Page last updated: 2024-10-28

hydralazine and Anesthesia

hydralazine has been researched along with Anesthesia in 30 studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"The role of the sympatho-adrenal system in the production of tachycardia accompanying the hypotensive response to hydralazine was studied in urethane-anesthetized rats subjected to previous bilateral adrenal demedullation or to pretreatment with 6-hydroxydopamine and compared with intact control animals."7.67Role of the sympatho-adrenal system in the reflex tachycardia produced by hydralazine in the anesthetized rat. ( García-Márquez, F; Vidrio, H, 1986)
" It has also been used intravenously in phaeochromocytoma, tetanus, clonidine withdrawal, and as an adjunct to halothane to produce hypotensive anaesthesia."4.76Combined alpha- and beta-receptor inhibition in the treatment of hypertension. ( Prichard, BN, 1984)
"The role of the sympatho-adrenal system in the production of tachycardia accompanying the hypotensive response to hydralazine was studied in urethane-anesthetized rats subjected to previous bilateral adrenal demedullation or to pretreatment with 6-hydroxydopamine and compared with intact control animals."3.67Role of the sympatho-adrenal system in the reflex tachycardia produced by hydralazine in the anesthetized rat. ( García-Márquez, F; Vidrio, H, 1986)
"Sixteen patients (13-38 yr) undergoing spinal fusion for scoliosis under controlled hypotension were studied to determine the haemodynamic and neuroendocrine responses to IV dihydralazine (1."3.67Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. ( Bourreli, B; Drouet, JC; Gunst, JP; Passuti, N; Pinaud, M; Remi, JP, 1988)
" Relative to the conscious state, ether anesthesia decreased mean arterial pressure 9%, total peripheral resistance 47%, oxygen extraction 37%, and heart rate 7%; changes were qualitatively similar to those produced by hydralazine (0."3.66Ether-induced vasodilation in the rat. ( Ferrone, RA; Walsh, GM, 1979)
" To determine if the enhanced sympathetic response to PH stimulation seen in adult SHR is an intrinsic difference rather than secondary to sustained hypertension, we maintained SHR normotensive from four weeks of age with antihypertensive drug therapy (clonidine or hydralazine)."3.66Effect of hypothalamic stimulation in spontaneously hypertensive and Wistar-Kyoto rats. ( Juskevich, JC; Robinson, DS; Whitehorn, D, 1978)
"Since 1955 standardized treatment applied uniformly to all cases of eclampsia at Parkland Memorial Hospital has consisted of (1) magnesium sulfate intravenously and intramuscularly to control convulsions, (2) intravenous hydralazine intermittently to lower diastolic blood pressure when it exceeded 110 mm."3.65Standardized treatment of 154 consecutive cases of eclampsia. ( Pritchard, JA; Pritchard, SA, 1975)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199024 (80.00)18.7374
1990's5 (16.67)18.2507
2000's1 (3.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vidrio, H4
Medina, M1
González-Romo, P1
Lorenzana-Jiménez, M1
Díaz-Arista, P1
Baeza, A1
HUEGIN, W1
HARDWICK, DF1
STRAUSS, J1
MISRAHY, GA1
DAVIS, CD1
ALEXANDER, JA1
ROGERS, SF1
JACOBS, WM1
WILLS, SH1
BALMER, VG1
Prichard, BN1
Chiba, T1
Hirohashi, M1
Suzuki, I1
Tanaka, S1
Watanabe, K1
Akashi, A1
Spokas, EG1
Wang, HH1
Dage, RC1
Hsieh, CP1
McLeod, RL1
Gertner, SB1
Hey, JA1
Johnson, BM1
Bing, J1
Poulsen, K1
Albrecht, RF1
Toyooka, ET1
Polk, SL1
Zahed, B1
Walsh, GM1
Ferrone, RA1
Juskevich, JC1
Robinson, DS1
Whitehorn, D1
Pritchard, JA1
Pritchard, SA1
Sansone, M1
Pavone, F1
Battaglia, M1
Daniel, W1
Vetulani, J1
Orallo, F1
Fontenla, JA1
Loza, MI1
Campos, M1
Calleja, JM1
Rankin, AJ1
Swift, FV1
García-Márquez, F2
Shapira, Y1
Gertel, M1
Yukimura, T1
Miura, K1
Tanaka, M1
Higashio, T1
Sakaguchi, S1
Kuroda, K1
Yamamoto, K1
Bourreli, B1
Pinaud, M1
Passuti, N1
Gunst, JP1
Drouet, JC1
Remi, JP1
Geh, SL1
Nott, MW1
Majewski, H1
Rand, MJ1
Morimoto, S1
Matsumura, Y1
Sasaki, Y1
Takakuwa, T1
Kageyama, M1
Siegl, PK1
Wenger, HC1
Bouclier, M1
Spedding, M1

