hydralazine has been researched along with Aortic Valve Insufficiency in 29 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sudden withdrawal of oral therapy with hydralazine for reduction of afterload in a patient precipitated severe congestive heart failure." | 7.66 | Precipitation of heart failure following sudden withdrawal of hydralazine. ( Black, JR; Mehta, J, 1979) |
| "Hydralazine is a smooth muscle relaxant and a potent arteriolar dilator." | 6.36 | Hydralazine in heart failure. ( Chatterjee, K, 1983) |
| "Sudden withdrawal of oral therapy with hydralazine for reduction of afterload in a patient precipitated severe congestive heart failure." | 3.66 | Precipitation of heart failure following sudden withdrawal of hydralazine. ( Black, JR; Mehta, J, 1979) |
| "Hydralazine-treated patients also had significant decreases in LV end-diastolic and end-systolic volume indexes, and a significant increase in ejection fraction." | 2.67 | Effects of long-term vasodilator therapy on electrocardiographic abnormalities in chronic aortic regurgitation. ( Bristow, JD; Cheitlin, M; Greenberg, B; Jacobson, N; Massie, B; Perlmutter, N; Siemienczuk, D; Szlachcic, J; Wilson, R, 1991) |
| "Hydralazine every 8 hr was associated with side effects in 25% to 86% of patients, but when the drug was given every 12 hr it was associated with side effects in only 5% to 19% of patients (p less than ." | 2.66 | Importance of internal controls, statistical methods, and side effects in short-term trials of vasodilators: a study of hydralazine kinetics in patients with aortic regurgitation. ( Chandraratna, PA; Elkayam, U; Kawanishi, DT; McKay, CR; Nana, M; Rahimtoola, SH; Weiss, JN, 1985) |
| "Hydralazine is a smooth muscle relaxant and a potent arteriolar dilator." | 2.36 | Hydralazine in heart failure. ( Chatterjee, K, 1983) |
| "The effect on myocardial function and structure of long-term administration of quinapril (10-20 mg daily), an angiotensin-converting-enzyme (ACE) inhibitor, was investigated in 24 patients (18 men, 6 women; mean age 48 [20-65] years) with chronic isolated asymptomatic aortic or mitral regurgitation." | 1.29 | [Long-term treatment with quinapril in chronic aortic and mitral insufficiency]. ( Schömig, A; Schön, HR, 1995) |
| "Symptomatic patients with chronic aortic regurgitation should undergo aortic valve replacement." | 1.27 | When to intervene in chronic aortic regurgitation. ( Gaasch, WH; Hoshino, PK, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (72.41) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, RM | 1 |
| Singh, M | 1 |
| Bhuriya, R | 1 |
| Molnar, J | 1 |
| Arora, RR | 1 |
| Khosla, S | 1 |
| Chatterjee, K | 2 |
| Greenberg, BH | 5 |
| Rahimtoola, SH | 7 |
| Sterz, H | 1 |
| Elkayam, U | 2 |
| McKay, CR | 2 |
| Weber, L | 1 |
| Eisenberg, D | 1 |
| Cohn, JN | 1 |
| Rouleau, JL | 1 |
| Massie, BM | 1 |
| Lanas, F | 1 |
| Stokins, B | 1 |
| Saavedra, J | 1 |
| Opazo, JA | 1 |
| Salvatici, R | 1 |
| Schulthess, L | 1 |
| DeMots, H | 2 |
| Murphy, E | 2 |
| Rahimtoola, S | 1 |
| Schön, HR | 1 |
| Schömig, A | 1 |
| Lin, M | 1 |
| Chiang, HT | 1 |
| Lin, SL | 1 |
| Chang, MS | 1 |
| Chiang, BN | 1 |
| Kuo, HW | 1 |
| Cheitlin, MD | 1 |
| Hoffmann, U | 1 |
| Frank, H | 1 |
| Stefenelli, T | 1 |
| Kaiser, B | 1 |
| Klaar, U | 1 |
| Globits, S | 1 |
| Black, JR | 1 |
| Mehta, J | 1 |
| Nauman, D | 1 |
| Greenberg, B | 3 |
| Massie, B | 3 |
| Bristow, JD | 3 |
