenal Gland Neoplasms; Angiotensin II; Animals; Aortic Aneurysm; Aortic Dissection; Brain Diseases

1979
Management of hypertensive crisis in children.
    Pediatric annals, 1977, Volume: 6, Issue:6

    Topics: Acute Disease; Adolescent; Cerebrovascular Disorders; Child; Child, Preschool; Diazoxide; Humans; Hy

1977
Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR). (2) Prophylactic effect of moderate control of blood pressure on stroke.
    Japanese circulation journal, 1975, Volume: 39, Issue:5

    Topics: Animals; Carbidopa; Carboxy-Lyases; Cerebrovascular Disorders; Heart Rate; Hydralazine; Hypertension

1975
Chronic treatment with captopril, SQ29,852, hydralazine and a 33% fish meal diet in malignant stroke-prone spontaneously hypertensive rats.
    Journal of hypertension, 1991, Volume: 9, Issue:12

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Captopril; Cerebrova

1991
Therapy and prevention of hypertension of M-SHRSP.
    Clinical and experimental hypertension. Part A, Theory and practice, 1991, Volume: 13, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cerebrovascular Disorders; Diet; Disea

1991
Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats.
    Hypertension (Dallas, Tex. : 1979), 1991, Volume: 17, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Blood Pressure; Cerebral Arteries; Ce

1991
Effect of antihypertensive therapy on focal stroke in spontaneously hypertensive rats.
    Stroke, 1991, Volume: 22, Issue:7

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebral Infarction; Cerebrovascular Disorders; Hy

1991
Rupture of the internal elastic lamina and vascular fragility in stroke-prone spontaneously hypertensive rats.
    Stroke, 1991, Volume: 22, Issue:4

    Topics: Animals; Arteries; Atenolol; Blood Pressure; Capillary Fragility; Captopril; Cerebrovascular Disorde

1991
[The effect of an antihypertensive drug budralazine on cerebrovascular lesions in salt-loaded SHR].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1989, Volume: 94, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Brain; Cerebrovascular Disorders; Hyd

1989
Antihypertensive drug therapy prevents cerebral microvascular abnormalities in hypertensive rats.
    Circulation research, 1987, Volume: 60, Issue:2

    Topics: Adaptation, Physiological; Animals; Antihypertensive Agents; Blood Flow Velocity; Cerebrovascular Ci

1987
Vascular reactivity in the spontaneously hypertensive stroke-prone rat. Effect of antihypertensive treatment.
    Hypertension (Dallas, Tex. : 1979), 1987, Volume: 9, Issue:5

    Topics: Animals; Blood Pressure; Calcium; Cerebrovascular Disorders; Female; Femoral Artery; Hydralazine; Hy

1987
Characteristics of hypertension in the black population.
    Circulation, 1974, Volume: 50, Issue:5

    Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders;

1974
[Indications of antihypertensive treatment in non-malignant hypertension].
    Revue medicale de la Suisse romande, 1974, Volume: 94, Issue:8

    Topics: Antihypertensive Agents; Aortic Aneurysm; Benzothiadiazines; Cerebrovascular Disorders; Coronary Dis

1974
Hypertension.
    The Nursing clinics of North America, 1974, Volume: 9, Issue:4

    Topics: Antihypertensive Agents; Blood Pressure Determination; Cerebrovascular Disorders; Diuretics; Drug Co

1974
Aggressive drug therapy in accelerated hypertension.
    The American journal of nursing, 1974, Volume: 74, Issue:12

    Topics: Antihypertensive Agents; Aortic Aneurysm; Brain Diseases; Cerebrovascular Disorders; Diazoxide; Ferr

1974
Hypertension: challenge in preventive medicine.
    Preventive medicine, 1973, Volume: 2, Issue:1

    Topics: Aged; Aneurysm; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebrovascular Disorders; Drug Therap

1973
An approach to the medical treatment of hypertension in the aged.
    Geriatrics, 1969, Volume: 24, Issue:4

    Topics: Age Factors; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Diuretics;

1969