hydralazine and Cardiac Remodeling, Ventricular studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Research Excerpts

Excerpt	Relevance	Reference
"To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF)."	9.41	Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients. ( Lu, Y; Qian, L; Xu, W; Yuan, X, 2021)
"Isosorbide dinitrate combined with hydralazine therapy compared with placebo in patients with heart failure resulted in a sustained increase in left ventricular (LV) ejection fraction (EF) indicative of regression of LV remodeling in the first Vasodilator-Heart Failure Trial (V-HeFT-I) in patients receiving only digoxin and diuretic."	9.12	Isosorbide dinitrate and hydralazine in a fixed-dose combination produces further regression of left ventricular remodeling in a well-treated black population with heart failure: results from A-HeFT. ( Anand, IS; Cohn, JN; Sabolinski, ML; Tam, SW; Taylor, AL; Worcel, M, 2007)
"To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF)."	5.41	Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients. ( Lu, Y; Qian, L; Xu, W; Yuan, X, 2021)
"Isosorbide dinitrate combined with hydralazine therapy compared with placebo in patients with heart failure resulted in a sustained increase in left ventricular (LV) ejection fraction (EF) indicative of regression of LV remodeling in the first Vasodilator-Heart Failure Trial (V-HeFT-I) in patients receiving only digoxin and diuretic."	5.12	Isosorbide dinitrate and hydralazine in a fixed-dose combination produces further regression of left ventricular remodeling in a well-treated black population with heart failure: results from A-HeFT. ( Anand, IS; Cohn, JN; Sabolinski, ML; Tam, SW; Taylor, AL; Worcel, M, 2007)
"Although amlodipine, a long-acting L-type calcium channel blocker, reportedly prevents left ventricular remodeling and dysfunction after myocardial infarction, the mechanism responsible is not yet well understood."	3.74	Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. ( Aoyama, T; Esaki, M; Fujiwara, H; Fujiwara, T; Kanamori, H; Kawasaki, M; Maruyama, R; Minatoguchi, S; Miyata, S; Nakagawa, M; Ogino, A; Okada, H; Takemura, G; Ushikoshi, H, 2007)
"Azelnidipine suppressed cardiac hypertrophy, fibrosis, NADPH oxidase and superoxide in spSHRs more potently than amlodipine, and was associated with lower heart rates than amlodipine."	3.73	Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis. ( Ito, T; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Ogawa, H; Tanaka, T; Tokutomi, Y; Yamamoto, E; Yamashita, T, 2006)
"Both medications prevented left ventricle remodeling, but olmesartan improved cardiomyocyte hypertrophy better than hydralazine."	1.35	Favorable cardiac and aortic remodeling in olmesartan-treated spontaneously hypertensive rats. ( de Souza Mendonça, L; Fernandes-Santos, C; Mandarim-de-Lacerda, CA, 2009)
"Left ventricular remodeling was profoundly changed by statin treatment."	1.31	Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study. ( Bauer, WR; Bauersachs, J; Ertl, G; Fraccarollo, D; Galuppo, P; Haase, A; Hiller, KH; Hu, K; Nahrendorf, M; Schweizer, G, 2002)
"Hydralazine treatment for 2 weeks was less effective on vascular regression with a mean yield of -7."	1.31	Antihypertensive drugs induce structural remodeling of the penile vasculature. ( Adams, MA; Hale, TM; Heaton, JP; Okabe, H, 2001)

Research

Studies (21)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Early Diastolic Mitral Annular Velocity

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (4.76)	18.2507
2000's	15 (71.43)	29.6817
2010's	4 (19.05)	24.3611
2020's	1 (4.76)	2.80

