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hydralazine and Anoxemia

hydralazine has been researched along with Anoxemia in 15 studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Research Excerpts

ExcerptRelevanceReference
" In this study, we have evaluated the potential of one such agent under study, namely hydralazine, which was shown earlier to enhance hypoxia inducible factor-1α (HIF-1α) levels in experimental animal systems."7.75Hypoxic pre-conditioning in a rat renal ischemia model: an evaluation of the use of hydralazine. ( Chander, P; Choudhury, M; Dorai, T; Grasso, M; Michels, C, 2009)
"To evaluate the potency of vasodilatory drugs in hypoxia, we studied the effects of nitroglycerin (NTG), prostaglandin E1 (PGE1), and hydralazine on porcine coronary artery constricted with endothelin-1 (ET-1) in both oxygenated and hypoxic conditions."7.69Hypoxia modifies the vasodilatory effects of nitroglycerin, prostaglandin E1, and hydralazine on isolated porcine coronary arteries. ( Fujihara, H; Fujiwara, N; Fukuda, S; Sakuma, K; Shimoji, K; Tanaka, T; Toriumi, T; Tsukui, A, 1994)
"Administration of hydralazine in patients with pulmonary hypertension has been reported to cause excessive systemic vasodilatation, limiting its clinical utility (N Engl J Med 1982; 306: 1326)."7.67Continuous, low dose of hydralazine, reduces acute hypoxic pulmonary hypertension without a corresponding fall in systemic arterial pressure. ( Kobayashi, T; Yoshimura, K, 1986)
" In this study, we have evaluated the potential of one such agent under study, namely hydralazine, which was shown earlier to enhance hypoxia inducible factor-1α (HIF-1α) levels in experimental animal systems."3.75Hypoxic pre-conditioning in a rat renal ischemia model: an evaluation of the use of hydralazine. ( Chander, P; Choudhury, M; Dorai, T; Grasso, M; Michels, C, 2009)
"To evaluate the potency of vasodilatory drugs in hypoxia, we studied the effects of nitroglycerin (NTG), prostaglandin E1 (PGE1), and hydralazine on porcine coronary artery constricted with endothelin-1 (ET-1) in both oxygenated and hypoxic conditions."3.69Hypoxia modifies the vasodilatory effects of nitroglycerin, prostaglandin E1, and hydralazine on isolated porcine coronary arteries. ( Fujihara, H; Fujiwara, N; Fukuda, S; Sakuma, K; Shimoji, K; Tanaka, T; Toriumi, T; Tsukui, A, 1994)
"Administration of hydralazine in patients with pulmonary hypertension has been reported to cause excessive systemic vasodilatation, limiting its clinical utility (N Engl J Med 1982; 306: 1326)."3.67Continuous, low dose of hydralazine, reduces acute hypoxic pulmonary hypertension without a corresponding fall in systemic arterial pressure. ( Kobayashi, T; Yoshimura, K, 1986)
"In contrast, N2 breathing to terminal anoxia and intravenous hydralazine produced a negligible increase in Hb, but large reductions in HbO and HbT."1.33The effects of tumour blood flow and oxygenation modifiers on subcutaneous tumours as determined by NIRS. ( Connelly, JP; Griffiths, JR; Howe, FA; Robinson, SP; Springett, R, 2005)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19908 (53.33)18.7374
1990's2 (13.33)18.2507
2000's2 (13.33)29.6817
2010's2 (13.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Voirin, AC1
Chatard, M2
Briançon-Marjollet, A1
Pepin, JL1
Perek, N2
Roche, F2
Kawaguchi, A1
Isayama, T1
Mori, R1
Minami, H1
Yang, Y1
Tamura, M1
Puech, C1
Michels, C1
Dorai, T1
Chander, P1
Choudhury, M1
Grasso, M1
KIRPEKAR, SM1
LEWIS, JJ1
Howe, FA1
Connelly, JP1
Robinson, SP1
Springett, R1
Griffiths, JR1
Rubin, LJ1
Bishop, MJ1
Kennard, S1
Artman, LD1
Cheney, FW1
Rüegger, M1
Medici, TC1
Stanbrook, HS1
Morris, KG1
McMurtry, IF1
Fukuda, S1
Sakuma, K1
Tsukui, A1
Fujiwara, N1
Tanaka, T1
Fujihara, H1
Toriumi, T1
Shimoji, K1
Abakumov, GZ1
Lukienko, PI1
Canby, CA1
Tomanek, RJ1
Bell, JM1
Whitmore, WL1
Slotkin, TA1
Yoshimura, K1
Kobayashi, T1