| Cheitlin, M | 3 |
| Wilson, R | 1 |
| Perlmutter, N | 1 |
| Jacobson, N | 1 |
| Siemienczuk, D | 2 |
| Szlachcic, J | 2 |
| Dumesnil, JG | 1 |
| Tran, K | 1 |
| Dagenais, GR | 1 |
| Crawford, MH | 1 |
| Wilson, RS | 1 |
| O'Rourke, RA | 1 |
| Vittitoe, JA | 1 |
| Topic, N | 1 |
| Wilson, RA | 1 |
| Thomas, D | 1 |
| Lavítola, Pde L | 1 |
| de Moraes, AV | 1 |
| Dallan, L | 1 |
| Grinberg, M | 1 |
| Sosa, EA | 1 |
| Higa, SS | 1 |
| Bessegato, L | 1 |
| Pileggi, F | 1 |
| Florenzano, F | 1 |
| Solé, C | 1 |
| Escobar, E | 2 |
| Morales, B | 1 |
| Kleaveland, JP | 1 |
| Reichek, N | 1 |
| McCarthy, DM | 1 |
| Chandler, T | 1 |
| Priest, C | 1 |
| Muhammed, A | 1 |
| Makler, PT | 1 |
| Hirshfeld, J | 1 |
| Jebavý, P | 1 |
| Koudelková, E | 1 |
| Jandová, R | 1 |
| Frídl, P | 1 |
| Nana, M | 1 |
| Kawanishi, DT | 1 |
| Chandraratna, PA | 1 |
| Weiss, JN | 1 |
| Jalil, J | 1 |
| Thumala, A | 1 |
| Domenech, R | 1 |
| Venegas, P | 1 |
| Hoshino, PK | 1 |
| Gaasch, WH | 1 |
4 reviews available for hydralazine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
Favorable effects of vasodilators on left ventricular remodeling in asymptomatic patients with chronic moderate-severe aortic regurgitation and normal ejection fraction: a meta-analysis of clinical trials.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aortic Valve Insufficiency; Calci | 2012 |
Hydralazine in heart failure.
Topics: Animals; Aortic Valve Insufficiency; Cardiac Output; Cats; Coronary Circulation; Exercise Test; Hear | 1983 |
Vasodilator therapy of congestive heart failure.
Topics: Aortic Valve Insufficiency; Captopril; Dobutamine; Heart Failure; Humans; Hydralazine; Isosorbide Di | 1980 |
Vasodilator therapy in chronic severe aortic regurgitation.
Topics: Aortic Valve Insufficiency; Chronic Disease; Digitalis Glycosides; Echocardiography; Hemodynamics; H | 1990 |
7 trials available for hydralazine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
Vasodilator therapy in chronic asymptomatic aortic regurgitation: enalapril versus hydralazine therapy.
Topics: Aged; Aortic Valve Insufficiency; Chronic Disease; Double-Blind Method; Echocardiography; Enalapril; | 1994 |
Effects of long-term vasodilator therapy on electrocardiographic abnormalities in chronic aortic regurgitation.
Topics: Adult; Aortic Valve Insufficiency; Cardiac Volume; Chronic Disease; Double-Blind Method; Electrocard | 1991 |
Effect of digoxin and vasodilators on left ventricular function in aortic regurgitation.
Topics: Adult; Analysis of Variance; Aortic Valve Insufficiency; Digoxin; Echocardiography; Exercise Test; H | 1989 |
Long-term vasodilator therapy of chronic aortic insufficiency. A randomized double-blinded, placebo-controlled clinical trial.
Topics: Administration, Oral; Adult; Aortic Valve Insufficiency; Blood Volume; Clinical Trials as Topic; Dia | 1988 |
[Comparative study of vasodilator drugs in heart valve diseases].
Topics: Adolescent; Adult; Aortic Valve Insufficiency; Clinical Trials as Topic; Echocardiography; Female; H | 1987 |
Effects of six-month afterload reduction therapy with hydralazine in chronic aortic regurgitation.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Clinical Trials as Topic; Echocardiography; E | 1986 |
Importance of internal controls, statistical methods, and side effects in short-term trials of vasodilators: a study of hydralazine kinetics in patients with aortic regurgitation.