Authors	Studies
Xu, W	1
Qian, L	1
Yuan, X	1
Lu, Y	1
Zamani, P	1
Akers, S	1
Soto-Calderon, H	1
Beraun, M	1
Koppula, MR	1
Varakantam, S	1
Rawat, D	1
Shiva-Kumar, P	1
Haines, PG	1
Chittams, J	1
Townsend, RR	1
Witschey, WR	1
Segers, P	1
Chirinos, JA	1
Fernandes-Santos, C	1
de Souza Mendonça, L	1
Mandarim-de-Lacerda, CA	1
Jacoby, D	1
Albajrami, O	1
Bellumkonda, L	1
Shah, RM	1
Singh, M	1
Bhuriya, R	1
Molnar, J	1
Arora, RR	1
Khosla, S	1
Westermann, D	1
Becher, PM	1
Lindner, D	1
Savvatis, K	1
Xia, Y	1
Fröhlich, M	1
Hoffmann, S	1
Schultheiss, HP	1
Tschöpe, C	1
Nahrendorf, M	1
Hu, K	1
Hiller, KH	1
Galuppo, P	1
Fraccarollo, D	1
Schweizer, G	1
Haase, A	1
Ertl, G	1
Bauer, WR	1
Bauersachs, J	1
Sanada, S	1
Node, K	1
Asanuma, H	2
Ogita, H	1
Takashima, S	1
Minamino, T	2
Asakura, M	1
Hori, M	2
Kitakaze, M	2
Levine, TB	1
Levine, AB	1
Bolenbaugh, J	1
Green, PR	1
Massie, BM	1
Liang, Q	1
Elson, AC	1
Gerdes, AM	1
Yamamoto, E	1
Lai, ZF	1
Yamashita, T	1
Tanaka, T	1
Kataoka, K	1
Tokutomi, Y	1
Ito, T	1
Ogawa, H	1
Kim-Mitsuyama, S	1
McNamara, DM	1
Tam, SW	2
Sabolinski, ML	2
Tobelmann, P	1
Janosko, K	1
Taylor, AL	2
Cohn, JN	3
Feldman, AM	1
Worcel, M	2
Li, Y	1
Takemura, G	2
Okada, H	2
Miyata, S	2
Kanamori, H	2
Maruyama, R	2
Esaki, M	2
Li, L	1
Ogino, A	2
Ohno, T	1
Kondo, T	1
Nakagawa, M	2
Minatoguchi, S	2
Fujiwara, T	2
Fujiwara, H	2
Anand, IS	1
Shi, YX	1
Chen, Y	1
Zhu, YZ	1
Huang, GY	1
Moore, PK	1
Huang, SH	1
Yao, T	1
Zhu, YC	1
Aoyama, T	1
Ushikoshi, H	1
Kawasaki, M	1
Yamazaki, T	1
Yazaki, Y	1
Papst, PJ	1
Ueda, Y	1
Sakata, Y	1
Ogai, A	1
Kuzuya, T	1
Terada, N	1
Hale, TM	1
Okabe, H	1
Heaton, JP	1
Adams, MA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Organic Nitrates and Hydralazine on Wave Reflections and Left Ventricular Structure and Function in Heart Failure With Preserved Ejection Fraction[NCT01516346]	Phase 2	44 participants (Actual)	Interventional	2012-01-31	Completed
Innovative Strategies for Implementing New CHF Guideline Recommendations[NCT00012974]	Phase 1/Phase 2	60 participants (Anticipated)	Interventional	2005-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Diastolic mitral annular velocity measured at the basal septal mitral annulus (NCT01516346)
Timeframe: 24 weeks

LV Mass

Intervention	cm/s (Mean)
Isosorbide Dinitrate	6.8
Isosorbide Dinitrate + Hydralazine	7.3
Placebo	6.5

LV mass measured by MRI, in grams normalized to height in meters raised to the 1.7 power (m^1.7) (NCT01516346)
Timeframe: 24 weeks

Myocardial Extracellular Volume Fraction

Intervention	grams / meters ^1.7 (Mean)
Isosorbide Dinitrate	68.2
Isosorbide Dinitrate + Hydralazine	66.2
Placebo	67.2

Myocardial extracellular volume, expressed as percent of total tissue volume, measured by MRI (T1 mapping pre and post-gadolinium administration) (NCT01516346)
Timeframe: 24 weeks

Quality of Life (Kansas City Cardiomyopathy Questionnaire Score)

Intervention	Percentage (Mean)
Isosorbide Dinitrate	29.0
Isosorbide Dinitrate + Hydralazine	31.3
Placebo	29.5

Quality of life, assessed with the Kansas City cardiomyopathy questionnaire (overall summary score, which ranges from 0 to 100). Higher values imply better quality of life. (NCT01516346)
Timeframe: 24 weeks

Wave Reflection Magnitude

Intervention	Points on a scale (Mean)
Isosorbide Dinitrate	62.1
Isosorbide Dinitrate + Hydralazine	44.9
Placebo	62.1

The dimensionless ratio of backward (reflected) to forward wave amplitude. Higher values imply more wave reflection. (NCT01516346)
Timeframe: 24 weeks