Reviews

5 reviews available for hydralazine and Anesthesia

ArticleYear
[PROBLEMS OF ANESTHESIA IN PATIENTS UNDER TREATMENT OF HYPERTENSION].
    Der Anaesthesist, 1963, Volume: 12

    Topics: Anesthesia; Antihypertensive Agents; Bretylium Compounds; Cardiovascular Diseases; Chlorothiazide; C

1963
ANTIHYPERTENSIVE DRUGS AND GENERAL ANAESTHESIA.
    The Medical journal of Australia, 1965, Jan-30, Volume: 1, Issue:5

    Topics: Anesthesia; Anesthesia, General; Antihypertensive Agents; Bretylium Compounds; Carbamates; Diuretics

1965
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.
    Drugs, 1984, Volume: 28 Suppl 2

    Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Antihyp

1984
Hydralazine therapy for hypertension during the anesthetic and postanesthetic periods.
    International anesthesiology clinics, 1978,Summer, Volume: 16, Issue:2

    Topics: Anesthesia; Humans; Hydralazine; Hypertension; Postoperative Care; Surgical Procedures, Operative; T

1978
[New drugs for deliberate hypotension in anesthesia].
    Harefuah, 1988, Jan-15, Volume: 114, Issue:2

    Topics: Anesthesia; Animals; Humans; Hydralazine; Hypotension, Controlled; Isoflurane; Labetalol

1988

Other Studies

25 other studies available for hydralazine and Anesthesia

ArticleYear
Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Amine Oxidase (Copper-Containing); Anesthesia; Animals; Aorta; Hydralazine; Hydrogen Peroxide; Hypot

2003
KIDNEY OXYGEN AVAILABILITY.
    The American journal of physiology, 1963, Volume: 205

    Topics: Amobarbital; Anesthesia; Anesthesia, Spinal; Arginine Vasopressin; Bone Marrow; Carbon Dioxide; Cats

1963
A SYSTEMATIC APPROACH TO THE THERAPY OF SEVERE PRE-ECLAMPSIA AND ECLAMPSIA.
    Connecticut medicine, 1963, Volume: 27

    Topics: Abortion, Therapeutic; Anesthesia; Anesthesia, Obstetrical; Anticonvulsants; Antihypertensive Agents

1963
CESAREAN SECTION IN THE ECLAMPTIC PATIENT ON ANTIHYPERTENSIVE THERAPY: A REVIEW OF FOURTEEN CASES.
    Southern medical journal, 1964, Volume: 57

    Topics: Adolescent; Anesthesia; Antihypertensive Agents; Cesarean Section; Child; Drug Therapy; Eclampsia; F

1964
Characterization of the vasodilator action of antihypertensive drug budralazine.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:1

    Topics: Anesthesia; Animals; Antihypertensive Agents; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Dogs; Ear, Ex

1983
Regional blood flow and cardiac responses to hydralazine.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 212, Issue:2

    Topics: Anesthesia; Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Carotid Arteries; Corona

1980
Direct vasodilatation by labetalol in anaesthetized dogs.
    British journal of pharmacology, 1980, Volume: 70, Issue:2

    Topics: Adrenalectomy; Anesthesia; Animals; Clonidine; Diazoxide; Dogs; Ethanolamines; Female; Hemodynamics;

1980
Production by R-alpha-methylhistamine of a histamine H3 receptor-mediated decrease in basal vascular resistance in guinea-pigs.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Adrenalectomy; Anesthesia; Animals; Cardiac Output; Dose-Response Relationship, Drug; Guinea Pigs; H

1993
The use of radioactive microspheres to compare the effects of hydralazine, guanethidine and SK & F 24260 on the redistribution of cardiac output in anaesthetized rabbits.
    British journal of pharmacology, 1975, Volume: 55, Issue:3