Topics: Adult; Aged; Aortic Valve Insufficiency; Clinical Trials as Topic; Dose-Response Relationship, Drug; | 1985 |
18 other studies available for hydralazine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
Long-term vasodilator therapy in aortic insufficiency. Evidence for regression of left ventricular dilatation and hypertrophy and improvement in systolic pump function.
Topics: Aortic Valve Insufficiency; Cardiac Catheterization; Cardiomegaly; Female; Humans; Hydralazine; Midd | 1980 |
[Causes of acute valve-conditioned left ventricular insufficiency-- attempt at a tabulated review].
Topics: Aortic Valve Insufficiency; Cardiac Glycosides; Dyspnea; Endocarditis, Bacterial; Humans; Hydralazin | 1984 |
Favorable effects of hydralazine on the hemodynamic response to isometric exercise in chronic severe aortic regurgitation.
Topics: Adult; Aged; Aortic Valve Insufficiency; Blood Pressure; Female; Heart Rate; Hemodynamics; Humans; H | 1984 |
Usefulness of vasodilator therapy in acute and chronic valvular regurgitation.
Topics: Aortic Valve; Aortic Valve Insufficiency; Combined Modality Therapy; Digoxin; Drug Therapy, Combinat | 1984 |
Hydralazine in chronic CHF.
Topics: Administration, Oral; Aortic Valve Insufficiency; Cardiac Output; Chronic Disease; Drug Therapy, Com | 1981 |
[Hydralazine in patients with severe aortic insufficiency. Effect on ventricular pressure and volume].
Topics: Adult; Aortic Valve Insufficiency; Cardiac Volume; Echocardiography; Exercise Test; Heart Ventricles | 1982 |
Vasodilator therapy for valvular heart disease.
Topics: Aortic Valve Insufficiency; Cardiac Output, Low; Heart Valve Diseases; Hemodynamics; Humans; Hydrala | 1981 |
Beneficial effects of hydralazine on rest and exercise hemodynamics in patients with chronic severe aortic insufficiency.
Topics: Adult; Aged; Aortic Valve Insufficiency; Blood Pressure; Chronic Disease; Exercise Test; Female; Hea | 1980 |
Mechanism for improved cardiac performance with arteriolar dilators in aortic insufficiency.
Topics: Adult; Aged; Aortic Valve Insufficiency; Arterioles; Blood Pressure; Female; Heart Rate; Humans; Hyd | 1981 |
[Long-term treatment with quinapril in chronic aortic and mitral insufficiency].
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Aortic Valve Insufficiency; Chronic Disease; | 1995 |
Afterload reduction in severe aortic regurgitation.
Topics: Adult; Aortic Valve Insufficiency; Feasibility Studies; Female; Hemodynamics; Humans; Hydralazine; M | 2001 |
Precipitation of heart failure following sudden withdrawal of hydralazine.
Topics: Administration, Oral; Aged; Aortic Valve Insufficiency; Digoxin; Furosemide; Heart Failure; Hemodyna | 1979 |
Effects of stopping long-term vasodilator therapy in patients with chronic aortic insufficiency.
Topics: Adult; Aortic Valve Insufficiency; Female; Follow-Up Studies; Humans; Hydralazine; Male; Radionuclid | 1992 |
Beneficial long-term effects of hydralazine in aortic regurgitation.
Topics: Adult; Aortic Valve Insufficiency; Echocardiography; Female; Follow-Up Studies; Humans; Hydralazine; | 1990 |
[Effect of hydralazine on the ventricular function in chronic aortic insufficiency].
Topics: Adolescent; Adult; Aortic Valve Insufficiency; Cardiac Output; Exercise Test; Female; Heart Ventricl | 1987 |
[The effect of dihydralazine on aortic regurgitation].
Topics: Adult; Aortic Valve Insufficiency; Dihydralazine; Female; Hemodynamics; Humans; Hydralazine; Male; M | 1986 |
[Vasodilator agents in chronic asymptomatic aortic insufficiency: echocardiographic study].
Topics: Adult; Aged; Aortic Valve Insufficiency; Captopril; Chronic Disease; Echocardiography; Female; Hemod | 1985 |
When to intervene in chronic aortic regurgitation.
Topics: Aortic Valve Insufficiency; Chronic Disease; Echocardiography; Heart Ventricles; Humans; Hydralazine | 1986 |