Article	Year
Favorable effects of vasodilators on left ventricular remodeling in asymptomatic patients with chronic moderate-severe aortic regurgitation and normal ejection fraction: a meta-analysis of clinical trials. Clinical cardiology, 2012, Volume: 35, Issue:10 Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aortic Valve Insufficiency; Calci	2012
Role of tissue angiotensin II in myocardial remodelling induced by mechanical stress. Journal of human hypertension, 1999, Volume: 13 Suppl 1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles;	1999
Left ventricle and arteries: structure, function, hormones, and disease. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2 Pt 2 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arginine Vasopressin; Dr	2001

Article	Year
Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients. Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:1(Special) Topics: Aged; Aged, 80 and over; Female; Heart Failure; Humans; Hydralazine; Intercellular Signaling Peptide	2021
Isosorbide Dinitrate, With or Without Hydralazine, Does Not Reduce Wave Reflections, Left Ventricular Hypertrophy, or Myocardial Fibrosis in Patients With Heart Failure With Preserved Ejection Fraction. Journal of the American Heart Association, 2017, 02-20, Volume: 6, Issue:2 Topics: Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Echocardiogr	2017
Isosorbide dinitrate and hydralazine in a fixed-dose combination produces further regression of left ventricular remodeling in a well-treated black population with heart failure: results from A-HeFT. Journal of cardiac failure, 2007, Volume: 13, Issue:5 Topics: Adult; Aged; Black or African American; Drug Therapy, Combination; Female; Heart Failure; Humans; Hy	2007

Article	Year
Favorable cardiac and aortic remodeling in olmesartan-treated spontaneously hypertensive rats. Heart and vessels, 2009, Volume: 24, Issue:3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Hydralazine; Hypertension; Imidazoles; Male; Myocy	2009
Natural history of end-stage LV dysfunction: has it improved from the classic Franciosa and Cohn Graph? Cardiology clinics, 2011, Volume: 29, Issue:4 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Cardiac Resynch	2011
Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo. Basic research in cardiology, 2012, Volume: 107, Issue:6 Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Cyclic GMP-Dependent Protein Kinase Typ	2012
Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study. Journal of the American College of Cardiology, 2002, Nov-06, Volume: 40, Issue:9 Topics: Animals; Disease Models, Animal; Hydralazine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnet	2002
[Opening of ATP-sensitive potassium channel attenuates cardiac remodeling induced by chronic inhibition of nitric oxide synthesis]. Journal of cardiology, 2003, Volume: 41, Issue:1 Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiomegaly; Chromans; Hydralazine; Mitogen-Activa	2003
Reversal of heart failure remodeling: is it maintained? Clinical cardiology, 2003, Volume: 26, Issue:9 Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Cardiomyopathies; Echocardiography; Female	2003
The year in heart failure: 2004. Journal of cardiac failure, 2005, Volume: 11, Issue:1 Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Defibrillator	2005
p38 MAP kinase activity is correlated with angiotensin II type 1 receptor blocker-induced left ventricular reverse remodeling in spontaneously hypertensive heart failure rats. Journal of cardiac failure, 2006, Volume: 12, Issue:6 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cardiomegaly; Female; Heart Failure; Hydralazine;	2006
Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis. Journal of hypertension, 2006, Volume: 24, Issue:10 Topics: Amlodipine; Animals; Azetidinecarboxylic Acid; Cardiomegaly; Dihydropyridines; Endomyocardial Fibros	2006
Aldosterone synthase promoter polymorphism predicts outcome in African Americans with heart failure: results from the A-HeFT Trial. Journal of the American College of Cardiology, 2006, Sep-19, Volume: 48, Issue:6 Topics: Aged; Alleles; Black or African American; Cardiac Output, Low; Cohort Studies; Cytochrome P-450 CYP1	2006
ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:2 Topics: Androstadienes; Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; Cell Proliferation; Fib	2007
Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:4 Topics: Animals; Antihypertensive Agents; Blood Chemical Analysis; Blood Pressure; Cardiomegaly; Cardiotonic	2007
Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:4 Topics: Amlodipine; Animals; Apoptosis; bcl-Associated Death Protein; Calcineurin; Calcineurin Inhibitors; C	2007
Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats. Cardiovascular drugs and therapy, 2000, Volume: 14, Issue:5 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomegaly; Coronary Vessels; D	2000
Antihypertensive drugs induce structural remodeling of the penile vasculature. The Journal of urology, 2001, Volume: 166, Issue:2 Topics: Angiotensin II; Animals; Antihypertensive Agents; Enalapril; Hydralazine; Male; Methoxamine; Penis;	2001

hydralazine and Cardiac Remodeling, Ventricular