Reviews

2 reviews available for hydralazine and Anoxemia

ArticleYear
Hydralazine in infants with persistent hypoxemic respiratory failure.
    The Cochrane database of systematic reviews, 2013, Feb-28, Issue:2

    Topics: Antihypertensive Agents; Humans; Hydralazine; Hypoxia; Infant; Infant, Newborn; Infant, Premature; R

2013
Cardiovascular effects of vasodilator therapy for pulmonary arterial hypertension.
    Clinics in chest medicine, 1983, Volume: 4, Issue:2

    Topics: Cardiac Output; Echocardiography; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Hypote

1983

Other Studies

13 other studies available for hydralazine and Anoxemia

ArticleYear
Loss of Blood-Brain Barrier Integrity in an In Vitro Model Subjected to Intermittent Hypoxia: Is Reversion Possible with a HIF-1α Pathway Inhibitor?
    International journal of molecular sciences, 2023, Mar-06, Volume: 24, Issue:5

    Topics: Astrocytes; Blood-Brain Barrier; Endothelial Cells; Humans; Hydralazine; Hypoxia

2023
Hypoxic Stress Induced by Hydralazine Leads to a Loss of Blood-Brain Barrier Integrity and an Increase in Efflux Transporter Activity.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Animals; Biological Transport; Biomarkers; Blood-Brain Barrier; Cell Survival; Hydralazine; Hypoxia;

2016
Hypoxic pre-conditioning in a rat renal ischemia model: an evaluation of the use of hydralazine.
    World journal of urology, 2009, Volume: 27, Issue:6

    Topics: Animals; Blood Urea Nitrogen; Disease Models, Animal; Hydralazine; Hypoxia; Hypoxia-Inducible Factor

2009
Antagonism to the actions of hydrallazine, reserpine, potassium cyanide, sodium azide and anoxia on arterial smooth muscle.
    The Journal of pharmacy and pharmacology, 1958, Volume: 10, Issue:5

    Topics: Arteries; Azides; Carbohydrate Metabolism; Carbohydrates; Cyanides; Fats; Hydralazine; Hypoxia; Lipi

1958
The effects of tumour blood flow and oxygenation modifiers on subcutaneous tumours as determined by NIRS.
    Advances in experimental medicine and biology, 2005, Volume: 566

    Topics: Animals; Carbon Dioxide; Female; Hemoglobins; Hydralazine; Hyperoxia; Hypoxia; Magnetic Resonance Im

2005
Hydralazine does not inhibit canine hypoxic pulmonary vasoconstriction.
    The American review of respiratory disease, 1983, Volume: 128, Issue:6

    Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Hydralazine; Hypoxia; Nitroprusside; Pulmonary Artery

1983
[New therapies for cor pulmonale?].
    Deutsche medizinische Wochenschrift (1946), 1983, Dec-09, Volume: 108, Issue:49

    Topics: Bloodletting; Humans; Hydralazine; Hypertension, Pulmonary; Hypoxia; Iron; Lung Diseases, Obstructiv

1983
Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists.
    The American review of respiratory disease, 1984, Volume: 130, Issue:1

    Topics: Animals; Dimethyl Sulfoxide; Hydralazine; Hypertension, Pulmonary; Hypoxia; Male; Nifedipine; Pulmon

1984
Hypoxia modifies the vasodilatory effects of nitroglycerin, prostaglandin E1, and hydralazine on isolated porcine coronary arteries.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:5

    Topics: Alprostadil; Analysis of Variance; Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Endothelins; H

1994
[Effect of apressin, obsidan, diprazine and their combination on the concentration of NAD and NADH2 in the liver and brain of hypoxic rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1978, Volume: 86, Issue:8

    Topics: Acute Disease; Animals; Brain Chemistry; Drug Combinations; Female; Hydralazine; Hypoxia; Liver; NAD

1978
Regression of ventricular hypertrophy abolishes cardiocyte vulnerability to acute hypoxia.
    The Anatomical record, 1990, Volume: 226, Issue:2

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Heart; Hemodynami

1990
Neonatal nutritional deprivation or enhancement: the cardiac-sympathetic axis and its role in cardiac growth and stress responses.
    Pediatric research, 1988, Volume: 23, Issue:4

    Topics: Age Factors; Animals; Animals, Newborn; Female; Heart; Hydralazine; Hypoxia; Isoproterenol; Male; My

1988
Continuous, low dose of hydralazine, reduces acute hypoxic pulmonary hypertension without a corresponding fall in systemic arterial pressure.
    Japanese circulation journal, 1986, Volume: 50, Issue:10

    Topics: Animals; Blood Pressure; Female; Hydralazine; Hypertension, Pulmonary; Hypoxia; Male; Sheep

1986