    Topics: Anesthesia; Animals; Blood Pressure; Cardiac Output; Dihydropyridines; Guanethidine; Heart Rate; Hyd

1975
Time course of changes in plasma renin after blockade of the renin-system. Studies of conscious and anaesthetized, normal, adrenalectomized and spontaneously hypertensive rats.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1975, Volume: 83, Issue:5

    Topics: Adrenalectomy; Anesthesia; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood

1975
Ether-induced vasodilation in the rat.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 24, Issue:1

    Topics: Anesthesia; Animals; Cardiac Output; Ether; Ethyl Ethers; Hemodynamics; Hydralazine; Male; Rats; Tim

1979
Effect of hypothalamic stimulation in spontaneously hypertensive and Wistar-Kyoto rats.
    European journal of pharmacology, 1978, Oct-15, Volume: 51, Issue:4

    Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Electric Stimulation; Hydralazine; Hypertension; Hyp

1978
Standardized treatment of 154 consecutive cases of eclampsia.
    American journal of obstetrics and gynecology, 1975, Nov-01, Volume: 123, Issue:5

    Topics: Abruptio Placentae; Anesthesia; Bradycardia; Delivery, Obstetric; Diuretics; Eclampsia; Female; Feta

1975
Similar effects of nifedipine and hydralazine on anaesthesia and hypermotility induced by pentobarbitone in mice.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:5

    Topics: Anesthesia; Animals; Drug Interactions; Hemodynamics; Hydralazine; Male; Mice; Motor Activity; Nifed

1992
Effect of urethane on hydralazine-induced tachycardia in rats.
    General pharmacology, 1992, Volume: 23, Issue:6

    Topics: Anesthesia; Animals; Blood Pressure; Decerebrate State; Heart Atria; Heart Rate; Hydralazine; In Vit

1992
Interaction with pyridoxal as a possible mechanism of hydralazine hypotension.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Cinnarizine; Dose-Response Relationship, Drug; Hydralazine; Inj

1990
The inotropic effect of atrial natriuretic factor in the anesthetized rabbit.
    Pflugers Archiv : European journal of physiology, 1990, Volume: 417, Issue:4

    Topics: Anesthesia; Animals; Atrial Natriuretic Factor; Blood Pressure; Coronary Vessels; Dose-Response Rela

1990
Role of the sympatho-adrenal system in the reflex tachycardia produced by hydralazine in the anesthetized rat.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 283, Issue:1

    Topics: Adrenal Glands; Adrenal Medulla; Anesthesia; Animals; Atropine; Blood Pressure; Heart Rate; Hydralaz

1986
Effects of cadralazine on systemic blood pressure, renal function and plasma renin activity in anesthetized dogs.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:1

    Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Drug Interactions; Female; Heart

1988
Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1988, Volume: 35, Issue:3 ( Pt 1)

    Topics: Adolescent; Adult; Anesthesia; Anesthetics; Dihydralazine; Drug Synergism; Enflurane; Female; Humans

1988
Effect of captopril on blood pressure responses to enkephalins in chloralose-anaesthetized rats.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 279, Issue:2

    Topics: Anesthesia; Animals; Blood Pressure; Captopril; Chloralose; Enkephalins; Heart Rate; Hydralazine; Ma

1986
Diuretic effect induced by intrarenal infusion of pinacidil in anesthetized dogs.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3

    Topics: Anesthesia; Animals; Blood Pressure; Bradykinin; Diuretics; Dogs; Glomerular Filtration Rate; Guanid

1987
Reversal by hypothermia of vasodilator-induced tachycardia in anesthetized rats.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 288, Issue:2

    Topics: Acetylcholine; Anesthesia; Animals; Blood Pressure; Body Temperature; Diazoxide; Heart Rate; Hydrala

1987
Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog.
    European journal of pharmacology, 1985, Jul-31, Volume: 113, Issue:3

    Topics: Anesthesia; Animals; Dinoprost; Dogs; Epoprostenol; Female; Hemodynamics; Hydralazine; Male; Nifedip

1985
Differential effects of calcium channel antagonists on histamine and pentagastrin-stimulated gastric acid secretion in the rat.
    Agents and actions, 1985, Volume: 16, Issue:6

    Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Gastric Acid; Histamine; Hydralazine;

1985